Conjugation of LasR Quorum-Sensing Inhibitors with Ciprofloxacin Decreases the Antibiotic Tolerance of P. aeruginosa Clinical Strains by Daria Bortolotti, Claudio Trapella, Alessandra Bragonzi, Paolo Marchetti, Vinicio Zanirato, Andrea Alogna, Valentina Gentili, Carlo Cervellati, Giuseppe Valacchi, Mariangela Sicolo, Giulia Turrin, Anna Fantinati, Dario Di Luca, Roberta Rizzo

“…Pseudomonas aeruginosa is a Gram-negative bacterium that commonly infects subjects with weakened immune system causing deadly infections above all at pulmonary level. …”
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From Acceptance to Dependence: Exploring Influences of Smart Healthcare on Continuous Use Intention of Mobile Health Services Among Older Adults with Chronic Illnesses in China by Jiacheng Luo, Kewei Zhang, Qianghong Huang, Shan Jiang, Younghwan Pan

“…With the acceleration of the aging process in China, chronic diseases have become one of the main health threats for older adults, creating significant pressure on society and the healthcare system. As information technology and artificial intelligence advance rapidly, smart health services have become readily accessible. …”
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Ductal Carcinoma In Situ (DCIS) Diagnosed by MRI-Guided Biopsy among BRCA1/BRCA2 Mutation Carriers by Renata Faermann, Eitan Friedman, Orit Kaidar-Person, Jonathan Weidenfeld, Malka Brodsky, Anat Shalmon, Osnat Halshtok Neiman, Michael Gotlieb, Yael Yagil, David Samoocha, Dana Madorsky Feldman, Miri Sklair-Levy

“…Clinical data, pathology information, and imaging characteristics were retrieved from the computerized archiving system. Results. 18/121 (15.2%) participating BRCA1 PSV carriers and 8/81 (10.1%) BRCA2 PSV-carriers who underwent MRI-guided biopsy were diagnosed with DCIS. …”
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Brain Age Prediction Using a Lightweight Convolutional Neural Network by Fatma Eltashani, Mario Parreno-Centeno, James H. Cole, Joao Paulo Papa, Fumie Costen

“…We developed a brain-age prediction system using a minimally preprocessed T1-weighted MRI images with a multi-site dataset of healthy individuals covering the whole human lifespan (2251 subjects, age range 6-90 years). …”
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Identification of major hemorrhage in trauma patients in the prehospital setting: diagnostic accuracy and impact on outcome by Nigel R M Tai, Evangelia Kyrimi, Jared M Wohlgemut, Zane B Perkins, William Marsh, Michael Christian, Erhan Pisirir, Rebecca S Stoner, Thomas Hurst

“…A second aim was to analyze factors associated with missed and overdiagnosis of MH, and the impact on mortality.Methods Retrospective evaluation of consecutive adult (≥16 years) patients injured in 2019–2020, assessed by expert trauma clinicians in a mature prehospital trauma system, and admitted to a major trauma center (MTC). …”
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Wastewater Monitoring During the COVID-19 Pandemic in the Veneto Region, Italy: Longitudinal Observational Study by Honoria Ocagli, Marco Zambito, Filippo Da Re, Vanessa Groppi, Marco Zampini, Alessia Terrini, Franco Rigoli, Irene Amoruso, Tatjana Baldovin, Vincenzo Baldo, Francesca Russo, Dario Gregori

“…ObjectiveWe aimed to evaluate the effectiveness of the cumulative sum (CUSUM) control chart method in detecting changes in SARS-CoV-2 concentrations in wastewater and its potential as an early warning system for COVID-19 outbreaks. Additionally, we aimed to validate these findings over different time periods to ensure robustness. …”
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Insufficient gene expression and lost gene regulatory network may underlie the mechanism of Hirschsprung Disease in 5p–syndrome by Yizhao Luan, Peng Li, Yuanyuan Luo, Hong Zhang, Xiaochun Zhu, Yan Zhang, Aihua Yin, Qiang Wu, Chengwei Chai

