Reims antique, acquis et perspectives by Magalie Cavé, Philippe Rollet, Régis Bontrond

“…Subsequently, and despite having preserved the center inherited from the oppidum, the city was entirely redesigned, its plan restructured according to a vast orthonormal system, its streets dividing different sectors into island like concentrations of various sizes. …”
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Observational study on the current status of thalassaemia in Malaysia: a report from the Malaysian Thalassaemia Registry by Hishamshah Mohd Ibrahim, Zulaiha Muda, Ida Shahnaz Othman, Mohamed Najib Mohamed Unni, Kok Hoi Teh, Asohan Thevarajah, Kogilavani Gunasagaran, Gek Bee Ong, Seoh Leng Yeoh, Aisyah Muhammad Rivai, Che Hadibiah Che Mohd Razali, Nazzlin Dizana Din, Zarina Abdul Latiff, Rahman Jamal, Norsarwany Mohamad, Hany Mohd Ariffin, Hamidah Alias

“…This study aims to report the current status of thalassaemia in Malaysia and provide a comprehensive understanding of the disease through data obtained from the Malaysian Thalassaemia Registry.Design Data were extracted from the Malaysian Thalassaemia Registry, a web-based system accessible to enrolled users through www.mytalasemia.net.my.Setting The Malaysian Thalassaemia Registry data was recorded from reports obtained from 110 participating government and university hospitals in Malaysia.Participants The patients were those attending the 110 participating hospitals for thalassaemia treatment.Intervention Data were collected from the Malaysian Thalassaemia Registry from 2007 until the fourth quarter of 2018.Primary outcome measure 7984 out of 8681 patients with thalassaemia registered in the Malaysian Thalassaemia Registry were reported alive.Results Majority of the patients were reported in the state of Sabah (22.72%); the largest age group affected was 5.0–24.9 years old (64.45%); the largest ethnic group involved was Malay (63.95%); and the major diagnosis was haemoglobin E/β-thalassaemia (34.37%). …”
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Biocompatibility and drug release kinetics of TiNbZrSn femtosecond laser-induced superhydrophilic structures by Tahir Nawaz, Vinod Paul, Sidrah Younus, Shahbaz Ahmad, Mehmet Egilmez, Wael Abuzaid, Ganjaboy Boltaev, Noor Akbar, Mustafa Khamis, Ghaleb A. Husseini, Ali S. Alnaser

“…Modifying the structure, improving the hydrophilicity, and developing controlled-release drug delivery systems can improve cellular adhesion, proliferation, osseointegration, and differentiation. …”
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Coronary Heart Disease Risk Prediction Model Based on Machine Learning by YUE Haitao, HE Chanchan, CHENG Yuyou, ZHANG Sencheng, WU You, MA Jing

“…Methods Utilizing cross-sectional survey data from the 2021 Behavioral Risk Factor Surveillance System (BRFSS) in the United States, a cohort of 112 606 participants was identified, featuring 24 variables related to risk behaviors and health status, with self-reported coronary heart disease (CHD) as the outcome measure. …”
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Satisfactory Evaluation of Call Service Using AI After Ureteral Stent Insertion: Randomized Controlled Trial by Ukrae Cho, Yong Nam Gwon, Seung Ryong Chong, Ji Yeon Han, Do Kyung Kim, Seung Whan Doo, Won Jae Yang, Kyeongmin Kim, Sung Ryul Shim, Jaehun Jung, Jae Heon Kim

“…Trial RegistrationClinical Research Information System KCT0008062; https://tinyurl.com/4s8725w2…”
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The current state of the quality of homeopathic clinical research by Patricia M. Herman, Cindy C. Crawford, Margaret A. Maglione, Sydne J. Newberry, Paul S. Amieux, Kimberlee Blyden-Taylor, Raheleh Khorsan, Marcia Prenguber, Elizabeth Rice, Andy Shollar, Tiesha Tyson, Nazanin Vassighi, Ian D. Coulter

“…Homeopathy is a system of therapeutics that treats disease with highly diluted substances based on the Law of Similars, which holds that “like cures like.” …”
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Purpurin suppresses Salmonella invasion of host cells by reducing the secretion of T3SS-1 effector proteins by Zhenxu Shi, Zhimin Guo, Siqi Li, Chenxiao Jiang, Jianfeng Wang, Xuming Deng, Hongtao Liu, Jiazhang Qiu

