Case report: Spontaneous renal hemorrhage in anti-neutrophil cytoplasmic antibody-associated vasculitis by Ruohan Yu, Lina Zhang, Ting Long, Hui Gao, Jing Xu, Tong Zhang, Shengguang Li

“…Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic necrotizing vasculitis that predominantly affects small vessels. …”
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Exploratory study on the efficacy of topical pan-JAK inhibitor in ocular and skin GVHD in a sclerodermatous GVHD mouse model by Shinri Sato, Yoko Ogawa, Kazuki Asai, Eisuke Shimizu, Shota Shimizu, Hiroko Taniguchi, Takahiro Okazaki, Shigeto Shimmura, Kazuno Negishi, Masatoshi Hirayama

“…Abstract Systemic administration of Janus kinase (JAK) inhibitors is effective in treating chronic graft-versus-host disease (cGVHD) but is associated with side effects. …”
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Carrageenan-induced acute inflammation in the mouse air pouch synovial model. Role of tumour necrosis factor by M. Romano, R. Faggioni, M. Sironi, S. Sacco, B. Echtenacher, E. Di Santo, M. Salmona, P. Ghezzi

“…In serum, the levels of interleukin 1 (IL-1), interleukin 6 (IL-6), tumour necrosis factor (TNF), serum amiloid-A (SAA) and Fe++ were never different from controls, indicating that no systemic inflammatory changes were induced. Locally the exudate volume and the number of leukocytes recruited into the pouch increased progressively until 7 days after carrageenan. …”
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Caspase-11 Modulates Inflammation and Attenuates Toxoplasma gondii Pathogenesis by Sheryl L. Coutermarsh-Ott, John T. Doran, Caroline Campbell, Tere M. Williams, David S. Lindsay, Irving C. Allen

“…This attenuated host response was associated with reduced local and systemic cytokine production, including diminished IL-1β. …”
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Modelling Seismically Induced Mesothermal Goldfields along the Deep-Rooted Cadillac-Larder Lake Fault, Abitibi, Canada by Pierre Bedeaux, Silvain Rafini, Pierre Pilote, Réal Daigneault

“…Various rheological factors are evaluated for optimizing the models’ ability to reproduce known gold occurrences, regarded as the fossil primary markers of synkinematic hydrothermal systems. We propose that the marked structural heterogeneities of the CLLF induced persistent seismic segmentation and recurrent ruptures of the same fault windows that arrested on robust node points. …”
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Elucidating the metabolic mechanisms and active constituents of ZuoGui Wan in combatting postmenopausal osteoporosis: A metabolomics and network pharmacology approach by Yanchen Feng, KaiKai Shi, Dingming Li, Shunzhi Yang, Xue Dang, Jinyao Li, Yan Chen, Jianping Yao, Yunke Zhang, Lu Sun, Feixiang Liu

“…Background: Postmenopausal osteoporosis (PMOP) is a systemic metabolic disease with an imbalance of bone resorption and bone formation coupling as the basic pathogenesis. …”
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3D printing driving innovations in extreme low-temperature energy storage by Shutong Qin, Jiao Dai, Haoran Tian, Hanyuan Zhang, Jingru Huang, Tianqi Guan, Weilin Xu, Jun Wan

“…Extreme low-temperature environments, such as those in aerospace, polar expeditions, and deep-sea exploration, demand efficient energy storage systems. Conventional technologies face major limitations under these conditions, including electrolyte freezing, restricted interfacial reaction kinetics, and microstructural instability. …”
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Safety and Biodistribution of an Autologous Bone Marrow-Derived Mononuclear Cell Infusion into Renal Arteries in Patients with Focal Segmental Glomerulosclerosis: A Phase 1 Study by Bruno Freire Botelho, André Luis Barreira, Marcio Gomes Filippo, Karina Dutra Asensi, Lanuza A P Faccioli, Anna Beatriz dos Santos Salgado, Elizabeth Figueiredo de Salles, Carlos Eduardo Cruz Marques, Pedro Leme Silva, Regina Coeli dos Santos Goldenberg, Angelo Maiolino, Bianca Gutfilen, Sergio Augusto Lopes de Souza, Maurilo Leite Junior, Marcelo Marcos Morales

“…Patients with focal segmental glomerulosclerosis (FSGS) who are refractory to drug treatment may present progressive loss of kidney function, leading to chronic kidney disease stage 5 under dialysis treatment. The safety of systemic administration of bone marrow-derived mononuclear cells (BMDMCs) has been shown in different preclinical models of kidney diseases. …”
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Effects of Stromal Cell-Derived Factor-1α Secreted in Degenerative Intervertebral Disc on Activation and Recruitment of Nucleus Pulposus-Derived Stem Cells by Jinwei Ying, Zhihua Han, Shishen Pei, Linghao Su, Dike Ruan

“…In addition to enhancement of viability, SDF-1α significantly increased the number of NPSCs migrating into the center of the nucleotomized bovine IVD ex vivo. After the systemic delivery of exogenous PKH26-labelled NPSCs into the rats in vivo, there was a significant difference in the distribution of the migrated cells between the normal and the degenerative IVDs, which might be caused by the different expression levels of SDF-1α. …”
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Research of the microwave generator and antenna emitters for hyperthermia of oncological diseases by V. V. Fedyanin

“…Software is used to develop high-frequency systems. Results. The directional patterns of the electric field of the developed antennas are obtained. …”
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Chlormethine Gel for Treatment of Patients with Mycosis Fungoides: Best Practices and Guidance to Clinicians by Larisa Geskin, Christiane Querfeld, Emmilia Hodak, Neda Nikbakht, Evangelia Papadavid, Marco Ardigò, Ulrike Wehkamp, Martine Bagot

