Engineering of l-threonine and l-proline biosensors by directed evolution of transcriptional regulator SerR and application for high-throughput screening by Wei Pu, Jinhui Feng, Jiuzhou Chen, Jiao Liu, Xuan Guo, Lixian Wang, Xiaojia Zhao, Ningyun Cai, Wenjuan Zhou, Yu Wang, Ping Zheng, Jibin Sun

“…The development of efficient high-throughput screening technologies utilizing biosensors is essential for the rapid identification of high-performance amino acid producers. …”
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Surgical treatment after neoadjuvant systemic therapy for HER2-positive invasive breast cancer in the Netherlands: 10-Year trends and the influence an accompanying DCIS component by Roxanne A.W. Ploumen, Thiemo J.A. van Nijnatten, Loes F.S. Kooreman, Adri C. Voogd, Kristien B.M.I. Keymeulen, Sabine Siesling, Marjolein L. Smidt

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Leveraging machine learning and rule extraction for enhanced transparency in emergency department length of stay prediction by Waqar A. Sulaiman, Charithea Stylianides, Andria Nikolaou, Andria Nikolaou, Zinonas Antoniou, Ioannis Constantinou, Lakis Palazis, Anna Vavlitou, Theodoros Kyprianou, Theodoros Kyprianou, Efthyvoulos Kyriacou, Antonis Kakas, Antonis Kakas, Marios S. Pattichis, Andreas S. Panayides, Constantinos S. Pattichis, Constantinos S. Pattichis

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Analisis dan Perbaikan Proses Bisnis Sistem Terintegrasi Pembayaran Uang Kuliah dengan Metode Business Process Improvement (BPI) pada Universitas X by Ni Wayan Emmy Rosiana Dewi, Putu Yogie Ayu Nirmala, I Made Suwija Putra, A.A. Kompiang Oka Sudana

“…Abstract   Over the past few years, the role of technology has grown rapidly. The implementation of the Integrated Tuition Payment System has helped the integrated campus management. …”
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The CD4/CD8 ratio is associated with T lymphocyte functions in long-term virally suppressed patients with HIV by Qing Xiao, Fengting Yu, Liting Yan, Xiaojie Lao, Xuelei Liang, Hongxin Zhao, Liuyue Zhai, Zailin Yang, Xiaomei Zhang, Yao Liu, Fujie Zhang

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The Prevalence of Star-forming Clumps as a Function of Environmental Overdensity in Local Galaxies by Dominic Adams, Hugh Dickinson, Lucy Fortson, Kameswara Mantha, Vihang Mehta, Jürgen Popp, Claudia Scarlata, Chris Lintott, Brooke Simmons, Mike Walmsley

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Deciphering the Transcriptional Metabolic Profile of Adipose-Derived Stem Cells During Osteogenic Differentiation and Epigenetic Drug Treatment by Giulia Gerini, Alice Traversa, Fabrizio Cece, Matteo Cassandri, Paola Pontecorvi, Simona Camero, Giulia Nannini, Enrico Romano, Francesco Marampon, Mary Anna Venneri, Simona Ceccarelli, Antonio Angeloni, Amedeo Amedei, Cinzia Marchese, Francesca Megiorni

“…In this study, we employed the NanoString nCounter technology, an advanced multiplexed digital counting method of RNA molecules, to comprehensively characterize differentially expressed transcripts involved in metabolic pathways at distinct time points in osteogenically differentiating ASCs treated with or without the pan-DNMT inhibitor RG108. …”
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Revealing the Neuroimaging Mechanism of Acupuncture for Poststroke Aphasia: A Systematic Review by Boxuan Li, Shizhe Deng, Bomo Sang, Weiming Zhu, Bifang Zhuo, Menglong Zhang, Chenyang Qin, Yuanhao Lyu, Yuzheng Du, Zhihong Meng

“…Acupuncture has been proven to have a beneficial effect on improving speech functions in repetition, oral speech, reading, comprehension, and writing ability. Neuroimaging technology provides a visualized way to explore cerebral neural activity, which helps reveal the therapeutic effect of acupuncture therapy. …”
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Muscular Performance and Blood Pressure After Different Pre-Strength Training Strategies in Recreationally Strength-Trained Women: Cross-Over Trial by Estêvão Rios Monteiro, Linda S. Pescatello, Luis Leitão, Marcelo José Colonna de Miranda, Paulo H. Marchetti, Michelle Ribeiro Novaes, Gleisson da Silva Araújo, Victor Gonçalves Corrêa Neto, Jefferson da Silva Novaes

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Preoperative carcinoembryonic antigen to lymphocyte ratio serves as a prognostic predictor in elderly patients with colorectal cancer: a multicentre retrospective study by Lei Jiang, Ning Tan, Xiaonan Zhang, Jiayi Jiang, Xinyi Li, Gang Deng, Tao Liang, Haohan Ma, Weiping Deng, Lichang Guan, Kaijun Zhang, Xujie Cai, Lishu Xu

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Modeling of historical and future changes in temperature and precipitation in the Panj River Basin in Central Asia under the CMIP5 RCP and CMIP6 SSP scenarios by Aminjon Gulakhmadov, Xi Chen, Nekruz Gulahmadov, Muhammmad Rizwan, Manuchekhr Gulakhmadov, Muhammad Umar Nadeem, Moldir Rakhimova, Tie Liu

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The Influence of the Cu-Al₂O₃ Ratio of the Receiving Tube in a 50 MW Hybrid Solar Plant by Guillermo Benítez-Olivares, Alejandro Torres-Aldaco, Raúl Lugo-Leyte, José Javier Valencia-López, Luis Alberto Romero-Vázquez, Helen D. Lugo-Méndez

