The first experience with sodium‐glucose cotransporter 2 inhibitor for the treatment of systemic right ventricular failure by Anastasia D. Egorova, Marieke Nederend, Laurens F. Tops, Hubert W. Vliegen, Monique R.M. Jongbloed, Philippine Kiès

“…Abstract In congenitally corrected transposition of the great arteries, the morphological right ventricle supports the systemic circulation. This chronic exposure to pressure overload ultimately leads to systemic right ventricular (sRV) dysfunction and heart failure. …”
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Electroencephalographic Features of Presumed Hepatic Encephalopathy in a Pediatric Dog with a Portosystemic Shunt—A Case Report by Raluca Adriana Ștefănescu, Vasile Boghian, Gheorghe Solcan, Mario Darius Codreanu, Mihai Musteata

“…As a result of this, the blood brought from the digestive tract through the portal vein bypasses the liver, and the unmetabolized components of the portal bloodstream enter directly into systemic circulation, causing clinical symptoms of metabolic encephalopathy (HE). …”
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Abernethy Malformation in Combination with Gilbert’s Syndrome by N. B. Gubergrits, E. L. Bondar, E. A. Dyadyk, E. V. Berezhnaya, Yu. E. Chirkov, N. V. Byelyayeva, G. M. Lukashevich, T. L. Mozhyna

“…Abernethy syndrome is a rare vascular anomaly associated with a congenital absence of the portal vein, as a result of which portal blood from the intestines and spleen drains directly into the systemic circulation bypassing the liver though a complete or partial shunt. …”
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Massive Central Pulmonary Embolism with Riding Embolus and Concomitant Aortic Arch Embolism—Should We Diagnose Patients Earlier for Blood Clotting Disorders? Case Report by Anna Lis, Paweł Kowalski, Marcin Wita, Tomasz Zawadzki, Tomasz Ilczak, Wojciech Żurawiński, Mateusz Majewski

“…Paradoxical embolism occurs when a clot originates in the venous system and traverses through a pulmonary or intracardiac shunt into the systemic circulation, with a mortality rate of around 18%. …”
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Paradoxical and Retrograde Air Embolism from Pressurized Peripheral Bolus by Joshua Santucci, Naresh Mullaguri, Anusha Battineni, Raviteja R. Guddeti, Christopher R. Newey

“…Caution must be exercised in patients with right-to-left shunting as air may gain access to systemic circulation.…”
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INFLUENCE OF EXO- AND ENDOGENOUS FACTORS ON THE MORPHOLOGICAL AND FUNCTIONAL STATE OF THE SPLEEN AS AN IMPORTANT MEDICAL AND SOCIAL PROBLEM OF THE HEALTH CARE SYSTEM by O.V. Mamai, S.M. Bilash, R.M. Grinko

“…We found that the spleen’s functions are focused on systemic circulation, so it has no afferent lymphatic vessels. …”
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Kinetic Profiles of Inflammatory Mediators in the Conjunctival Sac Fluid of Patients upon Photorefractive Keratectomy by Veronica Tisato, Paolo Perri, Erika Rimondi, Elisabetta Melloni, Giuseppe Lamberti, Daniela Milani, Paola Secchiero, Giorgio Zauli

“…The results have firstly highlighted the different pattern of cytokine expression between the microenvironment at the anterior surface of the eye and the systemic circulation. More importantly, the kinetic of modulation of cytokines/chemokines at the conjunctival level following PRK revealed that while the majority of cytokines/chemokines showed a significant decrease, MCP-1 emerged in light of its pronounced and significant increase soon after PRK and during the follow-up. …”
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Protection of Alzheimer’s disease progression by a human-origin probiotics cocktail by Santosh Kumar Prajapati, Shaohua Wang, Sidharth P Mishra, Shalini Jain, Hariom Yadav

“…The beneficial effects were linked to a reduced inflammatory microbiome, leading to decreased gut permeability and inflammation in both systemic circulation and the brain. Although both male and female mice showed overall improvements in cognition and biological markers, females did not exhibit improvements in specific markers related to inflammation and barrier permeability, suggesting that the underlying mechanisms may differ depending on sex. …”
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Serum Vascular Endothelial Growth Factor Levels before and after Intravitreous Ranibizumab Injection for Retinopathy of Prematurity by Xuting Chen, Lin Zhou, Qi Zhang, Yu Xu, Peiquan Zhao, Hongping Xia

“…To evaluate serum VEGF level in the systemic circulation after IVR and the complications associated with IVR for the premature infants with ROP. …”
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Advancing Therapeutic Strategies with Polymeric Drug Conjugates for Nucleic Acid Delivery and Treatment by Ullah A, Khan M, Zhang Y, Shafiq M, Ullah M, Abbas A, Xianxiang X, Chen G, Diao Y

“…It investigates how these conjugates address delivery obstacles, enhance systemic circulation, reduce immunogenicity, and provide controlled release, improving safety profiles. …”
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Predicting the clinical subcutaneous absorption rate constant of monoclonal antibodies using only the primary sequence: a machine learning approach by Ronghua Bei, Justin Thomas, Shiven Kapur, Mahlet Woldeyes, Adam Rauk, Jason Robarge, Jiangyan Feng, Kaoutar Abbou Oucherif

