PHARMACOECONOMICAL RESEARCH OF THE USE OF SORAFENIB IN MALIGNANT TUMORS by M. Y. Frolov, N. A. Avksentjev, I. G. Rusakov, E. V. Derkach

“…The use of sorafenib, instead of the combination of bevacizumab + interferon-α in patients with MRCC gives us the opportunity to release the funds and provide a systemic treatment of patients with other malignancies (HCC, DCT) while reducing the burden on the budget.…”
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TUBA1B as a novel prognostic biomarker correlated with immunosuppressive tumor microenvironment and immunotherapy response by Juntao Qi, Juntao Qi, Mingming Zhou, Na Yang, Huiyun Ma, Min He, Gujie Wu, Chang Ge, Liuyin Jin, Lin Cheng, Wei Liao, Hefei Ren, Caiyun Lei

“…It also influences immune functions within both the innate and adaptive immune systems, affecting immune-related signaling pathways. …”
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Impact of Sjögren’s disease on quality of sexual life using the Qualisex score by Eric Hachulla, Xavier Mariette, Jacques-Eric Gottenberg, Philippe Dieude, Aleth Perdriger, Emanuelle Dernis, Marion Couderc, Raphaele Seror, Gaetane Nocturne, Rakiba Belkhir, Valérie Devauchelle-Pensec, Veronique Le Guern, Alexandra Kachaner, Sophie Berville

“…The inability to obtain a score was associated with older age.Conclusion In SjD patients, sexual satisfaction assessed with the Qualisex score, was strongly associated with depression and, to lesser extent, with ESSPRI, but not with systemic activity.…”
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Antibiotic Prescription Practice and Resistance Patterns of Bacterial Isolates from a Neonatal Intensive Care Unit: A Retrospective Study from Jordan by Mariam Alameri, Lobna Gharaibeh, Mervat Alsous, Aseel Yaghi, Asma’a Tanash, Saqr Sa’id, Hanan Sartawi

“…<b>Background/Objectives</b>: Neonatal sepsis is a systemic inflammation in neonates caused by bacteria, viruses, or fungi that can progress into severe conditions. …”
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Revealing viral hepatitis epidemiology in the Democratic Republic of Congo: insights from yellow fever surveillance reanalysis by Patrick Mukadi-Kakoni, Yannick Munyeku-Bazitama, Gracia Kashitu-Mujinga, Marguerite Manwana-Pemba, Niclette Zenga-Bibi, Patient Okitale-Talunda, Christelle Mbelu-Kabongo, Fleurette Domai-Mbuyakala, Elisabeth Pukuta-Simbu, Pierre Mutantu-Nsele, Yoshinao Kubo, Sheila Makiala-Mandanda, Steve Ahuka-Mundeke, Koya Ariyoshi, Jean-Jacques Muyembe-Tamfum

“…Abstract Background Yellow fever surveillance systems are designed to identify cases of acute febrile jaundice, a clinical syndrome used to monitor the emergence of yellow fever outbreaks. …”
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Sorafenib as Adjuvant Therapy Post–Liver Transplant: A Single-center Experience by Hala Hassanain, MD, Ashton A. Connor, MD, PhD, Elizabeth W. Brombosz, PhD, Khush Patel, MD, MS, Ahmed Elaileh, MD, Tamneet Basra, MD, Sudha Kodali, MD, MSPH, David W. Victor, III, MD, Caroline J. Simon, MD, Yee Lee Cheah, MD, Mark J. Hobeika, MD, Constance M. Mobley, MD, PhD, Ashish Saharia, MD, Sadhna Dhingra, MD, Mary Schwartz, MD, Anaum Maqsood, MD, Kirk Heyne, MD, Ahmed O. Kaseb, MD, Jean-Nicolas Vauthey, MD, A. Osama Gaber, MD, Maen Abdelrahim, MD, PhD, R. Mark Ghobrial, MD, PhD

“…We investigate whether adjuvant systemic therapy can reduce recurrence, as shown with other malignancies. …”
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Hard rock aquifer architecture and water circulation levels in the Strengbach critical zone observatory (France) by Chabaux, François, Négrel, Philippe, Gal, Frederick, Viville, Daniel, Ranchoux, Coralie, Van der Woerd, Jérome, Delay, Frederick, Ackerer, Julien, Aquilina, Luc, Diraison, Marc, Masson, Frédéric, Mériaux, Anne-Sophie, Labasque, Thierry, Lucas, Yann, Pezard, Philippe Adrien, Reuschlé, Thierry, Schmitt, Anne-Désirée, Stille, Peter, Wyns, Robert, Lerouge, Catherine, Dezayes, Chrystel

