Construction and iterative redesign of synXVI a 903 kb synthetic Saccharomyces cerevisiae chromosome by Hugh D. Goold, Heinrich Kroukamp, Paige E. Erpf, Yu Zhao, Philip Kelso, Julie Calame, John J. B. Timmins, Elizabeth L. I. Wightman, Kai Peng, Alexander C. Carpenter, Briardo Llorente, Carmen Hawthorne, Samuel Clay, Niël van Wyk, Elizabeth L. Daniel, Fergus Harrison, Felix Meier, Robert D. Willows, Yizhi Cai, Roy S. K. Walker, Xin Xu, Monica I. Espinosa, Giovanni Stracquadanio, Joel S. Bader, Leslie A. Mitchell, Jef D. Boeke, Thomas C. Williams, Ian T. Paulsen, Isak S. Pretorius

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Feasibility and potential diagnostic value of [18F]PI-2620 PET in patients with down syndrome and Alzheimer’s disease: a case series by Olivia Wagemann, Olivia Wagemann, Matthias Brendel, Nicolai Franzmeier, Nicolai Franzmeier, Nicolai Franzmeier, Georg Nübling, Georg Nübling, Johannes Gnörich, Mirlind Zaganjori, Catharina Prix, Anna Stockbauer, Anna Stockbauer, Elisabeth Wlasich, Sandra V. Loosli, Sandra V. Loosli, Katja Sandkühler, Lukas Frontzkowski, Günter Höglinger, Günter Höglinger, Günter Höglinger, Johannes Levin, Johannes Levin, Johannes Levin

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Optimising Xpert-Ultra and culture testing to reliably measure tuberculosis prevalence in the community: findings from surveys in Zambia and South Africa by Richard Hayes, Sarah Fidler, Sian Floyd, María Rupérez, Helen Ayles, Redwaan Vermaak, Kwame Shanaube, Albertus Schaap, Eveline Klinkenberg, Petra de Haas, Barry Kosloff, Thomas Gachie, Pete J Dodd, Chali Wapamesa, Michael J Burnett, Nico Kalisvaart, Tila Mainga, Linda Mureithi

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Therapeutic Potential of <i>Cajanus cajan</i> (L.) <i>Millsp</i>. Leaf Extract in Modulating Gut Microbiota and Immune Response for the Treatment of Inflammatory Bowel Disease by Mingzhang Lin, Linghua Piao, Zhendong Zhao, Li Liao, Dayong Wang, Haiwen Zhang, Xiande Liu

“…<b>Conclusions:</b> The present results suggested that CCLE, comprising stilbenes like cajaninstilbene acid, longistylin A, and longistylin C, protects the epithelial barrier’s structure and function against DSS-induced acute IBD by restoring gut microbiota balance and systemic immune response as AhR agonists. Overall, CCLE represents a promising natural product-based therapeutic strategy for treating IBD by restoring gut microbiota balance and modulating systemic immune responses.…”
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Multinational retrospective analysis of bridging therapy prior to chimeric antigen receptor t cells for relapsed/refractory acute lymphoblastic leukemia in children and young adult... by Maike Breidenbach, Peter Bader, Andishe Attarbaschi, Claudia Rossig, Roland Meisel, Markus Metzler, Marion Subklewe, Fabian Mueller, Paul-Gerhardt Schlegel, Irene Teichert von Lüttichau, Jean-Pierre Bourquin, Gabriele Escherich, Gunnar Cario, Peter Lang, Ramona Coffey, Arend von Stackelberg, Semjon Willier, Brigitte Strahm, Christina Peters, Tobias Feuchtinger

“…Bridging therapy was classified into the categories 1) no systemic therapy (15/93 treatments), 2) low-intensity therapy (38/93 treatments) and 3) high-intensity therapy (39/93 treatments). …”
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Cross‐ethnicity face anti‐spoofing recognition challenge: A review by Ajian Liu, Xuan Li, Jun Wan, Yanyan Liang, Sergio Escalera, Hugo Jair Escalante, Meysam Madadi, Yi Jin, Zhuoyuan Wu, Xiaogang Yu, Zichang Tan, Qi Yuan, Ruikun Yang, Benjia Zhou, Guodong Guo, Stan Z. Li

