L’aqueduc de l’Yzeron : nouvelles données sur le double siphon de Craponne (Métropole de Lyon) by David Baldassari

“…The few disparities identified in the placement of the putlock holes may possibly reveal the use of a tilted scaffolding system.The C14 analysis of the charcoal extracted from the mortar from both piers reveals the correlation of dates ranging from 0 to 20 Calibrated AD.Two facts can be ascertained from analysis of the data arising from the building survey. …”
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Earth–lunar thermal effect on the temperature stability of TianQin telescope and the suppression methods by Wenbo Chang, Yuxiang Wang, Wenhai Tan, Guanhua Wu, Houyuan Chen, Wei Li, Zizheng Li, Fan Zhu, Zhu Li, Xuefeng Zhang, Shanqing Yang

“…Furthermore, the telescope operates as an open system directly exposed to the external environment. …”
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Single-cell transcriptome-wide Mendelian randomization and colocalization reveals immune-mediated regulatory mechanisms and drug targets for COVID-19Research in context by Hui Ying, Xueyan Wu, Xiaojing Jia, Qianqian Yang, Haoyu Liu, Huiling Zhao, Zhihe Chen, Min Xu, Tiange Wang, Mian Li, Zhiyun Zhao, Ruizhi Zheng, Shuangyuan Wang, Hong Lin, Yu Xu, Jieli Lu, Weiqing Wang, Guang Ning, Jie Zheng, Yufang Bi

“…Finally, we developed a tier system and identified immune-cell-based prioritized drug targets for COVID-19. …”
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Exploring the impacts of senescence on implantation and early embryonic development using totipotent cell-derived blastoids by Yuxin Luo, Chenrui An, Ke Zhong, Ping Zhou, Dan Li, Hui Liu, Qing Guo, Wei Wei, Hen Pan, Zheying Min, Rong Li, Yang Yu, Yong Fan

“…Methods: We used a novel three-dimensional system with totipotent blastomere-like cells (TBLCs) to construct TBL-blastoids and established senescence-related embryo models derived from oxidative stress-induced TBLCs. …”
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ATClean: A Novel Method for Detecting Low-luminosity Transients and Application to Pre-explosion Counterparts from SN 2023ixf by S. Rest, A. Rest, C. D. Kilpatrick, J. E. Jencson, S. von Coelln, L. Strolger, S. Smartt, J. P. Anderson, A. Clocchiatti, D. A. Coulter, L. Denneau, S. Gomez, A. Heinze, R. Ridden-Harper, K. W. Smith, B. Stalder, J. L. Tonry, Q. Wang, Y. Zenati

“…The latter limits rule out variability for unextinguished red supergiants with initial masses >22 M _⊙ , comparable to the most luminous predictions for the SN 2023ixf progenitor system. We also compare our limits to short-timescale outbursts, similar to those expected for Type IIn SN progenitor stars or the Type II SN 2020tlf, and rule out outburst ejecta masses of >0.021 M _⊙ , much lower than the inferred mass of circumstellar matter around SN 2023ixf in the literature. …”
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A Neural Circuit From Paraventricular Nucleus of the Thalamus to the Nucleus Accumbens Mediates Inflammatory Pain in Mice by Xi Liu, Xi Zhang, Dongxu Wang, Ya Cao, Ling Zhang, Zhonghua Li, Qin Zhang, Yu Shen, Xian Lu, Keyu Fan, Mingxia Liu, Jingqiu Wei, Siping Hu, He Liu

“…More research into the perception and modulation of pain within the central nervous system is essential. The nucleus accumbens (NAc) plays a pivotal role in the regulation of animal behavior, and extensive research has unequivocally demonstrated its significant involvement in the occurrence and development of pain. …”
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Risk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort studyResearch in context by Jack L. Janetzki, Jung Ho Kim, Evan Minty, Jung Ah Lee, Daniel R. Morales, Rohan Khera, Chungsoo Kim, Thamir M. Alshammari, Scott L. DuVall, Michael E. Matheny, Thomas Falconer, Seonji Kim, Thanh-Phuc Phan, Phung-Anh Nguyen, Min-Huei Hsu, Jason C. Hsu, Rae Woong Park, Kenneth K.C. Man, Sarah Seager, Mui Van Zandt, James P. Gilbert, Patrick B. Ryan, Martijn J. Schuemie, Marc A. Suchard, George Hripcsak, Nicole Pratt, Seng Chan You