“…Such a difference is associated with the existence of a knickpoint in the river bed, separating a downstream zone marked by currently active erosion from an upstream one, less prone to erosion, with preserved reliefs formed around 20 ka ago.The water circulation scheme within the Strengbach watershed involves two different systems: a subsurface circulation within the shallow aquifer, corresponding to the mobile saprolite horizon and the saprock, and a deeper circulation in the fractured bedrock. …”
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Distribution and species composition of potato viruses in the Novosibirsk region by V. S. Maslennikova, M. B. Pykhtina, K. A. Tabanyukhov, E. V. Shelikhova, K. I. Mosalev, A. V. Katokhin, A. A. Bondar, A. B. Beklemishev, M. I. Voevoda

“…The obtained results of the strain affiliation of NR samples lay the basis for the development of DNA and immunodiagnostic systems for identifying PVY circulating in NR, as well as for elucidating the source and routes of entry of specific virus strains.…”
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Extracellular vesicles, RNA sequencing, and bioinformatic analyses: Challenges, solutions, and recommendations by Rebecca T. Miceli, Tzu‐Yi Chen, Yohei Nose, Swapnil Tichkule, Briana Brown, John F. Fullard, Marilyn D. Saulsbury, Simon O. Heyliger, Sacha Gnjatic, Natasha Kyprianou, Carlos Cordon‐Cardo, Susmita Sahoo, Emanuela Taioli, Panos Roussos, Gustavo Stolovitzky, Edgar Gonzalez‐Kozlova, Navneet Dogra

“…Abstract Extracellular vesicles (EVs) are heterogeneous entities secreted by cells into their microenvironment and systemic circulation. Circulating EVs carry functional small RNAs and other molecular footprints from their cell of origin, and thus have evident applications in liquid biopsy, therapeutics, and intercellular communication. …”
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Understanding the dynamics of compliance to smoke-free policy regulations: Exploring the perspectives of venue owners and staff in Türkiye by Ezgi Baltacı, Aslı Çarkoğlu, Sejal Saraf, Toker Ergüder, Gül Ergör, Mutlu Hayran, Connie Hoe

“…Respondents’ suggested improvements were related to building infrastructure, such as the ventilation systems and educating the public on the harmful health effects of smoking. …”
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Policy and practice implication of - and tools to address - mental health and psychosocial support needs in Sierra Leone by Alastair Ager, Rebecca Horn, Abdulai Bah, Abdulai Bah, Haja Wurie, Mohamed Samai, Mohamed Samai

“…In 2017, the Ministry of Health and Sanitation (MoHS) worked with staff of the College of Medicine and Allied Health Sciences (COMAHS – part of the University of Sierra Leone) and Queen Margaret University (QMU) in Edinburgh – and other stakeholders, including members of the Mental Health Coalition Sierra Leone – to define a research agenda that would support the development of community-based mental health and systems support in the community. This paper summarizes work over the course of the following six years in relation to this agenda, and indicates its relevance to ongoing and planned service developments. …”
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Extracorporeal Hemadsorption versus Glucocorticoids during Cardiopulmonary Bypass: A Prospective, Randomized, Controlled Trial by Gordana Taleska Stupica, Maja Sostaric, Marija Bozhinovska, Lea Rupert, Zoran Bosnic, Ales Jerin, Alojz Ihan, Tomislav Klokocovnik, Matej Podbregar

“…Glucocorticoids have been used during open-heart surgery for alleviation of systemic inflammation after CPB. We compared intraoperative hemadsorption and methylprednisolone, with usual care, during complex cardiac surgery on CPB, for inflammatory responses, hemodynamics, and perioperative course. …”
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Childhood wasting and associated factors in Africa: evidence from standard demographic and health surveys from 35 countries by Tadesse Tarik Tamir, Alebachew Ferede Zegeye, Belayneh Shetie Workneh, Mohammed Seid Ali, Almaz Tefera Gonete, Masresha Asmare Techane, Mulugeta Wassie, Alemneh Tadesse Kassie, Medina Abdela Ahmed, Sintayehu Simie Tsega, Yilkal Abebaw Wassie, Berhan Tekeba, Enyew Getaneh Mekonen