“…On the one hand, leveraging human single-cell atlas for developing enteric nervous system, we demonstrated that some affected genes in these two patients overlapped with those showing expression changes along the development pseudotime of enteric nervous cells (ENC) and overlapped with known HSCR genes including RET, NRG1, ERBB (ERBB2 and ERBB3), ITGB (ITGB1). …”
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Positional embeddings and zero-shot learning using BERT for molecular-property prediction by Medard Edmund Mswahili, JunHa Hwang, Jagath C. Rajapakse, Kyuri Jo, Young-Seob Jeong

“…Abstract Recently, advancements in cheminformatics such as representation learning for chemical structures, deep learning (DL) for property prediction, data-driven discovery, and optimization of chemical data handling, have led to increased demands for handling chemical simplified molecular input line entry system (SMILES) data, particularly in text analysis tasks. …”
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Sistem Pendukung Keputusan untuk Penentuan Prioritas Pemberdayaan Masyarakat melalui Perilaku Hidup Bersih dan Sehat Menggunakan Metode Topsis by Alif Catur Murti, Ahmad Abdul Chamid

“…It can be said that this health promotion still cannot be said to be effective, because there is no system that can prioritize people who need empowerment in the form of health promotion and counseling. …”
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Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein by Yanxiao Han, John R.D. Dawson, Kevin R. DeMarco, Kyle C. Rouen, Khoa Ngo, Slava Bekker, Vladimir Yarov-Yarovoy, Colleen E. Clancy, Yang K. Xiang, Surl-Hee Ahn, Igor Vorobyov

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Prediction of digestible energy requirement in growing finishing stage of pigs using machine learning models by Nibas Chandra Deb, Jayanta Kumar Basak, Sijan Karki, Elanchezhian Arulmozhi, Dae Yeong Kang, Niraj Tamrakar, Eun Wan Seo, Junghoo Kook, Myeong Yong Kang, Hyeon Tae Kim

“…The livestock environment management system sensor and two load cells were used to measure the IT, IRH, ICO2, BW and DE intake of pigs, respectively. …”
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Impact of maternal nutritional literacy and feeding practices on the growth outcomes of children (6–23 months) in Gujranwala: a cross-sectional study by Aaiza Tahreem, Allah Rakha, Rimsha Anwar, Roshina Rabail, Cristina Maria Maerescu, Claudia Terezia Socol, Florin Leontin Criste, Gholamreza Abdi, Rana Muhammad Aadil

“…Higher odds of being stunted (β = 2.173, OR = 8.788, p < 0.05) were observed among those whose mothers had middle school education compared to those having higher education.ConclusionOverall results indicated a dire need not only to create nutritional awareness among mothers in Gujranwala but also to provide a support system for mothers to help them implement standard feeding practices.…”
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Preventing epileptogenesis by interaction between inositol isomers and proteins by Lia Tsverava, Luka Kharkhelauri, Vincenzo Lagani, Giorgi Gamkrelidze, Veriko Bokuchava, Tamar Kiguradze, Merab Kokaia, Revaz Solomonia

“…Abstract Objective Inositols play significant roles in biological systems. Myo‐inositol (MI), the most prevalent isomer, functions as an osmolyte and mediates cell signal transduction. …”
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Petrological controls on the engineering properties of carbonate aggregates through a machine learning approach by Javid Hussain, Tehseen Zafar, Xiaodong Fu, Nafees Ali, Jian Chen, Fabrizio Frontalini, Jabir Hussain, Xiao Lina, George Kontakiotis, Olga Koumoutsakou

“…Among these, the Gradient Boosting model demonstrated superior predictive capability, overcoming both traditional regression methods and other machine learning algorithms as validated through the Taylor diagram and ranking system (i.e., r = 0.998, R² = 997, Root mean square error = 0.075, Variance Accounted For = 99.50%, Mean Absolute Percentage Error = 0.385%, Alpha 20 Index = 100, and performance index = 0.975). …”
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Evaluating the quality of care for heart failure hospitalizations in inflammatory arthritis – A population-based cohort study by Bindee Kuriya, Lihi Eder, Sahil Koppikar, Jessica Widdifield, Anna Chu, Jiming Fang, Irene Jeong, Douglas Lee, Jacob Udell

