TLR7/8/9 agonists and low-dose cisplatin synergistically promotes tertiary lymphatic structure formation and antitumor immunity by Shuting Wu, Rong Xiang, Yiwei Zhong, Shushu Zhao, Zhiyu Zhang, Zhihua Kou, Shijie Zhang, Yi Zhao, Cheng Zu, Gan Zhao, Yanling Xiao, Sulin Ren, Xiaoming Gao, Bin Wang

“…Notably, the combo therapy also suppressed the growth of distant untreated 4T-1 tumors, demonstrating systemic antitumor effects. Moreover, combo-therapy led to full regression of 4T-1 tumors in a large percentage of mice, who became strongly resistant to secondary tumor challenge, a clear indication of antitumor immunological memory. …”
Get full text

Hemodynamic Evaluation of Nonselective β-Blockers in Patients with Cirrhosis and Refractory Ascites by Alberto Ferrarese, Valerie Tikhonoff, Edoardo Casiglia, Paolo Angeli, Silvano Fasolato, Diego Faggian, Alberto Zanetto, Giacomo Germani, Francesco Paolo Russo, Patrizia Burra, Marco Senzolo

“…During two consecutive LVP, while being, respectively, off and on NSBB, cardiac output (CO), systemic vascular resistances (SVR), peripheral vascular resistances (PVR), and plasma renin activity (PRA) were noninvasively assessed. …”
Get full text

Dufulin Impacts Plant Defense Against Tomato Yellow Leaf Curl Virus Infecting Tomato by Liping Huang, Yingying Tang, Shuaixin Wang, Jianbin Chen, Jiao Du, Shuo Yan, Deyong Zhang, Xiaobin Shi, Yong Liu, Fan Li

“…Additionally, this study assessed the expression levels of genes associated with systemic acquired resistance (SAR), specifically <i>proteinase inhibitor II</i> (<i>PI II</i>) and <i>non-expressor of pathogenesis-related genes 1</i> (<i>NPR1</i>), using real-time qRT-PCR. …”
Get full text

Implementing regional blue economy research and innovation strategies: a case study for the Black Sea by Baris Salihoglu, Baris Salihoglu, Mustafa Yücel, Pinar Uygurer, Ezgi Şahin Yücel, Evangelos Papathanassiou, Devrim Tezcan, Adrian Stanica, Irina Stanciu, Snejana Petrova Moncheva, Nina Dzhembekova, Kremena Blagovestova Stefanova, Viktor Komorin, Tudor Castravet, Kakhaber Bilashvili, Valerian Melikidze, Mamuka Gvilava, Salome Kobaidze

“…The Black Sea SRIA and IP address the fundamental research challenges of the region, promote the blue economy, and also build vital support systems and innovative research infrastructure and capacity together with academia, funding organizations, industry, policy, civil society and local communities. …”
Get full text

Enhanced motivated behavior mediated by pharmacological targeting of the FGF14/Nav1.6 complex in nucleus accumbens neurons by Nolan M. Dvorak, Paul A. Wadsworth, Guillermo Aquino-Miranda, Pingyuan Wang, Douglas S. Engelke, Jingheng Zhou, Nghi Nguyen, Aditya K. Singh, Giuseppe Aceto, Zahra Haghighijoo, Isabella I. Smith, Nana Goode, Mingxiang Zhou, Yosef Avchalumov, Evan P. Troendle, Cynthia M. Tapia, Haiying Chen, Reid T. Powell, Timothy J. Baumgartner, Jully Singh, Leandra Koff, Jessica Di Re, Ann E. Wadsworth, Mate Marosi, Marc R. Azar, Kristina Elias, Paul Lehmann, Yorkiris M. Mármol Contreras, Poonam Shah, Hector Gutierrez, Thomas A. Green, Martin B. Ulmschneider, Marcello D’Ascenzo, Clifford Stephan, Guohong Cui, Fabricio H. Do Monte, Jia Zhou, Fernanda Laezza

“…Consistent with the compound’s effects on Nav1.6 channel inactivation, 1028 enhances MSN excitability ex vivo and accumbal neuron firing rate in vivo in murine models. Systemic administration of 1028 maintains behavioral motivation preferentially during motivationally deficient conditions in murine models. …”
Get full text

