The sport and Lithuanian national identity by Ingvaras Butautas, Rasa Čepaitienė

“…More than one and a half years of lasting boycott of international sports federations almost ruined the Lithuanian sport system. Sudden changes harmed the sphere of sport much stronger than other reformatted spheres. …”
Get full text

Histopathologic Progression and Metastatic Relapse Outcomes in Small Cell Neuroendocrine Carcinomas of the Urinary Tract by Mohammad Jad Moussa, Georges C. Tabet, Arlene O. Siefker‐Radtke, Lianchun Xiao, Nathaniel R. Wilson, Jianjun Gao, Christopher J. Logothetis, Petros Grivas, Byron Lee, Amishi Y. Shah, Pavlos Msaouel, Roger Li, Leticia Campos Clemente, Jianping Zhao, Nizar M. Tannir, Ashish M. Kamat, Donna E. Hansel, Charles C. Guo, Matthew T. Campbell, Omar Alhalabi

“…Conclusions SCNEC‐URO is a systemic disease with high risk of distant relapse including CNS. …”
Get full text

Optimizing selenium-enriched yeast supplementation in laying hens: Enhancing egg quality, selenium concentration in eggs, antioxidant defense, and liver health by Longfei Zhang, Jianmin Zhou, Uchechukwu Edna Obianwuna, Cheng Long, Kai Qiu, Haijun Zhang, Xiaolong Qi, Shugeng Wu

“…Analysis of hepatic genes expression revealed that SY15 supplementation significantly upregulated key antioxidant-related genes (Nrf2, HO-1, CAT, and NQO1) and downregulated Keap1 expression (P < 0.05), suggesting strong activation of the antioxidant defense system. In conclusion, SY supplementation at 1.5 mg/kg improved egg quality, increased Se concentrations in eggs, and enhanced antioxidant capacity without affecting laying performance or liver health. …”
Get full text

Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors by Alfred Zippelius, Petra Herzig, Pratiksha Gulati, Christian Klein, Marta Trüb, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Marina Natoli, Klas Hatje, Fabian Junker, Zhiwen Jiang, Iakov I Davydov, Markus Germann, Daniel Marbach, Adrian Zwick, Patrick Weber, Stefan Seeber, Lothar Tietze, Laura Codarri-Deak, Henry Kao

“…Interestingly, LAG-3 protein upregulation was detected as a unique pharmacodynamic effect mediated by PD1-LAG3, but not by PD1-TIM3 or anti-PD-1.Conclusions Our in vitro system reliably assessed responses to bispecific antibodies co-targeting PD-1 together with LAG-3 or TIM-3 using patients’ tumor infiltrating immune cells and revealed transcriptional and phenotypic imprinting by bispecific antibody formats currently tested in early clinical trials.…”
Get full text

IFNβ drives ferroptosis through elevating TRIM22 and promotes the cytotoxicity of RSL3 by Huiyue Dong, Huiyue Dong, Ling Zhu, Ling Zhu, Jingjing Sun, Jingjing Sun, Qiuyan Chen, Qiuyan Chen, Pengyang Liu, Pengyang Liu, Wei Zhang, Huajing Zeng, Rong Lin, Rong Lin, Zongyang Yu, Zongyang Yu, Jun Lu, Jun Lu, Jun Lu, Jun Lu

“…BackgroundCyclic GMP-AMP synthase (cGAS)-stimulator-of-interferon genes (STING) pathway is a cytosolic DNA sensor system. The production of this pathway, interferon-β (IFNβ), could suppress the growth of tumor cells, yet it is unclear whether ferroptosis is involved in IFNβ-induced cell death.MethodsThe effects of IFNβ on ferroptosis were analyzed in HT1080, 4T1, HCT116 and 786-O cells. …”
Get full text

Bridging animal models and humans: neuroimaging as intermediate phenotypes linking genetic or stress factors to anhedonia by Huiling Guo, Yao Xiao, Shuai Dong, Jingyu Yang, Pengfei Zhao, Tongtong Zhao, Aoling Cai, Lili Tang, Juan Liu, Hui Wang, Ruifang Hua, Rongxun Liu, Yange Wei, Dandan Sun, Zhongchun Liu, Mingrui Xia, Yong He, Yankun Wu, Tianmei Si, Fay Y. Womer, Fuqiang Xu, Yanqing Tang, Jie Wang, Weixiong Zhang, Xizhe Zhang, Fei Wang

