Enhancing PDAC therapy: Decitabine-olaparib synergy targets KRAS-dependent tumors by Giorgia Anastasio, Michela Felaco, Alessia Lamolinara, Francesco del Pizzo, Elisa Cacciagrano, Carla Mottini, Margherita Mutarelli, Francesca Di Modugno, Manuela Iezzi, Luca Cardone

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Assessing caregiver stress and resource needs in pediatric cancer care by Shaimaa Mohamed Amin, Mahmoud Abdelwahab Khedr, Azza Medhat Aziz Mansy, Ahmed Hashem El-Monshed, Mohamed Gamal Noaman Malek, Ayman Mohamed El-Ashry

“…Understanding the socio-demographic factors influencing caregiver stress and identifying the specific needs and resources required by caregivers are crucial for improving support systems in pediatric cancer care. Aim of the study This study aimed to analyze the levels of caregiver stress and their resource needs within pediatric cancer care. …”
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A comparison of new and existing rootstocks to reduce canker of apple trees caused by Neonectria ditissima (Nectriaceae, Hypocreales) by Lucas A. Shuttleworth, Sonia Newman, Ioannis Korkos

“…Abstract The grafting of apple rootstocks on to scions confers benefits including reduced tree size/dwarfing for trellis based growing systems, increased tolerance to physiological stress, and pest and disease management. …”
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The effect of political will, information technology, and the quality of financial reporting information on fraud prevention by Haliah, Hasnawiya Hasan, Syamsuddin, Fatmawati, Andi Ratna Sari Dewi, Muhammad Alief Fahdal Imran Oemar, Linda Arisanty Razak

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Leveraging advanced deep learning and machine learning approaches for snow depth prediction using remote sensing and ground data by Haytam Elyoussfi, Abdelghani Boudhar, Salwa Belaqziz, Mostafa Bousbaa, Karima Nifa, Bouchra Bargam, Abdelghani Chehbouni

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Exploring the clinical profiles and management of juvenile dermatomyositis in Africa: a survey of African rheumatology care providers by Jessica Perfetto, Laura B. Lewandowski, Dawn M. Wahezi, Vanessa Ogega, Joan Ahimbisibwe, Kate Webb, Christiaan Scott, Angela Migowa

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Investigating male factors and their relationships with reproductive health outcomes: a case-control study protocol for Towards Optimal Fertility, Fathering, and Fatherhood studY (... by Fabian Yap, See Ling Loy, Yin Bun Cheung, Jerry Kok Yen Chan, Keith Godfrey, Chee Wai Ku, Jun Wei Pek, Melissa D/O Tharmalingam Durgahshree, Melinda Chan, Yie Hou Lee

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Public acceptance of microbiome management strategy in dairy calves: a European survey on colostrum, probiotic provision and prolonged cow-calf contact by A. Ait Sidhoum, A. Stygar, F. Bedoin, J.K. Niemi

“…For instance, individuals with greater familiarity with farming systems and microbiomes were more inclined to accept all four interventions, while women, compared to men, showed higher acceptance of prolonged cow-calf contact. …”
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Mechanism of <italic>Hindu Datura</italic> in the Treatment of Rheumatoid Arthritis from the Perspective of Network Pharmacology by Changlong FU, Yangyang MEI, Xihai LI, Zhiwei QIU, Changxing CHEN, Chunsong ZHENG

“…Objective:To construct the active component target of <italic>Hindu datura</italic> and the disease target of rheumatoid arthritis by using network pharmacology, to predict the specific molecular signal and pathway of <italic>hindu datura</italic> in the treatment of rheumatoid arthritis, and to analyze its potential therapeutic target and molecular mechanism.Methods:All the chemical components of <italic>hindu datura</italic> were summarized and screened through Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)database, retrieval was performed with the preset oral bioavailability(OB)≥30%and drug like(DL)≥0.18.Uniprot database was used to screen the entire correlation basis of the effective chemical compound.After screening the disease target with"rheumatoid arthritis"as the retrieval word using GeneCards and OMIM database, the superimposed target area between the drug target of <italic>hindu datura</italic> and the disease target of rheumatoid arthritis was summarized and analyzed, and it could be used as the prediction target gene of <italic>hindu datura</italic> for treating rheumatoid arthritis.Network targets were constructed and analyzed for the exported data based on Cytoscape 3.7.1 software and STRING 7.8 database.Finally, GO functional enrichment analysis and KEGG signal pathway analysis were performed to further screen the main targets and signal pathways.Results:①Through screening and analysis, 27 effective compounds, 318 corresponding target genes and 125 predicted target genes were obtained for the treatment of rheumatoid arthritis.②The core genes in PPI network mainly included JUN, AKT1, RELA, MAPK1, etc.③GO functional enrichment analysis showed that the biological process(BP)for the treatment of rheumatoid arthritis by <italic>hindu datura</italic> mainly involves response to lipopolysaccharide, response to lipopolysaccharide, response to molecule of bacterial origin, response to metalion, response to oxidative stress, response to steroid hormone, cellular response to oxidative stress, reactive oxygen species metabolic process, response to oxygen levels, etc..The cell component(CC)consisted of membrane raft, membrane region, plasma membrane raft and presynaptic membrane; molecular functions(MF)mainly involved the nuclear receptor activity, transcription factor activity(direct ligand regulated sequence-specific DNA binding), steroid hormone receptor activity, cytokine receptors, cytokine activity, DNA-binding transcription activator activity, RNA polymeraseⅡtranscription factor binding, kinase regulator activity, receptor ligand activity, etc.The analysis of KEGG signaling pathway showed that the obvious pathway of <italic>hindu datura</italic> in the treatment of rheumatoid arthritis may involve IL-17 signaling pathway, TNF signal pathway, HIF-1signalpathway, Toll-like receptor signal pathway, etc.Conclusion:The potential mechanism of <italic>hindu datura</italic> for the treatment of rheumatoid arthritis is to exert anti-inflammatory, analgesic and antioxidant effects, which involve a number of interactive signal pathways.…”
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New Technological Knowledge Integration in Industries with Long-Wave Innovation: Case Study of Iran Mining and Mineral Industry by akbar Mohammadi, Nima Garosi Mokhtarzade, Ahmad Jafar nejad