“…The study included 13,588,837 patients aged 35 or older who initiated systemic fluoroquinolones (FQs) or comparable antibiotics (trimethoprim with or without sulfamethoxazole [TMP] or cephalosporins [CPHs]) for UTI treatment in the outpatient setting between JAN 01, 2010 and DEC 31, 2019. …”
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Chronic Airflow Limitation, Lower Respiratory Symptoms, COPD and Chronic Rhinosinusitis in a Middle-Aged Population: The Swedish CArdioPulmonary bioImage Study (SCAPIS). A Link Bet... by Andersson A, Bergqvist J, Schiöler L, Bossios A, Farnebo L, Holmlund T, Janson C, Keceli S, Ljunggren M, Malinovschi A, Memarian E, Nihlén U, Nilsson PM, Pesonen I, Sjöström M, Stenfors N, Sundbom F, Werner M, Torén K, Sköld M, Hellgren J

“…In patients with CRS and in patients with lower airway inflammation, it is important to consider the inflammatory status of the entire airway system.Keywords: asthma, chronic bronchitis, chronic obstructive pulmonary disease, emphysema, CRS, smoking…”
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Correction: Surgical stabilization of rib fractures (SSRF): the WSES and CWIS position paper by Giacomo Sermonesi, Riccardo Bertelli, Fredric M. Pieracci, Zsolt J. Balogh, Raul Coimbra, Joseph M. Galante, Andreas Hecker, Dieter Weber, Zachary M. Bauman, Susan Kartiko, Bhavik Patel, SarahAnn S. Whitbeck, Thomas W. White, Kevin N. Harrell, Daniele Perrina, Alessia Rampini, Brian Tian, Francesco Amico, Solomon G. Beka, Luigi Bonavina, Marco Ceresoli, Lorenzo Cobianchi, Federico Coccolini, Yunfeng Cui, Francesca Dal Mas, Belinda De Simone, Isidoro Di Carlo, Salomone Di Saverio, Agron Dogjani, Andreas Fette, Gustavo P. Fraga, Carlos Augusto Gomes, Jim S. Khan, Andrew W. Kirkpatrick, Vitor F. Kruger, Ari Leppäniemi, Andrey Litvin, Andrea Mingoli, David Costa Navarro, Eliseo Passera, Michele Pisano, Mauro Podda, Emanuele Russo, Boris Sakakushev, Domenico Santonastaso, Massimo Sartelli, Vishal G. Shelat, Edward Tan, Imtiaz Wani, Fikri M. Abu-Zidan, Walter L. Biffl, Ian Civil, Rifat Latifi, Ingo Marzi, Edoardo Picetti, Manos Pikoulis, Vanni Agnoletti, Francesca Bravi, Carlo Vallicelli, Luca Ansaloni, Ernest E. Moore, Fausto Catena

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Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study by Heinz Wiendl, Frederik Barkhof, Frederik Barkhof, Xavier Montalban, Anat Achiron, Anat Achiron, Tobias Derfuss, Andrew Chan, Suzanne Hodgkinson, Alexandre Prat, Letizia Leocani, Letizia Leocani, Letizia Leocani, Klaus Schmierer, Klaus Schmierer, Finn Sellebjerg, Finn Sellebjerg, Patrick Vermersch, Hulin Jin, Anita Chudecka, Andreas Kloetgen, Dongdong Lin, Lidia Gardner, Nicola De Stefano