“…In contrast, the stress animal-like subtype did not show changes in genetic risk scores but exhibited enriched risk gene expression in somatic and endocrine tissues, along with mitochondrial dysfunction in the antioxidant stress system. Notably, these distinct subcortical-sensorimotor neuroimaging patterns predicted anhedonia, a core symptom of depression, in both rodent models and depressed subtypes. …”
Get full text

Targeting and reprogramming microglial phagocytosis of neutrophils by ginsenoside Rg1 nanovesicles promotes stroke recovery by Kaichao Hu, Junrui Ye, Pinglong Fan, Ruifang Zheng, Shasha Wang, Ye Peng, Yuan Ruan, Xu Yan, Zhao Zhang, Shifeng Chu, Naihong Chen

“…Here, we present a targeted delivery system utilizing neutrophil-like cell membrane vesicles (NCM), prepared via nitrogen cavitation, to enhance Rg1 delivery to the brain. …”
Get full text

Effect of Simultaneous Use of Different Amounts of Biochar and Soil Application of Common Sulfur and Spraying of Nanosulfur on Yield and Yield Components and Some Phytochemical Cha... by Vahid Mohammadzadeh Kakhki, mohmmad Hossein Aminifard, Mohamad Behzad Amiri

“…Also, the relatively high vitamin C and vitamin A content of savory may contribute to long-term health by boosting the natural state of the human immune system. Biochar is a solid material formed by high-temperature charring of biomass under anaerobic conditions. …”
Get full text

Higher education students' perceptions of ChatGPT: A global study of early reactions. by Dejan Ravšelj, Damijana Keržič, Nina Tomaževič, Lan Umek, Nejc Brezovar, Noorminshah A Iahad, Ali Abdulla Abdulla, Anait Akopyan, Magdalena Waleska Aldana Segura, Jehan AlHumaid, Mohamed Farouk Allam, Maria Alló, Raphael Papa Kweku Andoh, Octavian Andronic, Yarhands Dissou Arthur, Fatih Aydın, Amira Badran, Roxana Balbontín-Alvarado, Helmi Ben Saad, Andrea Bencsik, Isaac Benning, Adrian Besimi, Denilson da Silva Bezerra, Chiara Buizza, Roberto Burro, Anthony Bwalya, Cristina Cachero, Patricia Castillo-Briceno, Harold Castro, Ching Sing Chai, Constadina Charalambous, Thomas K F Chiu, Otilia Clipa, Ruggero Colombari, Luis José H Corral Escobedo, Elísio Costa, Radu George Crețulescu, Marta Crispino, Nicola Cucari, Fergus Dalton, Meva Demir Kaya, Ivo Dumić-Čule, Diena Dwidienawati, Ryan Ebardo, Daniel Lawer Egbenya, MoezAlIslam Ezzat Faris, Miroslav Fečko, Paulo Ferrinho, Adrian Florea, Chun Yuen Fong, Zoë Francis, Alberto Ghilardi, Belinka González-Fernández, Daniela Hau, Md Shamim Hossain, Theo Hug, Fany Inasius, Maryam Jaffar Ismail, Hatidža Jahić, Morrison Omokiniovo Jessa, Marika Kapanadze, Sujita Kumar Kar, Elham Talib Kateeb, Feridun Kaya, Hanaa Ouda Khadri, Masao Kikuchi, Vitaliy Mykolayovych Kobets, Katerina Metodieva Kostova, Evita Krasmane, Jesus Lau, Wai Him Crystal Law, Florin Lazăr, Lejla Lazović-Pita, Vivian Wing Yan Lee, Jingtai Li, Diego Vinicio López-Aguilar, Adrian Luca, Ruth Garcia Luciano, Juan D Machin-Mastromatteo, Marwa Madi, Alexandre Lourenço Manguele, Rubén Francisco Manrique, Thumah Mapulanga, Frederic Marimon, Galia Ilieva Marinova, Marta Mas-Machuca, Oliva Mejía-Rodríguez, Maria Meletiou-Mavrotheris, Silvia Mariela Méndez-Prado, José Manuel Meza-Cano, Evija Mirķe, Alpana Mishra, Ondrej Mital, Cristina Mollica, Daniel Ionel Morariu, Natalia Mospan, Angel Mukuka, Silvana Guadalupe Navarro Jiménez, Irena Nikaj, Maria Mihaylova Nisheva, Efi Nisiforou, Joseph Njiku, Singhanat Nomnian, Lulzime Nuredini-Mehmedi, Ernest Nyamekye, Alka Obadić, Abdelmohsen Hamed Okela, Dorit Olenik-Shemesh, Izabela Ostoj, Kevin Javier Peralta-Rizzo, Almir Peštek, Amila Pilav-Velić, Dilma Rosanda Miranda Pires, Eyal Rabin, Daniela Raccanello, Agustine Ramie, Md Mamun Ur Rashid, Robert A P Reuter, Valentina Reyes, Ana Sofia Rodrigues, Paul Rodway, Silvia Ručinská, Shorena Sadzaglishvili, Ashraf Atta M S Salem, Gordana Savić, Astrid Schepman, Samia Mokhtar Shahpo, Abdelmajid Snouber, Emma Soler, Bengi Sonyel, Eliza Stefanova, Anna Stone, Artur Strzelecki, Tetsuji Tanaka, Carolina Tapia Cortes, Andrea Teira-Fachado, Henri Tilga, Jelena Titko, Maryna Tolmach, Dedi Turmudi, Laura Varela-Candamio, Ioanna Vekiri, Giada Vicentini, Erisher Woyo, Özlem Yorulmaz, Said A S Yunus, Ana-Maria Zamfir, Munyaradzi Zhou, Aleksander Aristovnik

