A preliminary study of linear accelerator-based spatially fractionated radiotherapy by Young Kyu Lee, Yunji Seol, Byeong Jin Kim, Kyu Hye Choi, Ji Hyun Hong, Chan-beom Park, Sun Hwa Kim, Hyeong Wook Park, Wonjoong Cheon, Young Nam Kang, Byung‑Ock Choi

“…The research systematically evaluated the impact of varying vertex diameters and separations on dose distribution, peak-to-valley dose ratio (PVDR), and normal tissue dose.MethodsA cylindrical Virtual Water™ phantom was used to create LRT treatments using the Eclipse version 16.0 treatment planning system (Varian, Palo Alto, USA). The plans were optimized employing a 3 × 3 × 3 lattice structure with vertex diameters ranging from 0.5 to 2.0 cm and separations from 1.0 to 5.0 cm. …”
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Evaluation of Medical Care for Diabetic and Hypertensive Patients in Primary Care in Mexico: Observational Retrospective Study by Agustin Lara-Esqueda, Sergio A. Zaizar-Fregoso, Violeta M. Madrigal-Perez, Mario Ramirez-Flores, Daniel A. Montes-Galindo, Margarita L. Martinez-Fierro, Iram P. Rodriguez-Sanchez, José Guzman-Esquivel, Carmen Meza-Robles, Gabriel Ceja-Espiritu, Pablo A. Kuri-Morales, Josuel Delgado-Enciso, Armando Barriguete-Melendez, Hector R. Galvan-Salazar, Carlos E. Barajas-Saucedo, Elvin Guillermo-Espinosa, Agustin D. Lara-Basulto, Jesus F. Gonzalez-Roldan, Ivan Delgado-Enciso

“…The present study evaluated the quality of medical care for patients diagnosed with diabetes mellitus (DM), hypertension (HBP), and both pathologies (DM+HBP) within a public health system in Mexico. Methods. 45,498 patients were included from 2012 to 2015. …”
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Mapping outcomes for recovery of consciousness in studies from 1986 to 2020: a scoping review protocol by Monica Steiner, Elizabeth Burns, Trudy Mallinson, Joshua Rosenow, Jennifer Weaver, Alison Cogan, Parie Bhandari, Erica Jacobs, Ariana Pape, Chantal Nguyen, Ann Guernon, Tom Harrod, Theresa Bender Pape, Marilyn Pacheco, Catherine Burress Kestner, Kelsey Watters, Elizabeth Yost, Henk Eilander, Berno Overbeek, Sophie Leeds, Kelly Krese, Haylee Winden, Mary Philbin, Stefani Cleaver, Vanessa Silva, Konner Nelson, André Lindsey, Angela Hartman, Kristen Maisano, Erika Cooley, Jessica Rudin Portnoff, Bailey Widener, Sarah Hollingsworth, Coty Wardwell, Julianne Angel, Ladan Hakima, Jennifer Nebel, Bint-e Zainab Awan

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Bryostatin-1 enhances the proliferation and functionality of exhausted CD8+ T cells by upregulating MAP Kinase 11 by Ling Li, Manzhi Zhao, Marjan van Meurs, Inge Brouwers-Haspels, Renske J. H. den Dekker, Merel E. P. Wilmsen, Dwin G. B. Grashof, Harmen J. G. van de Werken, Shringar Rao, Casper Rokx, Yvonne M. Mueller, Peter D. Katsikis

“…By utilizing an established in vitro murine T cell exhaustion system, changes in inhibitory receptors, transcription factors, cytokine production and killing capacity of bryostatin-1 treated exhausted CD8+ T cells were determined by flow cytometry. …”
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Therapeutic Effect of High-Definition Transcranial Direct Current Stimulation Combined with Suspension Exercise Training on Lower Limb Motor Function of Stroke Patients by ZHANG Haiquan, HU Chuan, HUANG Lei, LU Wei, WANG Xin

