Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia by Emmanuel Amabebe, Zheping Huang, Sukanta Jash, Balaji Krishnan, Shibin Cheng, Akitoshi Nakashima, Yitong Li, Zhixong Li, Ruizhi Wang, Ramkumar Menon, Xiao Zhen Zhou, Kun Ping Lu, Surendra Sharma

“…These events may eventually damage the endothelium and cause systemic features of disorders such as preE. Despite impressive research and therapeutic advances in both fields of preE and neurodegenerative diseases, further investigation of Pin1-cis P-tau and ApoE-related mechanistic underpinnings may unravel novel therapeutic options, and new transcriptional and proteomic markers. …”
Get full text

The inflammatory markers combined with CA125 may predict postoperative survival in endometrial cancer by Hongxing Lin, Wenhui Zhong, Liying Zhong, Chengwen Que, Xiaosong Lin

“…Differences in each index at different EC stages and the correlation between the index and EC stage were analysed, and the influence of the index on EC prognosis was evaluated.Results Platelet distribution width (PDW) levels were significantly lower in patients with advanced EC than in those with early EC, whereas the systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and CA125 levels were significantly higher in patients with advanced EC (all P < 0.05). …”
Get full text

Exploring the effects of dietary methionine supplementation on European seabass mucosal immune responses against Tenacibaculum maritimum by Inês Carvalho, Inês Carvalho, Diogo Peixoto, Diogo Peixoto, Inês Ferreira, Inês Ferreira, Diego Robledo, Diego Robledo, Lourenço Ramos-Pinto, Rodolfo Miguel Silva, José Fernando Gonçalves, Marina Machado, Carolina Tafalla, Benjamin Costas, Benjamin Costas

“…`DiscussionOverall, these findings indicate that dietary methionine supplementation may significantly influence both systemic and local immune responses in European seabass, highlighting the need for careful consideration when supplementing diets with methionine.…”
Get full text

Critical pathomechanisms of NSAID-exacerbated respiratory disease (N-ERD) clarified by treatment with omalizumab, an anti-IgE antibody by Hiroaki Hayashi, Makoto Ishii, Yoshinori Hasegawa, Masami Taniguchi

“…Even when using standard treatments for respiratory and extra-respiratory symptoms, including systemic corticosteroids and aspirin desensitization, it is difficult to control the clinical symptoms and severe type 2 inflammation involved with mast cells, eosinophils, ILC2s, and platelet activation. …”
Get full text

Effect of non-surgical periodontal therapy on salivary and gingival crevicular fluid concentration of visfatin in periodontal health and disease by Hira Ismail, Anjani Kumar Pathak, Nand Lal, Pavitra Rastogi, Kaleem Ahmad, Mohd. Aamir Khan

“…Background and objective: Visfatin, a pleotropic mediator mostly produced by visceral fat, is crucial in controlling the immunological and defensive systems. It serves the roles of a cytokine, an enzyme involved in energy metabolism, and a growth factor. …”
Get full text

DGL-STFA: Predicting lithium-ion battery health with dynamic graph learning and spatial–temporal fusion attention by Zheng Chen, Quan Qian

“…Accurately predicting the State of Health (SOH) of lithium-ion batteries is a critical challenge to ensure their reliability and safety in energy storage systems, such as electric vehicles and renewable energy grids. …”
Get full text

Mitochondrial genome insights into the phylogenetics and biogeographic evolution of snow trout (Cyprinidae, Schizothorax) in the Tien Shan Mountains by Akbarjon Rozimov, Yufan Wang, Min Wang, Ming Zou, Jobir Sobirov, Erkin Karimov, Bakhtiyor Kholmatov, Jörg Freyhof, Sirojiddin Namozov, Chongnv Wang, Xinxin Li, Baocheng Guo

“…Snow trout (Schizothorax), endemic to the high-altitude freshwater systems of the Tibetan Plateau and the Tien Shan Mountains region, are key components of these ecosystems. …”
Get full text