“…Moreover, policymakers may also consider the findings when formulating strategies for secondary and higher education system development, especially in light of changing labor market needs and related digital skills development.…”
Get full text

Research on Current Situation and Countermeasure of Chinese Primary Care Physicians&apos; Community Rehabilitation Service Ability by LIAN Lu, WANG Di, CHEN Jiaying, LIU Wu

“…It is necessary to improve the construction of the tiered diagnosis and treatment system, promote primary care physicians&apos; experience and abilities. …”
Get full text

Long-term exposure to PM2.5 and its constituents and visual impairment in schoolchildren: A population-based survey in Guangdong province, China by Jia-Hui Li, Hui-Xian Zeng, Jing Wei, Qi-Zhen Wu, Shuang-Jian Qin, Qing-Guo Zeng, Bin Zhao, Guang-Hui Dong, Ji-Chuan Shen, Xiao-Wen Zeng

Get full text

Antispermatogenic Activity of the Benzothiazoline Ligand and Corresponding Organoantimony(V) Derivative in Male Albino Rats

“…<p>Triphenylantimony(V) derivative, <mml:math> <mml:msub> <mml:mtext>Ph</mml:mtext> <mml:mtext>3</mml:mtext> </mml:msub> <mml:mtext>Sb</mml:mtext><mml:mrow><mml:mo>(</mml:mo> <mml:mrow> <mml:msup> <mml:mrow> <mml:mtext>OPr</mml:mtext> </mml:mrow> <mml:mtext>i</mml:mtext> </mml:msup> </mml:mrow> <mml:mo>)</mml:mo></mml:mrow><mml:mrow><mml:mo>[</mml:mo> <mml:mrow> <mml:msub> <mml:mrow> <mml:mtext>SC</mml:mtext> </mml:mrow> <mml:mtext>6</mml:mtext> </mml:msub> <mml:msub> <mml:mtext>H</mml:mtext> <mml:mtext>4</mml:mtext> </mml:msub> <mml:mtext>N</mml:mtext><mml:mo>:</mml:mo><mml:mtext>C</mml:mtext><mml:mrow><mml:mo>(</mml:mo> <mml:mrow> <mml:msub> <mml:mrow> <mml:mtext>CH</mml:mtext> </mml:mrow> <mml:mtext>3</mml:mtext> </mml:msub> </mml:mrow> <mml:mo>)</mml:mo></mml:mrow><mml:msub> <mml:mrow> <mml:mtext>CH</mml:mtext> </mml:mrow> <mml:mtext>2</mml:mtext> </mml:msub> <mml:mtext>C</mml:mtext><mml:mrow><mml:mo>(</mml:mo> <mml:mtext>O</mml:mtext> <mml:mo>)</mml:mo></mml:mrow><mml:msub> <mml:mrow> <mml:mtext>CH</mml:mtext> </mml:mrow> <mml:mtext>3</mml:mtext> </mml:msub> </mml:mrow> <mml:mo>]</mml:mo></mml:mrow> </mml:math>, <mml:math> <mml:mtext mathvariant="bold">1b</mml:mtext> </mml:math>, and the corresponding benzothiazoline ligand [1, 2], <mml:math> <mml:mtext>H</mml:mtext><mml:mover accent='true'> <mml:mrow> <mml:msub> <mml:mrow> <mml:mtext>NC</mml:mtext> </mml:mrow> <mml:mtext>6</mml:mtext> </mml:msub> <mml:msub> <mml:mtext>H</mml:mtext> <mml:mtext>4</mml:mtext> </mml:msub> <mml:mtext>SC</mml:mtext> </mml:mrow> <mml:mo