Targeting Toll-Like Receptors for Treatment of SLE by Christopher G. Horton, Zi-jian Pan, A. Darise Farris

“…Nucleic acid-sensing TLRs, TLR 7 in particular, have been implicated in systemic lupus erythematosus (SLE) and are thought to exacerbate disease pathology. …”
Get full text

Polycystic Ovary Syndrome May Be an Autoimmune Disorder by Hifsa Mobeen, Nadeem Afzal, Muhammad Kashif

“…There is an association between PCOS and autoimmune diseases such as ANA and anti-TPO that have been documented in systemic lupus erythematosus and Hashimoto thyroiditis, respectively, and it is suspected that there are autoantibodies that might affect the long term clinical management of these patients. …”
Get full text

An Unusual Case of Kidney Injury in a Young Woman with a Connective Tissue Disease by Roberto Rivera, Salvador Vila

“…A diagnosis of systemic lupus erythematosus was made. Due to recalcitrant thrombocytopenia, serositis, and renal insufficiency methylprednisolone was prescribed in high doses. …”
Get full text

Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9 by Petar S. Lenert

“…Intracellular nucleic acid sensing TLRs play an important role in the pathogenesis of Systemic Lupus Erythematosus (SLE). In this review, we describe recent achievements in the development of oligonucleotide—(ODN)-based inhibitors of TLR9 and/or TLR7 signaling. …”
Get full text

Clinical and Pathological Roles of Ro/SSA Autoantibody System by Ryusuke Yoshimi, Atsuhisa Ueda, Keiko Ozato, Yoshiaki Ishigatsubo

“…Anti-Ro/SSA antibodies are among the most frequently detected autoantibodies against extractable nuclear antigens and have been associated with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). …”
Get full text

Case Report of Kikuchi-Fujimoto Disease from Sub-Saharan Africa: An Important Mimic of Tuberculous Lymphadenitis by Karishma Sharma, Fredrick Otieno, Reena Shah

“…Blood tests for systemic lupus erythematosus (SLE) were negative; she had already been commenced on anti-TB treatment and had responded well and so was continued with this therapy. …”
Get full text

Exploring the Safety and Effects of COVID-19 Vaccination in Patients with Autoimmune Disease by Kirttna Solai Vairavan, Loh Teng-Hern Tan, Jodi Woan Fei Law, Priyia Pusparajah, Vengadesh Letchumanan

“…The search results were limited to 4 distinct autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus, psoriasis, and myasthenia gravis). …”
Get full text

Adalimumab (TNFα Inhibitor) Therapy Exacerbates IgA Glomerulonephritis Acute Renal Injury and Induces Lupus Autoantibodies in a Psoriasis Patient by S. S. Wei, R. Sinniah

“…Use of TNFα inhibitors is associated with the induction of autoimmunity (systemic lupus erythematosus, vasculitis, and sarcoidosis or sarcoid-like granulomas) (Ramos-Casals et al. (2010)). …”
Get full text

Successful Treatment of Hemophagocytic Lymphohistiocytosis Associated with Lupus Nephritis by Using Mycophenolate Mofetil by Takashi Nawata, Makoto Kubo, Kosaku Shiragami, Yukinori Nakamura, Masafumi Yano

“…An estimated 0.9% to 2.4% of patients with systemic lupus erythematosus (SLE) also have hemophagocytic lymphohistiocytosis (HLH). …”
Get full text

Immunometabolism of Tregs: mechanisms, adaptability, and therapeutic implications in diseases by Yuming Lu, Yifan Wang, Tiantian Ruan, Yihan Wang, Linling Ju, Mengya Zhou, Luyin Liu, Dengfu Yao, Min Yao

“…The complex mechanisms of Tregs in metabolic diseases are intriguing, particularly in conditions like MASLD, where Tregs are significantly upregulated and contribute to fibrosis, while in diabetes, systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA), they show downregulation and reduced anti-inflammatory capacity. …”
Get full text

