Tumor aggression-defense index–a novel indicator to predicts recurrence and survival in stage II-III colorectal cancer by Tong Wu, Lin Fang, Yuli Ruan, Mengde Shi, Dan Su, Yue Ma, Ming Ma, Bojun Wang, Yuanyu Liao, Shuling Han, Xiaolin Lu, Chunhui Zhang, Chao Liu, Yanqiao Zhang

“…Abstract Background Although the TNM staging system plays a critical role in guiding adjuvant chemotherapy for colorectal cancer (CRC), its precision for risk stratification in stage II and III CRC patients with proficient DNA mismatch repair (pMMR) remains limited. …”
Get full text

The Role of Prenatal Exposure to Lead and Manganese in Child Cognitive Neurodevelopment at 18 Months: The Results of the Italian PHIME Cohort by Valentina Rosolen, Fabiano Barbiero, Marika Mariuz, Maria Parpinel, Luca Ronfani, Liza Vecchi Brumatti, Maura Bin, Luigi Castriotta, Francesca Valent, D’Anna Latesha Little, Janja Snoj Tratnik, Darja Mazej, Ingrid Falnoga, Milena Horvat, Fabio Barbone

“…Prenatal lead (Pb) and manganese (Mn) exposure can impair neurodevelopment, targeting the central nervous system. This study investigated the effects of prenatal exposure to Pb and Mn on neurodevelopment in children at 18 months of age, using data from 607 Italian mother–child pairs enrolled in the Northern Adriatic Cohort II (NAC-II). …”
Get full text

Cytosolic phospholipase A2 in infiltrating monocyte derived macrophages does not impair recovery after spinal cord injury in female mice by Ethan P. Glaser, Timothy J. Kopper, William M. Bailey, Hassan K. Kashif, Reena Kumari, Andrew N. Stewart, John C. Gensel

“…Furthermore, to investigate the role of cPLA2 in MDMs after SCI, we generated female bone marrow chimeras using cPLA2 knock-out donors and assessed locomotor recovery using the Basso Mouse Scale (BMS), CatWalk gait analysis system, and horizontal ladder task over six weeks. …”
Get full text

Assessing the determinants of out-of-pocket health expenditures among Cambodian households in informal employment using survey data by Andrea Hannah Kaiser, Sovathiro Mao, Jesper Sundewall, Marlaina Ross, Sokunthea Koy, Searivoth Vorn, Pichenda Koeut, Bjoern Ekman

“…Strategically engaging with private providers and pharmacies to improve access to essential services and medicines, coupled with the implementation of an effective referral system are important policy considerations to this end. …”
Get full text

Pengembangan Aplikasi Berlatih Membaca Cepat Berbahasa Inggris Berbasis Progressive Web App dengan Metode Prototyping by Muhammad Fajar Alfath, Lutfi Fanani, Agi Putra Kharisma

“…Hasil pengujian kepuasan pengguna melalui pengukuran System Usability Scale (SUS) mencapai nilai 84 dengan kategori grade B dan tergolong acceptable. …”
Get full text

Differential Effects of Angelicin Analogues on NF-κB Activity and IL-8 Gene Expression in Cystic Fibrosis IB3-1 Cells by Ilaria Lampronti, Maria Giulia Manzione, Gianni Sacchetti, Davide Ferrari, Susanna Spisani, Valentino Bezzerri, Alessia Finotti, Monica Borgatti, Maria Cristina Dechecchi, Giorgia Miolo, Giovanni Marzaro, Giulio Cabrini, Roberto Gambari, Adriana Chilin

“…Analogues able to inhibit NF-κB/DNA interaction at lower concentration than TMA were found and selected to investigate their biological activity on IB3-1 cells induced with TNF-α. In this biological system, NF-κB-mediated IL-8 gene expression was investigated. …”
Get full text

Lidar estimates of birch pollen number, mass, and CCN-related concentrations by M. Filioglou, P. Tiitta, P. Tiitta, X. Shang, A. Leskinen, P. Ahola, S. Pätsi, A. Saarto, V. Vakkari, V. Vakkari, U. Isopahkala, M. Komppula