stretchy='true'>&#xFE39;</mml:mo> </mml:mover> <mml:mrow><mml:mo>(</mml:mo> <mml:mrow> <mml:msub> <mml:mrow> <mml:mtext>CH</mml:mtext> </mml:mrow> <mml:mtext>3</mml:mtext> </mml:msub> </mml:mrow> <mml:mo>)</mml:mo></mml:mrow><mml:msub> <mml:mtext>CH</mml:mtext> <mml:mtext>2</mml:mtext> </mml:msub> <mml:mtext>C</mml:mtext><mml:mrow><mml:mo>(</mml:mo> <mml:mtext>O</mml:mtext> <mml:mo>)</mml:mo></mml:mrow><mml:msub> <mml:mtext>CH</mml:mtext> <mml:mtext>3</mml:mtext> </mml:msub> </mml:math>, <mml:math> <mml:mtext mathvariant="bold">1a</mml:mtext> </mml:math>, have been tested for their effects on the reproductive system of male albino rats. The oral administration of both <mml:math> <mml:mtext mathvariant="bold">1a</mml:mtext> </mml:math> and <mml:math> <mml:mtext mathvariant="bold">1b</mml:mtext> </mml:math> at the dose level of 10 mg/rat/day produced significant reduction in the weights of testes, epididymides, seminal vesicles, and ventral prostate. …”
Get full text

Aberrant functional connectome gradient and its neurotransmitter basis in Parkinson's disease by Tao Guo, Cheng Zhou, Jiaqi Wen, Jingjing Wu, Yaping Yan, Jianmei Qin, Min Xuan, Haoting Wu, Chenqing Wu, Jingwen Chen, Sijia Tan, Xiaojie Duanmu, Baorong Zhang, Xiaojun Xu, Minming Zhang, Xiaojun Guan

“…Transcription-neuroimaging association analyses showed that changes of the first gradient were mainly negatively correlated with nondopaminergic system, while alterations of the second gradient were positively correlated with both dopaminergic and nondopaminergic systems. …”
Get full text

ALMA Spectral Survey of an Eruptive Young Star, V883 Ori (ASSAY). II. Freshly Sublimated Complex Organic Molecules in the Keplerian Disk by Jae-Hong Jeong, Jeong-Eun Lee, Seonjae Lee, Giseon Baek, Ji-Hyun Kang, Seokho Lee, Chul-Hwan Kim, Hyeong-Sik Yun, Yuri Aikawa, Gregory J. Herczeg, Doug Johnstone, Lucas Cieza

“…We compared our results with various objects in different evolutionary stages, from Class 0 hot corinos to a solar system comet 67P/Churyumov-Gerasimenko, to examine the effect of evolution on the COM compositions. …”
Get full text

Effects of Electroacupuncture at Zusanli and Quchi on Neurological Function Recovery in Rats with Cerebral Infarction by Jiangcong HONG, Yingzheng WANG, Guangwen WU, Yulong ZOU

“…The changes in walking, hind limb standing and licking behaviors of the rats were observed with Homecage Scan monitoring system 1, 7 and 14 days after the cerebral ischemia reperfusion. …”
Get full text

