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  1. 50281
  2. 50282

    Whole-Body Physiologically Based Pharmacokinetic Modeling of GalNAc-Conjugated siRNAs by Emilie Langeskov Salim, Kim Kristensen, Erik Sjögren

    Published 2025-01-01
    “…We aimed to develop a generic GalNAc-siRNAs whole-body physiologically based pharmacokinetic–pharmacodynamic (WB-PBPK-PD) model for describing the pharmacokinetic–pharmacodynamic (PK-PD) relationship and overall tissue distribution in the open-source platform Open Systems Pharmacology Suite. <b>Methods</b>: Model development was performed using published studies in mice leveraging the PK-Sim<sup>®</sup> standard implementation for large molecules with added implementations of ASGPR-mediated liver disposition and downstream target effects. …”
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  3. 50283

    LAND USE CHANGES AND LAND DEGRADATION IN POST-SOCIALIST ROMANIA by DAN BĂLTEANU, ELENA-ANA POPOVICI

    Published 2010-12-01
    “…En même temps, on constate une dégradationaccentuée des terrains, comme résultat d’une utilisation irrationnelle du fonds foncier, de l’abandon on destruction des systèmes d’amélioration et de la faible fertilisation des terrains agricoles. …”
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  4. 50284

    SynoExtractor: A Novel Pipeline for Arabic Synonym Extraction Using Word2Vec Word Embeddings by Rawan N. Al-Matham, Hend S. Al-Khalifa

    Published 2021-01-01
    “…Automatic synonym extraction plays an important role in many natural language processing systems, such as those involving information retrieval and question answering. …”
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    Article
  5. 50285

    Details of Walker 256 carcinosarcoma growth in Brattleboro and ISIAH lines of rats by I. I. Khegay

    Published 2016-05-01
    “…The growth dynamics of transplantable Walker 256 carcinosarcoma was investigated in rats modeling inherited systemic pathological processes. Hypothalamic diabetes insipidus is developing in Brattleboro rats on the background of total vasopressin absence in the blood. …”
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  6. 50286

    Exosomes Regulate the Transformation of Cancer Cells in Cancer Stem Cell Homeostasis by Jiasheng Xu, Kaili Liao, Weimin Zhou

    Published 2018-01-01
    “…In different biological model systems, exosomes are considered mediators of cell-cell communication between different cell populations. …”
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  7. 50287

    Legal liability for theft under martial law: substantive and procedural aspects by Ostrohliad O.

    Published 2024-12-01
    “…The following methods of scientific knowledge were used during the study: terminological, systemic and structural, comparative legal and analytical methods (when analyzing and comparing existing judicial practice for several years). …”
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    Article
  8. 50288
  9. 50289

    An Ensemble Learning Based Intrusion Detection Model for Industrial IoT Security by Mouaad Mohy-Eddine, Azidine Guezzaz, Said Benkirane, Mourade Azrour, Yousef Farhaoui

    Published 2023-09-01
    “…Accordingly, Intrusion Detection Systems (IDSs) have been developed to forestall inevitable harmful intrusions. …”
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  10. 50290

    Long COVID in patients with rheumatologic disease: A single center observational study by Horacio Quinones-Moya, Armando Ocampo-Del Valle, Adolfo Camargo-Coronel, Francisco Javier Jimenez-Balderas, Miriam Berenice Bernal-Enriquez, Pedro Madinabeitia-Rodríguez, Kenia Nahomi Morales-Medino, Cynthia Roque-Ibanez, Mario Raúl Hernandez-Zavala

    Published 2023-01-01
    “…Results: We included 64 patients: 19 patients with rheumatoid arthritis (RA), 21 patients with systemic lupus erythematosus (SLE), and 24 with other rheumatological diseases. …”
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    Article
  11. 50291

    National, International and Legal Mechanisms of Control over the Activity of Non-Government Security Entities by M. V. Zavalnyi