“…Berg balance scale (BBS) was used to assess balance function, functional ambulation category (FAC) scale was used to assess functional walking ability. A video gait system was used to assess gait spatial-temporal parameters (stride frequency, stride speed, stride length, and walking cycle).ResultsCompared with that before treatment, FMA-LE, BBS, FAC scores and gait spatial-temporal parameters (stride frequency, stride speed, stride length, and walking cycle) of the four groups after 4 and 8 weeks of treatment improved, and the differences were statistically significant (<italic>P</italic>&lt;0.05). …”
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The Genetic Landscape of Human Glioblastoma and Matched Primary Cancer Stem Cells Reveals Intratumour Similarity and Intertumour Heterogeneity by Chiara Pesenti, Stefania Elena Navone, Laura Guarnaccia, Andrea Terrasi, Jole Costanza, Rosamaria Silipigni, Silvana Guarneri, Nicola Fusco, Laura Fontana, Marco Locatelli, Paolo Rampini, Rolando Campanella, Silvia Tabano, Monica Miozzo, Giovanni Marfia

“…Furthermore, K-means algorithm identified an impairment of pathways related to the development and progression of cancer, such as angiogenesis, as well as pathways related to the immune system regulation, such as T cell activation. Our data confirmed the preservation of the genomic landscape from tumour tissue to GSCs, supporting the relevance of this cellular model to test in vitro new target therapies for GBM.…”
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Quantification of ecosystem services from mangrove silvofishery by E. Sumarga, D. Rosleine, G.B. Hutajulu, R.P. Plaurint, Tsabita ., M. Basyuni, S.H. Larekeng, M.F. Taqiyudin, N.N. Shohihah, H. Ali

“…BACKROUND AND OBJECTIVES: Mangrove silvofishery, a unique system that combine aquaculture with mangrove forests, presents a promising sustainable solution for Indonesia's coastal communities. …”
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Relationship between bacteria and nitrogen dynamics in wastewater treatment oxidation ponds by S. Saneha, T. Pattamapitoon, S. Bualert, O. Phewnil, W. Wararam, N. Semvimol, K. Chunkao, C. Tudsanaton, M. Srichomphu, U. Nachaiboon, O. Wongsrikaew, P. Wichittrakarn, C. Chanthasoon

“…Oxidation ponds act as a natural treatment system for wastewater and are designed to promote the growth and activity of certain bacterial species that remove contaminants from the water. …”
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Development and utilization of Treponema pallidum expressing green fluorescent protein to study spirochete-host interactions and antibody-mediated clearance: expanding the toolbox... by Kristina N. Delgado, Crystal F. Vicente, Christopher M. Hennelly, Farhang Aghakhanian, Jonathan B. Parr, Kevin P. Claffey, Justin D. Radolf, Kelly L. Hawley, Melissa J. Caimano

“…Untreated syphilis can lead to infection of multiple organ systems, including the central nervous system. The alarming increase in syphilis cases globally underscores the importance of developing novel strategies to understand the complexities of syphilis pathogenesis. …”
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A cost-effectiveness analysis of sotorasib as second-line treatment for patients with KRAS-G12C-mutated metastatic non-small cell lung cancer (mNSCLC) in Switzerland by Tämer El Saadany, Judith Lupatsch, Michael Mark, Michaela Barbier, Tarun Mehra, Matthias Schwenkglenks, Roger von Moos

“…Our analysis assessed the cost-effectiveness of sotorasib as a second-line treatment in Swiss patients with non-small cell lung cancer from the perspective of the Swiss statutory health insurance system. METHODS: A partitioned survival model based on the CodeBreak 200 trial was constructed with a time horizon of 10 years and a discount rate of 3% for costs and quality-adjusted life years (QALYs). …”
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Increased risk for alcohol- and other substance-exposed pregnancies among women who smoke tobacco: A secondary analysis of a primary care-based intervention by Thomas F. Northrup, Angela L. Stotts, Stephen M. Fischer, Kirk L. von Sternberg, Mary M. Velasquez