Lactobacillus reuteri LR1 Improved Expression of Genes of Tight Junction Proteins via the MLCK Pathway in IPEC-1 Cells during Infection with Enterotoxigenic Escherichia coli K88 by Hongbo Yi, Li Wang, Yunxia Xiong, Zhilin Wang, Yueqin Qiu, Xiaolu Wen, Zongyong Jiang, Xuefen Yang, Xianyong Ma

“…Lactobacillus reuteri strains have probiotic functions in their modulation of the microbiota and immune system in intestines. In this study, the effects of L. reuteri LR1, a new strain isolated from the feces of weaning piglets, on intestinal epithelial barrier damage in IPEC-1 cells caused by challenge with enterotoxigenic Escherichia coli (ETEC) K88 were examined. …”
Get full text

Diagnostic Accuracy of Detective Flow Imaging Endoscopic Ultrasonography for Evaluating Blood Flow Within Mural Nodules of Intraductal Papillary Mucinous Neoplasms by Kazuki Endo, Haruo Miwa, Kazuya Sugimori, Kozue Shibasaki, Shoichiro Yonei, Yugo Ishino, Shotaro Tsunoda, Hayato Yoshimura, Akihiro Funaoka, Hiromi Tsuchiya, Ritsuko Oishi, Yuichi Suzuki, Satoshi Komiyama, Takashi Kaneko, Manabu Morimoto, Kazushi Numata, Shin Maeda

“…First, DFI-EUS images were evaluated using a predefined scoring system; thereafter, CE-EUS images were evaluated. …”
Get full text

Transfer of aflatoxin M1 and sterigmatocystin from buffalo milk to soft cheeses by Maurizio Cossu, Andrea Sanna, Giannina Chessa, Stefano Sdogati, Ivan Pecorelli, Ilaria Di Marco Pisciottano, Sara Lambiase, Pasquale Gallo, Stefania Massafra, Elena Torres, Marilena Gili, Giovanni Lo Cascio, Antonio Vella, Roberto Condoleo, Bruno Neri, Guglielmo Militello, Gilberto Giangolini, Carlo Boselli

“…All samples were analysed for AFM1, AFL, and STC was determined with the LC-MS/MS system. The  concentrations in milk were: AFM1 range of 6-87 ng/kg; STC range of 0.3-0.8 ng/kg (detected in only five lots). …”
Get full text

Life stage impact on the human skin ecosystem: lipids and the microbial community by Martin P. Pagac, Bala Davient, Luca Antonio Plado, Hilbert Yuen In Lam, Shi Mun Lee, Aarthi Ravikrishnan, Wee Ling Esther Chua, Sneha Muralidharan, Aishwarya Sridharan, Antony S. Irudayaswamy, Ramasamy Srinivas, Stephen Wearne, Ahmad Nazri Mohamed Naim, Eliza Xin Pei Ho, H. Q. Amanda Ng, Junmei Samantha Kwah, Eileen Png, Anne K. Bendt, Markus R. Wenk, Federico Torta, Niranjan Nagarajan, John Common, Yap Seng Chong, Elizabeth Huiwen Tham, Lynette Pei-Chi Shek, Evelyn Xiu Ling Loo, John Chambers, Yik Weng Yew, Marie Loh, Thomas L. Dawson

“…Our findings imply a complex host-microbe communication system mediated by lipid metabolism occurring on human skin, warranting further research into its role in skin health and disease and paving the way towards novel therapeutic targets and treatments.…”
Get full text

Geography and age drive racial and ethnic disparities in hospital mortality for paediatric community-acquired pneumonia in the United States: a retrospective population based cohor... by Cody-Aaron L. Gathers, Nadir Yehya, Anireddy Reddy, Paula M. Magee, Vanessa C. Denny, Michelle R. Mayeda, Amanda O’Halloran, Sanjiv D. Mehta, Stephanie Wanamaker, Jessica C. Fowler, Garrett Keim

“…Methods: This was a retrospective cohort study of children age < 18 years with community-acquired pneumonia hospitalized between 2016 and 2021 in the Public Health Information System (PHIS) database. Models included a priori stratification of age ≤ 1 year and geographic region. …”
Get full text