Novel Procedures for Evaluating Autism Online in a Culturally Diverse Population of Children: Protocol for a Mixed Methods Pathway Development Study by Venus Mirzaei, Jeanne Wolstencroft, Georgia Lockwood Estrin, Eleanor Buckley, Shermina Sayani, Panos Katakis, Reena Anand, Tessa Squire, Eleanor Short, Paige Frankson, David Skuse, Michelle Heys

“…Quantitative usability assessment will be gathered from all families using the System Usability Scale (where a mean above 68 indicates above-average usability). …”
Get full text

Is training policy for general practitioners in China charting the right path forward? a mixed methods analysis by Li Luo, Chen Chen, Wenya Yu, Qian Liu, Chunhua Chi, Yan Yang, Rui Liu, Jianwei Shi, Dehua Yu, Hua Jin, Zhaoxin Wang, Qingfeng Du, Xin Gong, Jiaoling Huang, Ning Chen

“…Objectives Since 2010, the Chinese government has gradually increased its investment in the training of general practitioners (GPs) to support their role as ‘gatekeepers’ in the healthcare system. However, this training is still organised from the perspective of specialist care. …”
Get full text

Clinical significance of Helicobacter pylori infection in iron-deficiency anemia: features of comprehensive treatment approach by I. V. Mayev, S. A. Kochetov

“…Presence of H. pylori infection and eradication control were carried out by urea breath test (Helic-test system). Efficacy of IDA treatment was evaluated by hemoglobin level, RBC color index, total iron-binding capacity (TIBC), serum ferritin and iron levels. …”
Get full text

The carbon cost of impaired welfare on sheep farms by L. Lanzoni, M.C. Reeves, K. Waxenberg, R. Ramsey, A.S. Atzori, J. Bell, R.M. Rees, G. Vignola, C.M. Dwyer

“…The present study aims to quantify the effects of impaired welfare on GHG emissions for common welfare challenges faced in UK lowland (L) and hill (H) sheep farming systems. Two case study research farms in Scotland, representative of high welfare conditions, were used as baselines for semi-intensive L and extensive H systems. …”
Get full text

Prospective analysis of the effects of RAS mutation on local tumor progression and overall survival after radiofrequency ablation for colorectal liver metastases by Ji-Chen Wang, Yu-Hui Liu, Bin-Bin Jiang, Li-Jin Shao, Song Wang, Wei Yang, Wei Wu, Kun Yan, Zhong-Yi Zhang

“…RAS mutation status was analyzed via the amplification refractory mutation system PCR method. The safety margin was measured via an anatomic landmark-based manual assessment method. …”
Get full text

Characterization of the colostrum proteome of primiparous Holstein cows and its association with colostrum immunoglobulin G concentrations by Ezequias Castillo-Lopez, Patrick Biber, Arife Sener-Aydemir, Karin Hummel, Ebrahim Razzazi-Fazeli, Nicole Reisinger, Qendrim Zebeli, Susanne Kreuzer-Redmer, Thomas Hartinger

“…Results On average, 428 proteins were identified per sample, which belonged mainly to cellular process, biological regulation, response to stimulus, metabolic process, and immune system process. Most abundant proteins were complement C3 (Q2UVX4), alpha-S1-casein (P02662), Ig-like domain-containing protein (A0A3Q1M032), albumin (A0A140T897), polymeric immunoglobulin receptor (P81265), lactotransferrrin (P24627), and IGHG1*01 (X16701_4). …”
Get full text

Botulinum toxin type A for the treatment of patients with post-stroke spasticity in Thailand: cost-utility and budget impact analysis by Phorntida Hadnorntun, Pattara Leelahavarong, Tanawan Kongmalai, Varalak Srinonprasert, Juthamas Prawjaeng, Phakamas Tanvijit, Chuenchom Chueluecha, Nawarat Jintakul, Tipyarat Saringcarinkul, Witsanu Kumthornthip

“…Integrating BoNT-A treatment delivery into the healthcare system would require a budget outlay of approximately US$413 246–US$966 103 that may vary annually by an additional US$50 260–US$335 064.Conclusion BoNT-A effectively reduces focal spasticity and improves quality of life in post-stroke patients. …”
Get full text

Gastrointestinal lesions of eosinophilic granulomatosis with polyangiitis: a prediction model and clinical patterns by Suying Liu, Yunjiao Yang, Linna Han, Chengmei He, Mengtao Li, Xinping Tian, Juan Meng, Li Wang, Fengchun Zhang

