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  1. 55861

    Sickle Cell Anemia Patients Display an Intricate Cellular and Serum Biomarker Network Highlighted by TCD4+CD69+ Lymphocytes, IL-17/MIP-1β, IL-12/VEGF, and IL-10/IP-10 Axis by Nadja Pinto Garcia, Alexander Leonardo S. Júnior, Geyse Adriana S. Soares, Thainá Cristina C. Costa, Alicia Patrine C. dos Santos, Allyson Guimarães Costa, Andréa Monteiro Tarragô, Rejane Nina Martins, Flávia do Carmo Leão Pontes, Emerson Garcia de Almeida, Erich Vinícius de Paula, Olindo Assis Martins-Filho, Adriana Malheiro

    Published 2020-01-01
    “…Sickle cell anemia (SCA) is associated with a chronic proinflammatory state characterized by elevated leukocyte count, mortality from severe recurrent infections, and subsequent vasoocclusive complications with leukocyte adhesion to the endothelium and increased plasma levels of inflammatory cytokines. The immune system has a close connection with morbidity in SCA, but further studies are needed to uncover the involvement of innate and adaptive immunities in modulating the SCA physiopathology. …”
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  2. 55862
  3. 55863

    Metazoan diversity in Chilean hypersaline lakes unveiled by environmental DNA by Mattia Saccò, Mattia Saccò, Mattia Saccò, Matthew A. Campbell, Pablo Aguilar, Pablo Aguilar, Pablo Aguilar, Gonzalo Salazar, Gonzalo Salazar, Gonzalo Salazar, Tina E. Berry, Tina E. Berry, Matthew J. Heydenrych, Angus Lawrie, Nicole E. White, Chris Harrod, Chris Harrod, Chris Harrod, Morten E. Allentoft, Morten E. Allentoft

    Published 2025-01-01
    “…Macroinvertebrate data via kick-net surveys further validated Salar de Tara as the most biodiverse system. Compared to net-based assessments, eDNA analysis allowed more refined taxonomic assignments for copepods and ostracods, while certain taxa such as Ephydridae or Hirudinea were not detected through molecular tests. …”
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  4. 55864

    Effect of Yanshiqiangxin Decoction on Cardiomyocyte Apoptosis in Heart Failure Rats Based on PI3K/Akt/Caspase-9 Signaling Pathway by ZHU Sixing, YAN Shiyun, XU Yan, QIN Yan, CHEN Liyun, JIA Meijun

    Published 2022-04-01
    “…One day after the last gavage, M-mode echocardiography [left ventricular ejection fraction (LVEF), left ventricular short-axis shortening (LVFS), left ventricular internal dimension diastole (LVIDd) and left ventricular internal dimension systole (LVIDs)] was performed through an ultra-high resolution small animal ultrasound imaging system; B-type natriuretic peptide (BNP) was measured by ELISA method; the apoptosis of cardiomyocytes was observed through laser confocal microscopy and the apoptosis index was calculated; the expression of apoptosis-related proteins Bax, Bcl-2 and PI3K/Akt/Caspase-9 signalling pathway proteins were detected by Western blot method.Results① Cardiac ultrasound test results: compared with the normal group, the left ventricular anterior wall motion waveform of the model group was not obvious, close to linear motion, and LVEF and LVFS decreased significantly (<italic>P</italic>&lt;0.05), LVIDd and LVIDs increased significantly (<italic>P</italic>&lt;0.05), the left ventricle was significantly enlarged and the contractility was reduced. …”
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  5. 55865

    A self-activated and protective module enhances the preclinical performance of allogeneic anti-CD70 CAR-T cells by Zhao Zhang, Lianfeng Zhao, Tinghui Huang, Zhengliang Chen, Zhengliang Chen, Yaoyao Zhao, Yaoyao Zhao, Junqing Liang, Xudong Ao, Xiaoqiong Jia, Lei Kang, Linghui Kong, Qi Jing, Jianhua Hu, Lili Gu, Feiyan Pan, Zhigang Hu, Lingfeng He, Muya Zhou, Jiannan Chen, Zhigang Guo

    Published 2025-01-01
    “…ResultsSAP UCAR-T cells demonstrated significantly reduced immune rejection from the innate immune system, as evidenced by enhanced survival and functionality both in vitro and in vivo. …”
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  6. 55866

    Biological activities of Usnea lethariiformis lichen extracts and UHPLC-ESI-QTOF-MS analysis of their secondary metabolites by Mauricio Piñeiro, Mauricio Piñeiro, Sofía Manrique, Jessica Gómez, Jessica Gómez, Juan Manuel Rodriguez, Patricia Barrera, Duilio Caballero, Miguel A. Sosa, Gabriel Vargas-Arana, Gabriel Vargas-Arana, Alejandro Tapia, Beatriz Lima, Beatriz Lima, Mario J. Simirgiotis