“…An understanding of the absorption process of a mAb from the injection site to the systemic circulation is critical to the process of subcutaneous mAb formulation development. …”
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Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations by Jingbo Xie, Jian Guo, Zaeema Kanwal, Mingzheng Wu, Xiangyang Lv, Nihal Abdalla Ibrahim, Ping Li, Manal Ali Buabeid, El-Shaimaa A. Arafa, Qingshan Sun

“…Calcitonin was discovered as a peptide hormone that was known to reduce the calcium levels in the systemic circulation. This hypocalcemic effect is produced due to multiple reasons such as inhibition of bone resorption or suppression of calcium release from the bone. …”
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Cola beverage reduces risk of lead poisoning from accidental ingestion of contaminated soil particles in rat and swine models by Xiaoyun Xu, Quan Qian, Yao Shi, Wenfeng Huang, Chengpeng Yuan, Lena Q. Ma, Willie G. Harris, Jiayin Dai, Deyi Hou, Xinde Cao

“…This method facilitated the direct passage of Pb in contaminated soil through the digestive system, enhancing its elimination without absorption into systemic circulation. Our results demonstrated that cola effectively reduced Pb bioaccessibility in 22 contaminated soils by 32.6%–98.8%. …”
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Investigation of Herb-Drug Interactions between Xylopia aethiopica, Its Principal Constituent Xylopic Acid, and Antidepressants by Christian C. Ndu, Wonder K. M. Abotsi, Priscilla K. Mante

“…Xylopia aethiopica extract and xylopic acid interacted synergistically with imipramine, fluoxetine, and venlafaxine and reduced the systemic circulation of imipramine.…”
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Lunasin protease inhibitor concentrate decreases pro-inflammatory cytokines and improves histopathological markers in dextran sodium sulfate-induced ulcerative colitis by Andrea Nieto-Veloza, Zhihong Wang, Qixin Zhong, Doris D’Souza, Hari B. Krishnan, Vermont P. Dia

“…In vivo, LPIC increased colonic bleeding and did not improve macroscopic markers of the disease, but reduced colonic IL-1β and IL-6, decreased systemic circulation of TNF-α, attenuated neutrophils infiltration and iNOS expression in colonic tissue, and diminished the damage in colonic architecture. …”
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Serum microRNAs as Diagnostic Markers in Polycystic Ovary Syndrome: A Narrative Review by K Lavanya, N Palaniappan, VM Vinodhini, Santhi Silambanan

“…This article was created to address the altered microRNA profiles in systemic circulation and in different ovarian tissues.…”
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Role of Inflammation and Motility Disorders in the Development, Course and Consequences of Functional Gastrointestinal and Biliary Tract Diseases (Literature Review and Expert Pane... by V. T. Ivashkin, D. S. Bordin, T. L. Lapina, M. A. Livzan, A. V. Okhlobystin, E. A. Poluektova, A. S. Trukhmanov, Yu. P. Uspenskiy, Yu. O. Shulpekova

“…Proinflammatory cytokines and matrix metalloproteinases can enter the systemic circulation, provoking the development of systemic manifestations. …”
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Amyloid-β and heart failure in Alzheimer’s disease: the new vistas by Hayder M. Al-Kuraishy, Ghassan M. Sulaiman, Hamdoon A. Mohammed, Sohaib G. Mohammed, Ali I. Al-Gareeb, Ali K. Albuhadily, Retaj A. Dawood, Amer Al Ali, Mohammed H. Abu-Alghayth

“…Aβ through deranged BBB can be transported into the systemic circulation from the brain and accumulated in the heart, leading to the development of HF. …”
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In Vivo Evaluation of the Ameliorating Effects of Small-Volume Resuscitation with Four Different Fluids on Endotoxemia-Induced Kidney Injury by Yan-ling Wang, Jing-hui Chen, Qiong-fang Zhu, Gao-feng Yu, Chen-fang Luo, Gang-jian Luo, Shang-rong Li, Zi-qing Hei

“…Small-volume perfusion with saline failed to improve renal and systemic circulation. However, small-volume perfusion with HES and HSH greatly improved the above parameters, while HTS only transiently improved systemic and renal hemodynamics with obvious renal injury. …”
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Characterization and in vitro anticancer study of PEGylated liposome dually loaded with ferulic acid and doxorubicin by Andang Miatmoko, Patricia Kinanti Christy, Alfionita Isnaini, Berlian Sarasitha Hariawan, Devy Maulidya Cahyani, Margaret Ahmad, Nuzul Wahyuning Diyah, Mohamad Faris Adrianto, Ravi Kiran Deevi, Iwan Sahrial Hamid, Juni Ekowati

“…Moreover, changes to the DSC thermogram were observed following the incorporation of ferulic acid into the liposome, while the Lipo DOX-FA exhibited a relatively rapid drug release compared to Lipo DOX suggesting a slightly shorter period necessary to attain both therapeutic efficacy and the maintenance of a stable drug encapsulation in the systemic circulation. An in vitro study of LLC and HeLa cells showed that the IC50 values of Lipo DOX-FA were 0.70 µg/mL and 1.56 µg/mL, while the CC50 value in normal HEK cells was 6.50 µg/mL. …”
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