Multi-functional role of apolipoprotein E in neurodegenerative diseases by Sadequl Islam, Arshad Noorani, Yang Sun, Makoto Michikawa, Kun Zou

“…Beyond its established role in amyloid β-protein (Aβ) metabolism and deposition, ApoE also impacts tau pathology, neurodegeneration, and the microglial response to AD. …”
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Patient stratification by genetic risk in Alzheimer's disease is only effective in the presence of phenotypic heterogeneity. by Jack Euesden, Muhammad Ali, Chloe Robins, Praveen Surendran, Padhraig Gormley, Alzheimer’s Disease Neuroimaging Initiative (ADNI), David Pulford, Carlos Cruchaga

“…Polygenic risk scores for AD risk did not reliably stratify fast from slow progressors; however, a deeper investigation found that APOE ε4 status predicts amyloid-β and tau positive versus negative patients (odds ratio for an additional APOE ε4 allele = 5.78 [95% confidence interval: 3.76-8.89], P<0.001) when restricting to a subset of patients with available CSF biomarker data. …”
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Olanzapine for young PEople with aNorexia nervosa (OPEN): results of a feasibility study by Olena Said, Dominic Stringer, Ece Sengun Filiz, Hiba Mutwalli, Sevgi Bektas, Melahat Nur Akkese, Vanessa Kellermann, Katie Ireland, Elizabeth Tyrrell-Bunge, Demelza Beishon-Murley, Joel W. T. Khor, Lee Allman, Joanna Barker, Nicus Kotze, Ben Carter, Mima Simic, Dilveer Singh Sually, Jessica Bentley, Allan H. Young, Sloane Madden, Sarah Byford, Sabine Landau, Vanessa Lawrence, Janet Treasure, Ulrike Schmidt, Dasha Nicholls, Hubertus Himmerich

“…Methods We assessed the feasibility of a future definitive trial on olanzapine in young people with AN in an open-label, one-armed feasibility study that aimed to include 55 patients with AN or atypical AN aged 12–24 who gained < 2 kg within at least one month of treatment as usual (TAU) during outpatient, inpatient, or day-care treatment. …”
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Megestrol acetate for appetite stimulation and weight gain in older adults with unintentional weight loss: a systematic review and meta-analysis by Larissa de Freitas do Lago-Abreu, Raphael Lopes Olegário, Luciana Lilian Louzada Martini, Einstein Francisco Camargos

“…We used the PEDro scale to assess methodological quality of the included studies and calculated measures of heterogeneity, such as the tau-squared (τ2), I-squared (I2), and Q test, to assess consistency across studies. …”
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Enhanced detection of mild cognitive impairment in Alzheimer’s disease: a hybrid model integrating dual biomarkers and advanced machine learning by John Sahaya Rani Alex, R. Roshini, G. Maneesha, Jeetashree Aparajeeta, B. Priyadarshini, Chih-Yang Lin, Chi-Wen Lung

“…AD is marked by the buildup of amyloid-beta (Aβ) plaques and tau neurofibrillary tangles (NFTs), which are believed to cause neuronal loss and cognitive decline. …”
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Detecting early cognitive deficits in preclinical Alzheimer’s disease using a remote digital multi-day learning paradigm by Roos J. Jutten, Daniel Soberanes, Cassidy P. Molinare, Stephanie Hsieh, Michelle E. Farrell, Aaron S. Schultz, Dorene M. Rentz, Gad A. Marshall, Keith A. Johnson, Reisa A. Sperling, Rebecca E. Amariglio, Kathryn V. Papp

“…Here, we examined BRANCH multi-day learning curves (MDLCs) in 167 cognitively unimpaired older adults (age = 74.3 ± 7.5, 63% female) with different amyloid-β (A) and tau (T) biomarker profiles on positron emission tomography. …”
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Changes in the transcriptome of the prefrontal cortex of OXYS rats as the signs of Alzheimer’s disease development by N. A. Stefanova, E. E. Korbolina, N. I. Ershov, E. I. Rogaev, N. G. Kolosova

“…Recently, we showed that senescence-accelerated OXYS rats represent a promis­ing model of AD; in these rats, accelerated aging of the brain is accompanied by the typical signs of AD: degenerative alterations and death of neurons, a de­crease in synaptic density, mitochondrial dysfunction, hyperphosphorylation of the tau protein, an increased level of amyloid β (Aβ1–42), and the formation of amyloid plaques. …”
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Plasma brain-related biomarkers and potential therapeutic targets in pediatric ECMO by Sue J. Hong, Bradley J. De Souza, Kristen K. Penberthy, Lisa Hwang, David E. Procaccini, John N. Kheir, Melania M. Bembea

“…Central nervous system (CNS) neuronal and astroglial cellular-derived neuron-specific enolase (NSE), tau, glial fibrillary acidic protein (GFAP) and S100β elevations have been detected in ABI and are associated with poorer outcomes. …”
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Effectiveness of a 5-day adapted swim instruction program for children with disabilities by Tana B. Carson, J. Megan Irwin, J. Megan Irwin, Tania Santiago Perez, Ivana Frampton, Lisa Ruby

“…., change score) and participant characteristics were examined using Kendall's tau-b for age and Chi-square for sex and diagnosis. …”
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Satellite microglia: marker of traumatic brain injury and regulator of neuronal excitability by Alicia B. Feichtenbiner, Karinn Sytsma, Ryan P. O’Boyle, Rhonda Mittenzwei, Heather Maioli, Kathryn P. Scherpelz, Daniel D. Child, Ning Li, Jeanelle Ariza Torres, Lisa Keene, Amanda Kirkland, Kimberly Howard, Caitlin Latimer, C. Dirk Keene, Christopher Ransom, Amber L. Nolan