“…Material and Methods Eligible women (N=261) were recruited from 12 primary care clinics in a public healthcare system, not pregnant, aged 18–44 years, drinking >3 drinks/ day or >7 drinks/week, sexually active, and not using effective contraception. …”
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Effect of Arthrospira platensis (Spirulina) as a dietary supplement during transition period in dairy buffaloes by Giuseppe De Rosa, Vittoria L. Barile, Carmela M.A. Barone, Claudia Lambiase, Francesco Serrapica, Giovanna De Matteis, Emanuela Rossi, Corrado Pacelli

“…Milk production was recorded daily on the farm’s computer system, and milk composition (protein, fat, and lactose) was determined at 30, 60, and 90 d after calving using Milkoscan (Foss, Denmark). …”
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Analyzing Iran's Legislative Criminal Policy in Dealing with Environmental Terrorism, Emphasizing the Need for Criminalization and Preventive Measures by behrouz sepehri, Nourooz Kargari, mohammad ashouri, ghassem ghassemi

“…Introduction: environmental security, is a necessary condition for the health and continuity of human life on earth and due to the vital, widespread and inevitable dependence of humans on the environment, if the environmental security is taken away and it is removed from the possibility of healthy living, as a result of the goal or the means of placing the environment, following environmental terrorism, with various methods such as polluting the natural and man-made environment with dangerous substances, extensive and irreparable damage is caused to human life and health And often, the most obvious effects of damage to the safety and health of the environment appear in the form of epidemics, and on the other hand, the cross-border effects of such actions and the possibility of transferring the said effects from through the flow of air or water or the carriers of disease agents to countries and regions beyond the place of the accident, and the possibility of spreading some of these effects on the life and health of future generations, reveals the seriousness of the danger of environmental terrorism, hence, The purpose of this thesis is to explain the vital necessity of legal, technical and specialized contrast, against environmental terrorism in the form of an efficient criminal policy with international interaction, with emphasizing the extent and irreparability of the effects caused by environmental terrorism, and the necessity and importance of preventive measures.Materials and Methods:  In terms of the goal, the current research will cause expansion the legal theories and doctrine and complete the previous theories with the fundamental method of the research results, and also with the practical approach, effective practical solutions to deal with environmental terrorism will be presented, and on the other hand, the materials and information used in the research, They are collected with the library method and after collecting and categorizing the materials and information, with the descriptive-analytical method, the findings and the collected materials are analyzed logically and legally and they are used as the basis of citation to strengthen the approach of the researcher in the relevant subject.Results: In a comprehensive and efficient criminal policy to contrast against environmental terrorism, in addition to criminalizing this criminal phenomenon along with the real conceptology and in addition to recognizing its specific elements, it is expected that with the necessary criminal measures, specialized measures will be taken to identify and criminalize behaviors that it has a preliminary aspect to dangerous crimes, and it is possible that environmental terrorism is also committed through them, and therefore, in order to prevent this criminal phenomenon, criminalize such behaviors in the form of obstruction crimes seems necessary.Discussion: In Iran's criminal system, environmental terrorism has not been considered as an independent criminal behavior, with specific elements and specific conditions, However, due to the inherent of the behaviors related to environmental terrorism, this type of terrorism is inherently reprehensible, and as a rule, it can be included in various legal elements in the criminal laws, and on the other hand, due to the analogy of some elements of this criminal phenomenon with the destruction of the earth, According to jurisprudence, significant examples of environmental terrorism behaviors can be considered as examples of corruption in the land subject to Article 286 of the Islamic Penal Code (approved in 2012). …”
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Potassium Current Signature of Neuronal/Glial Progenitors in Amniotic Fluid Stem Cells by Paola Sabbatini, Sabrina Cipriani, Andrea Biagini, Luana Sallicandro, Cataldo Arcuri, Rita Romani, Paolo Prontera, Alessandra Mirarchi, Rosaria Gentile, Diletta Del Bianco, Elko Gliozheni, Sandro Gerli, Irene Giardina, Maurizio Arduini, Alessandro Favilli, Antonio Malvasi, Andrea Tinelli, Bernard Fioretti