“…Salmonella pathogenicity island 1 (SPI-1), encoding type three secretion system 1 (T3SS-1), serves as a crucial virulence factor for the invasion of ST into host cells, making it an ideal target for screening anti-Salmonella virulence drugs. …”
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Association of Sociodemographic Factors With Overtriage, Undertriage, and Value of Care After Major Surgery by Tyler J. Loftus, MD, Matthew M. Ruppert, MS, Benjamin Shickel, PhD, Tezcan Ozrazgat-Baslanti, PhD, Jeremy A. Balch, MD, Kenneth L. Abbott, MD, Die Hu, MS, Adnan Javed, MD, Firas Madbak, MD, Faheem Guirgis, MD, David Skarupa, MD, Philip A. Efron, MD, Patrick J. Tighe, MD, William R. Hogan, MD, Parisa Rashidi, PhD, Gilbert R. Upchurch, Jr, MD, Azra Bihorac, MD

“…Background:. In a fair system, overtriage of low-acuity patients to intensive care units (ICUs) and undertriage of high-acuity patients to general wards would affect all sociodemographic subgroups equally. …”
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Effect of Different Doses of Intrathecal Nalbuphine as Adjuvant to Hyperbaric Bupivacaine on Characteristics of Subarachnoid Block in Pelvic and Lower Limb Orthopaedic Surgeries: A... by Anupama Kumari, Shraddha Jogani, Nilesh Shah, Sara Mary Thomas

“…It has less affinity and strength of depressant effects on myocardial and Central Nervous System (CNS) vital centers in pharmacodynamic studies, along with a superior pharmacokinetic profile. …”
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Exploring Brannerite-Type Mg_1−<i>x</i><i>M_x</i>V₂O₆ (<i>M</i> = Mn, Cu, Co, or Ni) Oxides: Crystal Structure and Optical Properties by Hua-Chien Hsu, Narayanan Lakshminarasimhan, Jun Li, Arthur P. Ramirez, Mas A. Subramanian

“…Magnetic property measurements revealed antiferromagnetic behavior for the compounds Mg_1−<i>x</i><i>M_x</i>V₂O₆ (<i>M</i> = Mn, Cu, Co, and Ni), and an oxidation state of +2 for the <i>M</i> ions was deduced from their Curie–Weiss behavior. The system Mg_1−<i>x</i>Mn<i>_x</i>V₂O₆ has a NIR reflectance in the range between 40% and 70%, indicating its potential to be utilized in the pigment industry.…”
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Dual Clinical Practice (DCP) policy to improve the retention of human resources for health in Rwanda: a mid-term review using a cross-sectional and retrospective study design by Kizito Kayumba, Corneille Ntihabose, Sabine Musange Furere, Bernard Ngabo, Piero Irakiza, Felix K. Rubuga, Nathalie Umutoni, Ina Rukundo Kalisa, Pascal Birindabagabo, Emile Rwamasirabo, Emmanuel Kayibanda, Patience Mukundirukuri, Gashaija Absolomon, Sumana Dhanani, Jeanine Condo

“…Quantitative and qualitative data were collected through key informant interviews (KIIs) and joint interviews (JIs), as well as through the analysis of health facility records obtained from the Health Management Information System (HMIS) and the Electronic Medical Record (EMR). …”
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Preservation of cellular structure via immersion fixation in brain banking by Macy Garrood, Emma L. Thorn, Adam Goldstein, Allison Sowa, William Janssen, Alyssa Wilson, Claudia S. López, Raakhee Shankar, Erin S. Stempinski, Kurt Farrell, John F. Crary, Andrew T. McKenzie

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The authority of the printed word in the Lithuanian village of the XIX century by Džiuljeta Maskoliūnienė

“…The increase in the standing of the book and reading is directly linked with the rise of the school system. Partially, Lithuania reflects general European consistent patterns: "the majority of European regions, assuredly, so to say, and finally, became alphabeticized only in the 19th century, when primary schools were established wide," the "History of European Mentality" admits. …”
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Convolutional neural networks for sea surface data assimilation in operational ocean models: test case in the Gulf of Mexico by O. Zavala-Romero, O. Zavala-Romero, A. Bozec, E. P. Chassignet, J. R. Miranda, J. R. Miranda

