Systemically circulating 17β-estradiol enhances the neuroprotective effect of the smoking cessation drug cytisine in female parkinsonian mice by Sara M. Zarate, Roger C. Garcia, Gauri Pandey, Rahul Srinivasan

“…To address the important question of whether circulating 17β−estradiol mediates this effect, we employ two mouse models aimed at depleting systemically circulating 17β-estradiol: (i) bilateral ovariectomy (OVX), and (ii) aromatase inhibition with systemically administered letrozole. …”
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Remaining of contrast dye ice cap during PVI by cryoballoon ablation; a case report by Ahmad Yamini Sharif, Entezar Mehrabi Nasab

“…If automatic balloon deflate occurs before the ice cap dissolves, embolization to the systemic circulation is possible. This case report describes the remaining of a contrast-colored ice cap to the systemic circulation in the left superior pulmonary vein (LSPV) and the remaining contrast-colored ice cap throughout the balloon deflate and its gradual melting a few seconds after the balloon deflate in the right superior pulmonary vein (RSPV). …”
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Gut Microbial Translocation in Critically Ill Children and Effects of Supplementation with Pre- and Pro Biotics by Paola Papoff, Giancarlo Ceccarelli, Gabriella d'Ettorre, Carla Cerasaro, Elena Caresta, Fabio Midulla, Corrado Moretti

“…Bacterial translocation as a direct cause of sepsis is an attractive hypothesis that presupposes that in specific situations bacteria cross the intestinal barrier, enter the systemic circulation, and cause a systemic inflammatory response syndrome. …”
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PHARMACEUTICAL TECHNIQUES FOR THE FABRICATION OF POOR WATERSOLUBLE DRUGS A REVIEW by Rabia Noor

“… Pharmaceutical technologies for increasing the solubility of drug substances have a prime role in its faster dissolution and maximum absorption in the systemic circulation. Majority of the drugs possesses low solubility leading to poor absorption and erratic bioavailability and thus failed to achieve a desired pharmacological response. …”
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Percutaneous transcatheter occlusion of large pulmonary arteriovenous fistula with Amplatzer Septal Occluder in a young cyanotic girl by K. Arun Kumar, Soumik Ghosh, Neeraj Awasthy, Om Shankar

“…Despite its efficacy in interventional occlusions of small- to medium-sized PAVFs, “classic” devices such as detachable balloons and intravascular coils are not recommended for bigger fistulas due to the potential risk of embolization to the systemic circulation. This case report is a unique case of a 17-year-old cyanotic girl who had a large symptomatic solitary PAVF that was effectively closed with a 26 mm Amplatzer Septal Occlude (ASO) device. …”
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Overview of Newer Glucocorticosteroid Preparations for Inflammatory Bowel Disease by R Brattsand

“…This suggests that after topical application to rectal or bowel mucosa, glucocorticosteroid activity in the systemic circulation is low. This is in contrast to prednisolone, which has a hepatic first pass metabolism of just 20%.…”
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Gut Microbiota in HIV Infection: Implication for Disease Progression and Management by Felix Chinweije Nwosu, Ekaterina Avershina, Robert Wilson, Knut Rudi

“…The role of underlying commensal microbes and microbial products that traverse the intestinal lumen into systemic circulation in the absence of overt bacteraemia is under current investigation. …”
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A Pharmacological and Toxicological Profile of Silver as an Antimicrobial Agent in Medical Devices by Alan B. G. Lansdown

“…The ion is absorbed into the systemic circulation from the diet and drinking water, by inhalation and through intraparenteral administration. …”
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Diagnosis of Intra-Abdominal Extralobar Pulmonary Sequestration by means of Ultrasound in a Neonate by Claudio Rodrigues Pires, Adriano Czapkowski, Edward Araujo Júnior, Sebastião Marques Zanforlin Filho

“…Pulmonary sequestration is a congenital abnormality consisting of a mass of pulmonary tissue that presents an abnormal connection with the tracheobronchial tree, with a blood supply coming from an anomalous artery derived from the systemic circulation. Extralobar pulmonary sequestration is characterized by having pleural coverings that are independent of the normal lungs, with vascular supply usually coming from the aorta or from one of its branches. …”
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Semi-Empirical Predictions on the Structure and Properties of ent-Kaurenoic Acid and Derivatives by Jose Isagani B. Janairo, Gerardo C. Janairo, Derrick Ethelbhert C. YU

