An HST Transmission Spectrum of the Closest M Dwarf Transiting Rocky Planet LTT 1445Ab by Katherine A. Bennett, David K. Sing, Kevin B. Stevenson, Hannah R. Wakeford, Zafar Rustamkulov, Natalie H. Allen, Joshua D. Lothringer, Ryan J. MacDonald, Nathan J. Mayne, Guangwei Fu

“…A mere 6.9 pc from Earth, LTT 1445A is the closest transiting M dwarf system, and its largest known planet, at 1.31 R _⊕ and 424 K, is one of the most promising targets in which to search for an atmosphere. …”
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Construction of a Vero cell line expression human KREMEN1 for the development of CVA6 vaccines by Dongqing Zhang, Yuxiang Zou, Jiaying Wu, Longfa Xu, Zhifeng Ke, Yuanyuan Wu, Zhenhong Zhou, Mujin Fang, Ling Chen, Henggang Xu, Jianping Chu, Ningshao Xia, Rui Zhu, Tong Cheng

“…Here, a Vero cell line with stable over-expressing of KREMEN1 (KRM1), a crucial receptor for CVA6, was constructed using the lentivirus system. The cloned cell line, called Vero-KRM1_#11, could efficiently support most CVA6 infections. …”
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Modeling feed efficiency over productive lifetime and integrating a submodel for body reserve management in Nordic dairy cattle by R.B. Stephansen, J. Lassen, V.M. Thorup, B.G. Poulsen, J. Jensen, G. Sahana, O.F. Christensen

“…To address this, we used production data and data from a camera-based feed intake and BW recording system, along with records of production, feed intake, and weight on Holstein cows from a research herd. …”
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Exploring Mortality and Prognostic Factors of Heart Failure with In-Hospital and Emergency Patients by Electronic Medical Records: A Machine Learning Approach by Yu CS, Wu JL, Shih CM, Chiu KL, Chen YD, Chang TH

“…After a series of data pre-processing in the electronic medical record system, several machine learning models were used to evaluate predictions of HF mortality. …”
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Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance by Henna Lehtonen, Heli Jokela, Julian Hofmann, Lauriina Tola, Arfa Mehmood, Florent Ginhoux, Burkhard Becher, Melanie Greter, Gennady G. Yegutkin, Marko Salmi, Heidi Gerke, Pia Rantakari

“…Altogether, these findings provide information on pituitary gland macrophages and advance our understanding of immune-endocrine system crosstalk.…”
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A national population-based study of mortality and risk factors in COVID-19-hospitalized patients in Spain (2020–2021) by José-Manuel Ramos-Rincón, José-Manuel Ramos-Rincón, José Sánchez-Paya, Pilar González-De-La-Aleja, Juan-Carlos Rodríguez-Díaz, Juan-Carlos Rodríguez-Díaz, Esperanza Merino, Esperanza Merino

“…The objective was to assess the impact of vaccination on IHM and identify associated risk factors, using data from Spain’s national hospitalization registry.MethodsThis retrospective analysis used data from the Spanish National Surveillance System for Hospital Data. The primary outcome was in-hospital mortality (IHM). …”
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Artemisinin supplementation in concentrated cottonseed protein basal diets enhances growth, antioxidant capacity, intestinal immunity and microbiota in hybrid grouper (Epinephelus... by Ling Pan, Qi Wang, Weikang Li, Xiaohui Dong, Shiwei Xie, Beiping Tan, Hongyu Liu, Yan Wang

“…Artemisinin supplementation significantly enhanced the activities of SOD, GSH-Px, CAT, and T-AOC in the liver and hindgut (P < 0.05),while also reducing MDA levels, thereby demonstrating its protective effect against oxidative stress and its ability to strengthen antioxidant defense system. Microbiome analysis demonstrated that artemisinin decreased microbial diversity and richness while selectively promoting the proliferation of beneficial gut microbiota, suppressing harmful bacteria, and enhancing the intestinal environment, thereby supporting overall growth. …”
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The near-optimal adjustment of carbon and nitrogen allocations into different organs in early-season rice cultivars with drastically different yield components under nitrogen appli... by Wen Ning, Wen Ning, Lin Su, Lin Su, Dandan Shi, Dandan Shi, Meina Ji, Meina Ji, Xiang Ouyang, Qingfeng Song, Caihong Shao, Xin-Guang Zhu, Shuoqi Chang, Shuoqi Chang

“…Early season rice can be used as a model system to study the growth strategy selection of plants to changing environment conditions.…”
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Comparison of global transcriptomes for nontyphoidal Salmonella clinical isolates from pediatric patients with and without bacteremia after their interaction with human intestinal... by Buyandelger Batsaikhan, Pei-Chun Lin, Katsumi Shigemura, Yu-Wei Wu, Reo Onishi, Pei-Ru Chang, Hung-Yen Cheng, Shiuh-Bin Fang

