IL-2-armored peptide-major histocompatibility class I bispecific antibodies redirect antiviral effector memory CD8+ T cells to induce potent anti-cancer cytotoxic activity with lim... by John S. Schardt, Even Walseng, Kim Le, Chunning Yang, Pooja Shah, Ying Fu, Kausar Alam, Cathryn R. Kelton, Yu Gu, Fengying Huang, Jia Lin, Wenhai Liu, Andrew Dippel, Hanzhi Zhang, Kathy Mulgrew, Stacy Pryts, Vijaykumar Chennupati, Hung-Chang Chen, Jessica Denham, Xiaoru Chen, Pallab Pradhan, Yuling Wu, Colin Hardman, Chihao Zhao, Michael Kierny, Yang Song, Simon J. Dovedi, Saso Cemerski, Yariv Mazor

“…Nevertheless, the widespread utility of classical CD3-targeted TCEs has been limited by narrow therapeutic index (TI) linked to systemic CD4+ T cell activation and aberrant cytokine release. …”
Get full text

Diagnostic and Predictive Values of Inflammatory Factors in Pathology and Survival of Patients Undergoing Total Cystectomy by Xingxing Tang, Yudong Cao, Jia Liu, Shuo Wang, Yong Yang, Peng Du

“…The values of neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio (dNLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and systemic immune-inflammation index (SII) were calculated by blood routine test results before operation. …”
Get full text

Association of over-the-counter mouthwash use with markers of nitric oxide metabolism, inflammation, and endothelial function—a cross-sectional study by Kai Guo, Kaumudi Joshipura, Karina Ricart, Rakesh P. Patel, Barbara A. Gower, Oelisoa Mireille Andriankaja, Evangelia Morou-Bermudez

“…IntroductionRegular use of mouthwash can disrupt nitrate reduction by oral bacteria and may affect systemic nitric oxide (NO) levels, which are important for inflammation and endothelial function. …”
Get full text

Target trial emulation to evaluate the effect of immune-related adverse events on outcomes in metastatic urothelial cancer by Renate Pichler, Josef Fritz, Sarah Maier, Melanie R. Hassler, Johanna Krauter, David D`Andrea, Ekaterina Laukhtina, Kilian Gust, Keiichiro Mori, Karl H. Tully, Dora Niedersuess-Beke, Lea Korber, Jasmin Alija Spiegelberg, Thomas Bauernhofer, José D. Subiela, Roman Mayr, Andreas Kronbichler, Marco Moschini, Jeremy Teoh, Benjamin Pradere, Shahrokh F. Shariat, Hanno Ulmer, Laura S. Mertens, European Association of Urology–Young Academic Urologists (EAU-YAU): Urothelial Carcinoma Working Group

“…In patients with irAEs, systemic corticosteroids did not negatively impact survival. …”
Get full text

Impact of Immune Checkpoint Inhibitors and Local Radical Treatment on Survival Outcomes in Synchronous Oligometastatic NSCLC by Mandy Jongbloed, MD, Valentina Bartolomeo, MD, Martina Bortolot, MD, Shahan Darwesh, MD, Jarno W.J. Huijs, MD, Safiye Dursun, MD, Juliette Degens, MD, PhD, Ben E.E.M. van den Borne, MD, PhD, Maggy Youssef-El Soud, MD, PhD, Marcel Westenend, MD, PhD, Cordula Pitz, MD, PhD, Dirk K.M. De Ruysscher, MD, PhD, Lizza E.L. Hendriks, MD, PhD

“…Introduction: The impact of an immune checkpoint inhibitor (ICI)–based systemic treatment strategy with or without local radical treatment (LRT) on outcomes for patients with NSCLC and synchronous oligometastatic disease (sOMD) is unknown. …”
Get full text

Atlas of multilineage stem cell differentiation reveals TMEM88 as a developmental regulator of blood pressure by Sophie Shen, Tessa Werner, Samuel W. Lukowski, Stacey Andersen, Yuliangzi Sun, Woo Jun Shim, Dalia Mizikovsky, Sakurako Kobayashi, Jennifer Outhwaite, Han Sheng Chiu, Xiaoli Chen, Gavin Chapman, Ella M. M. A. Martin, Di Xia, Duy Pham, Zezhuo Su, Daniel Kim, Pengyi Yang, Men Chee Tan, Enakshi Sinniah, Qiongyi Zhao, Sumedha Negi, Meredith A. Redd, Joseph E. Powell, Sally L. Dunwoodie, Patrick P. L. Tam, Mikael Bodén, Joshua W. K. Ho, Quan Nguyen, Nathan J. Palpant

Get full text

Biologic Therapy and Cardiometabolic Risk in Psoriasis: A Retrospective Review by Annika Smith, Aidin Karahasan, Deborah Yi, Sanjay Yapabandara, James Elhindi, Pablo Fernandez-Penas, Clara Chow, Sarah Zaman

“…Abstract Introduction Psoriasis is a systemic inflammatory disease with increased cardiometabolic risk including dyslipidaemia and diabetes. …”
Get full text

Small extracellular vesicles derived from sequential stimulation of canine adipose-derived mesenchymal stem cells enhance anti-inflammatory activity by Saranyou Oontawee, Parkpoom Siriarchavatana, Watchareewan Rodprasert, Irma Padeta, Yudith Violetta Pamulang, Poorichaya Somparn, Trairak Pisitkun, Boondarika Nambooppha, Nattawooti Sthitmatee, Daneeya Na Nan, Thanaphum Osathanon, Hiroshi Egusa, Chenphop Sawangmake

