Methylprednisolone substituted lipid nanoparticles deliver C3 transferase mRNA for combined treatment of spinal cord injury by Haoru Dong, Zongxing He, Shiyi Cai, Haiqiang Ma, Lili Su, Jianfeng Li, Huiying Yang, Rong Xie

“…This strategy aims to enhance the localization and concentration of MP at the injury site, thereby amplifying its therapeutic efficacy while mitigating systemic side effects. Furthermore, we explore the integration of C3 transferase mRNA into MP-LNPs. …”
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Oral Immunisation With Non‐GMO Surface Displayed SARS‐CoV‐2 Spike Epitopes on Bacteria‐Like Particles Provokes Robust Humoral and Cellular Immune Responses, and Modulated the Gut M... by Robie Vasquez, Ji Hoon Song, Remilyn M. Mendoza, In‐Chan Hwang, Bernadette B. Bagon, Lars Engstrand, Valerie Diane Valeriano, Dae‐Kyung Kang

“…Our results showed that mucosal immunisation of mice with surface‐displayed SARS‐CoV‐2 spike epitopes provoked high‐level secretory IgA and systemic IgG production. Moreover, the immunisation exhibited a Th1‐like immune response, characterised by an elevated IgG2a‐to‐IgG1 ratio and high antiviral IFN‐γ production. …”
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The ANFIS-RSM based multi-objective optimization and modelling of ultrasound-assisted extraction of polyphenols from jamun fruit (Syzygium cumini) by Mohammad Ganje, Somayyeh Gharibi, Fatemeh Nejatpour, Maryam Deilamipour, Kimia Goshadehrou, Sahra Saberyan, Gholamreza Abdi

“…In order to optimize polyphenol extraction from ripe jamun fruit pulp, including traditional and ultrasound-assisted methods, this study assessed the prediction power of response surface methodology (RSM) and adaptive neuro-fuzzy inference systems (ANFIS). It examined how temperature, process time, solvent type, and extraction method affected the yield of extracted polyphenols. …”
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Testing a multi-behavioral intervention to improve oral health behaviors in the pediatric dental surgery population: protocol for the PROTECT trial by Joanna Buscemi, Teresa G. Borowski, David Avenetti, Lisa Tussing-Humphreys, Lisa Tussing-Humphreys, Lisa Tussing-Humphreys, Molly Martin, Molly Martin, Marc S. Atkins, Teresa Marshall, Michael Berbaum, Helen H. Lee, Helen H. Lee

“…The ultimate goal of PROTECT is to prevent subsequent surgical events for children presenting with S-ECC to prevent further chronic disease and reduce costs and stress for families who already experience high levels of systemic barriers to their health.…”
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Ganciclovir Resistance-Linked Mutations in the HCMV <i>UL97</i> Gene: Sanger Sequencing Analysis in Samples from Transplant Recipients at a Tertiary Hospital in Southern Brazil by Anna Caroline Avila da Rocha, Grazielle Motta Rodrigues, Alessandra Helena da Silva Hellwig, Dariane Castro Pereira, Fabiana Caroline Zempulski Volpato, Afonso Luís Barth, Fernanda de-Paris

“…This approach could improve the understanding of HCMV strain dynamics and serve as a valuable tool for long-term patient monitoring, particularly within resource-constrained settings such as the public health systems of middle-income countries.…”
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Exploration of the Mountainous Urban Rail Transit Resilience Under Extreme Rainfalls: A Case Study in Chongqing, China by Chenhui Liu, Xue Su, Zhichun Wu, Yingjun Zhang, Cuizhu Zhou, Xiangguo Wu, Yong Huang

“…Extreme rainfalls could greatly affect operations of urban rail transit systems of mountainous cities, which are prone to have landslides and floods under rainfalls. …”
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A Retrospective Study to Investigate the Relationship Between Body Mass Index and Hemodynamic Characteristics in Hypertensive Patients by Wenqi Xiao, Ping Han, Liping Song, Jingwen Yang, Lin Zhou, Xiangning Deng, Zheng J. Ma, Yukun Lang, Hai Zhao, Yuzhuo Zhao, Hui Chen, Wenjing Zhang, Huixian Huang, Ningling Sun