“…The safety profile was consistent with previous reports.DiscussionDeep longitudinal immunophenotyping, analysis of transcriptional changes, reduction in cells expressing pro-inflammatory cytokines, along with the marker of neuroaxonal damage provide novel and innovative evidence of CladT rebalancing the immune system towards a more homeostatic and less pathogenic state.Clinical Trial Registrationhttps://clinicaltrials.gov/study/, identifier NCT03364036.…”
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Studying the Oncolytic Activity of <i>Streptococcus pyogenes</i> Strains Against Hepatoma, Glioma, and Pancreatic Cancer <i>In Vitro</i> and <i>In Vivo</i> by Anna N. Tsapieva, Alexander N. Chernov, Nadezhda V. Duplik, Anastasiya O. Morozova, Tatiana A. Filatenkova, Mariia A. Suvorova, Elena Egidarova, Elvira S. Galimova, Kseniya Bogatireva, Alexander N. Suvorov

“…Methods: The <i>in vitro</i> oncolytic cytotoxic activity of GAS strains was studied against human glioma U251, pancreatic cancer PANC02, murine hepatoma 22a, and normal skin fibroblast cells using the MTT assay and the real-time xCELLigence system. A syngeneic mouse model of hepatoma and pancreatic cancer was used to evaluate the <i>in vivo</i> oncolytic effect of GAS strains. …”
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Association of extreme high temperature weather with non-accidental deaths among residents of Yichang city: a time-stratified case-crossover analysis by Xiaoyan MING, Yang HAN, Zhongcheng YANG, Zaoxia WANG, Shuguang XIE, Chuangang FAN

“…MethodsData on 46 170 non-accidental deaths in urban areas of Yichang from 2014 to 2022 were collected from the death registration system of the Yichang Center for Disease Control and Prevention. …”
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Awareness about laryngopharyngeal reflux disease among Chinese otolaryngologists: a nationwide survey by Chen Zhao, Liang Tang, Ting Chen, Hui Yang, Xiong Chen, Xiaobo Cui, Li Shi, Xiangping Li, Jian He, Xiaoxia Peng, Shuifang Xiao, Jinrang Li, Hongliang Zheng, Junbo Zhang, Shuihong Zhou, Donghui Chen, Xuping Xiao, Hui Huangfu, Zhenfeng Tao, Yehai Liu, Shenhong Qu, Guangke Wang, Linli Tian, Wensheng Zhou, Hongyan Fang, Yongwang Huang, Guodong Yu, Zhenqun Lin, Ruixia Ma, Zhaoyan Yu

“…An analysis of the overall status of awareness using a scoring system suggested that otolaryngologists were better aware owing to more access, working at 3A hospitals, and postgraduate or above educational background (all p&lt;0.05).Conclusion Although the majority of Chinese otolaryngologists had heard of LPRD, their overall awareness about the disease was not encouraging. …”
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Association between short-term exposure to air pollutants and daily stroke incidence among residents in Qingdao city: a time series analysis of disease surveillance, environmental,... by Nan GE, Lu PAN, Xin ZHANG, Dandan LI, Yin WANG, Jingya YIN, Hui ZHOU, Haoyan YU, Xiuqin ZHANG, Chunsheng XU, Yuan FANG, Yan MA, Bingling WANG, Haiping DUAN

“…MethodsData on new cases of stroke reported in Qingdao municipality from 2014 to 2020 were collected from the National Chronic Disease Surveillance Network Reporting System, together with air pollution monitoring data from the Qingdao Ecological Environment Monitoring Center and meteorological monitoring data from the Qingdao Meteorological Observatory for the same period. …”
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Comprehensive genomic surveillance reveals transmission profiles of extensively drug-resistant tuberculosis cases in Pará, Brazil by Davi Josué Marcon, Davi Josué Marcon, Abhinav Sharma, Alex Brito Souza, Alex Brito Souza, Rafaella Bonfim Barros, Valnete das Graças Dantas Andrade, Ricardo José de Paula Souza Guimarães, Luana Nepomuceno Gondim Lima, Luana Nepomuceno Gondim Lima, Lúcia Helena Martins Tavares Monteiro, Ana Judith Pires Garcia Quaresma, Ana Judith Pires Garcia Quaresma, Layana Rufino Ribeiro, Layana Rufino Ribeiro, Philip Noel Suffys, Robin Mark Warren, Carlos Augusto Abreu Alberio, Karla Valéria Batista Lima, Karla Valéria Batista Lima, Emilyn Costa Conceição

