Disruption of tumor-intrinsic PGAM5 increases anti-PD-1 efficacy through the CCL2 signaling pathway by Yan Li, Hong Wang, Xiaoyang Li, Yuan He, Huiquan Liu, Dong Han, Ting Mei, Yixuan Li, Zilong Xu, Xiaoying Wei, Jianguo Wang, Peijie Zhou, Yuwen Wang, Ziye Li, Junhao Ning, Anlin Wang, Jingjing Cheng, Dong Qian

“…Mechanistically, we established an in vitro co-culture system and analyzed proteomics data to find out the bridge between tumor cell PGAM5 and tumor-associated macrophages (TAMs) in the microenvironment. …”
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Nomenclatural issues concerning cultured yeasts and other fungi: why it is important to avoid unneeded name changes by Andrey Yurkov, Artur Alves, Feng-Yan Bai, Kyria Boundy-Mills, Pietro Buzzini, Neža Čadež, Gianluigi Cardinali, Serge Casaregola, Vishnu Chaturvedi, Valérie Collin, Jack W. Fell, Victoria Girard, Marizeth Groenewald, Ferry Hagen, Chris Todd Hittinger, Aleksey V. Kachalkin, Markus Kostrzewa, Vassili Kouvelis, Diego Libkind, Xinzhan Liu, Thomas Maier, Wieland Meyer, Gábor Péter, Marcin Piątek, Vincent Robert, Carlos A. Rosa, Jose Paulo Sampaio, Matthias Sipiczki, Marc Stadler, Takashi Sugita, Junta Sugiyama, Hiroshi Takagi, Masako Takashima, Benedetta Turchetti, Qi-Ming Wang, Teun Boekhout

“…Consequently, the stability of the taxonomic system and the traceability of nomenclatural changes is crucial for a broad range of users and taxonomists. …”
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Alimentation et gestion de l’eau sur la colline de Fourvière à Lyon : les aménagements hydrauliques, la ville et ses monuments by Aldo Borlenghi, Éric Leroy

“…As seen in other cities in the Roman world, this system associated with cisterns/reservoirs can supply and distribute water on the pressure.In a context of water scarcity at the top of the hill, the cisterns made it possible to collect and conserve rainwater. …”
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Clinical trials to gene therapy development and production in Brazil: a review by Jonas Alex Morales Saute, Virginia Picanço-Castro, Ana Carolina de Freitas Lopes, João Batista da Silva Júnior, Johanna Henriques Nehm, Franciele dos Santos Maciel, Ida Vanessa Doederlein Schwartz, Juliana Maria Ferraz Sallum, Margareth Castro Ozelo, Roberto Giugliani, Martin Bonamino, Hilda Petrs-Silva, Guilherme Baldo

“…Focusing on gene replacement and CAR-T cell therapies, we discuss the main advances, limitations, and difficulties faced by the country in the production, approval, and incorporation of such products into the public health system. Finally, we highlight the potential leading role that low-to middle-income countries can have in this industry, not only by providing their own vector supply but also by addressing important issues related to the sustainability and long-term global affordability of gene therapy products.…”
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Multiple intracerebral hematomas during SEEG recording and intradural hemorrhage after spinal tap: A case report prompting more research on collagen IV gene mutation and oral nicot... by Markus Leitinger, Serena Broggi, Mathias Spendel, Gudrun Kalss, Ivan Petrović, Herbert Krainz, Fabio Rossini, Julia Höfler, Andreea Toma, Giorgi Kuchukhidze, Matthias Mauritz, Kai‐Nicolas Poppert, Bernardo Crespo‐Pimentel, Pilar Bosque‐Varela, Anna Pleyers, Patricia Ganger, Dieter Kotzot, Davor Lessel, Christoph J. Griessenauer, Eugen Trinka

“…We performed the investigation of the clotting system and whole‐exome sequencing (WES). WES identified a heterozygous mutation c.4698G>T, p.…”
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A Meta-Synthesis of the Integrated Model of Customer Value co-Destruction and Value co-Creation by Zohreh Dehdashti Shahrokh, Vahid Nasehifar, Mohammad Reza Karimi Alavijeh, Yazdan Rahmatabadi

“…This is also true regarding the co-destruction of customer value and the tendency of the system to create co-destruction is that by identifying the factors that cause co-destruction and curbing them using the appropriate strategy, it will be possible to create co-creation continuously and continuously. …”
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A novel oncolytic Vaccinia virus armed with IL-12 augments antitumor immune responses leading to durable regression in murine models of lung cancer by Lijuan Chen, Lijuan Chen, Pengju Wang, Carmela Di Gioia, Ming Yuan, Zhe Zhang, Jinxin Miao, Wenli Yan, Guanghao Zhao, Yangyang Jia, Na Wang, Zhongxian Zhang, Haoran Guo, Giulia Marelli, Louisa Chard Dunmall, Nicholas R. Lemoine, Nicholas R. Lemoine, Yaohe Wang, Yaohe Wang