“…The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways analysis identified that arginine biosynthesis, ascorbate and aldarate metabolism, and phosphotransferase system pathways were activated in bacteremic NTS strains after Caco-2 cell priming. …”
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Airway pressures generated by high flow nasal cannula in patients with acute hypoxemic respiratory failure: a computational study by Hossein Shamohammadi, Liam Weaver, Sina Saffaran, Roberto Tonelli, Marianna Laviola, John G. Laffey, Luigi Camporota, Timothy E. Scott, Jonathan G. Hardman, Enrico Clini, Declan G. Bates

“…Materials and methods We developed a high-fidelity mechanistic computational model of the cardiopulmonary system during HFNC therapy using data from healthy subjects, and then measured the mPaw and PEEP levels produced when different amounts of alveolar consolidation/collapse were incorporated into the model. …”
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Therapeutic Effect and Location of GFP-Labeled Placental Mesenchymal Stem Cells on Hepatic Fibrosis in Rats by Jiong Yu, Guangshu Hao, Dan Wang, Jingqi Liu, Xiaotian Dong, Yanni Sun, Qiaoling Pan, Yang Li, Xiaowei Shi, Lanjuan Li, Hongcui Cao

“…We demonstrated that liver fibrosis was significantly dampened in the hPMSC transplantation group according to the Laennec fibrosis scoring system and histological data. The Sirius red-stained collagen area and the elastography score were significantly reduced in the hPMSC-treated group. …”
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Inflammatory and Redox Blood Gene Expression Fingerprint of Severe Obstructive Sleep Apnoea in Patients With Mild Alzheimer&rsquo;s Disease by Romero-ElKhayat L, Dakterzada F, Huerto R, Carnes-Vendrell A, Mínguez O, Pujol Sabaté M, Targa A, Barbé F, Milanesi E, Dobre M, Manda G, Cuadrado A, Piñol-Ripoll G

“…Leila Romero-ElKhayat,1 Farida Dakterzada,1 Raquel Huerto,1 Anna Carnes-Vendrell,1 Olga Mínguez,2 Montserrat Pujol Sabaté,2 Adriano Targa,3,4 Ferran Barbé,3,4 Elena Milanesi,5,6 Maria Dobre,5 Gina Manda,5 Antonio Cuadrado,5,7– 10 Gerard Piñol-Ripoll1,11 1Unitat de Trastorns Cognitius, Cognition and Behavior Study Group, Universitat de Lleida, IRBLleida, Lleida, 25198, Spain; 2Unitat de Son, Hospital Universitari Santa Maria de Lleida, Lleida, Spain; 3Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain; 4Center for Biomedical Research in Respiratory Diseases Network (CIBERES), Madrid, Spain; 5“Victor Babes” National Institute of Pathology, Bucharest, 050096, Romania; 6Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, 050474, Romania; 7Department of Endocrine Physiology and Nervous System, Instituto de Investigaciones Biomédicas “Alberto Sols” UAM-CSIC, Madrid, 28029, Spain; 8Department of Biochemistry, Faculty of Medicine, Autonomous University of Madrid, Madrid, 28049, Spain; 9Neuroscience Section, Instituto de Investigación Sanitaria La Paz (Idipaz), Madrid, 28046, Spain; 10Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), ISCIII, Madrid, 28031, Spain; 11Alzheimer’s Disease and Other Cognitive Disorders Unit, Hospital Clínic de Barcelona, Fundació de Recerca Clínic Barcelona – Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, SpainCorrespondence: Gerard Piñol-Ripoll, Cognitive Disorders Unit, Hospital Universitari Santa Maria, Rovira Roure no. 44, Lleida, 25198, Spain, Tel +34-937-727222, Ext. 173, Fax +34-976-727366, Email gerard_437302@hotmail.comIntroduction: Obstructive sleep apnoea (OSA) is the sleep disorder most frequently found in patients with Alzheimer’s disease (AD). …”
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MnS/MnO heterostructures with dual ion defects for high-performance aqueous magnesium ion capacitors by Minghui Liu, Mudi Li, Siwen Zhang, Yaxi Ding, Ying Sun, Jiazhuo Li, Haixi Gu, Bosi Yin, Hui Li, Tianyi Ma

“…As anticipated, using a three-electrode system, the developed DID-MnS/MnO demonstrated a discharge specific capacity of 237.9 mAh/g at a current density of 0.1 A/g. …”
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Efficient Hydrolysis of Sugar Beet Pulp Using Novel Enzyme Complexes by Maria I. Komarova, Margarita V. Semenova, Pavel V. Volkov, Igor A. Shashkov, Alexandra M. Rozhkova, Ivan N. Zorov, Sergei A. Kurzeev, Aidar D. Satrutdinov, Ekaterina A. Rubtsova, Arkady P. Sinitsyn