“…Direct steam generation (DSG) is a promising technology for introducing solar energy into industrial applications, yet it still faces significant challenges. …”
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Development of a Recombinant Omicron BA.1 Subunit Vaccine Candidate in Pichia pastoris by Sibel Kalyoncu, Dogu Sayili, Ayca Zeybek Kuyucu, Hakan Soyturk, Seyda Gullu, Busra Ersayan, Ibrahim Oguzhan Tarman, Mehmet Ender Avci, Olcay Mert, Umut Haskok, Ege Tekin, Huseyin Akinturk, Ridvan Orkut, Aysegul Demirtas, Idil Tilmensagir, Ceren Ulker, Bilgi Gungor, Mehmet Inan

“…The RBD‐Omicron‐based vaccine candidate developed in this study is suitable for technology transfer and transition into the clinic.…”
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The availability of drugs for stable COPD treatment in China: a cross-sectional survey by Dongru Du, Xueru Hu, Qiunan Zuo, Dan Xu, Tao Zhu, Tao Fan, Jiao Yang, Weiguo Xu, Hailong Wei, Kangzhuo Baima, Ying Zhang, Yanhui Gu, Lei Chen, Fengming Luo, Yongchun Shen, Fuqiang Wen

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Dual-stack host discovery method based on SSDP and DNS-SD protocol by Fan SHI, Yao ZHONG, Pengfei XUE, Chengxi XU

“…With the exhaustion of the IPv4 addresses, the promotion and deployment of IPv6 has been accelerating.Dual-stack technology allows devices to enable both IPv4 and IPv6 protocols, which means that users are facing more security risks.Although the existing work can realize the identification and measurement of some dual-stack servers, the following problems still exist.Dual-stack host identification requires deep protocol identification of host services, but this method consumes too much scanning resources.Besides, network service providers may provide consistent services on distributed hosts, making it difficult to guarantee the accuracy of dual-stack host identification through service fingerprints.To solve these problems, the LAN service discovery protocol was used to bind host services to IP addresses, and a dual-stack host discovery method based on SSDP and DNS-SD protocols was proposed.In IPv4 network environment, the target host was induced to actively send a request to the constructed IPv6 server through SSDP protocol, and then the IPv6 address was extracted from the server’s log.Or the service list of the target host and its corresponding AAAA record was enumerated through the DNS-SD protocol and the IPv6 address of the target host was obtained, in order to realize the discovery of the dual stack address pairs.With this method, IPv6 addresses was obtained directly from the IPv4 host, which ensured the accuracy of the discovered dual-stack host.At the same time, only request packets for specific protocols were needed during the discovery process, which greatly saved scanning resources.Based on this method, the SSDP hosts and DNS-SD hosts accidentally exposed to the global IPv4 network were measured.A total number of 158k unique IPv6 addresses were collected, of which 55k were dual-stack host address pairs with globally reachable IPv6 addresses.Unlike existing work that focused on dual-stack servers, this method mainly targeted end-users and client devices, and built a unique set of active IPv6 devices and dual-stack host address pairs that have not been explored so far.Through the analysis of the obtained IPv6 address addressing type, it shows that IPv6 address is mainly generated in a random manner, which greatly reduces the possibility of IPv6 hosts being discovered by scanning.In particular, by measuring the ports and services of dual-stack hosts, we found that the security policy differences of dual-stack hosts on different protocol stacks.Especially, IPv6 protocol stack exposes more high-risk services, expanding the attack surface of hosts.The research results also show that the infeasibility of IPv6 address space traversal scanning mitigates the security risks of IPv6, but incorrect network configuration greatly increases the possibility of these high-risk IPv6 hosts being discovered and users should revisit IPv6 security strategy on dual-stack hosts.…”
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Metrics for Evaluating Telemedicine in Randomized Controlled Trials: Scoping Review by Yuka Sugawara, Yosuke Hirakawa, Masao Iwagami, Ryota Inokuchi, Rie Wakimizu, Masaomi Nangaku

“… BackgroundTelemedicine involves medical, diagnostic, and treatment-related services using telecommunication technology. Not only does telemedicine contribute to improved patient quality of life and satisfaction by reducing travel time and allowing patients to be seen in their usual environment, but it also has the potential to improve disease management by making it easier for patients to see a doctor. …”
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The value of metagenomic next-generation sequencing in the diagnosis of fever of unknown origin by Lan Min Lai, Qing-gen Chen, Yang Liu, Rui Zhao, Mei Ling Cao, Lei Yuan

“…Metagenomic next-generation sequencing (mNGS) technology is a promising diagnostic tool for identifying pathogenic microbes of FUO caused by infection. …”
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Study protocol for a stepped-wedge implementation study investigating the intersectoral collaboration of implementing the TREAT INTERACT intervention for primary school teachers an... by Ane-Marthe Solheim Skar, Ingunn Marie S. Engebretsen, Nora Braathu, Harriet Aber, Harald Bækkelund, Melf-Jakob Kühl, Marjorie Mukisa, Joyce Sserunjogi Nalugya, Norbert Skokauskas, Vilde Skylstad, Tore Wentzel-Larsen, TREAT research consortium, Juliet Ndimwibo Babirye

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Associations of Serum Cystatin C, DNAm Cystatin C, Renal Function, and Mortality in U.S. Adults by Yu-Wei Fang, Wei-Chung Huang, Chikang Wang, Chien-Yu Lin

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چاپ زیستی سه بعدی و جوهرهای زیستی طبیعی مورد استفاده: مفاهیم و کاربردها by امیرحسین جلالی کندلوس, سعید باستانی, شهره مشایخان

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