Genomic Insight into <i>Vibrio</i> Isolates from Fresh Raw Mussels and Ready-to-Eat Stuffed Mussels by Artun Yibar, Muhammed Duman, Hilal Ay, Nihed Ajmi, Gorkem Tasci, Fatma Gurler, Sabire Guler, Danny Morick, Izzet Burcin Saticioglu

“…The presence of nine different biosynthetic gene clusters (BGCs), 27 prophage regions, and eight CRISPR/Cas systems in 15 <i>Vibrio</i> strains provides information about their potential pathogenicity, survival strategies, and adaptation to different habitats. …”
Get full text

BA-ATEMNet: Bayesian Learning and Multi-Head Self-Attention for Theoretical Denoising of Airborne Transient Electromagnetic Signals by Weijie Wang, Xuben Wang, Xiaodong Yu, Debiao Luo, Xinyue Liu, Kai Yang, Wen Yang, Xiaolan Yang, Ke Hu, Wenyi Hu

“…Nonetheless, the secondary electromagnetic response signals captured by ATEM systems frequently suffer from numerous noise interferences, which impede effective data processing and interpretation. …”
Get full text

A Weighted Bayesian Kernel Machine Regression Approach for Predicting the Growth of Indoor-Cultured Abalone by Seung-Won Seo, Gyumin Choi, Ho-Jin Jung, Mi-Jin Choi, Young-Dae Oh, Hyun-Seok Jang, Han-Kyu Lim, Seongil Jo

“…These findings underscore the potential of advanced machine learning techniques in enhancing aquaculture practices and offer a robust framework for managing complex, multi-variable systems in sustainable farming.…”
Get full text

Directly Gel‐Thermal Processing of Linker‐Mixed Crystal‐Glass Composite Membranes for Sorption‐Preferential Gas Separation by Yihao Xiao, Yanqing Yu, Xinxi Huang, Da Chen, Wanbin Li

“…The membranes exhibit outstanding gas separation performance for the challenging systems of CH4/N2 and O2/N2, with mixture selectivities up to 9.3 and 9.6, respectively, far exceeding those of polymer, MOF, and mixed‐matrix membranes. …”
Get full text

Soil health of bananas cultivated in Ribeira River Valley – the major producing region of Brazil by Cavalieri-Polizeli Karina Maria Vieira, da Silva Anderson Lucas, Cremonesi Marcus, Lima Juliana Domingues, Cipriano Patriciani Estela, Cherubin Maurício Roberto, Rozane Danilo Eduardo

“…All soil quality indexes tested here can be used to verify soil health; however, soil quality index-2 was the best for a total dataset, and soil management assessment framework was the best for a minimum dataset, demonstrating no statistical difference in soil health between banana and forest soil systems.…”
Get full text

Frontal Face Generation Based on Attitude Point Guidance and Attention Mechanism Improvement by Jihui Zhao, Zhengyi Yuan, Junhu Zhang, Haitao Li, Hui Li

“…The deflection of face angle is the most important factor affecting the accuracy in face recognition, non-frontal faces make some face recognition systems lose their due functions, the existing frontal face conversion methods often have the phenomenon of distortion and lack of identity. …”
Get full text

Mesothelioma and Radical Surgery 2 (MARS 2): protocol for a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decorticati... by Liz Darlison, John Edwards, Apostolos Nakas, Nick A Maskell, Wendy Underwood, Chris Rogers, Matthew Callister, David Waller, Richard Milton, Victoria Ashford-Turner, Paul Taylor, Claire Matthews, Victoria Hughes, Kelvin Lau, Alan Kirk, Robert C Rintoul, Elizabeth A Stokes, Kate Ashton, Daisy Elliott, Rosie Harris, Marie Kirwan, Juliette Novasio, Sara Waplington, Eric Lim, Holly Mckeon, Charlotte Jacobs, Laura White, Mary O’Brien, Judith Moore, Louise Li, Nicola Mills, Sanjay Popat, Suzanne Miller, Nadia Yousaf, D A Fennell, Clinton Ali, Andrea Bille, Liz Fuller, Andreea Ionescu, Manjusha Keni, Pek Koh, Talal Mansy, Dakshinamoorthy Muthukumar, Tony Pope, Amy Roy, Riyaz Shah, Jonathan Shamash, Zacharias Tasigiannopoulos, Sarah Treece, Katherine Joyce, Barbara Warnes, Athanasia Gravani, Rachel Brophy, Nicola Farrar, Jane Elliott, Philip Noyes, Louise Nelson, Sara Tenconi, Laura Socci, Hilary Wood, Helena Hanratty, Helena Stanley, Robert Rintoul, Amy Gladwell, Jenny Castedo, Amanda Stone, Charlotte Ingle, Hayley Hewer, Eleanor Aynsley, Andrea Watson, Alison Hassall, Masuma Begum, Christopher Worth, Ellie Piggott, Elizabeth Nadin, Yvonne Summers, Raffaele Califano, Laura Cove-Smith, Matt Evison, Maria Blinston, Amal Ismail, Rachel Chant, Asmita Desai, Ian Morgan, Victoria Lake, Nichola Harris, Simon Hodge, Nadza Tokaca, Adam Januszewski, Avani Athauda, Anisha Ramessur, Emily Grist, Niamh Colman, Michael Flynn, Joan Joyce, Sarah Vaughan, Maria Piga, Derya Sahin, Agnieszka Yongue, Emma Turay, Jaishree Bhosle, Rajiv Kumar, Charlotte Milner-Watts, Jessica Brown, David Walder, Alexandros Georgiou, Xiaorong Wu, Naila Kaudeer, Kroopa Joshi, Michael Davidson, Shelize Khakoo, Bee Ayite, Kathryn Priest, James Dobbyn, Vasanthi Prathapan, Deborah McCrimmon, Natalie Ash, Alison Norton, Bianca Peet, Libby Hennessy, Rosemary Johnson