“…Here, we analyzed data from 1368 uncontrolled hypertensive patients, including key hemodynamic indicators such as heart rate (HR), cardiac index (CI), arterial stiffness (AS), systemic vascular resistance index (SVRI), and thoracic blood ratio (TBR). …”
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Cross-Sectional Analysis of IL-6, TNF-α, Adiponectin, Leptin, and Klotho Serum Levels in Relation to BMI Among Overweight and Obese Children Aged 10–14 in La Rioja, Spain by Beatriz Fernández-Vallejo, Francisco Jiménez Monteagudo, Lourdes Romero, Maria Isabel López Aznárez, María del Carmen Romero Cobas, Laura Pérez-Martínez

“…Even in childhood, obesity is associated with systemic low-grade inflammation, which is a critical factor in the development of atherosclerosis and a predictor of cardiovascular morbidity and mortality. …”
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A Comprehensive Review on Current Knowledge and Future Potential of Topical Therapies in Breast Cancer Treatment by N. Bharathi Sai Thilagam, V.P. Karthik, R. Gnanasambandan, C. Sowmya

“…Recently, topical drug delivery is transforming breast cancer therapy, offering precision and reduced systemic toxicity. Emu oil-enhanced tamoxifen showed superior transdermal effectiveness, while raloxifene gel achieved 2.77 times greater bioavailability than oral forms. …”
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Herbicide and irrigation management options in conventionally-tilled wheat: deciphering water and energy budgeting, and grain and monetary output in north-Indian plains by S. K. Verma, Chandra Bhushan, Sudhir Kumar Rajpoot, Richa Chaudhary, Ramawatar Meena, Sanjeev K. Kashyap, Vijay Pratap, P K. Jaysawal, S. B. Singh, Ram K. Singh, Deepak K. Yadav

“…The study recommends exploring additional weed control strategies and irrigation management options in future improve wheat yields in conventionally-tilled systems.…”
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Exploring gender-based disparities in emotional distress among university level athletes by Sohom Saha, Farjana Akter Boby, Arnav Sharma, Sourav Ganguly, Kautilya Upadhyay, Awesh Khati, Dev Karan Singh, Kamal Dhoni, Debajit Karmakar

“…Conclusions: Developing psychological support systems for university athletes can mitigate emotional challenges and optimize performance. …”
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Evaluation of variation in special educational needs provision and its impact on health and education using administrative records for England: umbrella protocol for a mixed-method... by Stuart Logan, Ruth Gilbert, Tamsin Ford, Johnny Downs, Jugnoo Rahi, Ania Zylbersztejn, Katie Harron, Kate Boddy, Bianca De Stavola, Vincent Nguyen, Isaac Winterburn, Kate Lewis, Lucy Karwatowska, Lorraine Dearden, Sarah Barnes, Jacob Matthews, Matthew Lilliman, Jennifer Saxton, Antony Stone, Kristine Black-Hawkins

“…The proportion of children with SEN provision varies between schools and demographic groups, which may reflect variation in need, inequitable provision and/or systemic factors. There is scant evidence on whether SEN provision improves health and education outcomes.Methods The Health Outcomes of young People in Education (HOPE) research programme uses administrative data from the Education and Child Health Insights from Linked Data—ECHILD—which contains data from all state schools, and contacts with National Health Service hospitals in England, to explore variation in SEN provision and its impact on health and education outcomes. …”
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The emergence of DNAM-1 as the facilitator of NK cell-mediated killing in ovarian cancer by Rachel Pounds, Rachel Pounds, Wayne Croft, Hayden Pearce, Tasnia Hossain, Kavita Singh, Janos Balega, David N. Jeevan, Sudha Sundar, Sudha Sundar, Sean Kehoe, Jason Yap, Jason Yap, Paul Moss, Jianmin Zuo

“…Expression of PVR, the DNAM-1 ligand, was significantly increased on tumours and DNAM-1 mediated NK cell lysis of primary tumour tissue was observed in vitro.DiscussionThese findings reveal profound modulation of the tumour tissue and systemic profile of NK cells which likely contributes to the high rates of local progression and metastasis seen with OC. …”
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Research progress on application of digital health interventions in patients with cutaneous ureterostomy (数字健康干预在输尿管皮肤造口患者中的应用进展) by JI Xuebi (吉学碧), WANG Jun (王俊), WANG Ping (王萍), YE Yingao (叶迎奥), WANG Haifeng (王海峰)