“…In turn, this demonstrates the potential of ground-based lidars such as a ceilometer network with the polarization capacity to document large-scale birch pollen outbursts in detail and thus to provide valuable information for climate, cloud, and air quality modeling efforts, elucidating the role of pollen within the atmospheric system.</p>…”
Get full text

MRI to digital medicine diagnosis: integrating deep learning into clinical decision-making for lumbar degenerative diseases by Baoyi Ke, Wenyu Ma, Junbo Xuan, Junbo Xuan, Yinghao Liang, Liguang Zhou, Wenyong Jiang, Jing Lin, Guixiang Li

“…IntroductionTo develop an intelligent system based on artificial intelligence (AI) deep learning algorithms using deep learning tools, aiming to assist in the diagnosis of lumbar degenerative diseases by identifying lumbar spine magnetic resonance images (MRI) and improve the clinical efficiency of physicians.MethodsThe PP-YOLOv2 algorithm, a deep learning technique, was used to design a deep learning program capable of automatically identifying the spinal diseases (lumbar disc herniation or lumbar spondylolisthesis) based on the lumbar spine MR images. …”
Get full text

The Effectiveness of pen‒culture construction for cultivation of sea cucumber by Pitjont Tomatala, Petrus Paulus Letsoin, Evangelin Martha Yulia Kadmaer

“…This research aimed to determine the effectiveness of two types of pen‒culture system for sea cucumber rearing to the influence of ocean waves and currents. …”
Get full text

Clinically relevant orthotopic pancreatic cancer models for adoptive T cell transfer therapy by Gregory B. Lesinski, Chrystal M. Paulos, Maggie Phillips, Jacklyn Hammons, Isaac Karpovsky, Zaid Mahdi, Natalie K. Horvat, Megan M. Wyatt, Margaret A. Hall, Cameron J. Herting, Richard A. Moffitt

“…Interestingly, we found that chimeric antigen receptor (CAR) T cells redirected to recognize mesothelin on these tumors that signal via CD3ζ and 41BB (Meso-41BBζ-CAR T cells) infiltrated the tumors of mice bearing stroma-devoid KPC-Luc orthotopic tumors, but not MT-5 tumors.Conclusions Our data establish for the first time a reproducible and realistic clinical system useful for modeling stroma-rich and stroma-devoid PDAC tumors. …”
Get full text

Genome drafting of nosocomial infection CRE Klebsiella pneumoniae confirming resistance to colistin and eravacycline, carrying blaNDM-1, mcr-1, and blaKPC-2, in neonatology from No... by Xinlong Zhou, Kailash Wagh, Guizhen Lv, Devender Sharma, Wei Lei

“…Identification and antimicrobial susceptibility testing were initially conducted using the Vitek®2 system with an N-395 card and further confirmed by 16S rRNA sequencing. …”
Get full text

Growth-Promoting Effects of Grass Root-Derived Fungi <i>Cadophora fastigiata</i>, <i>Paraphoma fimeti</i> and <i>Plectosphaerella cucumerina</i> on Spring Barley (<i>Hordeum vulgar... by Izolda Pašakinskienė, Violeta Stakelienė, Saulė Matijošiūtė, Justas Martūnas, Marius Rimkevičius, Jurga Būdienė, Algis Aučina, Audrius Skridaila

“…Before harvesting, the inoculated plants were grown in a greenhouse, with the barley being in multi-cavity trays for 30 days and ryegrass being placed in an original cylindric element system for 63 days. All three newly tested fungi had a positive effect on the growth of the barley and ryegrass plants, with the most pronounced impact observed in their root size. …”
Get full text

Prevalence and Knowledge of Hepatitis B Virus Infection among Pregnant Women in the Ningo-Prampram District, Ghana by Precious Kwablah Kwadzokpui, Elliot Elikplim Akorsu, Albert Abaka-Yawson, Solomon Sosu Quarshie, Stephen Adomako Amankwah, Philip Apraku Tawiah

“…Knowledge of the participants on HBV infection was classified as either excellent, good, or poor based on their cumulative percentage scores from the questionnaire according to Al Rubaish system of classification. Results. Overall low-intermediate prevalence of HBV infection was 3.3%; however, PPC recorded the highest prevalence of 4.0% while DCH and ONHC recorded 2.82% and 2.50%, respectively. …”
Get full text