Health and Educational Inequalities among the Third Gender Community in Lahore, Pakistan by Ayesha Humayun, Muhammad Hassan, Hira Ashfaq, Zulqarnain Haider, Nauman Naeem, Mubashar Munir

“…These barriers underscore the systemic challenges faced by the hijra population in accessing education and healthcare. …”
Get full text

Gender Differences in Blood Pressure Control Among Hypertensive Patients: A Cross‐Sectional Study at a Tertiary Hospital by Hussein Alhawari, Zain Albdour, Sameeha Alshelleh, Joud Musleh, Tala Qouzah, Tala Qudisat, Diala Al‐Sukhon, Karam Albdour

“…Among males, concurrent systemic medication use (p = 0.025) was a positive predictor of BP control, whereas smoking negatively impacted BP control (p = 0.019). …”
Get full text

Systematic review and meta-analysis of colistin plus meropenem therapy for the treatment of nosocomial pneumonia by Hazhir Moradi, Zahra Sadat Sajadi-Javan, Sarah Mousavi, Soodabeh Rostami, Bita Moradi Khaniabadi

“… Background and Objectives: Nosocomial pneumonia caused by multidrug-resistant gram-negative bacteria presents a significant challenge for healthcare systems, as there are limited effective treatments available. …”
Get full text

Synthesis, characterization and toxicity assessment of chlorantraniliprole nanoemulsion against Helicoverpa armigera by Geeta Devi, Lomash Kumar, Rahul Kumar Dhaka, Karuna Jain, Rahul Saini, Shubham Saini, Anil Jakhar, Sushil Ahlawat, Mehdi Rahimi

“…Consequently, this cutting-edge research holds great potential for revolutionizing targeted pesticide delivery systems, paving the way for more effective and precise pest management in agriculture.…”
Get full text

Research trends and prospects in global riverine carbon fluxes: A bibliometric analysis by Wei Fang, Mohd Remy Rozainy Mohd Arif Zainol, Xianbao Zha, Pingping Luo

“…The analysis of keywords demonstrates that current study on RCFs mainly focus on monitoring the fluxes of multiple forms of carbon in the fluvial systems, modeling the fluxes of riverine carbon at larger scales, elaborating the complex biogeochemical processes of riverine carbon transport. …”
Get full text

Influence of temperature on growth and oxidative status of juvenile Southern black drum (Pogonias courbina) by Felipe Kuroski, Lucas C. Maltez, Olivia Menossi, Thiago P.A.P. Oliveira, Brandon J.Q. Gamboa, Marcelo H. Okamoto, Ricardo V. Rodrigues, Luis A. Sampaio

“…Fifty fish were stocked in circular tanks (300 L) connected to recirculating aquaculture systems with temperature control. Fish were fed four times a day. …”
Get full text

Interhemispheric Asymmetries in the Ground Magnetic Response to Interplanetary Shocks: The Role of Shock Impact Angle by Z. Xu, M. D. Hartinger, D. M. Oliveira, S. Coyle, C. R. Clauer, D. Weimer, T. R. Edwards

“…Abstract Interplanetary (IP) shocks drive magnetosphere‐ionosphere (MI) current systems that in turn are associated with ground magnetic perturbations. …”
Get full text

Case Report: The Versatile Art of Reconstruction: A Decade‐Long Journey With Recurrent Facial Basal Cell Carcinoma by T. H. Pathirana, V. Bandaranayake, A. P. Nellihela, S. Nikeshala, T. Saranga, A. Abegunasekara, S. Gunathilake, N. J. Asanthi

“…Conclusion This case sheds light on the difficulties encountered in treating recurrent facial BCC in developing countries. In the absence of systemic therapies, advanced surgical techniques and intensive follow‐up resulted in a long disease‐free period with good functional and aesthetic outcomes, thanks to the successful use of innovative reconstruction even in a low‐resource setting.…”
Get full text

Integrating Drone Truthing and Functional Classification of Remote Sensing Time Series for Supervised Vegetation Mapping by Giacomo Quattrini, Simone Pesaresi, Nicole Hofmann, Adriano Mancini, Simona Casavecchia