“…Concurrently, the accelerated advancement of mobile technology and information systems has led to the integration of digital health interventions, which significantly enhance the convenience for these patients, thereby elevating their quality of life and providing assistance. …”
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Head-mounted camera as a debriefing tool for surgical simulation-based training: a randomized controlled study in Senegal by Abdourahmane Ndong, Adja C. Diallo, Armaun D. Rouhi, Diago A. Dia, Sebastian Leon, Cheikhou Dieng, Mohamed L. Diao, Jacques N. Tendeng, Noel N. Williams, Mamadou Cissé, Kristoffel R. Dumon, Ibrahima Konaté

“…Abstract Introduction Video feedback, particularly with a head-mounted camera, has previously been described as a useful debriefing tool in well-funded health systems but has never been performed in a low-resource environment. …”
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<i>In vitro</i> and <i>in vivo</i> tropism and biodistribution of recombinant simian adenovirus type 25 by Irina V. Vavilova, Tatiana A. Ozharovskaia, Olga V. Zubkova, Olga Popova, Daria V. Voronina, Polina P. Goldovskaya, Denis I. Zrelkin, Alina Sh. Dzharullaeva, Inna V. Dolzhikova, Dmitry V. Shcheblyakov, Denis Yu. Logunov, Alexander L. Gintsburg

“…The new platform based on the recombinant simian adenovirus type 25 is not inferior to the existing and well-established delivery systems based on human adenovirus types 5 and 26. …”
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Ketogenic Diet‐Associated Worsening of Osteoarthritis Histologic Secerity, Increased Pain Sensitivity and Gut Microbiome Dysbiosis in Mice by Gabby Dyson, Montana Barrett, Leoni Schlupp, Emmaline Prinz, Nicholas Hannebut, Aleksander Szymczak, Cindy Miranda Brawner, Matlock A. Jeffries

“…The objective of this study was to evaluate a well‐formulated ketogenic diet (KD) in the context of knee OA histology and pain using the destabilization of the medial meniscus (DMM) mouse model and correlate with gut microbiome and systemic cytokine levels. Methods Adult male mice underwent unilateral DMM or sham surgery and were then fed eight weeks of KD or chow. …”
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Land-use and land-cover changes and emerging non-tuberculous and tuberculous infectious diseases in humans and animals: a mixed-methods review of research findings from global and... by Jean-François Guégan, Carlos A Vargas Campos, Christine Chevillon, Ahmadou Sylla, Magdalene Dogbe, Kayla M Fast, Jennifer Pechal, Alex Rakestraw, Matthew E Scott, Michael W Sandel, Heather Jordan, M Eric Benbow

“…These depend on diverse LULC changes, different types of infectious disease systems, and spatio-temporal scales of studies. Here, using both a bibliometric and scoping review method, we summarize the reliability and availability of published relevant studies on LULC effects on mycobacteria, an important group of infectious bacteria that affect humans and both wild and domestic animals. …”
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BIOMECHANICAL EVALUATIONS OF IMPLANTO-PROSTHETIC RESTORATIONS by Resmerita Andreea, Cretu Cosmin Ionut, Scheuleac Alexandra, Agop-Forna Doriana, Adam Eduard, Forna Norina

“…Finally, it has been demonstrated that the prosthetic design (splinted crowns versus non-splinted crowns), as well as the different lengths and loading directions of the implant, influence the distribution of tension and the local accumulation of stress in the implant/prosthesis systems and the surrounding bone. Conclusions: Conclusion is that reduced diameter implants can be successfully used under axial and oblique forces. …”
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A Study on Diagnostic Accuracy of Dipsi Method Over Traditional Oral Glucose Tolerance Test Among Antenatal Women by Vijayadevi Shanmugam, Dharani Sudha Gopalraj, Shruthi Nanjudappan, Rajeswari Ravindran

“…Failure to identify true positive cases could have significant clinical implications, impacting maternal and neonatal outcomes and overburdening healthcare systems. Further research with larger and diverse populations is needed to establish more accurate diagnostic thresholds for GDM using the DIPSI method or alternative criteria.…”
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