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72361
Suberosin attenuates rheumatoid arthritis by repolarizing macrophages and inhibiting synovitis via the JAK/STAT signaling pathway
Published 2025-01-01“…Abstract Background Rheumatoid arthritis (RA) is a systemic disease that primarily manifests as chronic synovitis of the symmetric small joints. …”
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72362
Log odds of positive lymph nodes compared to positive lymph node ratio and number of positive lymph nodes in prognostic modeling for patients with NSCLC undergoing lobectomy or tot...
Published 2025-01-01“…The SHAP (SHapley Additive exPlanations) analysis of the XGBoost model demonstrated that the LODDS exhibited the highest SHAP values (0.25) for predicting overall survival in patients, consistently outperforming the LNR and the number of nPLN across both training and validation datasets.ConclusionsCompared to the nPLN and LNR staging systems, LODDS demonstrates superior prognostic power for patients with stage I–IIIA NSCLC undergoing lobectomy or pneumonectomy. …”
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72363
Retinoblastoma. Part 2. Treatment strategies for intraocular retinoblastoma
Published 2020-11-01“…This paper discusses the algorithms to determine risk factors and further systemic treatment strategy in several large study groups. …”
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72364
Evaluation and refinement of thresholds for early migration of total knee replacements as an estimator of late aseptic loosening: an updated systematic review of RSA and survival s...
Published 2025-01-01“…These findings support and refine the migration thresholds to improve the evidence-based introduction of new TKR systems. …”
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72365
Adherence to integrated care using the ‘Atrial fibrillation Better Care' pathway in asymptomatic patients with atrial fibrillation improves clinical outcomes: A report from the pro...
Published 2025-01-01“…Follow-up data were collected for 3 years to examine the composite endpoint (all-cause death, ischemic stroke/transient ischemic attack [TIA]/systemic embolism [SE], and major bleeding), and the impact of adherence to the ABC pathway. …”
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72366
Effect of practicing water-saving irrigation on greenhouse gas emissions and crop productivity: A global meta-analysis
Published 2025-03-01“…Moreover, WSI has attracted extensive attention for its potential to mitigate greenhouse gas (GHG) emissions in agriculture systems. In this study, a global meta-analysis of 1230 observations from 62 publications were conducted to investigate the global patterns and underlying drivers of soil GHG emissions and crop productivity (crop yield and water use efficiency) induced by WSI, and the contributions of key factors to GHG emissions and crop productivity were further quantified. …”
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72367
Fusion of EEG and EMG signals for detecting pre-movement intention of sitting and standing in healthy individuals and patients with spinal cord injury
Published 2025-01-01“…By enabling early detection of sitting and standing intentions, this method holds the potential to offer more accurate and timely interventions within rehabilitation systems.…”
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72368
Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions
Published 2025-01-01“…Abstract The aging process is marked by a time-dependent deterioration in cellular functions, particularly the immune and neural systems. Understanding the phenotype acquisition of microglia, the sentinel immune cells of the brain, is crucial for understanding the nature of age-related neurological diseases. …”
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72369
Effects of Stocking Density on Fatty Acid and Amino Acid Composition in Muscle, Serum Cortisol, Stress and Immune Response in Large Yellow Croaker (<i>Larimichthys crocea</i>)
Published 2024-12-01“…Overall, this study showed that the optimal final culturing density of large yellow croaker under flow-through systems should be between 14.41 kg/m<sup>3</sup> and 18.71 kg/m<sup>3</sup> to improve aquaculture efficiency and product quality.…”
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72370
Reflecting on the impact of the COVID pandemic on patient management and its subsequent influence on long-term outcomes: a case–control study in the field of esophago-gastric cance...
Published 2025-01-01“…These insights provide valuable lessons for healthcare systems in managing cancer care during global health emergencies.…”
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72371
Molecular Detection of Carbapenemase-Encoding Genes in Multidrug-Resistant Acinetobacter baumannii Clinical Isolates in South Africa
Published 2020-01-01“…Antimicrobial susceptibility testing was performed by VITEK® 2 and autoSCAN-4 systems. The MIC of imipenem and meropenem was rechecked by E-test. …”
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72372
Time-restricted feeding improves metabolic syndrome by activating thermogenesis in brown adipose tissue and reducing inflammatory markers
Published 2025-01-01“…However, there is limited research focusing on the effects of TRF on energy expenditure and systemic low-grade inflammation. This study aims to investigate the impact of TRF on weight management, glucose metabolism, insulin resistance, and lipid metabolism in male C57BL/6J mice, particularly in the context of metabolic disorders induced by a high-fat diet (HFD).MethodsC57BL/6J mice were divided into two groups: a normal diet (ND) group and a high-fat diet (HFD) group. …”
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72373
Predictive role of SLC1A5 in neuroblastoma prognosis and immunotherapy
Published 2025-01-01“…Targeting SLC1A5 through advanced drug delivery systems and combined metabolic-immunotherapeutic strategies may enhance treatment specificity and efficacy. …”
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72374
Related Pentacyclic Triterpenes Have Immunomodulatory Activity in Chronic Experimental Visceral Leishmaniasis
Published 2021-01-01“…Drugs employed in the treatment of leishmaniasis have limited efficacy and induce local and systemic side effects to the patients. Natural products are an interesting alternative to treat leishmaniasis, because some purified molecules are selective toward parasites and not to the host cells. …”
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72375
Systematic review and quantitative meta-analysis of age-dependent human T-lymphocyte homeostasis
Published 2025-01-01“…Our study introduces a quantitative description of the fundamental parameters characterizing the maintenance and evolution of T-cell subsets with age, based on a comprehensive integration of available organ-specific and systems-level flow cytometry datasets. Overall, it provides the most up-to-date view of physiological T-cell dynamics and its variance and may be used as a consistent reference for gaining further mechanistic understanding of the human immune status in health and disease.…”
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72376
Ultrahigh average zT realized in polycrystalline SnSe0.95 materials through Sn stabilizing and carrier modulation
Published 2025-03-01“…This strategy of introducing high-valence halides with heavy element can optimize the thermoelectric performance for other material systems.…”
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72377
Serum neuritin as a predictive biomarker of early neurological deterioration and poor prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study
Published 2025-01-01“…Furthermore, two specific weighted scoring systems were developed to optimize clinical prediction of poor prognosis and END after ICH.ConclusionElevated serum neuritin levels are strongly associated with disease severity, END, and 90-day poor neurological outcomes following ICH, establishing serum neuritin as a potential prognostic biomarker for ICH.…”
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72378
Going, going, gone: Landscape drying reduces wetland function across the American West
Published 2025-02-01“…Monitoring encompassed all freshwater palustrine and littoral systems, including anthropogenic wetlands sustained through human water use (e.g., irrigated agriculture and earthen livestock ponds). …”
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72379
Effect of Dendrobium Officinale on Radioactive Oral Mucositis of Nasopharyngeal Carcinoma and Changes of Oral Microecology
Published 2025-01-01“…Dendrobium officinale may reduce the symptoms of radiotherapy-induced oral mucositis by affecting the systemic cellular immune function. It may reduce the secretion of pro-inflammatory factors of the relevant flora by directly changing the oral flora and regulating the oral micro-ecology.…”
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72380
Epilepsy care pathway: The Finnish model
Published 2025-02-01“…This pathway can serve to model how integrated healthcare systems can effectively manage complex conditions. …”
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