“…Weight loss, central nervous system involvement, myalgia, and eosinophilic tissue infiltration were retained in the nomogram. …”
Get full text

A Study on the Inflammatory Response of the Brain in Neurosyphilis by Qiyu Zhang, Jie Ma, Jia Zhou, Hanlin Zhang, Mansheng Li, Huizi Gong, Yujie Wang, Heyi Zheng, Jun Li, Ling Leng

“…Abstract Neurosyphilis (NS) is a clinical condition caused by infection of the central nervous system (CNS) by Treponema pallidum (Tp) that can lead to asymptomatic meningitis and more serious neurological diseases, such as dementia and blindness. …”
Get full text

Ovarian development of female mud crab, Scylla serrata supplemented with cholesterol and injected with serotonin by Betsy J. Pattiasina, M. Zairin Junior, I. Mokoginta, R. Affandi, W. Manalu

“…The fiber tank was equipped with sands substrate and flow through seawater system. The experimental crabs were assigned into a completely randomized design with a 3 x 3 factorial arrangement. …”
Get full text

From structure prediction to function: defining the domain on the African swine fever virus CD2v protein required for binding to erythrocytes by Ana Luisa Reis, Anusyah Rathakrishnan, Vlad Petrovan, Muneeb Islam, Lynnette Goatley, Katy Moffat, Mai Tuyet Vuong, Yuan Lui, Simon J. Davis, Shinji Ikemizu, Linda K. Dixon

“…The interaction plays a key role in viral persistence in blood since it can allow the virus to “hide” from the host immune system. We identified the amino acids in the viral protein that mediate the interaction with erythrocytes and used this information to construct a mutant virus that is no longer able to bind these cells. …”
Get full text

Is first-line treatment with polatuzumab vedotin–rituximab–cyclophosphamide, doxorubicin and prednisone (pola-R-CHP) for previously untreated diffuse large B-cell lymphoma cost-eff... by Lin Yang, Ting Chen, Qiuling Zhao, Liangliang Dong, Wanfu Zhong, Wenbin Liu, Xiuliang Qiu, Ruyi Huang, Shengqiang Huang, Ruixiang Xie

“…The scenario analyses were also conducted.Setting Chinese healthcare system perspective.Participants A hypothetical cohort of adult patients presenting with CD20-positive, patients with previously untreated DLBCL.Interventions Pola-R-CHP versus R-CHOP.Main outcome measures The main outcomes of the study were QALYs, incremental cost-effectiveness ratio (ICER) and incremental net-health benefit (INHB).Results In China, the ICER and INHB of pola-R-CHP compared with R-CHOP were US$77 036.33/QALY and −1.11 QALYs, respectively. …”
Get full text

Ranirestat Improved Nerve Conduction Velocities, Sensory Perception, and Intraepidermal Nerve Fiber Density in Rats with Overt Diabetic Polyneuropathy by Saeko Asano, Tatsuhito Himeno, Tomohide Hayami, Mikio Motegi, Rieko Inoue, Hiromi Nakai-Shimoda, Emiri Miura-Yura, Yoshiaki Morishita, Masaki Kondo, Shin Tsunekawa, Yoshiro Kato, Koichi Kato, Keiko Naruse, Jiro Nakamura, Hideki Kamiya

“…However, few therapies address the etiology of neurodegeneration in the peripheral nervous systems of diabetic patients. Several metabolic mechanisms have been proposed as etiologies of this polyneuropathy. …”
Get full text

Online tools to predict individualised survival for primary oesophageal cancer patients with and without pathological complete response after neoadjuvant therapy followed by oesoph... by Jie Zhang, Xiang Chen, Dong Dong, Lijie Tan, Yajie Zhang, Hecheng Li, Yuqin Cao, Binhao Huang, Han Tang, Tianzheng Shen, Xijia Feng, Jiahao Zhang, Liqiang Shi, Chengqiang Li, Heng Jiao

“…The predictive models for pCR and non-pCR patients demonstrated good calibration and clinical utility, with acceptable discrimination that surpassed that of the current tumour, node, metastases staging system.Conclusions The web-based dynamic nomograms for pCR (https://predict-survival.shinyapps.io/pCR-eso/) and non-pCR patients (https://predict-survival.shinyapps.io/non-pCR-eso/) developed in this study can facilitate the calculation of OS probability for individual patients undergoing neoadjuvant therapy and radical oesophagectomy, aiding clinicians and patients in making personalised treatment decisions.…”
Get full text