    Published 2025-01-01
    “…The metabolite profiling was obtained using ultra-high-resolution liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (UHPLC-ESI-QTOF-MS) system. The trypanocidal and nematicidal activities were determined according to standardized protocols. …”
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  7. 55867

    Causes of growing middle-to-upper tropospheric ozone over the northwest Pacific region by X. Ma, X. Ma, J. Huang, J. Huang, M. I. Hegglin, M. I. Hegglin, P. Jöckel, T. Zhao

    Published 2025-01-01
    “…Utilizing the European Centre for Medium-Range Weather Forecasts (ECMWF) Hamburg (ECHAM)/Modular Earth Submodel System (MESSy) Atmospheric Chemistry (EMAC) nudged simulations, it is demonstrated that trends between model and ozonesonde measurements are overall consistent, thereby gaining confidence in the model's ability to simulate O<span class="inline-formula"><sub>3</sub></span> trends and confirming the utility of potentially imperfect observational data. …”
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  8. 55868
  9. 55869

    Characterization of Shigella flexneri serotype 6 strains from geographically diverse low- and middle-income countries by Caitlin E. Gabor, Charlotte E. Chong, Jose M. Lemme-Dumit, Tracy H. Hazen, Kate S. Baker, Karen L. Kotloff, Irene N. Kasumba, Sharon M. Tennant, Henry Badji, M. Jahangir Hossain, Richard Omore, Benjamin Ochieng, Alex O. Awuor, Billy Ogwel, Jane Juma, Eileen M. Barry, David A. Rasko

    Published 2025-01-01
    “…We identified Sf6 specific factors, including a potential novel Shigella virulence factor (type II secretion system). Additionally, we identified established Shigella virulence genes (ospG) and metabolic genes (rutABCDEFGR) that were absent in Sf6 strains while present in the majority of 728 non-Sf6 strains. …”
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  10. 55870

    Comparative and synergistic impacts of lime and biochar on soil properties, nitrogen transformation, and microbial function in acidic soils under tobacco cropping by Bianhong Zhang, Lina Tang, Zhicheng Chen, Xiaoyan Chen, Lindong You, Ruixin Pan, Ting Chen, Yifei Liu, Wenxiong Lin, Wenxiong Lin, Jinwen Huang

    Published 2025-02-01
    “…This study offers valuable insights into the synergistic use of lime and biochar for mitigating soil acidification and optimizing nitrogen management in agricultural systems.…”
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  11. 55871

    Network Meta-Analysis of Factors Influencing the Carbon Sink Capacity of Urban Park Green Spaces by Yutong JI, Tianyi LIN, Lian LIU, Xiong LI

    Published 2025-01-01
    “…Future research should expand the assessment system for the composite factors influencing the carbon sink capacity of urban park green space, so as to fill the data gaps in the research on carbon sinks of parks under special ecological environments, and further enrich the data used.…”
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  12. 55872
  13. 55873

    Protecting the Autonomy of Patients with Severe Mental Illness Through Psychiatric Advance Directive Peer-Facilitation by Nicholas Karasik

    Published 2023-08-01
    “…Capability theory can guide state leaders and directors in justifying the distribution of scarce resources to achieve these outcomes. I.     System-Level Barriers to Psychiatric Advanced Directive Uptake At least three barriers to PAD uptake exist at the system level. …”
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  14. 55874

    Designing a security-oriented leadership model of Mazandaran University of Medical Sciences by Saeid Miladigorji, Mohammad Hassan Shakki, Mojtaba Rezaei Rad

    Published 2024-11-01
    “…Considering that universities of medical sciences play an essential role in promoting the health of the society, it is recommended that in order to evaluate the sustainability in the university, careful planning should be done by the managers and practitioners of the higher health education system. In this context, the transformation and innovation package in medical science education has been implemented by the Ministry of Health, Treatment and Medical Education, one of the packages discusses the movement towards leadership systems and the role of management in influencing employees, which oversees three general policies of institutionalization of the management approach in the health system, being present in regional and global educational arenas, and producing and localizing valid scientific evidence for the promotion of higher health education (Obeydi et al, 2023). …”
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  15. 55875

    The effect of intellectual capital and strategic leadership on organizational citizenship behavior with the moderating role of employees' professional ethics by seyed reza mousavifard

    Published 2024-05-01
    “…Oregon et al (1988) used the term organizational citizenship behavior for the first time and defined it as follows: conscious and insightful individual behavior that is not directly and explicitly recognized by the formal reward system and generally improves the organization's functions. …”
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  16. 55876