First Experiences with Fusion of PET-CT and MRI Datasets for Navigation-Assisted Percutaneous Biopsies for Primary and Metastatic Bone Tumors by Hagen Fritzsche, Alexander Pape, Klaus-Dieter Schaser, Franziska Beyer, Verena Plodeck, Ralf-Thorsten Hoffmann, Patricia Hahlbohm, Elisabeth Mehnert, Anne Weidlich

“…Navigation was based on preoperative CT, PET-CT/-MRI, and MRI datasets, and tumor biopsies were performed using intraoperative 3D imaging combined with a navigation system. <b>Results:</b> A total of 22 navigated (main group: m/f = 10/12, mean age: 56 yrs.) and 57 CT-guided biopsies (reference group: m/f = 36/21, mean age: 63 yrs.) were performed. …”
Get full text

Physical modelling of damage mechanism of slopes containing near horizontal weak layers under rainfall conditions by Zhigang TAO, Chuang XU, Songyuan LIU, Yong LI, Kexin XIU

“…In order to investigate the damage mechanism of such slopes under rainfall conditions and the control effect of the NPR anchor cable support system on such slopes, model experiments and numerical simulations were used. …”
Get full text

Understanding Health-Related Discussions on Reddit: Development of a Topic Assignment Method and Exploratory Analysis by Garrett J Chan, Mark Fung, Jill Warrington, Sarah A Nowak

“…Social media data can be leveraged to understand patient concerns and provide insight into why patients may turn to the internet instead of the health care system for health advice. ObjectiveThis study aimed to develop a method to investigate Reddit posts discussing health-related conditions. …”
Get full text

Evaluation of two-dimensional ultrasound fetal thymus size in correlation to infection parameters in pregnancies complicated with preterm premature rupture of membranes by Amal Kotb Abdallah, Mohamed Mohesen, Nagwan Kamal, Sahar Mahmoud Abd Elsalam, Sondos Salem, Ehab Salama, Mazen Abdel-Rasheed, Mohamed Eweis

“…Background/aim The thymus is essential for developing the fetal immune system and may show involution upon exposure to acute stress. …”
Get full text

Native Italian poultry products: the factors influencing consumer perceptions by Eleonora Erika Cappone, Valeria Zambotto, Jatziri Mota-Gutierrez, Dominga Soglia, Giulia Maria Daniele, Marta Cianciabella, Andrea Pieroni, Renata Soukand, Mauro Penasa, Arianna Buccioni, Margherita Marzoni, Nicolaia Iaffaldano, Cesare Castellini, Silvia Cerolini, Claudio Forte, Achille Schiavone

“…Age, willingness to pay, the perceived productivity of native breeds, and chicken meat and egg preferences in terms of the rearing system were the main predicting factors influencing the importance consumers placed on the geographical proximity and the perceived quality traits of poultry products from native breeds. …”
Get full text

Dosimetry of automatic non-coplanar volumetric-modulated arc therapy for nasopharyngeal carcinoma by Kaiqiang Chen, Jihong Chen, Yanming Cheng, Danni Hong, Cairong Hu, Penggang Bai, Jinyong Lin, Yang Yang, Xiuchun Zhang

“…Treatment plans were redesigned using HA technology on the Eclipse planning system. Dosimetric parameters and verification passing rates were collected to assess the dosimetric quality of target coverage and organ-at-risk (OAR) sparing in both sets of plans. …”
Get full text

Selective light olefin synthesis with high ethylene abundance via CO2 hydrogenation over (Ga-In)2O3/SSZ-13 catalysts by Yasemen Kuddusi, Laura Piveteau, Mounir Mensi, Daniel C. Cano-Blanco, Andreas Züttel

“…Inspired by the promising catalytic activity of Ga2O3-based catalysts in alkane dehydrogenation, this study reveals that optimizing Ga content in the GaxIn2-xO3/SSZ-13 catalytic system can narrow the product distribution toward light olefins. …”
Get full text