Exploring the efficacy of fluorouracil and platinum based chemotherapy in advanced hepatocellular carcinoma to bridge the treatment gap in resource limited settings by Se Jun Park, Kabsoo Shin, In-Ho Kim, MyungAh Lee, Tae Ho Hong, Hyunho Kim

“…This study evaluates the effectiveness of 5-fluorouracil (5-FU) plus platinum-based chemotherapy as an alternative systemic treatment for advanced HCC. A retrospective analysis of advanced HCC patients treated with 5-FU plus platinum-based chemotherapy was conducted. …”
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A spatiotemporal optimization engine for prescribed burning in the Southeast US by Reetam Majumder, Adam J. Terando, J. Kevin Hiers, Jaime A. Collazo, Brian J. Reich

“…Today, landscape-scale prescribed fire is required to manage these systems for conservation objectives and to mitigate wildland fire risk. …”
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Rational metabolic engineering of <i>Corynebacterium glutamicum</i> to create a producer of L-valine by M. E. Sheremetieva, K. E. Anufriev, T. M. Khlebodarova, N. A. Kolchanov, A. S. Yanenko

“…Various aspects of L-valine biosynthesis in C. glutamicum are reviewed: process biochemistry, stoichiometry and regulation, enzymes and their corresponding genes, export and import systems, and the relationship of L-valine biosynthesis with central cell metabolism. …”
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Randomised trials in maternal and perinatal health in low and middle-income countries from 2010 to 2019: a systematic scoping review by Joshua P Vogel, Jack Williams, Tari Turner, Steve McDonald, Alexander John Eggleston, Annabel Richards, Elise Farrington, Wai Chung Tse, Ayeshini Sella Hewage

“…Hypertensive disorders of pregnancy, diabetes and health systems and policy—despite being high-priority topics—had relatively few trials.Conclusion Despite trials conducted in LMICs increasing from 2010 to 2019, there were significant gaps in geographical distribution, alignment with causes of maternal mortality and known research priority topics. …”
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Best practice mechanisms for biodiversity conservation law and policy by Callum Brockett, Katie Woolaston, Felicity Deane, Fran Humphries, Ethan Kumar, Amanda Kennedy, Justine Bell-James

“…The purpose of this paper is to evaluate the literature specifically on biodiversity conservation law, to review and describe the commonalities in laws and legal systems that can be considered successful, or unsuccessful. …”
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Clinical and radiological characteristics and 1-year self-reported outcomes from patients with encephalitis and coronavirus disease 2019 by Nathane Braga da Silva Rezende, Fernanda Gomes de Queiroz Barros-Aragão, Talita Pinto, Viviane Tavares Carvalho Crelier, Marcos Ravi Figueiredo, Carlos Otávio Brandão, Andrea Silveira de Souza, Fernanda Tovar-Moll, Gabriel R. de Freitas

“…Most of them were admitted for neurological symptoms (73%), and in 63% of cases, those symptoms occurred within the first 7 days of systemic symptoms. Most patients had minor pulmonary involvement assessed on chest computed tomography. …”
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A mouse model of immunosuppression facilitates oral Candida albicans biofilms, bacterial dysbiosis and dissemination of infection by Raja Veerapandian, Anuja Paudyal, Sarah M. Schneider, Sonny T. M. Lee, Govindsamy Vediyappan, Govindsamy Vediyappan

“…Opportunistic pathogens are a major threat to people, especially those with impaired immune systems. Two of the most important microbes in this category are the fungus Candida albicans and Gram-positive bacteria of the genus Enterococcus, which share overlapping niches in the oral cavity, gastrointestinal and urogenital tracts. …”
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Ferrostatin-1 inhibits osteoclast differentiation and prevents osteoporosis by suppressing lipid peroxidation by Wenbo Xu, Shiyan Lv, Xiaoyan Wang, Chengchao Song, Chunyang Xi, Jinglong Yan

“…Abstract Background Osteoporosis (OP) is a systemic disease characterized by low bone mass. New progress has been made in the study of OP, such as lipid peroxidation. …”
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A smartphone application to objectively monitor music listening habits in adolescents by Danique E. Paping, Jantien L. Vroegop, Simone P. C. Koenraads, Carlijn M.P. le Clercq, André Goedegebure, Robert J. Baatenburg de Jong, Marc P. van der Schroeff

“…A smartphone application for Android operating systems was developed to objectively monitor music listening habits for a period of 35 days. …”
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Effect of Green Roofs on the Thermal Environment of Prototype Broiler Houses by Maria Angela de Souza, Fernanda Campos de Sousa, Alex Lopes da Silva, Thauane Cordeiro Soares, Charles Paranhos Oliveira, Ricardo Brauer Vigoderis, Fernando da Costa Baêta, Ilda de Fátima Ferreira Tinôco

“…The research tested various roof types (ceramic, fiber cement, and metal) combined with emerald grass (<i>Zoysia japonica</i>) green roof systems. Parameters measured included air temperature, relative humidity, internal roof surface temperature, Temperature and Humidity Index (THI), Black Globe Humidity Index (BGHI), Human Comfort Index (HCI), and Thermal Radiation Load (TRL) under both open and closed conditions. …”
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Intranasal Immunization with DNA Vaccine HA-CCL19/Polyethylenimine/Chitosan Composite Provides Immune Protection Against H7N9 Infection by Yuqing Xiang, Hongbo Zhang, Youcai An, Ze Chen