“…The CNNs are trained to correct model errors from a 2-year, high-resolution (<span class="inline-formula"><math xmlns="http://www.w3.org/1998/Math/MathML" id="M1" display="inline" overflow="scroll" dspmath="mathml"><mrow><mn mathvariant="normal">1</mn><mo>/</mo><mn mathvariant="normal">25</mn><mi mathvariant="italic">°</mi></mrow></math><span><svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="31pt" height="14pt" class="svg-formula" dspmath="mathimg" md5hash="0fa693bbf5c78df25ed18818c53372c4"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="os-21-113-2025-ie00001.svg" width="31pt" height="14pt" src="os-21-113-2025-ie00001.png"/></svg:svg></span></span>) HYCOM dataset, assimilated using the Tendral Statistical Interpolation System (T-SIS). The CNNs are trained to replicate the increments generated by the T-SIS data assimilation package, aiming to correct model forecasts of sea surface temperature (SST) and sea surface height (SSH). …”
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Phthalates esters disrupt demersal fish behavior: Unveiling the brain-gut axis impact by Liuqingqing Liu, Xinyao Li, Xianxiang Luo, Xiao Wang, Linjia Liu, Zixi Yuan, Cuizhu Sun, Hao Zheng, Elvis Genbo Xu, Fengmin Li

“…This accumulation led to oxidative damage, inflammatory responses, and neurodegenerative changes in the optic tectum, resulting in cholinergic system dysfunction. In the gut, PAEs caused inflammatory lesions, disrupted the gut barrier, and altered the gut microbiome, exacerbating the neurotoxicity via “brain-gut” communication. …”
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Genomic changes during the evolution of the Coxiella genus along the parasitism-mutualism continuum by Santos-Garcia, Diego, Morel, Olivier, Henri, Hélène, El Filali, Adil, Buysse, Marie, Noël, Valérie, McCoy, Karen D., Gottlieb, Yuval, Klasson, Lisa, Zenner, Lionel, Duron, Olivier, Vavre, Fabrice

“…Indeed, the virulence factor Dot/Icm T4 Secretion System is present in most, but not all, Coxiellaceae. …”
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Analisis Dukungan Petugas Kesehatan Dalam Optimalisasi Competence Baby Care Pada Ibu muda Melalui Pendekatan Maternal Sensitivity Models Berbasis Keluarga (Analysis of Health Of... by diyan indriyani

“…ABSTRACT Introduction: Infants are extremely vulnerable group to various pain conditions because their immunity system is still low. The lack of proper baby care can cause the infants to be risky to illness. …”
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Tackling antimicrobial resistance in Bangladesh: A scoping review of policy and practice in human, animal and environment sectors. by Roksana Hoque, Syed Masud Ahmed, Nahitun Naher, Mohammad Aminul Islam, Emily K Rousham, Bushra Zarin Islam, Shaikh Hassan

“…AMR is aggravated by irrational use of antimicrobials in a largely unregulated pluralistic health system. This review presents a 'snap shot' of the current situation including existing policies and practices to address AMR, and the challenges and barriers associated with their implementation.…”
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Exploring the mechanisms of Devonian oceanic anoxia: impact of ocean dynamics, palaeogeography, and orbital forcing by J. Gérard, L. Sablon, J. J. C. Huygh, A.-C. Da Silva, A. Pohl, C. Vérard, M. Crucifix

“…Here, we perform multiple sensitivity experiments, using an Earth system model of intermediate complexity (cGENIE), to isolate the influences of specific Devonian climate and palaeogeography components on ocean oxygen levels, contributing to the better understanding of the intricate interplay of factors preconditioning the ocean to anoxia. …”
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Upregulation of Cardiac IL-10 and Downregulation of IFN-γ in Balb/c IL-4−/− in Acute Chagasic Myocarditis due to Colombian Strain of Trypanosoma cruzi by Marcos Vinicius da Silva, Vera Lúcia de Almeida, Wendyson Duarte de Oliveira, Natália Carasek Matos Cascudo, Pollyana Guimarães de Oliveira, Crislaine Aparecida da Silva, Aline Cristina Souza da Silva, Maria Luíza Gonçalves dos Reis Monteiro, Rosana Rosa Miranda Correa, Milton Adriano Pelli Oliveira, Ruy de Sousa Lino-Júnior, Mara Rúbia Nunes Celes, Juliana Reis Machado

“…It also decreased TNF-α systemic production and increased IL-10, both systemically and in situ. …”
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