“…Moreover, a renewed focus on tackling the multifaceted factors of undernutrition, strengthening health systems, and implementing evidence-based interventions tailored to the local context is crucial for achieving meaningful and sustained reductions in wasting prevalence across the region.…”
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HCV and HIV co-infection among people who inject drugs in Vietnam by Vu Toan THINH, Li LI, Dréan MATTHIEU, Van Dinh HOA, Nguyen Huu ANH, Le Minh GIANG

“…Introduction: HIV/HCV co-infection in people who inject drugs (PWID) continues to be a major chal- lenge for health care systems and the PWID themselves. PWID have driven the HIV epidemic in Vietnam but information on HIV/HCV co-infection is limited. …”
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Granger Test and ARDL Model for the Socio-Economic Challenges Investigation: Public Expenditure Components, Economic Growth, and Inflation by Fatma Zohra Hamadouche, Bekhta Hamadouche, Malak Mohammad Ghandour, Aicha Hamadouche, Brahim Boutrig

“…Additionally, fiscal discipline, transparency, and robust monitoring systems for public spending are crucial to ensuring efficient use of resources and controlling inflation.…”
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Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris by Pavel Borsky, Zdenek Fiala, Ctirad Andrys, Martin Beranek, Kvetoslava Hamakova, Andrea Malkova, Tereza Svadlakova, Jan Krejsek, Vladimir Palicka, Lenka Borska, Vit Rehacek

“…Psoriasis vulgaris is a chronic autoimmune disease associated with systemic inflammation. Increased levels of numerous cytokines, chemokines, growth factors, and other molecules were found in the skin and in the circulation of psoriatic patients. …”
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Can primary care research be conducted more efficiently using routinely reported practice-level data: a cluster randomised controlled trial conducted in England? by Jeremy Horwood, Alastair D Hay, Patricia Jane Lucas, Clare Clement, Peter S Blair, Jodi Taylor, Christie Cabral, Martin C Gulliford, Jenny Ingram, Padraig Dixon, Nick Francis, Athene Lane, Grace Young, Elizabeth Beech, Penny Seume, Scott Bevan, Sam T Creavin

“…Engagement with CRNs and installation of the intervention was straight-forward although the impact of updates to practice IT systems and lack of familiarity required extended support in some practices. …”
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Insights from the compositional evolution of a multi-coloured, zoned tourmaline from the Cruzeiro pegmatite, Minas Gerais, Brazil by G. B. Andreozzi, G. B. Andreozzi, C. Gori, H. Skogby, U. Hålenius, A. Altieri, F. Bosi, F. Bosi

“…Moreover, in uncontaminated granitic pegmatite systems such as that of Cruzeiro, the compositional evolution of tourmaline progresses from schorl to fluor-elbaite, rather than from schorl to elbaite, to reflect co-enrichment in Li and F during fractional crystallization.…”
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Elucidating the role of precipitated phase particles in modifying creep properties of as-cast Mg-Bi/Sn-based alloys by Gang Xu, Wei-li Cheng, Yi-hao Luo, Hui Yu, Li-fei Wang, Hang Li, Hong-xia Wang, Jin-hui Wang

“…The study developed the three alloy systems with different precipitates and examined the role of precipitated phase particles in modifying the creep properties of as-cast Mg-10Bi-0.5Mn-0.5Ag (BMQ1000), Mg-5Bi-5Sn-0.5Mn-0.5Ag (BTMQ5500) and Mg-10Sn-0.5Mn-0.5Ag (TMQ1000) alloys at temperatures ranging from 423 to 473 K and stresses of 45–85 MPa. …”
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Postoperative Tongqi Formula ameliorates postoperative ileus via p38 MAPK signaling pathway and metabolic disorder by Mengmeng Yang, Yuxuan Lu, Shufan Jin, Wanqiu Liu, Miaoshi Yao, Zhiwei Jiang, Yachun Shu

“…Results from the spleen index and charcoal powder propulsion rate indicated that PTQF alleviated the inflammatory phase of POI in rats by mitigating systemic and intestinal inflammation. This was supported by reduced levels of inflammatory factors, modulation of ZO-1 protein expression, and a decrease in p38 MAPK phosphorylation levels. …”
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