Metformin exerted tumoricidal effects on colon cancer tumoroids via the regulation of autophagy pathway by Roya Shabkhizan, Çığır Biray Avci, Sanya Haiaty, Marziyeh Sadat Moslehian, Fatemeh Sadeghsoltani, Ahad Bazmani, Mahdi Mahdipour, Leila Sabour Takanlou, Maryam Sabour Takanlou, Arezoo Rezaie Nezhad Zamani, Reza Rahbarghazi

“…Abstract Background Despite the existence of promising outcomes from standard 2D culture systems, these data are not completely akin to in vivo tumor parenchyma. …”
Get full text

Black Boarding Academies as a Prudential Reparation by Roy Brooks

“…The goal of such transitional reparations is to extinguish the menace of white supremacy and systemic racism across the board.  Restructuring in housing, education, employment, voting, law enforcement, health care, and the environment—social transformation—is absolutely needed in the United States if the race problem is ever to be resolved. …”
Get full text

“Salud Mamaria”, an internet-based psychoeducational program during the breast cancer diagnosis process: Protocol for a randomized controlled trial by Reyna Jazmín Martínez-Arriaga, Alejandro Dominguez-Rodriguez, Sergio Osvaldo Meza-Chavolla, Yineth Alejandra Muñoz-Anacona, Adrián Antonio Cisneros-Hernández, Joel Omar González-Cantero, Leivy Patricia González-Ramírez, Paulina Erika Herdoiza-Arroyo, Norma Alicia Ruvalcaba-Romero, Fabiola Macías-Espinoza, Said Jiménez

“…Anxiety symptoms, negative screening of consequences, sense of coherence, satisfaction with the intervention, and system usability will be measured. Patients will be assigned to an intervention based on their clinical situation: without cancer suspicion (A), with cancer suspicion (B), or diagnosed with cancer (C). …”
Get full text

Leveraging RRT^*: Probabilistically Interpreted Mechanisms Enhanced With P-HOPE and FLEX-OPT for Complex Path Planning by Yujie Miao, Haiyang Liu, Ziqiang Zhang, Yanju Liang

Get full text

Qualitative and quantitative characteristics of black patch trait in Oujiang color common carp by Ke Jing, Huifan Chen, Nusrat Hasan Kanika, Penghui Zhang, Roland Nathan Mandal, Chunxiao Zeng, Zhiyi Zhang, Jun Wang, Chenghui Wang

“…Gene editing on Ednrb by using the CRISPR/Cas9 system showed that the mutants displayed a significantly reduced number of black patches in comparison to the wild-type RB, accompanied by noticeably smaller melanocytes. …”
Get full text

On the issue of creating an algorithm for assessing safety culture in modern healthcare institutions by O.P. Yavorovsky, I.V. Serheta, R.P. Brukhno, Yu.M. Skaletskyi, V.D. Chopchyk, D.V. Varyvonchyk, V.I. Zenkina

“…Healthcare iшnstitutions with a high culture of patient safety are characterized by the appropriate level of mutual trust of employees, a general understanding of the importance of patient safety issues, the presence of an effective system of preventive measures to ensure the safety of both medical personnel and the patient, which has been implemented. …”
Get full text

Evaluating the Acceptance and Usability of an Independent, Noncommercial Search Engine for Medical Information: Cross-Sectional Questionnaire Study and User Behavior Tracking Analy... by Lisa Specht, Raphael Scheible, Martin Boeker, Erik Farin-Glattacker, Nikolas Kampel, Marina Schmölz, Andrea Schöpf-Lazzarino, Stefan Schulz, Christian Schlett, Fabian Thomczyk, Sebastian Voigt-Radloff, Constanze Wegner, Katharina Wollmann, Andy Maun

“…ConclusionsUser questionnaires and behavior tracking showed the platform was well received, particularly by older and less educated users, especially for its advertisement-free design and filtering system. While feedback highlighted areas for improvement in design and filter functionality, the search engine’s focus on transparency, evidence-based content, and user privacy shows promise in addressing health literacy and navigational needs. …”
Get full text

Restorative Neurostimulation Therapy Compared to Optimal Medical Management: A Randomized Evaluation (RESTORE) for the Treatment of Chronic Mechanical Low Back Pain due to Multifid... by Frank Schwab, Nagy Mekhail, Kiran V. Patel, Meredith Langhorst, Robert D. Heros, Jonathan Gentile, Sherif Costandi, Gregory Moore, Christopher Gilmore, Smith Manion, Krishnan Chakravarthy, S. Craig Meyer, Justin V. Bundy, Jordan L. Tate, Rebecca Sanders, Sandeep Vaid, Oszkar Szentirmai, Johnathan Goree, Vikas V. Patel, Jeff Lehmen, Mehul J. Desai, Jason E. Pope, Anthony Giuffrida, Salim Hayek, Sohrab Singh Virk, Richard Paicius, William R. Klemme, Robert Levy, Christopher Gilligan, the RESTORE investigators

