Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject ‘cold’ tumors by Laetitia Fend, Eric Quemeneur, Monika Semmrich, Jean-Baptiste Marchand, Matilda Rehn, Nathalie Silvestre, Linda Mårtensson, Johann Foloppe, Ingrid Teige, Björn Frendeus, Petra Holmkvist, Carolin Svensson, Christelle Remy, Patricia Kleinpeter, Jules Deforges, Fred Junghus, Kirstie L Cleary, Mimoza Bodén

“…Intratumoral administration of VVGM-αCTLA-4 achieved tumor-restricted CTLA-4 receptor saturation and Treg depletion, which elicited antigen cross-presentation and stronger systemic expansion of tumor-specific CD8+ T cells and antitumor immunity compared with systemic αCTLA-4 antibody therapy. …”
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Ophiostomatoid fungi associated with pine bark beetles and infested pines in south-eastern Australia, including Graphilbum ipis-grandicollis sp. nov. by Conrad Trollip, Angus J. Carnegie, Quang Dinh, Jatinder Kaur, David Smith, Ross Mann, Brendan Rodoni, Jacqueline Edwards

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Effects of information on consumer attitudes towards gene-edited foods: a comparison between livestock and vegetables by Naoko Kato-Nitta, Yusuke Inagaki, Tadahiko Maeda, Masashi Tachikawa

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Follow-up care needs and motivational factors for childhood cancer survivors and their parents in Germany by Aleshchenko Ekaterina, Langer Thorsten, Calaminus Gabriele, Glogner Juliane, Hellwig Kathrin, Trocchi Pietro, Swart Enno, Baust Katja

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Integrated technique of buffalo fertility management in Nepal by Bhuminand Devkota, Shatrughan Shah, Gokarna Gautam

“…Even though the buffalo farming systems range from large-scale and semi-intensive, with herd sizes of more than 50 animals, to small-scale, intensive systems in which farmers keep 1 to 5 animals, while large-scale farms are very few, and medium and small-scale farms predominate in the country. …”
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Screening for diabetic retinopathy at a health centre in South Africa: A cross-sectional study by Ntokozo Zulu, Patrick Ngassa Piotie, Elizabeth M. Webb, Wezi G. Maphenduka, Steve Cook, Paul Rheeder

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Machine learning-driven identification of critical gene programs and key transcription factors in migraine by Lei Zhang, Yujie Li, Yunhao Xu, Wei Wang, Guangyu Guo

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Multi-environment field trials for wheat yield, stability and breeding progress in Germany by Tien-Cheng Wang, Till Rose, Holger Zetzsche, Agim Ballvora, Wolfgang Friedt, Henning Kage, Jens Léon, Carolin Lichthardt, Frank Ordon, Rod J Snowdon, Andreas Stahl, Hartmut Stützel, Benjamin Wittkop, Tsu-Wei Chen

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Clinicopathological Review of 547 Bulbar Enucleations in Hungary (2006–2017) by Gábor Tóth, Nóra Szentmáry, Gábor László Sándor, Béla Csákány, Erika Maka, Jeannette Tóth, Zsuzsanna Antus, Milán Tamás Pluzsik, Achim Langenbucher, Zoltán Zsolt Nagy, Olga Lukáts

“…Primary enucleation indications were classified into trauma, tumours, systemic diseases, surgical diseases, infections or inflammations, miscellaneous diseases, and unclassifiable groups. …”
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An insight into brucellosis in wild boar and domestic pigs in Europe: A systematic review by Zita Martins Ruano, Teresa Letra Mateus, Madalena Vieira-Pinto

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An Initial Validation of the NASA TROPICS Pathfinder Microwave Radiometer Observations by Amelia Gagnon, Samantha N. Hasler, Juliana Chew, William J. Blackwell, R. Vincent Leslie, Michael DiLiberto, Kerri Cahoy

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Expecting the Unexpected: Predicting Panic Attacks From Mood, Twitter, and Apple Watch Data by Ellen W. McGinnis, Bryn Loftness, Shania Lunna, Isabel Berman, Skylar Bagdon, Genevieve Lewis, Michael Arnold, Christopher M. Danforth, Peter S. Dodds, Matthew Price, William E. Copeland, Ryan S. McGinnis

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Equality, Diversity and Inclusion characteristics measured or reported in randomised trials of intrapartum interventions: A Scoping Review [version 1; peer review: 2 approved] by Aoife Smith, John Gilmore, Susan Hannon, Valerie Smith

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Convolutional Attention Based Mechanism for Facial Microexpression Recognition by Hafiz Khizer Bin Talib, Kaiwei Xu, Yanlong Cao, Yuan-Ping Xu, Zhijie Xu, Muhammad Zaman, Adnan Akhunzada

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Preliminary Exploration of AlF-NOTA-FAPI-04 PET/CT in the Management of Ankylosing Spondylitis: A Prospective Clinical Study by Shibo Guo MD, Zhehao Lyu PhD, Chunyu Duan MD, Hui Wang PhD, Peng Xu MD, Wei Han BD, Peng Fu PhD

“…As a potential imaging method for the early assessment of AS, positron emission tomography (PET) can quantify systemic disease activity, which is conducive to monitoring the progression of disease activity and assisting in evaluating the efficacy of the treatment. …”
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THE ROLE OF DISPOSITION OF CONNECTING TISSUE IN THE RISE OF NONTRAUMATIC SUBARACHNOIDAL HEMORRHAGE IN YOUNG AGE by E. V. Petrova, T. F. Popova, I. A. Gribacheva, G. K. Taitubayeva

“…To identify possible effects of systemic dysmorphogenesis of connective tissue on the formation and characteristics of the course of nontraumatic subarachnoid hemorrhage at a young age, with further development of an algorithm for screening physical examination of patients with an increased risk of aneurysmal hemorrhage.Patients and methods. …”
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Pooled Multicenter Safety Analysis of Lupin’s Intravitreal Biosimilar Ranibizumab (Ranieyes) in Chorioretinal Vascular Diseases by Debdulal Chakraborty, Tushar Kanti Sinha, Sourav Sinha, Aniruddha Maiti, Angshuman Mukherjee, Krishnendu Nandi, Sudipta Das, Saptorshi Majumdar, Dinesh Rungta, Ranabir Bhattacharya

“…Patients were followed for a minimum of 6 months, and data on ocular and systemic adverse events (AEs) were collected and analyzed. …”
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Investigating Energy Performance Criteria in Compliance with Iranian National Building Regulations: The Role of Residential Building Envelope Adjacency by Payam Soltan Ahmadi, Ahmad Khoshgard, Hossein Ahmadi Danesh Ashtiani

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Accurate Prediction of Advanced Liver Fibrosis Using the Decision Tree Learning Algorithm in Chronic Hepatitis C Egyptian Patients by Somaya Hashem, Gamal Esmat, Wafaa Elakel, Shahira Habashy, Safaa Abdel Raouf, Samar Darweesh, Mohamad Soliman, Mohamed Elhefnawi, Mohamed El-Adawy, Mahmoud ElHefnawi

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The influence of electronic health record design on usability and medication safety: systematic review by Marie Cahill, Brian J. Cleary, Shane Cullinan

“…The design features described in these studies fit within seven broad design themes: searchability, automation, customisation, data entry, workflow, user guidance and interoperability. EHR systems that prioritised these areas were associated with higher reported usability and enhanced medication safety, while the opposite was found for systems that overlooked these design aspects. …”
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