Inhibitory Effect of Natural Anti-Inflammatory Compounds on Cytokines Released by Chronic Venous Disease Patient-Derived Endothelial Cells by Veronica Tisato, Giorgio Zauli, Erika Rimondi, Sergio Gianesini, Laura Brunelli, Erica Menegatti, Paolo Zamboni, Paola Secchiero

“…Among the cytokines/chemokines released by VEC, which recapitulated the systemic profile (IL-8, TNF-α, GM-CSF, INF-α2, G-CSF, MIP-1β, VEGF, EGF, Eotaxin, MCP-1, CXCL10, PDGF, and RANTES), we identified those targeted by ex vivo treatment with α-Lipoic acid and/or Ginkgoselect phytosome (GM-CSF, G-CSF, CXCL10, PDGF, and RANTES). …”
Get full text

Phenolic Extracts from Vaccinium corymbosum L. Loaded in Microemulsions and Liposomes as Enhancers of Olive Oil Oxidative Stability by Nikolina Liović, Perica Bošković, Ivana Drvenica, Anet Režek Jambrak, Ana Marija Dropulić, Greta Krešić, Viktor Nedović, Branko Bugarski, Zoran Zorić, Sandra Pedisić, Tea Bilušić

“…(raw, pasteurized, freeze-dried and treated with high-intensity ultrasound), and at testing their antioxidant potential in the prevention of olive oil oxidation in the native state and encapsulated into microemulsions and liposomes systems. Water-in-oil structured microemulsions used in this study were prepared using mechanical, ultrasonic, and high pressure homogenization. …”
Get full text

Utility and clinical significance of endoscopic ultrasound-guided tissue acquisition for diagnosing lymphadenopathies in biliary tract cancer by Katsuhiko Sato, Minoru Shigekawa, Syuhei Yamamoto, Takayuki Matsumae, Yu Sato, Teppei Yoshioka, Takahiro Kodama, Hayato Hikita, Tomohide Tatsumi, Tetsuo Takehara

“…All seven FNA cytology-positive patients who were diagnosed with distant metastasis received systemic chemotherapy. Multivariate analyses showed a neutrophil-to-lymphocyte ratio over 2.5 (odds ratio (OR) 4.69, p = 0.04), fluorodeoxyglucose uptake (OR 5.34, p = 0.014), and a short diameter over 10.6 mm (OR 6.11, p = 0.018) as factors related to FNA cytology positivity. …”
Get full text

Application of large language models in disease diagnosis and treatment by Xintian Yang, Tongxin Li, Qin Su, Yaling Liu, Chenxi Kang, Yong Lyu, Lina Zhao, Yongzhan Nie, Yanglin Pan, Yuanyuan Ji

“…These models can also assist in treatment planning by suggesting evidence-based interventions and improving clinical decision support systems through integrated analysis of patient records. …”
Get full text

Unraveling the function of TSC1-TSC2 complex: implications for stem cell fate by Shuang Wang, Ruishuang Ma, Chong Gao, Yu-Nong Tian, Rong-Gui Hu, Han Zhang, Lan Li, Yue Li

“…Abstract Background Tuberous sclerosis complex is a genetic disorder caused by mutations in the TSC1 or TSC2 genes, affecting multiple systems. These genes produce proteins that regulate mTORC1 activity, essential for cell function and metabolism. …”
Get full text

Evaluating the potential of Nature-based solutions to mitigate land use and climate change impacts on the hydrology of the Gefersa and Legedadi watersheds in Ethiopia by Yared Bayissa, Raghavan Srinivasan, Johannes Hunink, Douglas Nyolei, Semu Moges, David de Andrade Costa, Dereje Tadesse, Assefa Melesse, Seifu Tilahun

“…Study region: Surface water supply source of Addis Ababa, the capital city of Ethiopia, relies primarily on the small reservoirs in Gefersa and Legedadi water supply systems located upstream of Little and Big Akaki rivers. …”
Get full text

Correlation of Ischemia-Modified Albumin with SOFA and APACHE II Scores in Preoperative Patients with Colorectal Cancer by Masaaki Satoh, Kazuhiko Kotani, Alejandro Gugliucci, Hisanaga Horie, Russell Caccavello, Mamoru Takeuchi

“…The positive correlations between IMA and both SOFA and APACHE II scores suggest that serum IMA measurements reflect the severity of systemic failure in patients admitted for colorectal surgery in the preoperative phase.…”
Get full text

Deep learning and hyperspectral features for seedling stage identification of barnyard grass in paddy field by Siqiao Tan, Qiang Xie, Wenshuai Zhu, Yangjun Deng, Lei Zhu, Xiaoqiao Yu, Zheming Yuan, Zheming Yuan, Yuan Chen, Yuan Chen

“…By seamlessly integrating deep convolutional networks, DeepBGS independently extracts salient features, indicating that hyperspectral imaging technology can be used to effectively identify barnyard grass in the early stages, and pave the way for the development of advanced early detection systems.…”
Get full text

Can cattle blood be transformed into an organic source of nitrogen? by Md. Islam, S. M. Zaman, Md. Rasel, Jagadish Joardar

“…Purpose: A study was conducted to transform bovine blood, a slaughterhouse by-product, into an organic source of nitrogen, which is otherwise disposed of through sewer systems only to pollute the nearby water bodies.   …”
Get full text

Developing a semi-automated technique of surface water quality analysis using GEE and machine learning: A case study for Sundarbans by Sheikh Fahim Faysal Sowrav, Sujit Kumar Debsarma, Mohan Kumar Das, Khan Mohammad Ibtehal, Mahfujur Rahman, Noshin Tabassum Hridita, Atika Afia Broty, Muhammad Sajid Anam Hoque