“…Introduction Mesothelioma remains a lethal cancer. To date, systemic therapy with pemetrexed and a platinum drug remains the only licensed standard of care. …”
Get full text

Anaesthetic Management of a Neonate with Ebstein’s Anomaly Undergoing a Meningomyelocele Surgery: A Case Report by Prakriti, Monika Yadav, Vaishali Gupta, Komal Yadav, Shikha Garg

“…Key cardiovascular goals for this patient included maintaining normal sinus rhythm, ensuring adequate preload while avoiding significant changes in Systemic Vascular Resistance (SVR) or PVR, avoiding medications and factors that depress myocardial function, and promptly identifying haemodynamic instability or inadequate tissue perfusion with appropriate corrections. …”
Get full text

Protective Effect of Liposome-Encapsulated Glutathione in a Human Epidermal Model Exposed to a Mustard Gas Analog by Victor Paromov, Sudha Kumari, Marianne Brannon, Naga S. Kanaparthy, Hongsong Yang, Milton G. Smith, William L. Stone

“…Liposomes containing water-soluble antioxidants and/or lipid-soluble antioxidants were evaluated using in vitro model systems. Initially, we found that liposomes containing encapsulated glutathione (GSH-liposomes) increased cell viability and attenuated production of reactive oxygen species (ROS) in HaCaT cells exposed to CEES. …”
Get full text

Temporal and spatial characterization of keratinocytes supporting orf virus replication by Byung-Joon Seung, Sushil Khatiwada, Daniel L. Rock, Gustavo Delhon

“…Keratinocytes, the main cells of the epidermis, are found in different stages of a differentiation program that produces the critical barrier against environmental damage. While systemic poxviruses (e.g. smallpox virus, sheeppox virus) also infect other cell types, the parapoxvirus orf virus (ORFV), which causes localized infections in sheep and goats, has not been shown to replicate in cells other than keratinocytes. …”
Get full text

Generation of transgenic chicken through ovarian injection by Jinghua Jiang, Caiying Wang, Xuguang Du, Fei Gao, Sen Wu

“…This technique simplifies the transgenic process for chickens and has the potential to be adapted for other avian species, especially those without established PGCs culture systems.…”
Get full text

PD-1 suppresses human CD38+ circulating Tfr cells and regulates humoral immunity by Heng Zhang, Hui Zheng, Lin Guo, Ying Tong, Xiaolu Ma, Yanchun Wang, Renquan Lu, Cuncun Chen, Suhong Xie

“…However, the impact of anti-PD-1 therapy on host humoral immunity in humans during cancer immunotherapy requires further investigation.Methods We evaluated immunoglobulin titers by ELISA and screened the immune landscape of immune cells from 25 healthy donors and 50 cases including 25 new-onset hepatocellular carcinoma (HCC) patients prior to systemic treatment and 25 HCC patients undergoing anti-PD-1 therapy by multicolor flow cytometry. …”
Get full text

Microbial succinate promotes the response to metformin by upregulating secretory immunoglobulin a in intestinal immunity by Ying Zhang, Aiting Wang, Wei Zhao, Jia’an Qin, Yu Zhang, Bing Liu, Chengcheng Yao, Jianglan Long, Mingxia Yuan, Dan Yan