“…Given the proposed mechanisms of toxic protein production and neuroinflammation as possible initiators or contributors to progressive pathology, we examined phosphorylated tau accumulation, microgliosis and astrogliosis using immunostaining in the orbitofrontal cortex, a region often vulnerable across traumatic brain injury exposures, in an age and sex-matched cohort of community traumatic brain injury including both mild and severe cases in midlife. …”
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Phytomedicine Potential of <i>Oroxylum indicum</i> Root and Its Constituents: Targeting Alzheimer’s Disease by Rattana Summat, Pornthip Waiwut, Supawadee Daodee, Natsajee Nualkaew, Khemjira Phemphunananchai, Puguh Novi Arsito, Yaowared Chulikhit, Orawan Montakantirat, Charinya Khamphukdee, Chantana Boonyarat

“…Furthermore, they reduced the expression of amyloidogenic proteins (BACE1) and phosphorylated tau. These findings suggest that <i>O. indicum</i> root extract, particularly baicalein, possesses multifaceted neuroprotective properties, targeting various aspects of AD pathogenesis, including oxidative stress, cholinergic dysfunction, β-amyloid formation, aggregation, and apoptosis. …”
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Therapeutic effects of mirodenafil, a phosphodiesterase 5 inhibitor, on stroke models in rats by Fred Kim, Padmanabh Singh, Hyunji Jo, Tianyang Xi, Dong-Keun Song, Sae Kwang Ku, Jai Jun Choung

“…The drug, which is currently used for treatment of erectile dysfunction, reduces Aβ and pTau levels and improves cognitive function in mouse models of Alzheimer's disease. …”
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Bioinformatics and Deep Learning Approach to Discover Food-Derived Active Ingredients for Alzheimer’s Disease Therapy by Junyu Zhou, Chen Li, Yong Kwan Kim, Sunmin Park

“…Random forest regression models were utilized to predict the IC₅₀ (pIC₅₀) values of ligands interacting with AD-related target proteins, including acetylcholinesterase (<i>AChE</i>), amyloid precursor protein (<i>APP</i>), beta-secretase 1 (<i>BACE1</i>), microtubule-associated protein tau (<i>MAPT</i>), presenilin-1 (<i>PSEN1</i>), tumor necrosis factor (<i>TNF</i>)<i>-α</i>, and valosin-containing protein (<i>VCP</i>). …”
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Copper homeostasis and neurodegenerative diseases by Yuanyuan Wang, Daidi Li, Kaifei Xu, Guoqing Wang, Feng Zhang

“…Additionally, copper can bind aberrantly to several neuronal proteins, including alpha-synuclein, tau, superoxide dismutase 1, and huntingtin, thereby inducing neurotoxicity and ultimately cell death. …”
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Patient‐Reported Fatigue Associated with Joint Histopathology in Rheumatoid Arthritis by Diyu Pearce‐Fisher, Melanie H. Smith, Bella Y. Mehta, Edoardo Spolaore, Edward DiCarlo, Dongmei Sun, Susan M. Goodman

“…Relationships between fatigue and studied variables were evaluated with Kendall's tau. A directed acyclic graph (DAG) was used to illustrate associations of exposures, outcome variables, mediators, and confounders. …”
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Agency development of high school students in the process of professional self-determination by Evgeniya S. Volkova, Alexander V. Kaptsov

“…Mathematical processing of the obtained data was carried out by using the Wilcoxon T-test to compare changes in parameters over time, and the non-parametric tau-Kendall correlation coefficient to identify relationships. …”
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Prospective analysis of CKM element |Vcd| and D+-meson decay constant from leptonic decays D+ → ℓ+ν by Ya-Xiong Wang, Hai-Jiang Tian, Yin-Long Yang, Tao Zhong, Hai-Bing Fu

“…Accordingly, we compute the branching fractions B(D+→ℓ+νℓ) with the electron, muon and tau channels, which are B(D+→e+νe)=(8.260−0.118+0.119)×10−9, B(D+→μ+νμ)=(3.508−0.050+0.051)×10−4 and B(D+→τ+ντ)=(0.935−0.013+0.013)×10−3. …”
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Smartphone apps for mental health: systematic review of the literature and five recommendations for clinical translation by Aljawharah Almuqrin, Ryan Hammoud, Ilham Terbagou, Stefania Tognin, Andrea Mechelli

“…Studies were excluded if they focused on web-based interventions, combined apps with non-TAU treatments or targeted physical health apps.Data extraction and synthesis Two independent reviewers screened and selected studies, with a third reviewer resolving inconsistencies. …”
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Astrocytic proteins involved in regulation of the extracellular environment are increased in the Alzheimer's disease middle temporal gyrus by Henry Liu, Adelie Y.S. Tan, Nasim F. Mehrabi, Clinton P. Turner, Maurice A. Curtis, Richard L.M. Faull, Mike Dragunow, Malvindar K. Singh-Bains, Amy M. Smith

“…We found increased astrocytic glial acidic fibrillary protein (GFAP), AQP-4, GLT-1 and Kir4.1 expression that correlates with advancing Braak stage, increasing amyloid pathology and, to a greater extent, the degree of tau pathology. We confirmed that Kir4.1 immunostaining is predominantly found in astrocytes and revealed a novel redistribution of Kir4.1 protein expression into astrocytic processes in the AD MTG. …”
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Molecular Mechanisms of Neurodegeneration Related to C9orf72 Hexanucleotide Repeat Expansion by Mirjana Babić Leko, Vera Župunski, Jason Kirincich, Dinko Smilović, Tibor Hortobágyi, Patrick R. Hof, Goran Šimić

“…The neuropathological correlate of FTD is frontotemporal lobar degeneration (FTLD), characterized by tau-, TDP-43-, and FUS-immunoreactive neuronal inclusions. …”
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