The Impact of Amniotic Fluid Interleukin-6, Interleukin-8, and Metalloproteinase-9 on Preterm Labor: A Narrative Review by Theodoros Karampitsakos, Despoina Mavrogianni, Nikolaos Machairiotis, Anastasios Potiris, Periklis Panagopoulos, Sofoklis Stavros, Panos Antsaklis, Peter Drakakis

“…Conclusions: Elevated IL-6 levels and specific gene polymorphisms are strongly associated with preterm delivery risk, with IL-8 concentrations correlating with systemic inflammation and histologic chorioamnionitis. …”
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Real-World Efficacy and Safety of Avelumab Plus Axitinib in Metastatic Renal Cell Carcinoma: Results from the Ambispective RAVE-Renal Study by Ilya Tsimafeyeu, Vyacheslav Chubenko, Olga Baklanova, Alexey Kalpinskiy, Sufia Safina, Andrei Lebedinets, Vladislav Petkau, Elvira Parsadanova, Maria Turganova, Aleksei Shkurat, Natalia Tovbik, Elena Tkacheva, Yulia Anzhiganova, Olga Novikova, Varvara Bragina, Ruslan Zukov, Rashida Orlova

“…The study included adult patients with histologically confirmed mRCC, measurable disease per RECIST version 1.1, and no prior systemic therapy. Patients received avelumab (800 mg intravenously every 2 weeks) plus axitinib (5 mg orally twice daily). …”
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Computed tomography–guided percutaneous biopsy in diagnosis of suspected metastatic renal cell carcinoma: which location is the most suitable? by Petr Hoffmann, Michal Balik, Martina Hoffmannova, Jindrich Kopecky, Pavel Ryska, Jana Draganovicova, Petr Dvorak

“…Introduction: Systemic targeted therapy options are commonly used in patients with metastatic renal cell carcinoma (mRCC). …”
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A synthetic cyclic peptide for promoting antigen presentation and immune activation by Jiahui Zhang, Harrison Y. R. Madge, Asmaa Mahmoud, Lantian Lu, Wanyi Wang, Wenbin Huang, Prashamsa Koirala, Jazmina L. Gonzalez Cruz, Wei Yang Kong, Sahra Bashiri, Ahmed O. Shalash, Waleed M. Hussein, Zeinab G. Khalil, James W. Wells, Istvan Toth, Rachel J. Stephenson

“…All vaccine candidates self-assembled into sub-500 nm nanoparticles and induced high antigen-specific systemic IgG titers and opsonic potential compared to the antigen co-administered with a commercial adjuvant, complete Freund’s adjuvant. …”
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Nonlinear Structural Fusion for Multiplex Network by Nianwen Ning, Feiyu Long, Chunchun Wang, Youjie Zhang, Yilin Yang, Bin Wu

“…Many real-world complex systems have multiple types of relations between their components, and they are popularly modeled as multiplex networks with each type of relation as one layer. …”
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Allogenic Cultured Limbal Epithelial Transplantation and Cultivated Oral Mucosal Epithelial Transplantation in Limbal Stem Cells Deficiency: A Comparative Study by Mohamed Elalfy, Kareem Elsawah, Sundas Maqsood, Nigel Jordan, Mansour Hassan, Ahmed Zaki, Zisis Gatzioufas, Samer Hamada, Damian Lake