Penggabungan Best Worst Method, Moora Dan Copeland Score Pada Sistem Pendukung Keputusan Kelompok Penentuan Penerima Bantuan Pada Dinas Sosial by Willy Bima Alfajri, Dinar Mutiara Kusumo Nugraheni, Bayu Surarso

“…And copeland score method has an effective advantage as a tool in the voting system. The combined methods were then evaluated in a case study involving the identification of aid recipients. …”
Get full text

Cost-savings and health impact of strategies for prevention of Respiratory Syncytial Virus with nirsevimab in Chile based on the integrated analysis of 2019–2023 national databases... by Denis Sauré, Miguel O’Ryan, Juan Pablo Torres, Natalia Trigo, Gonzalo Diaz, Marcel Goic, Charles Thraves, Jorge Pacheco, Patricio Aguilera, Andrea Caro, Leonardo J. Basso

“…This strategy would have significantly decreased the strain on the healthcare system during the seasonal surge, reducing 13,533 ICU (77·81/1000 live newborns) and 27,465 hospital bed requirements (157·91/1000 live newborns), alongside 46,886 emergency room visits (269·58/1000 live newborns). …”
Get full text

Polysaccharides of Atractylodes Macrocephala Koidz Alleviate LPS-Induced Bursa of Fabricius Injury in Goslings by Inhibiting EREG Expression by Shuying Gong, Bingqi Zhang, Xiang Sun, Weijun Liang, Longsheng Hong, Xiang Zhou, Wanyan Li, Yunbo Tian, Danning Xu, Zhongping Wu, Bingxin Li

“…The bursa of Fabricius (BF) plays crucial roles in the goslings’ immune system. During waterfowl breeding, the presence of lipopolysaccharides (LPSs) in the environment can induce inflammatory damage in geese. …”
Get full text

Diagnostic Efficacy of ¹²³Iodo-Metaiodobenzylguanidine SPECT/CT in Cardiac vs. Neurological Diseases: A Comparative Study of Arrhythmogenic Right Ventricular Cardiomyopa... by Johannes M. Hagen, Maximilian Scheifele, Mathias J. Zacherl, Sabrina Katzdobler, Alexander Bernhardt, Matthias Brendel, Johannes Levin, Günter U. Höglinger, Sebastian Clauß, Stefan Kääb, Andrei Todica, Guido Boening, Maximilian Fischer

“…<b>Background/Objectives</b>: ¹²³Iodo-metaiodobenzylguanidine single photon emission computed tomography/computed tomography (¹²³I-MIBG SPECT/CT) is used to evaluate the cardiac sympathetic nervous system in cardiac diseases such as arrhythmogenic right ventricular cardiomyopathy (ARVC) and α-synucleinopathies such as Parkinson’s diseases. …”
Get full text

Associations of Retinal Microvascular Density and Fractal Dimension with Glaucoma: A Prospective Study from UK Biobank by Qi Chen, MD, Suyu Miao, MD, Yuzhe Jiang, MD, Danli Shi, MD, PhD, Weiyun You, MD, Lin Liu, MD, PhD, Mayinuer Yusufu, MTI, Yufan Chen, MD, Ruobing Wang, MD, PhD

“…Methods: We employed the Retina-based Microvascular Health Assessment System to utilize the noninvasive nature of fundus photography and quantify retinal microvascular parameters including retinal vascular skeleton density (VSD) and fractal dimension (FD). …”
Get full text

ASSOCIATION BETWEEN LEUKEMIC EVOLUTION AND UNCOMMON CHROMOSOMAL ALTERATIONS IN PEDIATRIC MYELODYSPLASTIC SYNDROME by Viviane Lamim Lovatel, Beatriz Ferreira da Silva, Eliane Ferreira Rodrigues, Maria Luiza Rocha da Rosa Borges, Rita de Cássia Barbosa Tavares, Ana Paula Silva Bueno, Elaine Sobral da Costa, Terezinha de Jesus Marques, Teresa de Souza Fernandez

“…According to the Revised International Prognostic Scoring System, cytogenetic analysis has demonstrated an essential role in diagnosis and prognosis. …”
Get full text