Blimp-1 orchestrates macrophage polarization and metabolic homeostasis via purine biosynthesis in sepsis by Wenjuan Peng, Qiushi Qin, Rui Li, Yujia Liu, Lan Li, Yue Zhang, Liuluan Zhu

“…Abstract Sepsis is a life-threatening condition characterized by a dysregulated immune response to infection, leading to systemic inflammation and organ dysfunction. Macrophage polarization plays a critical role in pathogenesis of sepsis, and the influence of B lymphocyte-induced maturation protein-1 (Blimp-1) on this polarization is an underexplored yet pivotal aspect. …”
Get full text

Satellite monitoring of annual US landfill methane emissions and trends by Nicholas Balasus, Daniel J Jacob, Gabriel Maxemin, Carrie Jenks, Hannah Nesser, Joannes D Maasakkers, Daniel H Cusworth, Tia R Scarpelli, Daniel J Varon, Xiaolin Wang

“…We use satellite observations of atmospheric methane from the TROPOMI instrument to estimate total annual methane emissions for 2019–2023 from four large Southeast US landfills with gas collection and control systems. The emissions are on average 6× higher than the values reported by the landfills to the US Greenhouse Gas Reporting Program (GHGRP) which are used by the US Environmental Protection Agency for its national Greenhouse Gas Inventory (GHGI). …”
Get full text

Clinicopathological features of Lynch syndrome pedigrees with MSH2 c.351G>A gene variant by Shuai Zhang, Guanyu Fu, Gongping Sun, Yuanxin Tang, Jin Meng, Zhigang Wang, Rongjun Su, Wei Liu, Xiaoxia Li

“…Results Nine patients with 19 primary cancers were found in this family, with a wide spectrum of synchronous and metachronous cancers, including digestive, reproductive, respiratory, urinary, and other systems. In addition, one member of this family is found to have both thyroid and lung cancers, which have been reported only once in LS patients before but have not been considered extracolonic in the LS spectrum. …”
Get full text

Type I IFN induces long-chain acyl-CoA synthetase 1 to generate a phosphatidic acid reservoir for lipotoxic saturated fatty acids by Shelley Barnhart, Masami Shimizu-Albergine, Eyal Kedar, Vishal Kothari, Baohai Shao, Melissa Krueger, Cheng-Chieh Hsu, Jingjing Tang, Jenny E. Kanter, Farah Kramer, Danijel Djukovic, Vadim Pascua, Yueh-Ming Loo, Lucrezia Colonna, Sadie J. Van den Bogaerde, Jie An, Michael Gale, Jr., Karen Reue, Edward A. Fisher, Sina A. Gharib, Keith B. Elkon, Karin E. Bornfeldt

“…Our results show that IFN-I induces ACSL1 in macrophages via its interferon-α/β receptor, and consequently that expression of ACSL1 is increased in myeloid cells from individuals with systemic lupus erythematosus (SLE), an autoimmune condition characterized by increased IFN production. …”
Get full text

Characterization of H460R, a Radioresistant Human Lung Cancer Cell Line, and Involvement of Syntrophin Beta 2 (SNTB2) in Radioresistance by Chang-Nim Im, Byeong Mo Kim, Eun-Yi Moon, Da-Won Hong, Joung Whan Park, Sung Hee Hong

“…H460R cells could be helpful in in vitro systems for elucidating the molecular mechanisms of and discovering drugs to overcome radioresistance in lung cancer therapy.…”
Get full text

Causal association between non-thyroidal autoimmune diseases and Graves' ophthalmopathy: A mendelian randomization study by Lan Ma, Xue Jiang, Zhijia Hou, Dongmei Li

“…Materials: Single nucleotide polymorphisms (SNPs) associated with inflammatory bowel disease (IBD), multiple sclerosis (MS), psoriasis vulgaris (PV), type 1 diabetes (T1D), systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA) were obtained from the IEU Open genome-wide association studies (GWAS) database, GWAS data for GO were obtained from the FinnGen database. …”
Get full text