“…Clinical and bacteriological information was obtained from the National Laboratory Management Environment and the Special TB Treatment Information System. Genomic DNA was extracted from bacterial cultures performed at the Pará Central Laboratory (LACEN-PA). …”
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Nomenclatural issues concerning cultured yeasts and other fungi: why it is important to avoid unneeded name changes by Andrey Yurkov, Artur Alves, Feng-Yan Bai, Kyria Boundy-Mills, Pietro Buzzini, Neža Čadež, Gianluigi Cardinali, Serge Casaregola, Vishnu Chaturvedi, Valérie Collin, Jack W. Fell, Victoria Girard, Marizeth Groenewald, Ferry Hagen, Chris Todd Hittinger, Aleksey V. Kachalkin, Markus Kostrzewa, Vassili Kouvelis, Diego Libkind, Xinzhan Liu, Thomas Maier, Wieland Meyer, Gábor Péter, Marcin Piątek, Vincent Robert, Carlos A. Rosa, Jose Paulo Sampaio, Matthias Sipiczki, Marc Stadler, Takashi Sugita, Junta Sugiyama, Hiroshi Takagi, Masako Takashima, Benedetta Turchetti, Qi-Ming Wang, Teun Boekhout

“…Consequently, the stability of the taxonomic system and the traceability of nomenclatural changes is crucial for a broad range of users and taxonomists. …”
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Alimentation et gestion de l’eau sur la colline de Fourvière à Lyon : les aménagements hydrauliques, la ville et ses monuments by Aldo Borlenghi, Éric Leroy

“…As seen in other cities in the Roman world, this system associated with cisterns/reservoirs can supply and distribute water on the pressure.In a context of water scarcity at the top of the hill, the cisterns made it possible to collect and conserve rainwater. …”
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Clinical trials to gene therapy development and production in Brazil: a review by Jonas Alex Morales Saute, Virginia Picanço-Castro, Ana Carolina de Freitas Lopes, João Batista da Silva Júnior, Johanna Henriques Nehm, Franciele dos Santos Maciel, Ida Vanessa Doederlein Schwartz, Juliana Maria Ferraz Sallum, Margareth Castro Ozelo, Roberto Giugliani, Martin Bonamino, Hilda Petrs-Silva, Guilherme Baldo

“…Focusing on gene replacement and CAR-T cell therapies, we discuss the main advances, limitations, and difficulties faced by the country in the production, approval, and incorporation of such products into the public health system. Finally, we highlight the potential leading role that low-to middle-income countries can have in this industry, not only by providing their own vector supply but also by addressing important issues related to the sustainability and long-term global affordability of gene therapy products.…”
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Multiple intracerebral hematomas during SEEG recording and intradural hemorrhage after spinal tap: A case report prompting more research on collagen IV gene mutation and oral nicot... by Markus Leitinger, Serena Broggi, Mathias Spendel, Gudrun Kalss, Ivan Petrović, Herbert Krainz, Fabio Rossini, Julia Höfler, Andreea Toma, Giorgi Kuchukhidze, Matthias Mauritz, Kai‐Nicolas Poppert, Bernardo Crespo‐Pimentel, Pilar Bosque‐Varela, Anna Pleyers, Patricia Ganger, Dieter Kotzot, Davor Lessel, Christoph J. Griessenauer, Eugen Trinka

“…We performed the investigation of the clotting system and whole‐exome sequencing (WES). WES identified a heterozygous mutation c.4698G>T, p.…”
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A Meta-Synthesis of the Integrated Model of Customer Value co-Destruction and Value co-Creation by Zohreh Dehdashti Shahrokh, Vahid Nasehifar, Mohammad Reza Karimi Alavijeh, Yazdan Rahmatabadi

“…This is also true regarding the co-destruction of customer value and the tendency of the system to create co-destruction is that by identifying the factors that cause co-destruction and curbing them using the appropriate strategy, it will be possible to create co-creation continuously and continuously. …”
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