“…Oncolytic vaccinia viruses (VVs) are potent stimulators of the immune system and induce immune-mediated tumor clearance and long-term surveillance against tumor recurrence. …”
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AutoLDP: An accurate and efficient artificial intelligence-based tool for automatic labeling of digital pathology by Yingnan Zhao, Huifen Ye, Jing Yang, Su Yao, Maohua Lv, Zhihong Chen, Yunrui Ye, Qingru Hu, Cheng Lu, Zaiyi Liu, Ke Zhao, Zhihua Chen

“…Results: The AutoLDP system was 20 times faster than manual labeling. The files per minute in the solid-state drives of CRAFT ​+ ​ParSeq were the highest among all methods at 136.95 in validation set 1 and 170.95 in validation set 2. …”
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Basic Molecular Biology, Metabolic and Immunological Mechanisms of Fecal Microbiota Transplantation by O. V. Goloshchapov, A. V. Beynarovich, A. B. Chukhlovin, R. V. Klementeva, A. A. Shcherbakov, E. A. Bakin, I. K. Golubovskaya, N. D. Ventslovayte, O. S. Yudintseva, M. V. Gorchakova, V. E. Karev, M. A. Kucher, M. A. Suvorova, E. V. Svetkina, G. G. Rodionov, V. V. Gostev, S. V. Sidorenko, I. S. Moiseev, A. D. Kulagin

“…FMT may be a component of complex therapy aimed at early reconstitution of immune system and organic acid metabolism in patients after allo-HSCT. …”
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Effect and safety analysis of auricular acupoint pressing therapy at different frequencies on insomnia and constipation (不同治疗频次耳穴压豆干预失眠和便秘的效果及安全性分析)... by LIU Hongbo (刘泓博), JIN Xianglan (金香兰), SONG Jiale (宋佳乐), LI Jiaji (李佳霁), LIU Yanna (刘燕娜), WANG Xuesong (王雪送), GUO Jingrui (郭经睿), HU Shirong (胡世荣)

“…The Pittsburgh Sleep Quality Index (PSQI) score and Constipation scoring system (CSS) points of the three groups were improved compared with those before treatment (P < 0. 05). fter 14 days of treatment, the PSQI score and CSS scores of the observation group A and the observation group B were lower than those of the control group (P < 0. 05), and PSQI score and CSS scores in the observation group A were lower than those in the observation group B (P < 0. 05). …”
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Mental health disorder symptom changes among public safety personnel after emotional resilience skills training by R.N. Carleton, S. Sauer-Zavala, T.A. Teckchandani, K.Q. Maguire, L. Jamshidi, R.E. Shields, T.O. Afifi, J. Nisbet, K.L. Andrews, S.H. Stewart, A.J. Fletcher, R. Martin, R.S. MacPhee, J.C. MacDermid, T.M. Keane, A. Brunet, M. McCarron, L.M. Lix, N.A. Jones, G.P. Krätzig, J.P. Neary, G. Anderson, R. Ricciardelli, H. Cramm, J. Sareen, G.J.G. Asmundson

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Editorial by Pieter Vanhuysse, Antony Mason, Jörg Tremmel, Markus Rutsche, Maria Lenk

“…Taking the five largest EU countries, they show that seemingly worrying levels of unsustainability in the pension system can go hand in hand with modest sustainability worries at the level of the economy. …”
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Rice Leaf Disease Image Enhancement Based on Improved CycleGAN by YAN Congkuan, ZHU Dequan, MENG Fankai, YANG Yuqing, TANG Qixing, ZHANG Aifang, LIAO Juan

“…Furthermore, a perception similarity loss function, designed to align with the human visual system, was incorporated into the overall loss function. …”
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Binding of LncDACH1 to dystrophin impairs the membrane trafficking of Nav1.5 protein and increases ventricular arrhythmia susceptibility by Genlong Xue, Jiming Yang, Yang Zhang, Ying Yang, Ruixin Zhang, Desheng Li, Tao Tian, Jialiang Li, Xiaofang Zhang, Changzhu Li, Xingda Li, Jiqin Yang, Kewei Shen, Yang Guo, Xuening Liu, Guohui Yang, Lina Xuan, Hongli Shan, Yanjie Lu, Yang Baofeng, Zhenwei Pan