“…Abstract Face anti‐spoofing is critical to prevent face recognition systems from a security breach. The biometrics community has achieved impressive progress recently due to the excellent performance of deep neural networks and the availability of large datasets. …”
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Regenerative viticulture and climate change resilience by Flora O'Brien, Alistair Nesbitt, Rebecca Sykes, Belinda Kemp

“…Findings illustrate the emerging status of RV as a researched and/or applied concept, and this review supports those establishing RV systems and contributes to evidence-based RV approaches. …”
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Snake Venom Pharmacokinetics and Acute Toxic Outcomes Following <i>Daboia siamensis</i> Envenoming: Experimental and Clinical Correlations by Sethapong Lertsakulbunlue, Wipapan Khimmaktong, Orawan Khow, Wittawat Chantkran, Jureeporn Noiphrom, Kanyanat Promruangreang, Lawan Chanhome, Janeyuth Chaisakul

“…<i>Daboia siamensis</i> (Eastern Russell’s viper) envenoming causes systemic coagulopathy and severe hemorrhage including acute kidney injury. …”
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Microbial Predominance and Antimicrobial Resistance in a Tertiary Hospital in Northwest China: A Six-Year Retrospective Study of Outpatients and Patients Visiting the Emergency Dep... by Caifeng Wang, Wen Li, Juanjuan Gao, Dancheng Zhang, Yali Li, Fang Li, Jine Lei

“…Antimicrobial susceptibility was tested by automated systems and/or the Kirby–Bauer disc diffusion method. …”
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Expression Profile of Genes Potentially Associated with Adequate Glycemic Control in Patients with Type 2 Diabetes Mellitus by Sâmia Cruz Tfaile Corbi, Alliny Souza Bastos, Rafael Nepomuceno, Thamiris Cirelli, Raquel Alves dos Santos, Catarina Satie Takahashi, Cristiane S. Rocha, Silvana Regina Perez Orrico, Claudia V. Maurer-Morelli, Raquel Mantuaneli Scarel-Caminaga

“…This demonstrated a systemic exacerbation of the gene expression related to immune response in T2D patients. …”
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The transcriptional analysis of pepper shed light on a proviral role of light-harvesting chlorophyll a/b binding protein 13 during infection of pepper mild mottle virus by Weihong Lin, Shugen Zhang, Hao Zhang, Xiaomei Deng, Tong Jiang, Xifeng Chen, Laihua Dong, Qin Yan, Lianyi Zang, Yongping Xing, Zhenquan Wang, Qin Zhang, Kaitong Du, Huolin Shen, Junmin Zhang, Tao Zhou

“…We identified 462 and 401 differentially expressed genes (DEGs) in the systemically-infected leaves of the susceptible and resistant lines, respectively, when compared to their healthy counterparts. …”
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Food-Induced Adverse Reactions: A Review of Physiological Food Quality Control, Mucosal Defense Mechanisms, and Gastrointestinal Physiology by Dongdong Guo, Chang Liu, Hongkang Zhu, Yuliang Cheng, Xiang Huo, Yahui Guo, He Qian

“…Organisms utilize several systems to coexist with symbiotic microbes, regulate them, and concurrently avoid, expel, or neutralize harmful pathogens. …”
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Effect of molybdenum supply on crop performance through rhizosphere soil microbial diversity and metabolite variation by Muhammad Shoaib Rana, Muhammad Shoaib Rana, Dikhnah Alshehri, Dikhnah Alshehri, Rui-Long Wang, Muhammad Imran, Yousif Abdelrahman Yousif Abdellah, Faiz Ur Rahman, Marfat Alatawy, Hanaa Ghabban, Hanaa Ghabban, Amany H. A. Abeed, Cheng-xiao Hu

“…Candidatus Koribacter and Kaistobacter were commonly significantly higher in both crops under Mo-applied conditions in both cropping systems. These taxa, sharing similar functions, could serve as potential markers for nutrient availability and soil fertility. …”
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The Level of hs-CRP in Coronary Artery Ectasia and Its Response to Statin and Angiotensin-Converting Enzyme Inhibitor Treatment by Yilmaz Ozbay, Mehmet Akbulut, Mehmet Balin, Hidayet Kayancicek, Adil Baydas, Hasan Korkmaz