“…Participants were randomized to either restorative neurostimulation with the ReActiv8 system or OMM. The primary endpoint was a comparison of the mean change in the Oswestry Disability Index (ODI) between the treatment and control arms at 1 year, and secondary endpoints included pain (numeric rating scale [NRS]) and health-related quality of life (EuroQol Five-Dimension [EQ-5D-5L]). …”
Get full text

Exploring the role of district clinical specialist teams in maternal health outcomes in a South African district: A mixed method study from 2012 to 2020 by J Basu, A Stewart, D Basu, J Wing, U Feucht

“…Interviews were conducted by the interviewer using a data collection tool focused on the scope of work and acceptance of the DCST in improving maternal health services in a geographically defined district health system. Data collection tools were completed by the interviewer upon questioning the participants. …”
Get full text

Eye Collateral Channel Characteristic Analysis and Identification Model Construction of Mild Cognitive Impairment by WU Tiecheng, CAO Lei, YIN Lianhua, HE Youze, LIU Zhizhen, YANG Minguang, XU Ying, WU Jinsong

“…Using the general demographic data sheet, neuro-psychological test scale, syndrome identification system of TCM and Boao visual diagnosis instrument, basic information, cognitive test results, and information on eye collateral channel characteristics and TCM symptom elements of the subjects were collected. …”
Get full text

Exploring the Relationship Between Sleep Apnea, Myocardial Infarct Size, and Coronary Collaterals in Acute Myocardial Infarction: A Multidisciplinary Study by Kundel V, Devarakonda K, Khan S, Suarez-Farinas M, Cohen O, Santos-Gallego C, Menegus MA, Kini A, Vengrenyuk Y, Okamoto N, Ueda H, Gidwani U, Kizer JR, Redline S, Kaplan R, Shah N

“…Vaishnavi Kundel,1 Kavya Devarakonda,1 Samira Khan,1 Mayte Suarez-Farinas,1 Oren Cohen,1 Carlos Santos-Gallego,1 Mark A Menegus,2 Annapoorna Kini,1 Yuliya Vengrenyuk,1 Naotaka Okamoto,1 Hiroshi Ueda,1 Umesh Gidwani,1 Jorge R Kizer,3 Susan Redline,4 Robert Kaplan,2,5 Neomi Shah1 1Icahn School of Medicine at Mount Sinai, New York, NY, USA; 2Albert Einstein College of Medicine, Bronx, NY, USA; 3Cardiology Section, San Francisco Veterans Affairs Health Care System and Departments of Medicine, Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA; 4Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; 5Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USACorrespondence: Vaishnavi Kundel, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, Box 1232, New York, NY, 10029, USA, Tel +1-212-241-1967, Email Vaishnavi.kundel@mssm.eduPurpose: We designed a study investigating the cardioprotective role of sleep apnea (SA) in patients with acute myocardial infarction (AMI), focusing on its association with infarct size and coronary collateral circulation.Methods: We recruited adults with AMI, who underwent Level-III SA testing during hospitalization. …”
Get full text

Adoption and implementation of extended producer responsibility for sustainable management of end-of-life solar photovoltaic panels by S.E. Kabir, M.N.I. Mondal, M.K. Islam, I.A. Alnaser, M.R. Karim, M.A. Ibrahim, K. Sopian, M. Akhtaruzzaman

“…Nonetheless, successful implementation required addressing specific domestic concerns, such as the absence of a pre-existing waste take-back system and weak institutional capacity. Regulators should also proactively take measures to leverage enabling factors, including gaining users' acceptance, reducing costs, and potentially tapping into secondary material markets. …”
Get full text

Designing a Model for Implementing Digital Banking Policy Based on Using Big Data in Iranian Banking Industry by Rahmatollah Gholipour Souteh, Hamed Esmaeili Rad

“…Results The resulting model identifies 15 main themes, including Big Data Management, Data Governance (encompassing Data Collection, Data Refinement, Data Design and Modeling, Data Security), Data Regulation, Various Sources of Data Acquisition, Trust in Big Data Analysis, the Banking System Ecosystem, Organizational Agility, Big Data Analysis Tools, Scenario Development (practical application of data), Executive Structure, Improvement of Banks' Business, Customer Orientation, Transparency, Technological Infrastructure, and Dominant Culture. …”
Get full text