“…Strikingly, activation of Dystrophin transcription by dCas9-SAM system in lncDach1-TG mice rescued the impaired membrane distribution of dystrophin and Nav1.5, and prevented the occurrence of ventricular arrhythmia. …”
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Perspectives from the 2nd International Post-Tuberculosis Symposium: mobilising advocacy and research for improved outcomes by B.W. Allwood, R. Nightingale, G. Agbota, S. Auld, G.P. Bisson, A. Byrne, R. Dunn, D. Evans, G. Hoddinott, G. Günther, Z. Islam, J.C. Johnston, G. Kalyatanda, C. Khosa, S. Marais, G. Makanda, O.M. Mashedi, J. Meghji, C. Mitnick, C. Mulder, E. Nkereuwem, O. Nkereuwem, O.B. Ozoh, A. Rachow, K. Romanowski, J.A. Seddon, I. Schoeman, F. Thienemann, N.F. Walker, D.T. Wademan, R. Wallis, M.M. van der Zalm

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LungDiag: Empowering artificial intelligence for respiratory diseases diagnosis based on electronic health records, a multicenter study by Hengrui Liang, Tao Yang, Zihao Liu, Wenhua Jian, Yilong Chen, Bingliang Li, Zeping Yan, Weiqiang Xu, Luming Chen, Yifan Qi, Zhiwei Wang, Yajing Liao, Peixuan Lin, Jiameng Li, Wei Wang, Li Li, Meijia Wang, YunHui Zhang, Lizong Deng, Taijiao Jiang, Jianxing He

“…To address this issue, we developed LungDiag, an artificial intelligence (AI)‐based diagnostic system that utilizes natural language processing (NLP) to extract key clinical features from electronic health records (EHRs) for the accurate classification of respiratory diseases. …”
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Constructing Identities: Amos Tutuola and the Ibadan Literary Elite in the wake of Nigerian Independence by Mackenzie Finley

“…I’m trying my best to bring out our traditional things for the people to know a little about us, about our beliefs, our character, and so on.”2 Tutuola’s didactics during the lecture at Palermo reflect his distinct intellectual and cultural commitment to a Yoruba cosmology, one that was not so much learned in his short years of schooling in the colonial education system as it was absorbed from his life of engagement with Yoruba oral tradition. …”
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Photon sensor-based monitoring of spatial variations in canopy FIPAR for crop growth assessment by Jian Wang, Zhenggui Zhang, Xin Li, Lu Feng, Xiaofei Li, Minghua Xin, Shiwu Xiong, Yingchun Han, Shijie Zhang, Xiaoyu Zhi, Beifang Yang, Guoping Wang, Yaping Lei, Zhanbiao Wang, Yabing Li

“…The photon sensor-based fraction of intercepted photosynthetically active radiation (FIPAR) monitoring system was demonstrated to provide accurate real-time tracking of crop growth. …”
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Retrieving the atmospheric concentrations of carbon dioxide and methane from the European Copernicus CO2M satellite mission using artificial neural networks by M. Reuter, M. Hilker, S. Noël, A. Di Noia, M. Weimer, O. Schneising, M. Buchwitz, H. Bovensmann, J. P. Burrows, H. Bösch, R. Lang

“…Since CO2M will not be launched until 2026, our study exploits simulated measurements over land surfaces from a comprehensive observing system simulation experiment (OSSE) that includes realistic meteorology, aerosols, surface bidirectional reflectance distribution function (BRDF), solar-induced chlorophyll fluorescence (SIF), and CO<span class="inline-formula">₂</span> and CH<span class="inline-formula">₄</span> concentrations. …”
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Single-cell microbiota phenotyping reveals distinct disease and therapy-associated signatures in Crohn’s disease by Lisa Budzinski, Gi-Ung Kang, René Riedel, Toni Sempert, Leonie Lietz, René Maier, Janine Büttner, Bettina Bochow, Marcell T. Tordai, Aayushi Shah, Amro Abbas, Tanisha Momtaz, Jannike L. Krause, Robin Kempkens, Katrin Lehman, Gitta A. Heinz, Anne E. Benken, Stefanie Bartsch, Kathleen Necke, Ute Hoffmann, Mir-Farzin Mashreghi, Robert Biesen, Tilmann Kallinich, Tobias Alexander, Bosse Jessen, Carl Weidinger, Britta Siegmund, Andreas Radbruch, Anja Schirbel, Benjamin Moser, Hyun-Dong Chang

“…However, the correlation between other cellular properties of intestinal bacteria and disease has not been explored further, especially for features that are not directly driven by the host immune-system, e.g. the expression of surface sugars by bacteria. …”
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