Dual Clinical Practice (DCP) policy to improve the retention of human resources for health in Rwanda: a mid-term review using a cross-sectional and retrospective study design by Kizito Kayumba, Corneille Ntihabose, Sabine Musange Furere, Bernard Ngabo, Piero Irakiza, Felix K. Rubuga, Nathalie Umutoni, Ina Rukundo Kalisa, Pascal Birindabagabo, Emile Rwamasirabo, Emmanuel Kayibanda, Patience Mukundirukuri, Gashaija Absolomon, Sumana Dhanani, Jeanine Condo

“…Quantitative and qualitative data were collected through key informant interviews (KIIs) and joint interviews (JIs), as well as through the analysis of health facility records obtained from the Health Management Information System (HMIS) and the Electronic Medical Record (EMR). …”
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Use of real-world data to study health services utilisation and comorbidities in long-term breast cancer survivors (the SURBCAN study): study protocol for a longitudinal population... by Xavier Castells, Beatriz Poblador-Plou, Alexandra Prados-Torres, Maria Sala, Javier Gorricho, Anna Jansana, Isabel Del Cura, Teresa Sanz Cuesta, A Gimeno Miguel, Manuela Lanzuela, Berta Ibañez, Ibai Tamayo, Conchi Moreno-Iribas, María Padilla-Ruiz, Maximino Redondo, Mercè Comas, Laia Domingo, Antonio Díaz-Holgado, Francisco Javier Salamanca, Mercè Abizanda, Talita Duarte, Javier Louro, María del Carmen Martínez, Cristóbal Molina, Guillermo Pérez, Ana María Muñoz, Óscar Toldos, Javier Baquedano, Rossana Burgui

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Preservation of cellular structure via immersion fixation in brain banking by Macy Garrood, Emma L. Thorn, Adam Goldstein, Allison Sowa, William Janssen, Alyssa Wilson, Claudia S. López, Raakhee Shankar, Erin S. Stempinski, Kurt Farrell, John F. Crary, Andrew T. McKenzie

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The authority of the printed word in the Lithuanian village of the XIX century by Džiuljeta Maskoliūnienė

“…The increase in the standing of the book and reading is directly linked with the rise of the school system. Partially, Lithuania reflects general European consistent patterns: "the majority of European regions, assuredly, so to say, and finally, became alphabeticized only in the 19th century, when primary schools were established wide," the "History of European Mentality" admits. …”
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Convolutional neural networks for sea surface data assimilation in operational ocean models: test case in the Gulf of Mexico by O. Zavala-Romero, O. Zavala-Romero, A. Bozec, E. P. Chassignet, J. R. Miranda, J. R. Miranda

“…The CNNs are trained to correct model errors from a 2-year, high-resolution (<span class="inline-formula"><math xmlns="http://www.w3.org/1998/Math/MathML" id="M1" display="inline" overflow="scroll" dspmath="mathml"><mrow><mn mathvariant="normal">1</mn><mo>/</mo><mn mathvariant="normal">25</mn><mi mathvariant="italic">°</mi></mrow></math><span><svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="31pt" height="14pt" class="svg-formula" dspmath="mathimg" md5hash="0fa693bbf5c78df25ed18818c53372c4"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="os-21-113-2025-ie00001.svg" width="31pt" height="14pt" src="os-21-113-2025-ie00001.png"/></svg:svg></span></span>) HYCOM dataset, assimilated using the Tendral Statistical Interpolation System (T-SIS). The CNNs are trained to replicate the increments generated by the T-SIS data assimilation package, aiming to correct model forecasts of sea surface temperature (SST) and sea surface height (SSH). …”
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Phthalates esters disrupt demersal fish behavior: Unveiling the brain-gut axis impact by Liuqingqing Liu, Xinyao Li, Xianxiang Luo, Xiao Wang, Linjia Liu, Zixi Yuan, Cuizhu Sun, Hao Zheng, Elvis Genbo Xu, Fengmin Li

“…This accumulation led to oxidative damage, inflammatory responses, and neurodegenerative changes in the optic tectum, resulting in cholinergic system dysfunction. In the gut, PAEs caused inflammatory lesions, disrupted the gut barrier, and altered the gut microbiome, exacerbating the neurotoxicity via “brain-gut” communication. …”
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Genomic changes during the evolution of the Coxiella genus along the parasitism-mutualism continuum by Santos-Garcia, Diego, Morel, Olivier, Henri, Hélène, El Filali, Adil, Buysse, Marie, Noël, Valérie, McCoy, Karen D., Gottlieb, Yuval, Klasson, Lisa, Zenner, Lionel, Duron, Olivier, Vavre, Fabrice