“…For patients with late-stage MF, skin-directed treatments such as chlormethine gel should be combined with systemic therapies. Conclusions Chlormethine gel is a safe and effective treatment option that can be used in all stages of MF, either as monotherapy or in combination, depending on disease stage and patient characteristics and needs.…”
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Integrated Photonic Neural Networks for Equalizing Optical Communication Signals: A Review by Luís C. B. Silva, Pablo R. N. Marciano, Maria J. Pontes, Maxwell E. Monteiro, Paulo S. B. André, Marcelo E. V. Segatto

“…The demand for high-capacity communication systems has grown exponentially in recent decades, constituting a technological field in constant change. …”
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Chemogenomic Screening in a Patient‐Derived 3D Fatty Liver Disease Model Reveals the CHRM1‐TRPM8 Axis as a Novel Module for Targeted Intervention by Sonia Youhanna, Aurino M. Kemas, Shane C. Wright, Yi Zhong, Britta Klumpp, Kathrin Klein, Aikaterini Motso, Maurice Michel, Nicole Ziegler, Mingmei Shang, Pierre Sabatier, Aimo Kannt, Hongda Sheng, Nuria Oliva‐Vilarnau, Florian A. Büttner, Brinton Seashore‐Ludlow, Jonas Schreiner, Maike Windbergs, Martin Cornillet, Niklas K. Björkström, Andreas J. Hülsmeier, Thorsten Hornemann, Jesper V. Olsen, Yi Wang, Roberto Gramignoli, Michael Sundström, Volker M. Lauschke

“…Combined, this study presents the first patient‐derived 3D MASH model, identifies a novel signaling module with anti‐fibrotic effects, and highlights the potential of organotypic culture systems for phenotype‐based chemogenomic drug target identification at scale.…”
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How Much Time Should Be Waited and What Are the Main Findings to Evaluate the Hepatocellular Carcinoma Response to Regorafenib? A Real-Life Experience by Gustavo Hideki Kawanami, Leopoldo Katsuda, Thiara Barcelos Rocha, Fabio da Silva Yamashiro, Leonardo Pelafsky, Xingshun Qi, Fernando Gomes Romeiro

“…This case report is about a cirrhotic patient who received many types of treatment, from surgery and chemoembolization during early stages to first- and second-line systemic therapy when the disease turned to be advanced. …”
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Impact of High Glucose on Bone Collagenous Matrix Composition, Structure, and Organization: An Integrative Analysis Using an Ex Vivo Model by Rita Araújo, Ricardo N. M. J. Páscoa, Raquel Bernardino, Pedro S. Gomes

“…Diabetes mellitus is a widespread metabolic disorder linked to numerous systemic complications, including adverse effects on skeletal health, such as increased bone fragility and fracture risk. …”
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Flood Risk Assessment and Zoning for Niamey and Lokoja Metropolises in Niger and Nigeria by Youssoufa Doulla Nouhou, Martins Yusuf Otache, Salamatou Abdourahamane Illiassou, Olasunkanmi Habeeb Okunola, Appollonia Aimiosino Okhimamhe, Thanh Thi Nguyen

“…This comparative study between Niamey and Lokoja employs Geographic Information Systems (GIS) and the Analytical Hierarchy Process (AHP) to delineate flood susceptibility, vulnerability, and risk zones. …”
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In Situ Gelling Dexamethasone Oromucosal Formulation: Physical Characteristics Influencing Drug Delivery by Daniel Krchňák, Ľudmila Balážová, Michal Hanko, Dominika Žigrayová, Miroslava Špaglová

“…Overall, the research highlights the potential of mucoadhesive systems in improving the therapeutic efficacy of oromucosal drug delivery for managing painful oral lesions.…”
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Lysosome and Cytoskeleton Pathways Are Robustly Enriched in the Blood of Septic Patients: A Meta-Analysis of Transcriptomic Data by Jie Ma, Chuanxi Chen, Andreas S. Barth, Chris Cheadle, Xiangdong Guan, Li Gao

“…A better understanding of the blood systems response to sepsis should expedite the identification of biomarkers for early diagnosis and therapeutic interventions. …”
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ANALYSIS OF THE INTERACTIONS OF NEURONAL APOPTOSIS GENES IN THE ASSOCIATIVE GENE NETWORK OF PARKINSON’S DISEASE by M. A. Yankina, O. V. Saik, P. S. Demenkov, E. K. Khusnutdinova, E. I. Rogaev, I. N. Lavrik, V. А. Ivanisenko

“…Analysis of gene networks is one of the key approaches in systems biology. We previously developed the ANDSystem tool, designed to automatically extract knowledge from scientific publications and reconstruct on this basis associative gene networks describing the molecular genetic mechanisms of biological processes. …”
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Silicon and Phosphorus Co-doping of Aluminium Nitride Nanotube (SiP-AlNNT) as Sensors for Polycyclic Aromatic Hydrocarbon Fuel Pollutants: A Computational Approach by Musa Runde, Uzairu Muhammad Sada, Friday Odey Izachi, Odey S. Eburu, Anthony M.S. Pembere

“…The novelty of this study is modelled aluminium nitride nanotube with silicon and phosphorus co-doping (SiP-AlNNT) to study its potential towards the sensing and adsorption of PAHs, particularly, anthracene, naphthalene, phenanthrene, and pyrene through the density functional theory (DFT) at the B3LYP-D3/def2svp level of theory. The systems underwent a series of analyses and the results are promising. …”
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