Efficacy of Anti-Cancer Immune Responses Elicited Using Tumor-Targeted IL-2 Cytokine and Its Derivatives in Combined Preclinical Therapies by Sahar Balkhi, Giorgia Bilato, Andrea De Lerma Barbaro, Paola Orecchia, Alessandro Poggi, Lorenzo Mortara

“…Durable outcomes require targeting both tumor cells and the TME while minimizing systemic toxicity. Interleukin-2 (IL-2)-based therapies have shown efficacy in cancers such as metastatic melanoma and renal cell carcinoma but are limited by severe side effects. …”
Get full text

Renal Transplantation Dramatically Reduces IgA Anti-beta-2-glycoprotein I Antibodies in Patients with Endstage Renal Disease by Manuel Serrano, Jose Angel Martínez-Flores, Maria José Castro, Florencio García, David Lora, Dolores Pérez, Esther Gonzalez, Estela Paz-Artal, Jose M. Morales, Antonio Serrano

“…Patients with different etiologies of ESRD showed higher levels of IgA aB2GPI than blood donors, except the groups of non-IgA glomerular disease and systemic erythematosus lupus, whose nonsignificant differences were observed. …”
Get full text

Effect of 12 weeks of selective cardiorespiratory endurance and plyometrics training on 800-meter rural collegiate athletes: a randomised controlled trial by Neeraj Kumar, Anand N. Badwe

“…Introduction The 800-meter race is a middle-distance run where both anaerobic and aerobic energy systems contribute significantly. The purpose of the present study was to determine the effects of 12 weeks of selective plyometrics training in addition to their regular cardiorespiratory endurance training on the running performance in 800-meterrural collegiate athletes. …”
Get full text

Temporal Analysis of the Incidence, Mortality and Disability-Adjusted Life Years of Benign Gallbladder and Biliary Diseases in High-Income Nations, 1990–2019 by Dominic W. Proctor, BMBS, MSc, Richard Goodall, BSc, MBChB, MRCS, FHEA, Kim Borsky, MBBS, MMRCS, Justin D. Salciccioli, MBBS, MA, Dominic C. Marshall, MBBS, MRCP, BSc, Kumaran Shanmugarajah, MD, PhD, Joseph Shalhoub, BSc, MBBS, FHEA, PhD, DIC, MEd, FFSTEd, FRCS, FEBVS

“…Benign gallbladder and biliary diseases place a substantial burden on healthcare systems in high-income countries. Accurate characterization of the disease burden may help optimize healthcare policy and resource distribution. …”
Get full text

Fully Automated Production of (((<i>S</i>)-1-Carboxy-5-(6-([¹⁸F]fluoro)-2-methoxynicotinamido)pentyl)carbamoyl)-<span style="font-variant: small-caps">l</span>-glutamic... by Philipp Krapf, Thomas Wicher, Boris D. Zlatopolskiy, Johannes Ermert, Bernd Neumaier

“…Although this procedure could be automated on two-reactor modules like the GE TRACERLab FX2N (FXN) to afford the tracer in modest radiochemical yields (RCY) of 18–25%, it is unsuitable for cassette-based systems with a single reactor. <b>Methods:</b> To simplify implementation on an automated synthesis module, the radiosynthesis of [¹⁸F]JK-PSMA-7 was devised as a one-pot, two-step reaction. …”
Get full text

Protective Role of Genistein in Acute Liver Damage Induced by Carbon Tetrachloride by Nalan Kuzu, Kerem Metin, Adile Ferda Dagli, Fatih Akdemir, Cemal Orhan, Mehmet Yalniz, Ibrahim Hanifi Ozercan, Kazim Sahin, Ibrahim Halil Bahcecioglu

“…Genistein reduces liver damage by preventing lipid peroxidation and strengthening antioxidant systems.…”
Get full text

The autoimmune disease risk variant NCF1-His90 is associated with a reduced risk of tuberculosis in women by Xinjun Hu, Shasha Li, Renliang Huang, Ziwei Fu, Chenyu Ma, Zheng Cheng, Hongjun Hu, Qiaomiao Zhou, Frank Petersen, Xinhua Yu, Xinhua Yu, Junfeng Zheng

“…This casual variant confers an increased risk for multiple autoimmune disorders, including primary Sjögren’s syndrome and systemic lupus erythematosus. Given the high prevalence of this autoimmune disease risk variant in East Asia, we hypothesized that it may confer an evolutionary advantage by providing protection against infectious diseases.MethodsTo test this hypothesis, we investigated whether the NCF1 rs201802880 variant offers a protective effect against tuberculosis (TB), a historically significant and deadly infectious disease. …”
Get full text

Ginsenoside Rg1 Regulates SIRT1 to Ameliorate Sepsis-Induced Lung Inflammation and Injury via Inhibiting Endoplasmic Reticulum Stress and Inflammation by Qian-Lu Wang, Lei Yang, Yue Peng, Min Gao, Ming-Shi Yang, Wei Xing, Xian-Zhong Xiao

“…Cultured human pulmonary epithelial cell line A549 was challenged with LPS to induce cell injury, and CLP mouse model was generated to mimic clinical condition of systemic sepsis. Rg1 was applied to cells or animals at indicated dosage. …”
Get full text

Development of the relationship between visual selective attention and auditory change detection by Yuanjun Kong, Xuye Yuan, Yiqing Hu, Bingkun Li, Dongwei Li, Jialiang Guo, Meirong Sun, Yan Song

“…Understanding the developmental trajectories of the auditory and visual systems is crucial to elucidate cognitive maturation and its associated relationships, which are essential for effectively navigating dynamic environments. …”
Get full text