Get full text

Aux sources de la spécialisation hémisphérique cérébrale du langage : l'intérêt de l'IRM anatomique chez le babouin by Adrien Meguerditchian, Damien Marie, Muriel Roth, Romain Lacoste, Bruno Nazarian, Ivan Balansard, Jean-Luc Anton, Olivier Coulon, Alice Bertello, Jean-Noël Benoit, Scott A. Love, Thomas Brochier, Martine Meunier, Sandrine Melot‑Dusseau, Jean‑Christophe Marin, William D Hopkins

“…Nous avons ainsi suggéré l'hypothèse selon laquelle la communication gestuelle pourrait impliquer davantage l'hémisphère gauche et constituer ainsi un système latéralisé précurseur de celui du langage chez l'homme. …”
Get full text

Gender differences in use of cigarette and non-cigarette tobacco products among adolescents aged 13–15 years in 20 African countries by Israel T. Agaku, Rose Sulentic, Adriana Dragicevic, Gibril Njie, Candace K. Jones, Satomi Odani, Tina Tsafa, Joy Gwar, Constantine I. Vardavas, Olalekan Ayo-Yusuf

Get full text

Family-focused intervention programme to foster adolescent mental health and well-being: protocol for a multicountry cluster randomised factorial trial (FLOURISH Phase 2) by Heather M Foran, Marija Raleva, Nina Heinrichs, Graham Moore, Yulia Shenderovich, Xiang Zhao, Judith Simon, Antonio Piolanti, Viorel Babii, Janina Mueller, Franziska Waller, Dennis Wienand, Swetha Sampathkumar, Ivo Kunovski

Get full text

Aspirin modulates generation of procoagulant phospholipids in cardiovascular disease, by regulating LPCAT3 by Majd B. Protty, Victoria J. Tyrrell, Ali A. Hajeyah, Bethan Morgan, Daniela Costa, Yong Li, Anirban Choudhury, Rito Mitra, David Bosanquet, Alex Reed, Iuliia K. Denisenko, Katsuyuki Nagata, Hideo Shindou, Benjamin F. Cravatt, Alastair W. Poole, Takao Shimizu, Zaheer Yousef, Peter W. Collins, Valerie B. O’Donnell

Get full text

Observational study: effect of varying transport durations and feed withdrawal on the physiological status and health of dairy calves by Luca L. van Dijk, Susanne Siegmann, Niamh L. Field, Katie Sugrue, Cornelis G. van Reenen, Eddie A. M. Bokkers, Muireann Conneely, Gearoid Sayers

Get full text

Effective rain rate model for analysing overestimated rain fade in short millimetre-wave terrestrial links due to distance factor by Asma Ali Budalal, Ibraheem Shayea, Md. Rafiqul Islam, Jafri Din, Abdulsamad Ebrahim Yahya, Yousef Ibrahim Daradkeh, Marwan Hadri Azmi

“…The findings emphasize the importance of developing region-specific models that consider local meteorological variations, potentially offering significant improvements to the reliability and design of mm-wave communication systems and realizing the future goal of 6G wireless mobile fronthaul.…”
Get full text

AGD1/USP10/METTL13 complexes enhance cancer stem cells proliferation and diminish the therapeutic effect of docetaxel via CD44 m6A modification in castration resistant prostate can... by Hong Wang, Chunli Cui, Weiyi Li, Hui Wu, Jianjun Sha, Jiahua Pan, Wei Xue

“…Additionally, liposomal-chitosan nanocomplex drug delivery systems were designed to explore AGD1’s role in regulating docetaxel treatment resistance in CRPC. …”
Get full text

Controls on coastal saline groundwater across North America by Daniel V Kretschmer, Holly A Michael, Nils Moosdorf, Gualbert H P Oude Essink, Marc F P Bierkens, Thorsten Wagener, Robert Reinecke

Get full text

3D echocardiography derived reference values and determinants of left ventricular twist and torsion from the population-based STAAB cohort study by Julia Napp, Götz Gelbrich, Floran Sahiti, Vladimir Cejka, Dora Pelin, Lena Schmidbauer, Mengmeng Chen, Niklas Hitschrich, Marcus Schreckenberg, Stefan Frantz, Peter U. Heuschmann, Stefan Störk, Caroline Morbach

Get full text

Metodología de análisis y diseño de lechos de frenado Methodology for assessement and design of arrestor beds by Tomás Echaveguren, Sergio Vargas, Juan Ñancufíl

“…To mitigate the potential damage, exist several systems that permits heavy vehicles leave the lane and stop. …”
Get full text

Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability by Petr Smirnov, Moritz J. Przybilla, Milena Simovic-Lorenz, R. Gonzalo Parra, Hana Susak, Manasi Ratnaparkhe, John KL. Wong, Verena Körber, Jan-Philipp Mallm, George Philippos, Martin Sill, Thorsten Kolb, Rithu Kumar, Nicola Casiraghi, Konstantin Okonechnikov, David R. Ghasemi, Kendra Korinna Maaß, Kristian W. Pajtler, Anna Jauch, Andrey Korshunov, Thomas Höfer, Marc Zapatka, Stefan M. Pfister, Wolfgang Huber, Oliver Stegle, Aurélie Ernst

Get full text

Overall Survival of Patients with Metastatic Renal Cell Carcinoma Following the Introduction of Targeted and Immunotherapies: A Norwegian Retrospective, Real-World Registry Data St... by Puco K, Notland CS, Szulkin R, Jonasson C, Beisland C, Johannesen TB, Solli O, Oldenburg J, Heinrich D

“…Fifty-five percent (55%) of the patients received systemic treatment. No differences were observed in the number of treatment lines administered over time or in the number of lines of treatment administered according to tumor histology. …”
Get full text