    The pediatric cardiac anesthesia handbook / by Nasr, Viviane G

    Published 2024
    Table of Contents: “…Cardiovascular Development -- Important Concepts in Congenital Heart Disease -- Preoperative Evaluation -- Intraoperative Management -- Developmental Hemostasis and Patient Blood Management -- Interpretation of Cardiac Catheterization Data -- Management of Cardiopulmonary Bypass -- Echocardiography -- Risk Scoring Systems in Patients with Congenital Heart Disease -- Mechanical Circulatory Support (MCS) -- Post-Operative CICU Care -- Patent Ductus Arteriosus -- Aortopulmonary Window -- Coarctation of the Aorta -- Atrial Septal Defect -- Ventricular Septal Defect -- Atrioventricular Canal Defects -- Double Outlet Right Ventricle -- Truncus Arteriosus -- Total Anomalous Pulmonary Venous Return -- Left Ventricular Outflow Tract Obstruction -- Mitral Valve -- Pulmonary Atresia/Intact Ventricular Septum (PA/IVS) -- Tetralogy of Fallot (TOF) -- Tetralogy of Fallot with Pulmonary Atresia (TOF/PA) -- Tetralogy of Fallot with Absent Pulmonary Valve (TOF/APV) -- Transposition of the Great Arteries (TGA) -- Single-Ventricle Lesions -- Hypoplastic Left Heart Syndrome -- Interrupted Aortic Arch -- Vascular Rings -- Tricuspid Atresia -- Heart Transplantation -- Heart-Lung and Lung Transplantation -- Anomalous Origin of the Left Coronary Artery from the Pulmonary Artery (ALCAPA) and&nbsp; Anomalous Aortic Origin of a Coronary Artery (AAOCA) -- Heterotaxy -- Ebstein Anomaly.…”
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  17. 55877

    Repairbads: An automatic and adaptive method to repair bad channels and segments for OPM-MEG by Fulong Wang, Yujie Ma, Tianyu Gao, Yue Tao, Ruonan Wang, Ruochen Zhao, Fuzhi Cao, Yang Gao, Xiaolin Ning

    Published 2025-02-01
    “…The optically pumped magnetometer (OPM) based magnetoencephalography (MEG) system offers advantages such as flexible layout and wearability. …”
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  18. 55878

    LRP11 promotes stem-like T cells via MAPK13-mediated TCF1 phosphorylation, enhancing anti-PD1 immunotherapy by Zhishui Chen, Gang Chen, Li Chen, Xiangli Zhao, Lingjuan Sun, Zhibo Ma, Xiaosheng Tan, Yuhao Tu, Jingzeng Wang, Peixiang Lan

    Published 2024-01-01
    “…Using a cell-based chimeric receptor screening system, we showed that LRP11 interacted with LDL and activated TCF1. …”
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  19. 55879

    Hypertension Subtypes among Thai Hypertensives: An Analysis of Telehealth-Assisted Instrument in Home Blood Pressure Monitoring Nationwide Pilot Project by Sakolwat Montrivade, Pairoj Chattranukulchai, Sarawut Siwamogsatham, Yongkasem Vorasettakarnkij, Witthawat Naeowong, Patchaya Boonchayaanant, Anut Sakulsupsiri, Aekarach Ariyachaipanich, Vorarit Lertsuwunseri, Voravut Rungpradubvong, Sudarat Satitthummanid, Sarinya Puwanant, Somchai Prechawat, Suphot Srimahachota, Jarkarpun Chaipromprasit, Wacin Buddhari, Smonporn Boonyaratavej, Surapun Sitthisook, Peera Buranakitjaroen, Apichard Sukonthasarn, Somkiat Sangwatanaroj

    Published 2020-01-01
    “…The HBP, CBP, and baseline demographic data were recorded on the web-based system. HT subtypes were classified according to the treatment status, CBP (≥or <140/90 mmHg), and mean HBP (≥or <135/85 mmHg) into the following eight subtypes: in nonmedicated hypertensives, there are four subtypes that are normotension, white-coat HT, masked HT, and sustained HT; in treated hypertensives, there are four subtypes that are well-controlled HT, HT with white-coat effect, masked uncontrolled HT, and sustained HT. …”
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  20. 55880

    High-quality targeted temperature management combined with decompressive craniectomy in patients with poor-grade aneurysmal subarachnoid hemorrhage: a secondary analysis of a multi... by Yang Liu, Bingsha Han, Yanru Li, Zhiqiang Ren, Yong Chen, Ming Zhang, Jiao Li, Jv Wang, Fan Yang, Mengyuan Xu, Jiaqi Zhang, Pengzhao Zhang, Tiancai Wang, Jinying Tian, Guang Feng

    Published 2025-01-01
    “…The TTM-DC group used automated devices with a temperature feedback system (TFS). TTM was initiated with core temperatures between 36°C-37°C immediately after diagnosing poor-grade aSAH, and concurrent emergency aneurysm repair. …”
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