“…These cells are highly appealing due to their numerous potential applications in the field of regenerative medicine for tissues and organs as well as for treating conditions such as traumatic or ischemic injuries to the nervous system, myocardial infarction, or cancer. AF-SCs, when subcultured in the presence of basic Fibroblast Growth Factor (bFGF), have been shown to survive and migrate when transplanted into the striatum of the rat brain, exhibiting behavior characteristics of neuronal/glial progenitor cells. …”
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Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation by Mohammad Alhashmi, Abdulrahman M. E. Gremida, Santosh K. Maharana, Marco Antonaci, Amy Kerr, Shijian Fu, Sharna Lunn, David A. Turner, Noor A. Al-Maslamani, Ke Liu, Maria M. Meschis, Hazel Sutherland, Peter Wilson, Peter Clegg, Grant N. Wheeler, Robert J. van ‘t Hof, George Bou-Gharios, Kazuhiro Yamamoto

“…Finally, using Xenopus as a model system, we show the regulatory role for LRP1 in Wnt/PCP signalling. …”
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Feasibility of trancutaneous auricular vagus nerve stimulation in Black and Hispanic/Latino people with peripheral neuropathy by Marlon L. Wong, Eva Widerström-Noga, Jessica L. Bolanos, Gabriel Gonzalez, Frank J. Penedo, Peter J. Hosein, Melissa M. Tovin, Juan P. Gonzalez, Lisa M. McTeague

“…Participants were recruited from the University of Miami medical system, with culturally sensitive approaches to enhance minority participation.ResultsThe survey included 62 respondents, 78% Black or Hispanic/Latino, revealing high symptom burden and significant interest in taVNS (82% expressed moderate to high interest). …”
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Investigating the effects of knee valgus orthosis on knee joint contact forces among subjects with knee osteoarthritis: A case series study by Mohammad Taghi KARIMI, Mahmood BAHRAMIZADEH, Hanieh KHALILIYAN, Majid ANSARI, Kavita BATRA, Aanuoluwapo AFOLABI, Olayinka ILESANMI, Lukasz SZARPAK, Hicham KHABBACHE, Gabriella NUCERA, Aldo SITIBONDO, Farhad GHAFFARI, Arash SHARAFATVAZIRI, Francesco CHIRICO

“…Methods: Ten subjects with knee OA were recruited for this study. A motion analysis system with seven high-speed cameras and a Kistler force plate were used to record the motion of the subjects in walking and the forces applied on the leg. …”
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Reproducibility of indirect persistent inward current indicators with neuromuscular electrical stimulation by Timothée Popesco, Davide D'Amato Brunetta, Stefano Pata, Nicolas Place

“… Introduction Neuromuscular electrical stimulation (NMES) has been validated as an efficient tool to train and evaluate the neuromuscular system. Recently, it has been used to estimate persistent inward currents (PICs) in motoneurons (Donnelly et al., 2021). …”
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Rancang Bangun Purwarupa Pemilah Sampah Pintar Berbasis Deep Learning by Kahlil Muchtar, Nyak Twoman Anshari, Chairuman Chairuman, Khalid Alhabibie, Khairul Munadi

“…Based on these problems, the researcher proposes a system that is able to recognize and sort organic waste, and inorganic waste. …”
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Free-Space Optical (FSO) Satellite Networks Performance Analysis: Transmission Power, Latency, and Outage Probability by Jintao Liang, Aizaz U. Chaudhry, Eylem Erdogan, Halim Yanikomeroglu, Gunes Karabulut Kurt, Peng Hu, Khaled Ahmed, Stephane Martel

“…., Kuiper&#x0027;s biggest shell) constellations for different LISL ranges and different inter-continental connections. We use appropriate system models for calculating the average satellite transmission power (i.e., the average of the transmission power of all satellites on the shortest path) and network latency (i.e., the end-to-end latency of the shortest path). …”
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