“…Additionally, our results indicated that the composite formed by the HA-CCL19 DNA in combination with PEI and CS effectively activates local mucosal immunity as well as systemic humoral and cellular immunity, offering 100% protection against lethal doses of homologous virus challenges. …”
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Advances in Therapy for Urothelial and Non-Urothelial Subtype Histologies of Advanced Bladder Cancer: From Etiology to Current Development by Whi-An Kwon, Ho Kyung Seo, Geehyun Song, Min-Kyung Lee, Weon Seo Park

“…For localized disease, curative options such as surgical resection or radiotherapy are available; however, treatment options become more limited in recurrence or metastasis, where systemic therapy is primarily used to control disease progression and palliate symptoms. …”
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Enhancing diagnostic outcomes in kidney genetic disorders: the KidGen national kidney genomics study protocol by Amali Mallawaarachchi, Hugh McCarthy, Thomas A. Forbes, Kushani Jayasinghe, Chirag Patel, Stephen I. Alexander, Tiffany Boughtwood, Jeffrey Braithwaite, Aron Chakera, Sam Crafter, Ira W. Deveson, Randall Faull, Trudie Harris, Lilian Johnstone, Matthew Jose, Anna Leaver, Melissa H. Little, Daniel MacArthur, Tessa Mattiske, Christine Mincham, Kathy Nicholls, Catherine Quinlan, Michael C. J. Quinn, Gopala Rangan, Jessica Ryan, Cas Simons, Ian Smyth, Madhivanan Sundaram, Peter Trnka, Laura Wedd, Erik Biros, Zornitza Stark, Andrew Mallett

“…Precise genetic diagnosis in GKD promises to improve patient outcomes, provide access to targeted treatments, and reduce the disease burden for individuals, families, and healthcare systems. Genetic investigations are increasingly used in nephrology practice; however, many patients who undergo testing still lack a definitive diagnosis. …”
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Customer Loyalty Based on Service Quality, Banking Image, and Fairness Mediating Role of Customer Satisfaction by Abdul Fatah Rusydi, Muhtadi Ridwan, Vivin Maharani Ekowati, Achmad Sani Supriyanto, Fuadah Binti Johari

“…Background: Technological advances have impacted intense business competition in the banking world, requiring all banks to compete in updating systems to maintain customer loyalty, which is essential to a business' success. …”
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The Accumulation Characteristics of the Paleozoic Reservoir in the Central-Southern Ordos Basin Recorded by Organic Inclusions by Ruijing Zhu, Rongxi Li, Xiaoli Wu, Xiaoli Qin, Bangsheng Zhao, Futian Liu, Di Zhao

“…The early-phase inclusions show weak yellow fluorescence and recorded the early formation of liquid hydrocarbons, while the late-phase inclusions are nonfluorescent natural gas inclusions distributed in the late tectonic fractures and recorded the late accumulation of natural gas. The brine systems of the Permian and Ordovician fluid inclusions are, respectively, dominated by CaCl2-H2O and MgCl2-NaCl-H2O. …”
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Comparative evaluation of management practices among large-scale broiler farms of Punjab, Pakistan by Muhammad Tahir Amin, Muhammad Usman, Hafiz Muhammad Ishaq, Asad Ali, Muzamal Tariq, Mian Mubashar Saleem, Syed Ghulam Mohayud Din Hashmi, Kinza Saleem, Sohail Ahmad

“…The results of the survey revealed that the majority of the farms had environmentally controlled housing systems with rearing capacity of 75,000 broiler chickens or more; mostly having Cobb 500 and Ross 308 broiler strains. …”
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Polymer-Free Electrospinning of β-Cyclodextrin–Oligolactide for Magnolol and Honokiol Pharmaceutical Formulations by Diana-Andreea Blaj, Catalina A. Peptu, Mihaela Balan-Porcarasu, Cristian Peptu, Cristina Gabriela Tuchilus, Lacramioara Ochiuz

“…<b>Conclusions:</b> This study demonstrates the potential of MG and HK-loaded β-CDLA fibrous formulations as delivery systems with prolonged antioxidant activity and notable antibacterial efficacy, providing a promising platform for biomedical applications.…”
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Trimodal organ‑preserving treatment of muscle‑invasive bladder cancer by A. V. Troianov, I. O. Dementev, I. N. Zaborsky, V. S. Chaykov, O. B. Karyakin, Yu. V. Gumenetskaya

“…The literature was searched in Medline, Cochrane Library, Elibrary and PubMed systems. Publications describing the modern possibilities of organ‑preserving treatment of muscle‑invasive bladder cancer were included, 58 of which were used to write this review.Results. …”
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Electrocardiographic Changes in Pregnant Patients With Congenital Heart Disease by Maria A. Pabon, Amrit Misra, Kimberlee Gauvreau, Madeline E. Duncan, Ava Conklin, Katherine E. Economy, Fred M. Wu, Thomas Tadros, Anne Marie Valente, For the STORCC Investigators

“…Patients were included if they had at least two EKGs across the perinatal period and were grouped by specific conditions: atrial septal defect (ASD), tetralogy of Fallot, congenital pulmonary stenosis, coarctation of the aorta (CoA), bicuspid aortic valve (BAV), systemic right ventricle (SRV), and Fontan circulation. …”
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Human Platelets Take up Anti-VEGF Agents by B. Sobolewska, B. Fehrenbacher, P. Münzer, H. Kalbacher, S. Geue, Konstantinos Stellos, M. Schaller, F. Ziemssen

“…Growing evidence suggests different systemic exposure of anti-vascular endothelial growth factor (anti-VEGF) agents with repeated intravitreal application. …”
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