Expert Consensus on the Management of Acute Otitis Media in India: A Delphi Study by Tanu Singhal, Shyam Kukreja, Jaydeep Choudhury, Vijay Yewale, Balasubramanian Sundaram, Jagdish Chinnappa, Suhas Prabhu, Balaji Veeraraghavan, Camilla Rodrigues, Vidya Krishna, Winsley Rose, Samir Bhargava

“…Conclusion: The consensus recommendations provide systematic guidance to clinicians on the appropriate management of AOM and OME. …”
Get full text

A new strategy for pharmacodynamic substance screening and research on gut microbiota pathway mechanisms based on UPLC-Q-orbitrap-MS and 16S rRNA by Zhiying Yu, Tong Li, Jie Yang, Jianghua He, Weijiang Zhang, Siyuan Li, Yunpeng Qi, Yihui Yin, Ling Dong, Wenjuan Xu

“…Conclusion: This study focused on the key issues in the gut microbiota pathway and developed a progressive research strategy to understand the transformation mechanisms of colonic components. This research systematically analyzed the active components and metabolic transformation of GQD in the colon during the pathological state of UC, as well as changes in the structure and function of the gut microbiota, clarified the mechanism of GQD and its active components in improving UC via the gut microbiota pathway.…”
Get full text

Optimization of a microarray for fission yeast by Dong-Uk Kim, Minho Lee, Sangjo Han, Miyoung Nam, Sol Lee, Jaewoong Lee, Jihye Woo, Dongsup Kim, Kwang-Lae Hoe

“…Bar-code (tag) microarrays of yeast gene-deletion collections facilitate the systematic identification of genes required for growth in any condition of interest. …”
Get full text

Red Stellar Populations and Dust Extinction toward W3 by J. L. Campbell, P. G. Martin, S. Song, M. Rahman, L. Einstein

“…We constrain the observed parallax and proper motion of OB stars in W3, demonstrating the importance of considering systematic effects in the parallax bias, and assign parallax- and proper-motion-based cloud membership to our stellar samples. …”
Get full text

Dwarf Galaxies with Radio-excess Active Galactic Nuclei in the Very Large Array Sky Survey by John-Michael Eberhard, Amy E. Reines, Hansung B. Gim, Jeremy Darling, Jenny E. Greene

“…We present a systematic search for radio active galactic nuclei (AGNs) in dwarf galaxies using recent observations taken by the Very Large Array Sky Survey (VLASS). …”
Get full text

THE ROLE OF DIET DURING HEALTH EDUCATION PROGRAMS FOR THE IMPROVEMENT OF CLINICAL OUTCOMES IN COPD PATIENTS: LITERATURE REVIEW by Rita Citarella, Adriano Brenca, Myriam Palomba, Maria Guarnaccia, Giuseppina Gargiulo, Diodato Ferrante, Jessica Marano, Aniello Lanzuise, Serena Pannetta

“…Studies that responded to the hypotheses of bibliographic research were considered. Primary studies, systematic reviews and guidelines were included. Bibliographic research was conducted from 1 June 2024 to 24 October 2024. …”
Get full text

Impact of underweight status on mortality in sepsis patients: a meta-analysis by Jiaan Chen, Fan Zhang, Li Liang, Xuming Pan, Jiancheng Zhang, Guangjun Jin

“…Physicians should pay more attention to the management of underweight sepsis patients.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?…”
Get full text

Creation of a Strategically Oriented Social Responsibility Management System in a Georgian Organization by Maia Chechelashvili, Nino Chikviladze, Irina Iashvili, Tamar Kajaia, Khatuna Kharkhelauri, Elisabed Malania

“…In the research process, methods of analysis and synthesis, statistical methods, time series visualization, induction and deduction, and systematic approach were used. Data were collected through surveys using Computer Assisted Web Interviewing (CAWI) and processed in Microsoft Excel. …”
Get full text

E‐CHAIM as a Model of Total Electron Content: Performance and Diagnostics by D. R. Themens, Ben Reid, P. T. Jayachandran, Bion Larson, A. V. Koustov, Sean Elvidge, A. M. McCaffrey, Chris Watson

“…In contrast to the vTEC results, however, E‐CHAIM and the IRI exhibit comparable performance at Swarm altitudes, except within the polar cap, where the IRI exhibits systematic underestimation of electron density by up to 1.0 × 1011 e/m3. …”
Get full text

Genome sequence and evaluation of safety and probiotic potential of Lacticaseibacillus paracasei LC86 and Lacticaseibacillus casei LC89 by Ting Chen, Yunjiao Zhao, Yunjiao Zhao, Yixuan Fan, Yao Dong, Zhonghui Gai

“…AimA comprehensive safety assessment of potential probiotic strains was essential for their application in the food industry. This article systematically evaluated the probiotic characteristics, whole-genome sequence analysis and safety of Lacticaseibacillus paracasei LC86 and Lacticaseibacillus casei LC89.MethodsFirstly, the two strains of lactic acid bacteria selected were identified. …”
Get full text

Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer by Abhishek Chauhan, Hemant Joshi, Divya Kandari, Diwakar Aggarwal, Ritu Chauhan, Hardeep Singh Tuli, Arpit Mehrotra, Abhilasha Sood, Ujjawal Sharma, Darin Mansor Mathkor, Shafiul Haque, Naveen Chandra Joshi, Laurent Dufossé

“…Purpose: This article investigates the apoptotic mechanisms and anticancer potential of oridonin, including its modulatory effects on signaling pathways and its derivatives' enhanced efficacy against drug-resistant cancer cells. Methods: A systematic literature search was conducted using Scopus, PubMed, SpringerLink, ScienceDirect, Wiley Online, and Web of Science databases, covering the period from 2007 to 2024. …”
Get full text

Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms by Ali Mohammadkhanizadeh, Mohammad Sheibani, Soroush Taherkhani, Davood Nourabadi, Seyed Mahdi Mohamadi-Zarch, Farnaz Nikbakht, Yaser Azizi

“…The literature surveyed spans from 1980 to 2024. Also, systematic search was performed in Embase, MEDLINE, Scopus, Web of Science Core Collection, and Google Scholar for relevant references. …”
Get full text

A Survey on Reconfigurable Intelligent Surface for Physical Layer Security of Next-Generation Wireless Communications by Ravneet Kaur, Bajrang Bansal, Sudhan Majhi, Sandesh Jain, Chongwen Huang, Chau Yuen

“…Then, a detailed and systematic classification of the various RIS-assisted wireless system topologies exhibiting multiple scenarios, system models, channel fading models, performance metrics and objectives is done. …”
Get full text

Machine learning and SHAP value interpretation for predicting comorbidity of cardiovascular disease and cancer with dietary antioxidants by Xiangjun Qi, Shujing Wang, Caishan Fang, Jie Jia, Lizhu Lin, Tianhui Yuan

“…Benchmarking provided a systematic approach to evaluating and comparing model performance. …”
Get full text

The effects of low-carbohydrate diet on glucose and lipid metabolism in overweight or obese patients with T2DM: a meta-analysis of randomized controlled trials by Wende Tian, Shuyu Cao, Yongxin Guan, Zihao Zhang, Qiyu Liu, Jianqing Ju, Ruixi Xi, Ruina Bai

“…Low-carbohydrate diets have emerged as a potential intervention, yet clinical evidence remains inconclusive.PurposeThis meta-analysis assesses the impact of low-carbohydrate diets on metabolic profiles in overweight or obese T2DM patients, aiming to guide clinical practice.MethodsA systematic review identified randomized clinical trials (RCTs) comparing low-carbohydrate diets to control diets in T2DM patients from PubMed, Embase, and the Cochrane Library databases up to April 2023.ResultsSeventeen RCTs, encompassing 1,197 participants, demonstrated that low-carbohydrate diets significantly improved HbA1c levels and fasting plasma glucose (mean difference [MD] = −0.36, 95% CI −0.44 to −0.29, p < 0.00001; MD = −10.71, 95% CI −14.39 to −7.03, p < 0.00001). …”
Get full text

Habitat Quality Dynamics in Urumqi over the Last Two Decades: Evidence of Land Use and Land Cover Changes by Siying Chen, Ümüt Halik, Lei Shi, Wentao Fu, Lu Gan, Martin Welp

“…Rapid urbanization has led to habitat degradation and loss of biodiversity, posing severe threats to regional sustainability, particularly in extremely vulnerable arid zones. However, systematic research on the assessment indicators, limiting factors, and driving mechanisms of habitat quality in arid regions is notably lacking. …”
Get full text

Developing a core outcome set for interventions in people with mild cognitive impairment: study protocol by Angus G K McNair, Nicholas Turner, Alan Richardson, Elizabeth Coulthard, Jemima Dooley, Julie Clayton, Sam Harding, Sarah Rudd, Victoria Grace Gabb, Winsome Barrett-Muir, Natalie Woodward, Sophie Alderman, Joseph Webb

“…This study aims to develop a COS for adults living with MCI intended for use in interventional and clinical settings.Methods and analysis The COS will be developed using a five-stage study design: (1) systematic literature search, (2) qualitative interviews, (3) evidence synthesis from stages 1 and 2, (4) two-round Delphi survey and (5) consensus meeting(s). …”
Get full text

Quantifying LAGA mutated mouse IgG2a monoclonal antibody with a rapid pepsin digestion enabled immunoaffinity LC/MS/MS assay by Linlin Dong, Susan Chen, Konstantin Piatkov, Dong Wei, Mark G. Qian

“…To overcome these challenges, a trypsin alternative pepsin, an aspartic protease, was systematically investigated for its use in digesting the mutated mIgG2a antibody to allow generation of signature peptides for the bioanalytical quantification purpose. …”
Get full text

Improving drug repositioning with negative data labeling using large language models by Milan Picard, Mickael Leclercq, Antoine Bodein, Marie Pier Scott-Boyer, Olivier Perin, Arnaud Droit

“…Results We proposed a novel strategy using Large Language Models (GPT-4) to analyze all clinical trials on prostate cancer and systematically identify true negatives. This approach showed remarkable improvement in predictive accuracy on independent test sets with a Matthews Correlation Coefficient of 0.76 (± 0.33) compared to 0.55 (± 0.15) and 0.48 (± 0.18) for two commonly used PU learning approaches. …”
Get full text

Long-term hypoxic atmosphere enhances the stemness, immunoregulatory functions, and therapeutic application of human umbilical cord mesenchymal stem cells by Qi-Ming Huang, You-Qiong Zhuo, Zhong-Xin Duan, Yin-lin Long, Jia-Nan Wang, Zhou-hang Zhang, Shao-Yong Fan, Yong-Ming Huang, Ke-Yu Deng, Hong-Bo Xin

“…The comparison between both atmospheres systematically analyzed the biological functions of MSCs, mainly including stemness maintenance, immune regulation, and resistance to chondrocyte apoptosis, and studied their joint function and anti-inflammatory effects in osteoarthritis (OA) rats constructed by collagenase II. …”
Get full text