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Impacts of Land Use on Soil Erosion: RUSLE Analysis in a Sub-Basin of the Peruvian Amazon (2016–2022) by Moises Ascencio-Sanchez, Cesar Padilla-Castro, Christian Riveros-Lizana, Rosa María Hermoza-Espezúa, Dayan Atalluz-Ganoza, Richard Solórzano-Acosta

“…The present study aimed to evaluate the increase in erosion levels, at a sub-basin of the central–eastern Amazon of Peru, in a Geographic Information System (GIS) environment. The revised universal soil loss equation (RUSLE) model was used for assessing the effect of vegetation cover change from 2016 to 2022. …”
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Video-feedback intervention for promoting social engagement in children with neurodevelopmental disabilities by Rosario Montirosso, Serena Micheletti, Camilla Pisoni, Eleonora Mascheroni, Elisa Scarano, Elisa Scarano, Cecilia Naboni, Elisa Rosa, Annalisa Castagna, Margherita Bonino, Elisa Fazzi, Elisa Fazzi, Simona Orcesi, Simona Orcesi

“…Using the Global Rating Scale coding system (GRS), child behaviors (engagement and emotionality) and maternal behavior (sensitivity) were assessed during the FFSF.ResultsAnalyses of variance (ANOVA) indicated significant improvement post-intervention in child engagement in the Reunion episode, with an increase in mother-directed gaze communicative gestures and positive vocalization. …”
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Potential of Liposomal FTY720 for Bone Regeneration: Proliferative, Osteoinductive, Chemoattractive, and Angiogenic Properties Compared to Free Bioactive Lipid by Mouzoura P, Marazioti A, Gkartziou F, Metsiou DN, Antimisiaris SG

“…Herein we developed FTY720-loaded liposomes as a potential delivery system that could retain and prolong the bioactivity of the bioactive lipid and at the same time reduce its cytotoxicity (at high doses).Methods: FTY720 liposomes were prepared by thin-lipid hydration and microfluidic flow focusing, and evaluated for their ability to induce proliferation, osteoinduction, and chemoattraction in three cell types: MC3T3-E1 pre-osteoblast cells, L929 fibroblast cells, and ATDC5 chondrogenic cells. …”
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Analysis of the Heterogeneity of CD4+CD25+ T Cell TCR β CDR3 Repertoires in Breast Tumor Tissues, Lung Metastatic Tissues, and Spleens from 4T1 Tumor-Bearing BALB/c Mice by Teng Zhang, Fangfang Duan, Danhua Su, Long Ma, Jiezuan Yang, Bin Shi, Xiaoyan He, Rui Ma, Suhong Sun, Xinsheng Yao

“…However, the number and characteristics of overlapping CDR3 sequences suggested that there were some different CD4+CD25+ T cells in tumors and in the circulatory immune system. The study may be used to further explore the characteristics of the CDR3 repertoires and determine the source of the CD4+CD25+ T cells in the breast cancer microenvironment.…”
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Virulence profile of carbapenem-resistant Klebsiella pneumoniae strains by an in vivo model of Galleria mellonella by María Guembe, Rama Hafian, Marta Díaz-Navarro, Andrés Visedo, Flavio De Maio, Fulvia Pimpinelli, Ilaria Cavallo, Mauro Truglio, Francesca Sivori, Enea Gino Di Domenico

“…The G. mellonella model may serve as an effective in vivo system for evaluating the virulence of emerging K. pneumoniae lineages.IMPORTANCEWe demonstrate that the Galleria mellonella model is a useful tool to analyze the virulence of carbapenem-resistant Klebsiella pneumoniae strains. …”
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