PT109改善链脲佐菌素诱导的散发性阿尔茨海默病小鼠认知功能障碍的作用及机制 by 陈秋荷, 涂亚林, 侯加卫, 陈晨, 鲁俊锋, 皮荣标

“…结论PT109可改善icv-STZ诱导的小鼠学习记忆障碍，可能与调节GSK3β/Tau相关通路有关。…”
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Association of Alzheimer’s and Lewy body disease pathology with basal forebrain volume and cognitive impairment by Julia Schumacher, Stefan Teipel, Alexander Storch

“…Cognitive deficits are primarily associated with tau pathology which is partly mediated by hippocampus, but not basal forebrain atrophy.…”
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Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences by Gloria Ortiz-Guerrero, Diana Amador-Muñoz, Carlos Alberto Calderón-Ospina, Daniel López-Fuentes, Mauricio Orlando Nava Mesa

“…Although neurological side effects secondary to PPIs are rare, several preclinical reports indicate that PPIs might increase Aβ levels, interact with tau protein, and affect the neuronal microenvironment through several mechanisms. …”
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Blood-based biomarkers in mild behavioral impairment: an updated overview by Efthalia Angelopoulou, Xenia Androni, Chiara Villa, Alexandros Hatzimanolis, Nikolaos Scarmeas, Sokratis Papageorgiou

“…In this context, MBI has been associated with lower plasma Aβ42/Αβ40 ratio, higher plasma phosphorylated tau at threonine 181 (p-tau181), increased neurofilament light chain (NfL) levels, as well as disturbances in metabolic markers, including homocysteine, insulin and ferritin, suggesting a multifaceted neurobiological basis for this syndrome. …”
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A Pilot Trial of Pioglitazone HCl and Tretinoin in ALS: Cerebrospinal Fluid Biomarkers to Monitor Drug Efficacy and Predict Rate of Disease Progression by Todd D. Levine, Robert Bowser, Nicole C. Hank, Stephen Gately, Dietrich Stephan, David S. Saperstein, Kendall Van Keuren-Jensen

“…To determine if therapy with pioglitazone HCl and tretinoin could slow disease progression in patients with ALS. Levels of tau and pNFH in the cerebrospinal fluid were measured to see if they could serve as prognostic indicators. …”
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7,8-Dihydroxyflavone Protects Nigrostriatal Dopaminergic Neurons from Rotenone-Induced Neurotoxicity in Rodents by Shuke Nie, Kai Ma, Mingkuan Sun, Matthew Lee, Yang Tan, Guiqin Chen, Zhentao Zhang, Zhaohui Zhang, Xuebing Cao

“…Western blot analyses were used to examine the expressions of TH, BDNF/TrkB signaling cascades, phospho-α-synuclein (Ser129), α-synuclein, and phospho-tau (Ser396) in SN. The results revealed that treatment with 7,8-DHF improved PD model’s behavioral performance and reduced dopaminergic neuron loss in the SN and striatum, associated with the activation of TrkB receptors and its signaling cascades, and reduced p-MAPK, p-α-synuclein, and p-tau. …”
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Effects of a Single Universal Extra Dimension in Bc→Ds,Dl+l- Decays by U. O. Yilmaz, E. Danapinar

“…The sensitivity of differential and total branching ratios and polarization asymmetries of final state leptons to the compactification parameter are presented, for both muon and tau decay channels. Considering the ability of available experiments, it would be useful to study these effects.…”
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Atmospheric Neutrinos by Takaaki Kajita

“…It was found that neutrino oscillations between muon-neutrinos and tau-neutrinos explain these data well. This paper discusses atmospheric neutrino experiments and the neutrino oscillation studies with these neutrinos.…”
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A note on improved differentiability for the Banach-space valued Finsler $\gamma $-Laplacian by Goering, Max, Koch, Lukas

“…We obtain improved fractional differentiability of solutions to the Banach-space valued Finsler $\gamma $-Laplacian defined on a $\sigma $-convex, $\tau $-smooth Banach space. The operators we consider are non-linear and very degenerately elliptic. …”
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Perturbed Galerkin Method for Solving Integro-Differential Equations by K. Issa, J. Biazar, T. O. Agboola, T. Aliu

“…Examples to justify the effectiveness and accuracy of the method are presented and their numerical results are compared with Galerkin’s method, Taylor’s series method, and Tau’s method which provide validation for the proposed approach. …”
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Left- and Right-Shifted Fractional Legendre Functions with an Application for Fractional Differential Equations by Haidong Qu, Xiaopeng Yang, Zihang She

“…As an application, it is effective for solving the fractional-order differential equations with the initial value problem by using the SFLP tau method.…”
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On point-dissipative systems of differential equations with quadratic nonlinearity by Anile K. Bose, Alan S. Cover, James A. Reneke

“…The system x′=Ax+f(x) of nonlinear vector differential equations, where the nonlinear term f(x) is quadratic with orthogonality property xTf(x)=0 for all x, is point-dissipative if uTAu<0 for all nontrivial zeros u of f(x).…”
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Effectiveness of Contrast Agents and Molecular Indicators in Alzheimer's Diagnosis Through PET and SPECT Imaging on Animal Models by Yasaman Abaszadeh, Ramin Ardalani, Athena Dehghan Najm Abadi