“…Indeed, the virulence factor Dot/Icm T4 Secretion System is present in most, but not all, Coxiellaceae. …”
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Manifestaciones neurológicas asociadas a la vacuna contra COVID-19 by R. Alonso Castillo, J.C. Martínez Castrillo

“…The most frequently reported adverse events were Bell's palsy 4936/13809 (35.7%), headache (4067/13809), cerebrovascular events 2412/13809 (17.47%), Guillain-Barré syndrome 868/13809 (6.28%), central nervous system demyelination 258/13809 (1.86%) and functional neurological disorder 398/13809 (2.88%). …”
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Analisis Dukungan Petugas Kesehatan Dalam Optimalisasi Competence Baby Care Pada Ibu muda Melalui Pendekatan Maternal Sensitivity Models Berbasis Keluarga (Analysis of Health Of... by diyan indriyani

“…ABSTRACT Introduction: Infants are extremely vulnerable group to various pain conditions because their immunity system is still low. The lack of proper baby care can cause the infants to be risky to illness. …”
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Tackling antimicrobial resistance in Bangladesh: A scoping review of policy and practice in human, animal and environment sectors. by Roksana Hoque, Syed Masud Ahmed, Nahitun Naher, Mohammad Aminul Islam, Emily K Rousham, Bushra Zarin Islam, Shaikh Hassan

“…AMR is aggravated by irrational use of antimicrobials in a largely unregulated pluralistic health system. This review presents a 'snap shot' of the current situation including existing policies and practices to address AMR, and the challenges and barriers associated with their implementation.…”
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Exploring the mechanisms of Devonian oceanic anoxia: impact of ocean dynamics, palaeogeography, and orbital forcing by J. Gérard, L. Sablon, J. J. C. Huygh, A.-C. Da Silva, A. Pohl, C. Vérard, M. Crucifix

“…Here, we perform multiple sensitivity experiments, using an Earth system model of intermediate complexity (cGENIE), to isolate the influences of specific Devonian climate and palaeogeography components on ocean oxygen levels, contributing to the better understanding of the intricate interplay of factors preconditioning the ocean to anoxia. …”
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Upregulation of Cardiac IL-10 and Downregulation of IFN-γ in Balb/c IL-4−/− in Acute Chagasic Myocarditis due to Colombian Strain of Trypanosoma cruzi by Marcos Vinicius da Silva, Vera Lúcia de Almeida, Wendyson Duarte de Oliveira, Natália Carasek Matos Cascudo, Pollyana Guimarães de Oliveira, Crislaine Aparecida da Silva, Aline Cristina Souza da Silva, Maria Luíza Gonçalves dos Reis Monteiro, Rosana Rosa Miranda Correa, Milton Adriano Pelli Oliveira, Ruy de Sousa Lino-Júnior, Mara Rúbia Nunes Celes, Juliana Reis Machado

“…It also decreased TNF-α systemic production and increased IL-10, both systemically and in situ. …”
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A Metapopulation Model to Assess Water Management Impacts on the Threatened Australian Lungfish, <i>Neoceratodus forsteri</i> by Charles R. Todd, Andrew J. McDougall, Scott M. C. Raymond, Robin Hale, Timothy R. Brown, John D. Koehn, Henry F. Wootton, Steven G. Brooks, Adrian M. Kitchingman, Tom Espinoza, Benjamin G. Fanson, Peter K. Kind, Sharon M. Marshall, David T. Roberts

“…Our modeling approach substantially advances conservation management of this species, as it can be adapted to suit other populations in other river systems and used to test sensitivity to recovery actions.…”
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Gain-of-function ANXA11 mutation cause late-onset ALS with aberrant protein aggregation, neuroinflammation and autophagy impairment by Qing Liu, Ye Sun, Baodong He, Haodong Chen, Lijing Wang, Gaojie Wang, Kang Zhang, Ximeng Zhao, Xinzhe Zhang, Dongchao Shen, Xue Zhang, Liying Cui