“…Although COMET has lower graft survival rate than ACLET, it does not mandate systemic immunosuppression therapy to protect against potential graft rejection.…”
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Socioeconomic status has direct impact on asthma control: Turkish adult asthma registry by Bahar Arslan, Murat Türk, Serhat Hayme, Ömür Aydin, Derya Gokmen, Gozde Koycu Buhari, Zeynep Celebi Sozener, Bilun Gemicioglu, Ismet Bulut, Sengul Beyaz, Cihan Orcen, Secil Kepil Ozdemir, Metin Keren, Ebru Damadoglu, Tugce Yakut, Ayse Fusun Kalpaklioglu, Ayse Baccioglu, Sumeyra Alan Yalim, Insu Yilmaz, Ilkay Koca Kalkan, Elif Yelda Ozgun Niksarlioglu, Ali Fuat Kalyoncu, Gul Karakaya, Muge Erbay, Sibel Nayci, Fatma Merve Tepetam, Asli Akkor Gelincik, Hulya Dirol, Ozlem Goksel, Selen Karaoglanoglu, Ferda Oner Erkekol, Sacide Rana Isik, Fusun Yildiz, Yasemin Yavuz, Dilek Karadogan, Nurgul Bozkurt, Ummuhan Seker, Ipek Kivilcim Oguzulgen, Ilknur Basyigit, Serap Argun Baris, Elif Yilmazel Ucar, Tuba Erdogan, Mehmet Polatli, Dane Ediger, Fatma Esra Gunaydin, Leyla Pur, Zeynep Yegin Katran, Yonca Sekibag, Enes Furkan Aykac, Dilsad Mungan, Ozcan Gul, Ali Cengiz, Bulent Akkurt, Seyma Ozden, Semra Demir, Derya Unal, Ayse Feyza Aslan, Ali Can, Reyhan Gumusburun, Gulhan Bogatekin, Hatice Serpil Akten, Sinem Inan, Munevver Erdinc, Aliye Candan Ogus, Murat Kavas, Demet Polat Yulug, Mehmet Erdem Cakmak, Saltuk Bugra Kaya, Gulistan Alpagat, Eylem Sercan Ozgur, Oguz Uzun, Sule Tas Gulen, Gulseren Pekbak, Deniz Kizilirmak, Yavuz Havlucu, Halil Donmez, Gulden Pacaci Cetin, Sadan Soyyigit, Bilge Yilmaz Kara, Gulden Pasaoglu Karakis, Adile Berna Dursun, Resat Kendirlinan, Ayse Bilge Ozturk, Can Sevinc, Gokcen Omeroglu Simsek, Oznur Abadoglu, Pamir Cerci, Taskin Yucel, Irfan Yorulmaz, Zahide Ciler Tezcaner, Emel Cadalli Tatar, Ahmet Emre Suslu, Serdar Ozer, Engin Dursun, Arzu Yorgancioglu, Gulfem Elif Celik, Mehmet Atilla Uysal

“…Therewithal, being aged between 40 and 60 (OR: 1.435 [95% CI: 1.074–1.917]; p = 0.015), illiteracy (OR: 2.188 [95% CI: 1.262–3.795]; p = 0.005) and being employed (OR: 1.466 [95% CI: 1.085–1.847]; p = 0.011) were considered as independent risk factors for systemic corticosteroid use at least 3 days within last 1 year. …”
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Multi-Temporal Image Fusion-Based Shallow-Water Bathymetry Inversion Method Using Active and Passive Satellite Remote Sensing Data by Jie Li, Zhipeng Dong, Lubin Chen, Qiuhua Tang, Jiaoyu Hao, Yujie Zhang

“…In the three study areas selected in the South China Sea (SCS), the validation is performed by comparing with the measurement data obtained using shipborne single-beam or multi-beam and airborne laser bathymetry systems. The root mean square errors (RMSEs) of the model using the band information after image fusion and median filter processing are better than 1.82 m, and the mean absolute errors (MAEs) are better than 1.63 m. …”
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Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination by Colette B. Rogers, Wendy Leung, Ryan M. Baxley, Rachel E. Kram, Liangjun Wang, Joseph P. Buytendorp, Khoi Le, David A. Largaespada, Eric A. Hendrickson, Anja-Katrin Bielinsky

“…RAD18 also regulates homologous recombination (HR) repair of DNA breaks; however, the current literature describing the contribution of RAD18 to HR in mammalian systems has not reached a consensus. To investigate this, we examined three independent <i>RAD18</i>-null human cell lines. …”
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The Role of Positron Emission Tomography Imaging in Breast Implant Illness by Siham Azahaf, MD, Karlinde A. Spit, MD, Christel J.M. de Blok, MD, PhD, Peter Bult, MD, PhD, Prabath W.B. Nanayakkara, MD, PhD, FRCP

“…All women underwent PET imaging due to persistent systemic symptoms after explantation (n = 17) or replacement (n = 1). …”
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TLR4/AP-1-Targeted Anti-Inflammatory Intervention Attenuates Insulin Sensitivity and Liver Steatosis by Xiang Hu, Jing Zhou, Sha-sha Song, Wen Kong, Yan-Chuan Shi, Lu-Lu Chen, Tian-Shu Zeng

“…Our results indicated that TLR4/AP-1 siRNA transfection alleviated high-fat diet-induced systemic and hepatic inflammation, obesity, and insulin resistance in mice. …”
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Impact of advanced lung cancer inflammation index on all-cause mortality among patients with heart failure: a systematic review and meta-analysis with reconstructed time-to-event d... by Ahmed Mazen Amin, Ramy Ghaly, Hossam Elbenawi, Abdelrahman Ewis, Ubaid Khan, Khaled S. M. Elshaer, Mohamed Abuelazm, Basel Abdelazeem, Brijesh Patel, Farris K. Timimi, Islam Y. Elgendy