Autoimmune Diseases and Their Manifestations on Oral Cavity: Diagnosis and Clinical Management by Matteo Saccucci, Gabriele Di Carlo, Maurizio Bossù, Francesca Giovarruscio, Alessandro Salucci, Antonella Polimeni

“…This review is aimed at describing oral presentations, diagnosis, and treatment strategies for systemic lupus erythematosus, Sjögren syndrome, pemphigus vulgaris, mucous membrane pemphigoid, and Behcet disease.…”
Get full text

Th17 Cells in Immunity and Autoimmunity by Simone Kennedy Bedoya, Brandon Lam, Kenneth Lau, Joseph Larkin

“…However, strong evidence also implicates the Th17 lineage in several autoimmune disorders including multiple sclerosis, psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma. The Th17 subset has also been connected with type I diabetes, although whether it plays a role in the pathogenicity of or protection from the disease remains a controversial issue. …”
Get full text

Neuroendocrine Tumour as a Diagnostic and Prognostic Criterion for Autoimmune Gastritis by S. I. Mozgovoi, M. A. Livzan, T. S. Krolevets, A. G. Shimanskaya

“…The patient also suffered from systemic lupus erythematosus with skin lesions (discoid rash, palmar and plantar capillaries) and joint lesions (migrating polyarthritis). …”
Get full text

Ignoring Gender-Based Immunometabolic Reprograming, a Risky Business in Immune-Based Precision Medicine by Vijay Kumar

“…However, further research has indicated sex/gender-based immune differences, which further increase higher incidences of various autoimmune diseases (AIDs), such as systemic lupus erythematosus (SLE), myasthenia gravis, and rheumatoid arthritis (RA) in females. …”
Get full text

Herpes Simplex Virus-2 Hepatitis: A Case Report and Review of the Literature by Amna Ahmed, Alejandro Granillo, Ethan Burns, Kerri Glassner, Nishath Naseem, Christopher Force, Suzanne M. Crumley, Ashley Drews

“…We present a case of a young female on chronic prednisone and hydroxychloroquine for systemic lupus erythematosus (SLE) who was diagnosed with HSV-2 hepatitis after presenting with right-sided chest and abdominal discomfort. …”
Get full text

Lupus Flare: An Uncommon Presentation of Disseminated Gonorrhea by Uyen To, Joyce Kim, David Chia

“…Here we discuss a rare case of a patient with systemic lupus erythematosus (SLE) who developed septic shock from disseminated gonorrhea infection (DGI). …”
Get full text

Vascular cytoprotection, autoimmune disease, and premature atherosclerosis by Justin C Mason

“…Systemic inflammatory diseases including rheumatoid arthritis and systemic lupus erythematosus are associated with endothelial dysfunction, increased aortic stiffness, and accelerated atherogenesis. …”
Get full text

sNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE by TAK1 Pathway by Yatao Bao, Meng Lian, Yong Chen, Xiaotian Gu, Kunyu Cao, Xiaoping Du, Jiyu Ju

“…Genetic factors play an important role in the pathogenesis of systemic lupus erythematosus (SLE), and abnormal Toll-like receptor (TLR) signaling pathways are closely related to the onset of SLE. …”
Get full text

A Mechanistic Insight into the Pathogenic Role of Interleukin 17A in Systemic Autoimmune Diseases by Radjesh Bisoendial, Erik Lubberts

“…Accumulating evidence now underscores an integral role of IL-17A in driving the pathophysiology and clinical manifestations in three potentially life-threatening autoimmune diseases, namely, systemic lupus erythematosus, Sjögren’s syndrome, and systemic sclerosis. …”
Get full text

A Case of Relapsing Kikuchi-Fujimoto Disease by Talayeh Rezayat, Matthew B. Carroll, Bryan C. Ramsey, Andria Smith

“…KFD can mimic other serious conditions such as lymphoma, systemic lupus erythematosus (SLE), herpes simplex, and Epstein Barr virus. …”
Get full text