“…C-reactive protein (CRP) which is among the most sensitive markers of systemic inflammation, and elevation of systemic and local levels of this inflammatory marker which has been associated with an increased risk for cardiovascular disease in the obstructive coronary artery disease (O-CAD) are well known, but little was known in CAE. …”
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Stapled End-To-Side Ileocolic Anastomosis in Crohn’s Disease: Old Dog, Reliable Tricks? A Retrospective Two-Center Cohort Study by Volkan Doğru, MD, Jean H. Ashburn, MD, Umut Akova, BS, Alton G. Sutter, MD, Eren Esen, MD, Emily M. Gardner, MD, Andre da Luz Moreira, MD, Arman Erkan, MD, John Kirat, MD, Michael J. Grieco, MD, Feza H. Remzi, MD

“…Before surgery, 80% were exposed to at least 1 cycle of systemic steroids and 71% had at least 1 biologic agent; 60% exhibited penetrating disease and 38% developed an intra-abdominal abscess. …”
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Fatigue in patients with chronic obstructive pulmonary disease: protocol of the Dutch multicentre, longitudinal, observational FAntasTIGUE study by Mirjam A G Sprangers, Martijn A Spruit, Emiel F M Wouters, Daisy J A Janssen, Jean W M Muris, Judith B Prins, Yvonne M J Goërtz, Milou Looijmans, Melissa S Y Thong, Jeannette B Peters, Chris Burtin, Yvonne Meertens-Kerris, Arnold Coors, Jan H Vercoulen

“…The precipitating and perpetuating factors of fatigue (physical, psychological, behavioural and systemic) will be assessed at baseline and at 12 months. …”
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Modeling TEC Maps Over China Using Particle Swarm Optimization Neural Networks and Long‐Term Ground‐Based GPS, COSMIC, and Fengyun Data by Shuangshuang Shi, Kefei Zhang, Jiaqi Shi, Andong Hu, Dongsheng Zhao, Zhongchao Shi, Peng Sun, Huajing Wu, Suqin Wu

“…The new model is developed using a hybrid method composed of the particle swarm optimization (PSO) and artificial neural network and long‐term observations from 257 ground‐based global navigation satellite systems (GNSS) stations and space‐borne GNSS radio occultation systems (COSMIC and Fengyun) during the 14‐year period of 2008–2021. …”
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Prognostic role of aetiological agent vs. clinical pattern in candidates to lead extraction for cardiac implantable electronic device infections by Giulia Massaro, Renato Pascale, Mauro Biffi, Cristian Martignani, Matteo Ziacchi, Andrea Simeone, Raimondo Pittorru, Manuel De Lazzari, Federico Migliore, Igor Diemberger

“…Abstract Cardiac implantable electronic devices infections (CIEDI) are associated with poor survival despite the improvement in transvenous lead extraction (TLE). Aetiology and systemic involvement are driving factors of clinical outcomes. …”
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Highly Sensitive Non-Dispersive Infrared Gas Sensor with Innovative Application for Monitoring Carbon Dioxide Emissions from Lithium-Ion Battery Thermal Runaway by Liang Luo, Jianwei Chen, Aisn Gioronara Hui, Rongzhen Liu, Yao Zhou, Haitong Liang, Ziyuan Wang, Haosu Luo, Fei Fang

“…Notably, carbon dioxide (CO₂) gas sensors are emphasized for their ability to enhance early-warning systems, facilitating the timely detection of potential issues and, in turn, improving the overall safety standards of electric vehicles. …”
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The association between the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio and delirium in ischemic stroke patients by Pangbo Wang, Pangbo Wang, Jing Huang, Liwei Xu, Rong Hu

“…BackgroundDelirium is a severe neuropsychiatric symptom following acute ischemic stroke (IS) and is associated with poor outcomes. Systemic inflammation and immune dysregulation are believed to contribute to the pathophysiology of delirium. …”
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