“…Abstract Background Heart failure (HF) is associated with systemic inflammation and hypercatabolic syndrome, impacting body metabolism. …”
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Exploring the effects of cannabidiol encapsulation in liposomes on their physicochemical properties and biocompatibility by Inga Jurgelane, Karina Egle, Andra Grava, Dana Galkina, Margarita Brante, Maksims Melnichuks, Marite Skrinda-Melne, Girts Salms, Arita Dubnika

“…Encapsulation in drug delivery systems, particularly liposomes, offers a promising solution. …”
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The Effect of Oral Potentially Malignant Disorders (OPMD) on Dental Implants Survival—A Systematic Review by Sebahat Kaya, Christian Walter, Aya Khamis, Lena Katharina Müller-Heupt, Stefanie Zimmer, Lorena Cascant Ortolano, Keyvan Sagheb, Bilal Al-Nawas, Eik Schiegnitz

“…Data from a patient with proliferative verrucous leukoplakia (PVL) indicated a 100% implant survival rate, while patients with systemic lupus erythematosus (SLE) showed an implant survival rate of 97.67%. …”
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Gut Microbiota, Microinflammation, Metabolic Profile, and Zonulin Concentration in Obese and Normal Weight Subjects by Agnieszka Żak-Gołąb, Piotr Kocełak, Małgorzata Aptekorz, Maria Zientara, Łukasz Juszczyk, Gayane Martirosian, Jerzy Chudek, Magdalena Olszanecka-Glinianowicz

“…Gut microbiota-related systemic microinflammation in the obese is reflected by circulating zonulin level, a potential marker of interstitial permeability.…”
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Renal transplant recipient and deceased-donor risk profiles at Wits Donald Gordon Medical Centre, Johannesburg, South Africa: A 9-year review by F van der Schyff, M Barnard, B Ströbele, M de Jager, R Britz, P Gaylard, J Loveland

“…Decision-making around the acceptance of deceased-donor organs is complex and time sensitive. Risk scoring systems for both donors and recipients attempt to simplify the allocation of renal grafts to the most appropriate recipient. …”
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Effect of Transglutaminase and Bacterial Concentrates on the Development of Functional and Technological Properties of Minced Meat by Svetlana Merenkova, Oksana Zinina, Olga Loretts, Olga Neverova, Pavel Sharaviev

“…Thus, the results showed that the combination of BC and TG demonstrates a synergistic effect on the functional and technological properties of meat systems.…”
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CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite by Juliana Costa Ferreira Neves, Hiochelson Najibe Santos Ibiapina, Fábio Magalhães-Gama, Jacqueline Almeida Gonçalves Sachett, Iran Mendonça Silva, Kerolaine Fonseca Coelho, Eliane Campos Alves, Andréa Monteiro Tarragô, Luiz Carlos de Lima Ferreira, Adriana Malheiro, Wuelton Marcelo Monteiro, Allyson Guimarães Costa

“…B. atrox (BaV) venom can cause systemic pathophysiological changes such as acute kidney injury (AKI), which leads to the production of chemokines and cytokines in response to the envenomation. …”
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Knowledge, attitudes, motivations and expectations regarding antimicrobial use among community members seeking care at the primary healthcare level: a scoping review protocol by Stephen M Campbell, Brian Godman, Eunice Bolanle Turawa, Nishana Ramdas, Johanna C Meyer, Natalie Schellack

“…Introduction Inappropriate antibiotic use in (primary healthcare, PHC) settings fuels antimicrobial resistance (AMR), threatens patient safety and burdens healthcare systems. Patients’ knowledge, attitudes, motivations and expectations play a crucial role in antibiotic use behaviour, especially in low-income and middle-income countries including South Africa. …”
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Total Adiponectin Is Inversely Associated with Platelet Activation and CHA2DS2-VASc Score in Anticoagulated Patients with Atrial Fibrillation by Roberto Carnevale, Daniele Pastori, Mariangela Peruzzi, Elena De Falco, Isotta Chimenti, Giuseppe Biondi-Zoccai, Ernesto Greco, Antonino G. M. Marullo, Cristina Nocella, Francesco Violi, Pasquale Pignatelli, Camilla Calvieri, Giacomo Frati

“…Atrial fibrillation (AF) is burdened by enhanced systemic inflammation and platelet activation, as documented by increased blood levels of soluble CD40L (sCD40L). …”
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