“…However, the study acknowledges limitations, including the variability in data availability and the inherent uncertainties in ML predictions for dynamic water systems. Overall, this research contributes to the advancement of water quality monitoring techniques, supporting sustainable environmental management practices and the resilience of the Sundarbans against emerging climate challenges.…”
Get full text

Association between Ophthalmic Timolol and Hospitalisation for Bradycardia by Nicole L. Pratt, Emmae N. Ramsay, Lisa M. Kalisch Ellett, Tuan A. Nguyen, Elizabeth E. Roughead

“…Ophthalmic timolol, a topical nonselective beta-blocker, has the potential to be absorbed systemically which may cause adverse cardiovascular effects. …”
Get full text

HVSR Analysis of Rockslide Seismic Signals to Assess the Subsoil Conditions and the Site Seismic Response by Alessia Lotti, Veronica Pazzi, Gilberto Saccorotti, Andrea Fiaschi, Luca Matassoni, Giovanni Gigli

“…Finally, the continuous on-line data reveal interesting applications to provide near-real time warning systems for emerging potentially disastrous rockslides.…”
Get full text

Prolonged Cardiopulmonary Bypass Time-Induced Endothelial Dysfunction via Glypican-1 Shedding, Inflammation, and Matrix Metalloproteinase 9 in Patients Undergoing Cardiac Surgery by Shiyi Li, Katherine V. Nordick, Iván Murrieta-Álvarez, Randall P. Kirby, Rishav Bhattacharya, Ismael Garcia, Camila Hochman-Mendez, Todd K. Rosengart, Kenneth K. Liao, Nandan K. Mondal

“…Conclusions: A prolonged CPB triggers a systemic inflammatory response and activates MMP9, leading to glypican-1 shedding and endothelial dysfunction.…”
Get full text

KPC pancreatic cancer cells are a novel immunocompetent murine model supporting human adenovirus replication and tumor oncolysis by Marc Otero-Mateo, Francesc Estrany Jr, Sabrina Arcas-Márquez, Laura Moya-Borrego, Giancarlo Castellano, Miquel Castany, Ramon Alemany, Cristina Fillat

“…A comparative study with the semipermissive murine CMT64.6 cells reveals that adenoviral infection of KPC-I cells substantially increases the release of infective particles, with a correlating enhanced susceptibility to adenovirus-induced autophagy. Remarkably, systemic delivery of the oncolytic adenovirus AdNuPARE1A in athymic mice bearing KPC-I tumors results in significant inhibition of tumor growth. …”
Get full text

History and prospects of flax genetic markers by Daiana A. Zhernova, Elena N. Pushkova, Tatiana A. Rozhmina, Elena V. Borkhert, Alexander A. Arkhipov, Alexander A. Arkhipov, Elizaveta A. Sigova, Elizaveta A. Sigova, Ekaterina M. Dvorianinova, Ekaterina M. Dvorianinova, Alexey A. Dmitriev, Alexey A. Dmitriev, Nataliya V. Melnikova

“…For the further development of marker-assisted and genomic selection of flax, it is necessary to analyze exhaustively phenotyped sample sets, to identify DNA polymorphisms that determine valuable traits, and to develop efficient DNA test systems.…”
Get full text

Experimental approach to obtaining subcutaneous xenograft of non-small cell lung cancer by E. A. Lukbanova, M. V. Mindar, E. A. Dzhenkova, A. Yu. Maksimov, A. S. Goncharova, Yu. S. Shatova, A. A. Maslov, A. V. Shaposhnikov, E. V. Zaikina, Yu. N. Lazutin

“…The created PDX models can be recommended as test systems for preclinical studies of the effectiveness of new pharmacological substances with potential antitumor activity.…”
Get full text

Enhancing Maize Production Through Timely Nutrient Supply: The Role of Foliar Fertiliser Application by Brian Ssemugenze, Akasairi Ocwa, Ronald Kuunya, Costa Gumisiriya, Csaba Bojtor, János Nagy, Adrienn Széles, Árpád Illés

“…Foliar fertilisation offers a complementary method to traditional soil fertilisation amongst resource-limited agricultural systems, providing a more efficient solution to nutrient deficiencies, especially in suboptimal soil conditions. …”
Get full text

Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion by Estela Regina Ramos Figueira, Joel Avancini Rocha-Filho, Cinthia Lanchotte, Ana Maria Mendonça Coelho, Mauro Nakatani, Eduardo Ryoiti Tatebe, Jonathan Augusto Venceslau Lima, Camilla Oliveira Mendes, Bruno Camargo Rocha Paim de Araujo, Emilio Elias Abdo, Luiz Carneiro D’Albuquerque, Flavio Henrique Ferreira Galvão

“…Furthermore, sevoflurane postconditioning promoted systemic hemodynamic recovery with a decrease in inflammatory response.…”
Get full text

Keratin/chitosan film promotes wound healing in rats with combined radiation-wound injury by Yu-mei Wang, Tong Xin, Hao Deng, Jie Chen, Shen-lin Tang, Li-sheng Liu, Xiao-liang Chen

“…A rat model of combined radiation-wound injury was employed to evaluate the therapeutic efficacy of the KRT/CS film. Finally, the systemic biotoxicity of KRT/CS film was assessed through histological analysis. …”
Get full text

Uncertainty Analysis of Biogas Generation and Gas Hydrate Accumulations in the Baiyun Sag, South China Sea by Pibo Su, Jinqiang Liang, Huai Cheng, Yaoyao Lv, Wei Zhang, Zuofei Zhu

“…In this study, we use petroleum systems modeling (PSM) to quantitatively simulate the uncertainty of biogenic gas generation modes and their impact on the spatial distribution and resource assessment of gas hydrates in the Baiyun Sag, South China Sea. …”
Get full text