“…Respectively, Amyloid beta, Tau protein, Translocator protein (TSPO), Acetylcholinesterase (AChE), Monoamine oxidase B (MAO-B), and Gonadotropin-releasing hormone receptor (GnRHR) were identified the most as biomarkers in studies. …”
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HUBUNGAN TINGKAT KEPATUHAN MINUM OBAT HIPERTENSI MENGGUNAKAN KUESIONER HILL-BONE TERHADAP KUALITAS HIDUP PASIEN DI PUSKESMAS PEKAUMAN BANJARMASIN SELATAN by Sri Desi Safitri, Dedi Hartanto, Tuty Mulyani

“…Pengumpulan data menggunakan kuesioner Hill-Bone untuk mengetahui tingkat kepatuhan dan kuesioner EQ-5D-5L untuk mengetahui kualitas hidup pasien lalu diuji menggunakan spss 25 dengan jenis uji kendall’s tau-b. Hasil dari penelitian ini menunjukkan bahwa dari 68 responden, 3 orang (4,40%) dengan tingkat kepatuhan sedang memiliki kualitas hidup sedang, 59 orang (86,80%) dengan tingkat kepatuhan sedang memiliki kualitas hidup tinggi dan 6 orang (8,8%) dengan tingkat kepatuhan tinggi memiliki kualitas hidup tinggi, yang didapat dari uji Kendall’s tau-B nilai p = 0,000 < 0,05. …”
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Clinical Efficacy of Subhypothermia in the Treatment of Neonatal Hypoxic-Ischemic Encephalopathy Combined with Myocardial Damage by XiaoPing Dang, XiaoJian Hu, Xun Jiang, WeiGuo Chen, YuanCui Meng, Qi Pan, Fen Yang

“…After treatment, the serum levels of S-100β protein, Tau protein, NSE, CK, CK-MB, LDH, ɑ-HBDH, Myo, CT-1, cTnI, ROS, IL-1β, IL-8, and TNF-ɑ were reduced in both groups, and the study group was lower than the control group (P<0.05). …”
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Cerebrospinal Fluid Biomarkers in Multiple System Atrophy Relative to Parkinson’s Disease: A Meta-Analysis by Dan Xie, Ling Feng, Hongyan Huang, Quanzhen Zhao, Pingping Ning, Qiuyan Shen, Haitao Lu, Fang Xu, Yanming Xu

“…MSA patients had higher CSF t-tau (SMD=0.41, 95% CI: 0.10 to 0.72) and YKL-40 (SMD=0.63, 95% CI 0.12 to1.15) as well as DJ-1 (SMD=1.05, 95% CI 0.67 to 1.42) levels than PD patients, while CSF p-tau (SMD=−0.17, 95% CI, -0.31 to -0.02) and Aβ-42 (SMD=−0.33, 95% CI, -0.55 to -0.12) levels in MSA patients were lower than those in PD patients. …”
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Is epinephrine still the drug of choice during cardiac arrest in the emergency department of the hospital? A meta-analysis by Hou Min, Dong Su, Kan Qing, Ouyang Meng, Zhang Yun

“…Similarly, the risk ratio of 1.89 (95 % CI 1.47–2.43) with a tau2 value of 0.19, chi2 value of 11,530.67, df value of 11, I2 value of 100 %, Z-value of 4.95, and p-value < 0.000001. …”
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Sur certains invariants des algèbres artiniennes commutatives by Aleksandrov, Alexandre

“…We then prove, employing the canonical duality in the cotangent complex, that if the corresponding thick point is smoothable, then its Tjurina and Milnor numbers satisfy the inequality $\tau \geqslant \mu $.…”
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Taurine inhibits acute ammonia-induced oxidative stress, immune response, and apoptosis of large yellow croaker (Larimichthys crocea) during keep-live transport by Xin Zhao, Zhenkun Xu, Jun Mei, Jing Xie

“…Taurine might reduce the production of reactive oxygen species (ROS), and the content of malondialdehyde (nmol/mL) could be decreased from 96.09 (AM group) to 62.15 (50TAU + AM group), thus reducing DNA damage. SOD and GPx activities increased from 3.47 to 13.23 (AM group) to 9.4 and 55.48 (50TAU + AM group), immunosuppression (lysozyme activity increased). …”
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Association between herpes simplex virus infection and Alzheimer’s disease biomarkers: analysis within the MAPT trial by Morgane Linard, Isabelle Garrigue, Bruno Vellas, Nicola Coley, Henrik Zetterberg, Kaj Blennow, Nicholas James Ashton, Pierre Payoux, Anne-Sophie Salabert, Jean-François Dartigues, Joachim Mazere, Sandrine Andrieu, Catherine Helmer

“…Plasma Aβ42/40 ratio, neurofilament light chain and p-tau181 were also available for a sub-sample of participants. …”
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