“…This study examines the clinical features of ALS patients harboring the ANXA11 hotspot mutation p.P36R, characterized by late-onset motor neuron disease and occasional multi-system involvement. To elucidate the pathogenesis, we developed a knock-in mouse model carrying the p.P36R mutation. …”
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Analisis Kualitas Website Balai Besar Taman Nasional Gunung Gede Pangranggo (BBTNGGP) menggunakan Metode Webqual 4.0 by Muhammad Syahid Qadhafi, Atit Pertiwi

“…Dengan harapan mengetahui tingkat kualitas layanan website Balai Besar Taman Nasional Gunung Gede Pangranggo dari persepsi pengguna akhir dengan menganalisis system yang sesuai harapan para penggunanya.   Abstract In this century the use of information technology has become a crucial need for each individual, organization, education, business to government. …”
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Seroconversion and dynamics of IgG anti-SARS-CoV-2 antibodies during the pandemic: A two-month observation cohort study on the population of Sleman in Indonesia. by Jajah Fachiroh, Septi Kurnia Lestari, Dewi Kartikawati Paramita, Bagas Suryo Bintoro, Fatwa Sari Tetra Dewi, Lutfan Lazuardi, Cici Permata Rusadi, Erti Nur Sagenah, Eggi Arguni

“…<h4>Methods</h4>We performed a longitudinal study of the population at Health and Demographic Surveillance System (HDSS) Sleman, Yogyakarta, Indonesia. Study subjects were recruited between April and December 2021 using convenience sampling and were followed up 2 times, i.e. 4-5 and 8-9 weeks. …”
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Effectiveness of a technical support program with women’s self-help groups in catalyzing health and nutrition behaviors in Bihar—a multicomponent analysis by Sudipta Mondal, Indu Bisht, Santosh Akhauri, Indrajit Chaudhuri, Narottam Pradhan, Sweta Kumari, Shuchi Sree Akhouri, Rakesh Kumar Jha, Manoj Kumar Singh, Suman Das, Apollo Purty, Arko Mukherjee, Tanmay Mahapatra

“…JTSP showcases collaboration within a government system and emphasizes systematic introduction and strengthening at multiple levels. …”
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A comprehensive, population level evaluation of previously reported drug triggers of pemphigus highlights immunomodulatory capacity as a common characteristic by Justin Baroukhian, Kristina Seiffert-Sinha, Animesh A. Sinha

“…FindingsIn this series of observational, retrospective, case-control, pharmacovigilance analyses of the FDA Adverse Event Reporting System, the odds of reporting the adverse event pemphigus were significantly elevated among individuals exposed to 11/36 previously reported trigger drugs namely, gold sodium thiomalate, penicillamine, piroxicam, rifampin, hydroxychloroquine, imiquimod, hydrochlorothiazide, irbesartan, lisinopril, nivolumab, and nifedipine.MeaningEnvironmental exposures such as drugs are relevant players in the pathogenesis of autoimmune diseases and clinicians who treat patients with autoimmune blistering diseases such as pemphigus should consider performing a detailed medication history leveraging this information regarding deleterious drug-disease interactions at initial evaluation as well as longitudinal monitoring of patients to better inform clinical care decisions.ImportancePemphigus vulgaris (PV) is a rare, potentially fatal autoimmune disease with pathogenic contributions from both genetic as well as environmental factors, notably drug exposures. …”
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Role of PI3K/AKT/mTOR signaling pathway and sirtuin genes in chronic obstructive pulmonary disease development by G. F. Korytina, L. Z. Akhmadishina, V. A. Markelov, Y. G. Aznabaeva, O. V. Kochetova, T. R. Nasibullin, A. P. Larkina, N. N. Khusnutdinova, N. Sh. Zagidullin, T. V. Victorova

“…Chronic obstructive pulmonary disease (COPD) is a multifactorial disease of the respiratory system which develops as a result of a complex interaction of genetic and environmental factors closely related to lifestyle. …”
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High-accuracy crRNA array assembly strategy for multiplex CRISPR by Xiangtong Zhao, Lixian Yang, Peng Li, Zijing Cheng, Yongshi Jia, Limin Luo, Aihong Bi, Hanchu Xiong, Haibo Zhang, Hongen Xu, Jinrui Zhang, Yaodong Zhang

“…Simultaneous targeting of multiple loci with the CRISPR system, a tool known as multiplex CRISPR, offers greater feasibility for manipulating and elucidating the intricate and redundant endogenous networks underlying complex cellular functions. …”
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