“…Unlike traditional ground truthing activities, drone truthing enabled the generation of large, spatially balanced reference datasets, which are critical for machine learning classification systems. These datasets improved classification accuracy by ensuring a comprehensive representation of vegetation spectral variability, enabling the classifier to identify the key phenological patterns that best characterize and distinguish different vegetation types across the landscape. …”
Get full text

Smart village concept in Indonesia: ICT as determining factor by Anindya Puteri Eka Susilowati, Rini Rachmawati, R. Rijanta

“…The results show that ICT is one of the determining factors in the smart village concept in Indonesia through the utilization of village information systems in government (explained 15,972 % variance), community interest in ICT (explained 10,628 % variance), and the availability of communication access (explained 8509 % variance). …”
Get full text

Handshake antimicrobial stewardship for adult surgical patients by Abby Kosharek, Elizabeth Neuner, Emily Welch, Spenser January, Alice Bewley, Kevin Hsueh, Sena Sayood

“…The handshake stewardship team consisted of an infectious diseases (ID) physician and pharmacist who reviewed charts of patients receiving systemic antimicrobials without a formal ID consult. …”
Get full text

Hydrothermal Pre-Carbonization Triggers Structural Reforming Enabling Pore-Tunable Hierarchical Porous Carbon for High-Performance Supercapacitors by Cuihua Kang, Mingyuan Zuo, Chang Qiu, Fanda Zeng, Yuehui Wang, Zhuo Chen, Tingting Liang, Daping Qiu

“…Owing to the large ion-accessible, remarkable supermesoporous and macroporous pore volume, HJPC-4 exhibited ultra-high specific capacitance (6 M KOH: 316 F g⁻¹ at 1 A g⁻¹; EMIMBF₄: 204 F g⁻¹ at 1 A g⁻¹), excellent rate performance (6 M KOH: 231 F g⁻¹ at 100 A g⁻¹; EMIMBF₄: 154 F g⁻¹ at 30 A g⁻¹), outstanding cycling stability (6 M KOH: the retention rate is 92.11% after 60,000 cycles at 10 A g⁻¹; EMIMBF₄: the retention rate is 80% after 10,000 cycles at 5 A g⁻¹), and ultimate energy/power density up to 91.09 Wh kg⁻¹/24.25 kW kg⁻¹ in EMIMBF₄ two-electrode systems. This work presents unique insights into the effect of the pore structure of carbon-based materials on their capacitive energy storage.…”
Get full text

Risk factors for malignancy in pediatric subacute/chronic focal craniocervical lymphadenopathy by Yishai Haimi-Cohen, Yishai Haimi-Cohen, Yishai Haimi-Cohen, Eyal Elron, Eyal Elron, Lital Oz-Alcalay, Lama Hejly, Roy Hod, Roy Hod, Liat Ashkenazi-Hoffnung, Liat Ashkenazi-Hoffnung, Liat Ashkenazi-Hoffnung

“…In univariate analysis, factors associated with malignancy included older age, increased nodal size, location (supraclavicular and lateral cervical), systemic signs such as decreased appetite and weight loss, and abnormal imaging studies. …”
Get full text

Zellweger syndrome; identification of mutations in PEX19 and PEX26 gene in Saudi families by Abdulfatah M. Alayoubi, Ambreen Ijaz, Abdul Wali, Jamil A. Hashmi, Azizah Alharbi, Sulman Basit

“…Background Peroxisome biogenesis disorders (PBD) affect multiple organ systems. It is characterized by neurological dysfunction, hypotonia, ocular anomalies, craniofacial abnormalities, and absence of peroxisomes in fibroblasts. …”
Get full text

The Age–Velocity Dispersion Relations of the Galactic Disk as Revealed by the LAMOST-Gaia Red Clump Stars by Weixiang Sun, Han Shen, Biwei Jiang, Xiaowei Liu

“…These results indicate that the thin disk stars are likely heated by long-term heating from giant molecular clouds and spiral arms, while thick disk stars are likely heated by some violent heating process from merger and accretion, and/or formed by the inside-out and upside-down star formation scenarios, and/or born in the chaotic mergers of gas-rich systems and/or turbulent interstellar medium. Our results also suggest that the disk perturbation by a recent minor merger from Sagittarius may have occurred within 3.0 Gyr.…”
Get full text