“…Results revealed that the molecule possess favourable attributes which renders it possible to be considered as a drug lead only that its very hydrophobic nature can result to poor bioavailabilty, low absorption and poor systemic circulation. In silico simulations revealed that this setback can be overcome by introduction of hydroxyl group to the tertiary carbon of ent-kaurenoic acid employing m-CPBA catalyzed hydroxylation, thus, unleashing its full drug potency. …”
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The Impact of Polyphenol on General Nutrient Metabolism in the Monogastric Gastrointestinal Tract by Mohammed Sharif Swallah, Hongling Fu, He Sun, Raïfatou Affoh, Hansong Yu

“…The metabolised product, however, is the main bioactive component due to their ability to enter the systemic circulation and reach the targeted organs. There is limited knowledge on the cellular uptake, phenolic metabolite, and polyphenolic effect in the gastrointestinal ecosystem. …”
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Carrier-Based Drug Delivery System for Treatment of Acne by Amber Vyas, Avinesh Kumar Sonker, Bina Gidwani

“…Topical treatment of acne with active pharmaceutical ingredients (API) makes direct contact with the target site before entering the systemic circulation which reduces the systemic side effect of the parenteral or oral administration of drug. …”
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Uptake of Single-Walled Carbon Nanotubes Conjugated with DNA by Microvascular Endothelial Cells by Joseph Harvey, Lifeng Dong, Kyoungtae Kim, Jacob Hayden, Jianjie Wang

“…SWCNTs conjugated with drugs or genes travel in the systemic circulation to reach target cells or tissues following extravasation from microvessels although the interaction between SWCNT conjugates and the microvascular endothelial cells (ECs) remains unknown. …”
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Advanced Glycation End Products Play Adverse Proinflammatory Activities in Osteoporosis by Roberta Sanguineti, Alessandra Puddu, François Mach, Fabrizio Montecucco, Giorgio Luciano Viviani

“…The synthesis and accumulation of AGEs (both localized within the bone or in the systemic circulation) might trigger a vicious circle (in which inflammation and aging merged in the word “Inflammaging”) which can establish and sustain the development of osteoporosis. …”
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Incidental diagnosis of intra-lobar pulmonary sequestration in an asymptomatic young male: A case report by Prabin Duwadee, MBBS, Suraj Sharma, MD, Radiology, Prabin Kumar Bam, MBBS, Amrit Bhusal, MBBS, Tek Nath Yogi, MBBS, Tilak Khatri, MBBS, Sajiva Aryal, MBBS, Pratick Shrestha, MBBS

“…The sequestration receives its blood supply from anomalous systemic circulation in contrast to pulmonary circulation and can manifest in either intrapulmonary or extrapulmonary forms. …”
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The Use of Coupled Plasma Filtration Adsorption in Traumatic Rhabdomyolysis by Mario Pezzi, Silvia Renda, Anna Maria Giglio, Anna Maria Scozzafava, Simona Paola Tiburzi, Patrizia Casella, Fabrizio Iannelli, Mario Verre

“…Severe musculoskeletal injuries induce the release of sarcoplasmic elements such as muscle enzymes, potassium, and myoglobin in the systemic circulation. The circulating myoglobin damages the glomerulus and renal tubules. …”
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Morphological Changes in the Bone Marrow of the Dogs with Visceral Leishmaniasis by Claudia Momo, Ana Paula Prudente Jacintho, Pamela Rodrigues Reina Moreira, Danísio Prado Munari, Gisele Fabrino Machado, Rosemeri de Oliveira Vasconcelos

“…Consequently, it affects the profile of hematopoietic cells in the bone marrow and systemic circulation.…”
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Tissue-Related Hypoxia Attenuates Proinflammatory Effects of Allogeneic PBMCs on Adipose-Derived Stromal Cells In Vitro by Polina I. Bobyleva, Elena R. Andreeva, Aleksandra N. Gornostaeva, Ludmila B. Buravkova

“…Depending on the application mode ASC/allogeneic immune cell interaction can occur in the systemic circulation under plenty high concentrations of O2 and in target tissues at lower O2 levels. …”
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Estimation and identification of parameters in a lumpedcerebrovascular model by Scott R. Pope, Laura M. Ellwein, Cheryl L. Zapata, Vera Novak, C. T. Kelley, Mette S. Olufsen

“…These quantitiesare parameters in a simple lumped parameter model that predicts pressure andflow in the systemic circulation. The model is combined with experimentalmeasurements of blood flow velocity from the middle cerebral artery andarterial finger blood pressure. …”
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Beyond tissue: Liquid biopsy's promise in unmasking oral cancer by Sakshi Deorah, Akanchha Singh, Shalini Gupta

“…CtDNA, in particular, represents tumor-derived DNA fragments in the systemic circulation, offering valuable insights into the disease's status. …”
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