A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor by Rebecca L. Brouillette, Christine E. Mona, Michael Desgagné, Malihe Hassanzedeh, Émile Breault, Frédérique Lussier, Karine Belleville, Jean-Michel Longpré, Michel Grandbois, Pierre-Luc Boudreault, Élie Besserer-Offroy, Philippe Sarret

“…To study their functional role in regulating specific receptor systems, current research relies mainly on genetic tools, as few pharmacological options are available. …”
Get full text

Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease by L. M. O. Caram, R. A. F. Amaral, R. Ferrari, S. E. Tanni, C. R. Correa, S. A. R. Paiva, I. Godoy

“…COPD was associated with lower serum concentrations of vitamin A without relationship with the systemic inflammation. Conclusions. Serum concentration of vitamin A is negatively associated with the presence of COPD and positively associated with smoking status. …”
Get full text

Comparison of dairy production based on feed of Pennisetum sp., Pennisetum purpureum and CIAT 36087 by Noel Ernesto Blanco–Roa, Hernaldo Ramón Novoa–Novoa, Eveling Cristina Berríos, Omar Alfredo Soto–Gutiérrez, Carlos Alberto Zúniga–González, Silvio Javier Sáenz–Rojas, José de Jesús Nuñez–Rodriguez

“… In dairy production systems, efficient pasture management is crucial for maximizing milk output while minimizing costs. …”
Get full text

Loss of protein C vs protein S results in discrepant thrombotic phenotypes by Chia-Jui Ku, Xinge Yu, Queena Y. Zhao, Steven J. Grzegorski, Jeffrey G. Daniel, Allison C. Ferguson, Jordan A. Shavit

“…Although both mutants demonstrated spontaneous thrombosis, proc−/− was localized to the cardiac and venous systems, whereas pros1−/− was intracardiac. Aside from coagulation, PC has been shown to have PS-independent roles in inflammation. proc mutants displayed altered inflammatory markers and defects in neutrophil migration independent of pros1. …”
Get full text

The impact of the COVID-19 pandemic on time to treatment in head and neck cancer management: a systematic review by Malte Grumstrup Simonsen, Amanda-Louise Fenger Carlander, Kathrine Kronberg Jakobsen, Christian Grønhøj, Christian von Buchwald

“…Background and purpose: Coronavirus disease 2019 (COVID-19) caused a need for reorganization in the healthcare systems. First, we aimed to determine the impact of the COVID-19 pandemic on time to treatment in head and neck cancer (HNC) patients. …”
Get full text

DualTransAttNet: A Hybrid Model with a Dual Attention Mechanism for Corn Seed Classification by Fei Pan, Dawei He, Pengjun Xiang, Mengdie Hu, Daizhuang Yang, Fang Huang, Changmeng Peng

“…The model’s rapid inference capability and low parameter count make it an excellent technical solution for agricultural automation and intelligent systems, thereby enhancing the efficiency and profitability of agricultural production.…”
Get full text

Assessing the Colorectal Cancer Landscape: A Comprehensive Exploration of Future Trends in 216 Countries and Territories from 2021 to 2040 by Meysam Olfatifar, Fariba Rafiei, Amir Sadeghi, Elnaz Ataei, Mohammad Amin Habibi, Mehdi Pezeshgi Modarres, Zohreh Ghalavand, Hamidreza Houri

“…Abstract Background Colorectal cancer (CRC) has become a significant global concern, presenting formidable challenges to healthcare systems and leading to substantial healthcare expenses. …”
Get full text

Supply-Side Practices and Constraints of the Kola Nut (Cola nitida (Vent) Schott. and Endl.) Value Chain in Ghana: A Descriptive Evidence by Frederick Amon-Armah, Solomon Sefa Oduro, Eric Kofi Doe, Moses Asani, Daniel Nyadanu, Sampson Konlan

“…To overcome some marketing challenges, there is a need for policy support to standardize pricing and grading systems for the mutual benefit of all the stakeholders.…”
Get full text

Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia by Emmanuel Amabebe, Zheping Huang, Sukanta Jash, Balaji Krishnan, Shibin Cheng, Akitoshi Nakashima, Yitong Li, Zhixong Li, Ruizhi Wang, Ramkumar Menon, Xiao Zhen Zhou, Kun Ping Lu, Surendra Sharma

“…These events may eventually damage the endothelium and cause systemic features of disorders such as preE. Despite impressive research and therapeutic advances in both fields of preE and neurodegenerative diseases, further investigation of Pin1-cis P-tau and ApoE-related mechanistic underpinnings may unravel novel therapeutic options, and new transcriptional and proteomic markers. …”
Get full text

Exploring the effects of dietary methionine supplementation on European seabass mucosal immune responses against Tenacibaculum maritimum by Inês Carvalho, Inês Carvalho, Diogo Peixoto, Diogo Peixoto, Inês Ferreira, Inês Ferreira, Diego Robledo, Diego Robledo, Lourenço Ramos-Pinto, Rodolfo Miguel Silva, José Fernando Gonçalves, Marina Machado, Carolina Tafalla, Benjamin Costas, Benjamin Costas

“…`DiscussionOverall, these findings indicate that dietary methionine supplementation may significantly influence both systemic and local immune responses in European seabass, highlighting the need for careful consideration when supplementing diets with methionine.…”
Get full text

Effect of non-surgical periodontal therapy on salivary and gingival crevicular fluid concentration of visfatin in periodontal health and disease by Hira Ismail, Anjani Kumar Pathak, Nand Lal, Pavitra Rastogi, Kaleem Ahmad, Mohd. Aamir Khan

“…Background and objective: Visfatin, a pleotropic mediator mostly produced by visceral fat, is crucial in controlling the immunological and defensive systems. It serves the roles of a cytokine, an enzyme involved in energy metabolism, and a growth factor. …”
Get full text