“…Conclusion This study reveals that activities such as aligning new technology with operational functions, adopting new technology at the right time to match the firm's knowledge base, maintaining equipment, evaluating product compatibility with international standards, and implementing integrated technology information systems are crucial for firms to achieve greater success in knowledge integration. …”
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Gut dysbiosis narrative in psoriasis: matched-pair approach identifies only subtle shifts correlated with elevated fecal calprotectin by Bayazit Yunusbayev, Anna Bogdanova, Nadezhda Nadyrchenko, Lavrentii Danilov, Viktor Bogdanov, Grigory Sergeev, Radick Altinbaev, Fanil Bilalov, Milyausha Yunusbaeva

“…We next showed that these enriched species were correlated with elevated biomarkers of intestinal and systemic inflammation and liver function. Functionally, one of the top species, Megasphaera elsdenii, is a potent lactate utilizer in the context of intestinal lactic acidosis and inflammation. …”
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Spatiotemporal variations of surface and groundwater interactions under climate and land use land cover change scenarios by Kotapati Narayana Loukika, Venkata Reddy Keesara, Eswar Sai Buri, Venkataramana Sridhar

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Development of Stylistics and Rhetoric in Lithuania by Irena Smetonienė, Marius Smetona

“…However, evident changes are occurring, as everything in the world undergoes reevaluation, from social relations and value systems to language. The established understanding within the rhetoric canon is being disrupted, and new rules and traditions are taking shape. …”
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Air Pollution Levels Related to Peak Expiratory Flow Rates among Adult Asthmatics in Lampang, Thailand by Wanwisa Chujit, Phongtape Wiwatanadate, Athavudh Deesomchok, Khajornsak Sopajaree, Kamal Eldeirawi, Ying I. Tsai

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Personal, environmental and behavioral predictors associated with online fraud victimization among adults. by Vimala Balakrishnan, Umayma Ahhmed, Faris Basheer

“…Additionally, addressing systemic factors like social norms and digital literacy gaps is crucial for creating equitable and effective solutions to reduce online fraud victimization.…”
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E-MAC: Enhanced In-SRAM MAC Accuracy via Digital-to-Time Modulation by Saeed Seyedfaraji, Salar Shakibhamedan, Amire Seyedfaraji, Baset Mesgari, Nima Taherinejad, Axel Jantsch, Semeen Rehman

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Quand les routes fermées de montagne racontent les territoires. L’exemple du Vercors : entre invisibilités, réappropriations et mises en valeur (XIXe -XXIe siècles) by Emma-Sophie Mouret

“…Elles sont construites à flanc de falaise et deviennent rapidement des itinéraires d’excursions touristiques, ce qui entraine la structuration d’un système socio-économique associant de nombreux acteurs. …”
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Statut foncier et services écosystémiques fournis par les palmiers dattiers (Phoenix dactylifera L) des oasis du Kawar (Nord-Est du Niger) by Malam Moussa Dagrama, Tidjani Adamou Didier, Moustapha Moustapha Aboubacar, Elhadji Mohamoud Chekou Koré

“…Le système oasien du Kawar constitue un écosystème unique situé entre l’erg du Ténéré et celui de Bilma. …”
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Biochemical blood parameters in platinum fox females and males in ontogenesis by I. I. Okulova, Yu. A. Berezina, A. S. Syutkina, I. A. Plotnikov, O. Yu. Bespyatykh, I. A. Domsky

“…Changes in its composition allows veterinary practitioners to identify disorders in various systems and organs of animals, as well as to assess metabolism in animals. …”
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Classification of Aortic Stenosis Patients via ECG-Independent Multi-Site Measurements of Cardiac-Induced Accelerations and Angular Velocities at the Skin Level by Chiara Romano, Emanuele Maiorana, Annunziata Nusca, Simone Circhetta, Sergio Silvestri, Schena Emiliano, Gian Paolo Ussia, Carlo Massaroni

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