“…New recombinant strains were created using the expression system of the mycelial fungus <i>P. verruculosum</i> B1-537, which is capable of simultaneously producing pectin lyase and arabinofuranosidase, as well as homologous cellulases. …”
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Preclinical model for evaluating human TCRs against chimeric syngeneic tumors by Olivier Michielin, Philippe Guillaume, Melita Irving, Patrick Reichenbach, Vincent Zoete, Elise Gray-Gaillard, Evangelos Stefanidis, Aikaterini Semilietof, Julien Pujol, Alessia D'Esposito

“…Moreover, with our chimeric syngeneic tumor model, we were able to track dynamic and favorable changes in the TME upon DMβ-T cell transfer.Conclusions We have developed a robust, simple, and inexpensive preclinical strategy for evaluating human TCRs in the context of a fully competent murine immune system that can aid in the development of coengineered TCR-T cells and combination treatments translated to the clinic.…”
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Bridging Land and Sea: Geophysical insights into coastal karstic groundwater dynamics, freshwater plumes and saltwater intrusions in the urban regions of Antalya (Türkiye) by Jasper J.L. Hoffmann, Ercan Erkul, Simon Fischer, Irfan Yolcubal, Pritam Yogeshwar, Wolfgang Rabbel, Amir Haroon, Şerif Bariş, Ahmet Şener, Jens Schneider von Deimling, Ismail Kaplanvural, Bülent Tezkan, Elif Şen, Felix Gross, Ertan Pekşen, Elnur Gasimov, Aaron Micallef

“…Study Region: This study investigates the on- and offshore fresh to saline groundwater distribution as well as the submarine groundwater discharge within a coastal karstic aquifer system in Antalya (Türkiye). Study Focus: Groundwater acts as a critical link between on- and offshore environments, connecting freshwater systems to the saline oceans. …”
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Out-of-Pocket Expenditure (OOPE) on Selected Surgeries in the Obstetrics and Gynaecology Department incurred by Ayushman Bharat Pradhan Mantri Jan Arogya  Yojana (AB-PMJAY), Privat... by Dr. Kumar Sumit, Reena Verma, Prajwal Salins, Helmut Brand, Siddhartha Sankar Acharya, Sagarika Kamath, rajesh kamath, Dr. Vidya Prabhu

“…Introduction OOPE for healthcare services is a major concern within the Indian healthcare system. 30% of the population remains uninsured despite increasing health insurance coverage. …”
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Enhanced Safety and Efficacy of O‐Arm Navigation Over C‐Arm Guidance in Percutaneous Kyphoplasty for Patients With Osteoporotic Vertebral Compression Fractures and Spinal Deformity... by Zhong‐Wei Ji, Min‐Jie Shen, Jia‐Jia Sun, Jia‐Le Wang, Yong‐Kang Deng, Yao Zhang, Xie‐Xing Wu, Kang‐Wu Chen, Hai‐Qing Mao

“…ABSTRACT Objective Although percutaneous kyphoplasty (PKP) under C‐arm guidance is an effective treatment for osteoporotic vertebral compression fractures (OVCF), obtaining high‐definition images in patients with OVCF and spinal deformities can be challenging or insufficient using traditional C‐arm guidance, prompting our institution to adopt the O‐arm navigation system—which offers comprehensive 3D imaging and precise navigation—and this study compares its safety and efficacy with conventional C‐arm‐assisted PKP. …”
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Betulinic acid protects against ovarian impairment by decreasing F-2 toxin-induced oxidative stress and inflammation associated with the downregulation of p38 expression in mice by Li Kong, Xinyu Gao, Lijuan Zhu, Xing Lin, You Huang, Chunlin Huang, Wenjiang Yang, Yazhi Chen, Haoqiang Zhao, Jing Wu, Zhihang Yuan, Jin’e Yi

“…Moreover, BA restored the balance of F-2 toxin-induced ovarian redox system disorders. Subsequently, we found that 0.25 mg/kg BA played an anti-inflammatory role in the F-2 toxin-induced ovarian impairment by decreasing interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) mRNA expression, as well as inhibiting p38 protein expression.These data demonstrated that BA exerts its protective effect on F-2 toxin-induced ovarian oxidative impairment and inflammation by inhibiting p38 expression, which implies a natural product-based medicine to ameliorate F-2 toxin-caused female reproductive toxicity and provides a detoxifying method for food contaminated by mycotoxin.…”
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Distinguishable Immunologic Characteristics of COVID-19 Patients with Comorbid Type 2 Diabetes Compared with Nondiabetic Individuals by Ruxing Zhao, Yujing Sun, Yongyuan Zhang, Weili Wang, Shouyu Wang, Chuang Wang, Jinbo Liu, Ling Gao, Zhao Hu, Jianchun Fei, Xinguo Hou, Huizhen Zheng, Li Chen

“…COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has threatened every civilian as a global pandemic. The immune system poses the critical interactive chain between the human body and the virus. …”
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