From Waste to Innovation: A Circular Economy Approach for Tissue Engineering by Transforming Human Bone Waste into Novel Collagen Membranes by Lorena Gallego, Kimberly Harvey, Marta Pevida, Luis García-Consuegra, Olivia García-Suárez, Álvaro Meana, María Alvarez-Viejo, Luis Junquera

“…This innovative approach not only contributes to sustainability in healthcare by optimizing biological waste but also exemplifies efficient resource use in line with the circular economy, offering a cost-effective, biocompatible option that could benefit national health systems.…”
Get full text

Exploring perceived barriers to palliative and end of life care provision in South-West England: bringing together the perspectives of professionals, patients, and families by Gary Hodge, Gina Kallis, Tomasina M. Oh, Hannah Wheat, Susie Pearce, Susie Pearce

“…This is occurring amidst a wider backdrop of health and social care systems facing unprecedented pressure, particularly as they recover from the long-term impact of the COVID-19 pandemic. …”
Get full text

Safety and immunogenicity of a bivalent norovirus vaccine candidate in infants from 6 weeks to 5 months of age: A phase 2, randomized, double-blind trial by Xavier Sáez-Llorens, Rodrigo deAntonio, Eduardo López-Medina, Pío López, Taisei Masuda, Paul M Mendelman, Jim Sherwood, Frank Baehner, Astrid Borkowski

“…Solicited injection-site and systemic adverse events (AE) were collected within 7 days after each dose, unsolicited AEs were collected within 28 days after each, and serious AEs throughout the study. …”
Get full text

Interfacial charge transfer on hierarchical synergistic shell wall of MXene/MoS2 on CdS nanospheres: heterostructure integrity for visible light responsive photocatalytic H2 evolut... by Kugalur Shanmugam Ranjith, Ali Mohammadi, Ganji Seeta Rama Raju, Yun Suk Huh, Young-Kyu Han

“…Abstract Energy scarcity and environmental pollution have prompted research in hydrogen generation from solar to develop clean energy through highly efficient, effective, and long-lasting photocatalytic systems. Designing a catalyst with robust stability and an effective carrier separation rate was achieved through heterostructure assembly, but certain functionalities must be explored. …”
Get full text

In silico molecular docking and molecular dynamic simulation of agarwood compounds with molecular targets of Alzheimer’s disease  [version 2; peer review: 2 approved, 1 not approve... by Tewin Tencomnao, Krishna Swamy V. K. D, Prem Kumar Borugadda, Vishwambar Vishnu Bhandare, Vishal S. Patil, Phaniendra Alugoju

“…Aquilaria is as an endangered medicinal plant genus (commonly called agarwood plants) and various products of Aquilaria plant spp. including resinous heartwood, leaves, bark, and stem have been widely used in various traditional medicine systems. Research on agarwood plants is sparse and only a few previous studies demonstrated their neuroprotective properties in vitro. …”
Get full text

Pearls on a String: Dark and Bright Galaxies on a Strikingly Straight and Narrow Filament by M. Arabsalmani, S. Roychowdhury, B. Schneider, V. Springel, E. Le Floc’h, F. Bournaud, A. Burkert, J.-C. Cuillandre, P.-A. Duc, E. Emsellem, D. Galárraga-Espinosa, E. Pian, F. Renaud, M. A. Zwaan

“…The filament galaxies are mainly star forming and have stellar masses in a range of 10 ^9.1 −10 ^10.7 M _⊙ . We search for systems with similar geometrical properties in the full-sky mock galaxy catalog of the MillenniumTNG simulations and find that, although such straight filaments are unusual and rare, they are predicted by ΛCDM simulations (4% incidence). …”
Get full text

Protocol for a systematic review on routine use of antibiotics for infants less than 6 months of age with growth failure/faltering by Jai K Das, Zulfiqar Ahmed Bhutta, Abigail Smith, Aamer Imdad, Emily Tanner-Smith, Melissa François, Fanny F Chen, Olivia J Tsistinas

“…We will consider the following outcomes: mortality, clinical deterioration, antimicrobial resistance, recovery from comorbidity, adverse events, markers of intestinal inflammation, markers of systemic inflammation, hospital-acquired infections, non-response. …”
Get full text