    Published 2019-06-01
    “…The author has distinguished four possible ways to influence private security companies: national legal systems and courts; corporate norms; international and regional voluntary initiatives; international and legal regulation.…”
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  12. 50292

    EDUCATIONAL SOFTWARE AND ARTIFICIAL INTELLIGENCE: STUDENTS' EXPERIENCES AND INNOVATIVE SOLUTIONS by Norbert Annuš

    Published 2024-06-01
    “… The digitisation of education systems has been a growing trend in recent years. …”
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  13. 50293

    Future Studies of Tourism Development Planning (Case study: Ardabil province) by hossein nazmfar, ameneh alibakhshi

    Published 2021-12-01
    “…In the second step, using the Micmac method, 14 key Factors, including the comprehensive tourism plan, the media, stimulus policies, macro policies of the state, distribution of facilities, infrastructure, recreational centers, increased private incentive to invest in the region, the region's susceptibility to Investment in tourism, planning, security facilities, budget, the existence of hot and mineral water springs, improvement of information systems, such as site and blog, have been identified as key to the development of Ardebil province. …”
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  14. 50294

    Method to Calculate Working Surface Abutment Pressure Based on Key Strata Theory by Hongkai Han, Jialin Xu, Xiaozhen Wang, Jianlin Xie, Yantuan Xing

    Published 2019-01-01
    “…The calculated results were verified using measurements from borehole stress meters and microseismic monitoring systems, as well as numerical simulations. In addition, the calculation results were used to determine a reasonable position for the stopping line and remaining width of the roadway’s protection coal pillar in working surface 207. …”
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  15. 50295

    Tissue-Related Hypoxia Attenuates Proinflammatory Effects of Allogeneic PBMCs on Adipose-Derived Stromal Cells In Vitro by Polina I. Bobyleva, Elena R. Andreeva, Aleksandra N. Gornostaeva, Ludmila B. Buravkova

    Published 2016-01-01
    “…Depending on the application mode ASC/allogeneic immune cell interaction can occur in the systemic circulation under plenty high concentrations of O2 and in target tissues at lower O2 levels. …”
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  16. 50296

    THE ROLE OF DIGITAL MEDIA IN DEVELOPING AN ONLINE ANATOMY COURSE FOR THE ACQUISITION OF PRE-SERVICE SCIENCE TEACHERS' HEALTH LITERACY by Handan Ürek

    Published 2024-12-01
    “…The instruction process covered the systems in human body. Each course began with the examination of several digital media news regarding the focus of the course. …”
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  17. 50297

    PARTICULARITIES OF THE FUNCTIONAL PROFILE AND URBAN RELATIONS IN POST-SOCIALIST LUGOJ MUNICIPALITY by IOAN SEBASTIAN JUCU

    Published 2010-07-01
    “…Le profil fonctionnel d’une ville est déterminé par son héritagehistorique, son évolution sociale et économique, par ses traditions mises en évidence petit à petit et par les effets des systèmes politiques qui l’a gouverné à diverses périodes. …”
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  18. 50298
  19. 50299

    Hörerwartung im zeitlichen Fluss der Musik. Überlegungen zum Expektanzbegriff by Helga de la Motte-Haber

    Published 2013-01-01
    “…Special attention is devoted to the question of the relationship between musical expectancy and the phenomenology of time experience, since the latter has penetrated music-theoretical systems. The synoptical view on the diverse perspectives results in a critical assessment of research on musical expectancy, as this type of research has developed into a rather closed, hermetic field. …”
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  20. 50300

    A flexible PI/MXene triboelectric nanogenerator for energy harvesting and motion monitoring in table tennis by Dazhong Xu, Xiaoxin Ma, Yong Ma

    Published 2025-01-01
    “…This research demonstrates the PC-TENG’s potential for efficient energy harvesting and dynamic sensing, offering innovative solutions for self-powered devices and monitoring systems.…”
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