“…The study of IgA˗/˗ mice confirmed that downregulated expression or deficiency of SIgA resulted in non-response to metformin, meaning that metformin was unable to improve dysfunctional glucose metabolism and reduce intestinal and adipose tissue inflammation, ultimately leading to systemic insulin resistance. Furthermore, supplementation with succinate, a microbial product of B. thetaiotaomicron, potentially reversed the non-response to metformin by inducing the production of SIgA. …”
Get full text

Exploring damped and undamped frequencies in beam structures with viscoelastic supports using GFEM and state-space formulation by Gulnaz Kanwal, Hani Alahmadi, Rab Nawaz, Tayyab Nawaz

“…Additionally, the study introduces the application of state-space formulations combined with the Runge–Kutta method (RK4) to precisely analyze the response of damped systems, which adds significant value in exploring complex beam dynamics. …”
Get full text

Personalized medicine: An alternative for cancer treatment by Devendra Singh, Vinay Kumar Dhiman, Minakshi Pandey, Vivek Kumar Dhiman, Avinash Sharma, Himanshu Pandey, Sunil Kumar Verma, Rajeev Pandey

“…The incidence of cancer continues to increase worldwide, resulting in significant physical, emotional, and financial challenges for individuals, families, communities, and healthcare systems. Cancer is projected to be responsible for approximately 10 million deaths in 2020, accounting for one in six deaths globally. …”
Get full text

Mendelian randomization analysis does not support a causal influence between lipoprotein(A) and immune-mediated inflammatory diseases by Yun Ti, Dan Xu, Xiaoning Qin, Yang Hu, Yuru Xu, Qingzhao Zhao, Peili Bu, Jingyuan Li

“…We performed a bidirectional two-sample mendelian randomization analyses based on genome-wide association study (GWAS) summary statistics of Lp(a) and nine IMIDs, specifically celiac disease (CeD), Crohn’s disease (CD), ulcerative colitis (UC), inflammatory bowel disease (IBD), multiple sclerosis (MS), psoriasis (Pso), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type 1 diabetes (T1D), and summary-level data for lipid traits. …”
Get full text

Necrostatin-1 Alleviates Diffuse Pulmonary Haemorrhage by Preventing the Release of NETs via Inhibiting NE/GSDMD Activation in Murine Lupus by Xinai Han, Xiaoming Zhang, Rui Song, Shiqi Li, Shujing Zou, Quanguang Tan, Tianyang Liu, Shugeng Luo, Zhe Wu, Hongyu Jie, Jinhong Wang

“…Diffuse alveolar haemorrhage (DAH) is a rapidly developing condition owing to a lack of effective treatment and resulting in a high mortality rate in systemic lupus erythematosus (SLE). Neutrophil extracellular traps (NETs) contain numerous antigens and proinflammatory substances that directly damage the vascular endothelium and aggravate vascular inflammation, which is considered an important pathogenic factor of DAH in SLE. …”
Get full text

cAMP analogues downregulate the expression of granulocyte macrophage colony-stimulating factor (GM-CSF) in human bone marrow stromal cells in vitro by G. Bug, J. Aman, C. Huber, C. Peschel, H. G. Derigs

“…The stimulation of granulocyte macrophage-colony stimulating factor (GM-CSF) by interleukin-1 (IL-1) has been shown to be counteracted in different mesenchymal cell systems by cyclic adenosine monophosphate (cAMP) agonists. …”
Get full text

Lymphoid Progenitor Cells from Childhood Acute Lymphoblastic Leukemia Are Functionally Deficient and Express High Levels of the Transcriptional Repressor Gfi-1 by Jessica Purizaca, Adriana Contreras-Quiroz, Elisa Dorantes-Acosta, Eduardo Vadillo, Lourdes Arriaga-Pizano, Silvestre Fuentes-Figueroa, Horacio Villagomez-Barragán, Patricia Flores-Guzmán, Antonio Alvarado-Moreno, Hector Mayani, Isaura Meza, Rosaura Hernandez, Sara Huerta-Yepez, Rosana Pelayo

“…By phenotype analyses, in vitro proliferation assays, and controlled culture systems, the lymphoid differentiation potentials were evaluated in BM primitive populations from B-cell precursor ALL pediatric patients. …”
Get full text

COVID-19’s effects on microvascular structure in a healthy retina: an OCTA study by Kazim Kiratli, Hazan Gul Kahraman, Yusuf Ziya Guven, Fahrettin Akay, Murat Aysin

“…Future ischemia-related alterations in the retina caused by a prior COVID-19 infection may arise in situations without comorbidities and may require concern in the patient's systemic assessment.…”
Get full text