European standard clinical practice recommendations for paediatric high-grade gliomas by Elwira Szychot, Géraldine Giraud, Darren Hargrave, Dannis van Vuurden, Jacques Grill, Veronica Biassoni, Maura Massimo, André O. Von Büren, Rejin Kebudi, Maria João Gil-da-Costa, Sophie Veldhuijzen van Zanten, Simon Bailey, Michael Karremann, Stephanie Bolle, Thankamma Ajithkumar, Mechthild Krause, Yasmin Lassen-Ramshad, Geert Janssens, Giovanni Morana, Ulrike Löbel, Shivaram Avula, Brigitte Bison, Maarten Lequin, Kristian Aquilina, Ulrich Thomale, Pelle Nilsson, Sami Bui-Quy Abu Hamdeh, Torsten Pietsch, Pascale Varlet, Thomas S. Jacques, Pieter Wesseling, David Jones, Uri Tabori, Anirban Das, David Mulligan, Francesca Kozmann, Christof M. Kramm

“…Paediatric high-grade gliomas (pedHGGs) are highly invasive brain tumours accounting for approximately 15 % of all central nervous system (CNS) tumours in children and adolescents. …”
Get full text

Perencanaan Coverage Jaringan 5G Berdasarkan Propagasi Rugi Rugi Lintasan dan Shadowing by Made Niama Dwi Susila, Linawati Linawati, Nyoman Gunantara

“…So that in this study, a 5G network planning was carried out using a 5G system with a frequency of 869 MHz in Denpasar City using a rooftop tower. …”
Get full text

Overexpression of Tear Inflammatory Cytokines as Additional Finding in Keratoconus Patients and Their First Degree Family Members by Ioana Catalina Ionescu, Catalina Gabriela Corbu, Cristiana Tanase, Gabriela Ionita, Cristina Nicula, Valeria Coviltir, Vasile Potop, Mihaela Constantin, Elena Codrici, Simona Mihai, Ionela Daniela Popescu, Ana-Maria Enciu, Dana Dascalescu, Miruna Burcel, Radu Ciuluvica, Liliana-Mary Voinea

“…The diagnosis of keratoconus had to be confirmed in addition to a minimum of 47 D corneal refractive power by corneal topography readings provided by a Placido-based topography system and analysis of the pattern: irregular astigmatism with an asymmetric “bow-tie.” …”
Get full text

Effect of Exercise Preconditioning on Autophagy and Apoptosis of Cardiomyocytes in Aged Rats with Myocardial Ischemia Reperfusion Injury by LI Hongyu, YIN Xia, WANG Yanxia, Li Yuting, ZHU Luwen, TANG Qiang

“…The isolated rat myocardial ischemia/reperfusion model was established using the Langendorff in vitro perfusion system. Cardiomyocyte autophagosomes were observed by transmission electron microscope (TEM); cardiomyocyte apoptosis was detected by TUNEL staining; Beclin-1, LC3-Ⅱ, Bax, Caspase-9, Bcl-2, Bcl-XL protein expression levels were detected by Western blot method.Results① TEM observation results: a small amount of autolysosomes were observed in the Con group; more autolysosomes and autophagy vesicles were observed in the IR group; a small amount of autolysosomes were observed in the EP+IPC group; a small number of autophagic vesicles were observed in the EP+IPC+saline group; there wasn't typical autophagic vesicles and lysosomes were observed in the EP+IPC+3-MA group. ② TUNEL positive cell ratio results: only a few TUNEL positive cells were found in the Con group. …”
Get full text

Healthy at home for COPD: an integrated digital monitoring, treatment, and pulmonary rehabilitation intervention by Laurel O’Connor, Stephanie Behar, Seanan Tarrant, Pamela Stamegna, Caitlin Pretz, Biqi Wang, Brandon Savage, Thomas Scornavacca, Jeanne Shirshac, Tracey Wilkie, Michael Hyder, Adrian Zai, Shaun Toomey, Marie Mullen, Kimberly Fisher, Emil Tigas, Steven Wong, David D. McManus, Eric Alper, Peter K. Lindenauer, Eric Dickson, John P. Broach, Vik Kheterpal, Apurv Soni

Get full text

Tuberculosis disease burden in China: a spatio-temporal clustering and prediction study by Jingzhe Guo, Ce Liu, Fang Liu, Erkai Zhou, Runxue Ma, Ling Zhang, Bin Luo

“…This research seeks to contribute significantly to China’s existing tuberculosis prevention and control system.Materials and methodsThis research draws upon publicly available pulmonary tuberculosis (PTB) incidence and mortality statistics from 31 provinces and municipalities of mainland China between 2004 and 2018. …”
Get full text

Therapeutic potential of the neutralizing monoclonal antibody 45G3 against encephalomyocarditis virus by Yanfang Zhang, Zhiying Wang, Yaohui Fang, Qiong Zhu, Jie Fu, Sijing Hu, Jiayin Jin, Min Zhou, Xijia Liu, Danna Zhang, Shouwei Huang, Yali Deng, Lingling Xie, Shu Shen, Jing Ye, Fei Deng, Shengbo Cao

“…Using recombinant DNA technology, we engineered a baculovirus system to express EMCVs P12A and 3C, facilitating the production of VLPs in Sf9 cells. …”
Get full text