Transdermal delivery of PeptiCRAd cancer vaccine using microneedle patches by Carmine D'Amico, Manlio Fusciello, Firas Hamdan, Federica D'Alessio, Paolo Bottega, Milda Saklauskaite, Salvatore Russo, Justin Cerioni, Khalil Elbadri, Marianna Kemell, Jouni Hirvonen, Vincenzo Cerullo, Hélder A. Santos

“…Microneedles (MNs) are a prospective system in cancer immunotherapy to overcome barriers regarding proper antigen delivery and presentation. …”
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Changes in DNA methylation profile in liver tissue during progression of HCV-induced fibrosis to hepatocellular carcinoma by I. A. Goncharova, A. A. Zarubin, N. P. Babushkina, I. A. Koroleva, M. S. Nazarenko

“…The genes hypermethylated in the tumor are located at the 7p15.2 locus in the HOXA cluster region, and the hypomethylated CpG sites occupy extended regions of the genome in the gene clusters of olfactory receptors (11p15.4), keratin and keratin-associated proteins (12q13.13, 17q21.2, and 21q22.11), epidermal differentiation complex (1q21.3), and immune system function loci 9p21.3 (IFNA, IFNB1, IFNW1 cluster) and 19q13.41–19q13.42 (KLK, SIGLEC, LILR, KIR clusters). …”
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Oral behaviors in Chinese temporomandibular disorder patients: insights from exploratory and confirmatory factor analyses by Tiqian Liu, Tiqian Liu, Adrian Ujin Yap, Adrian Ujin Yap, Adrian Ujin Yap, Yanyu Sun, Yanyu Sun, Yunhao Zheng, Yunhao Zheng, Tianqi Wang, Tianqi Wang, Shiya Zeng, Shiya Zeng, Zhen Liu, Xin Xiong, Xin Xiong

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Review and Prospect of Research on Urban Walking Safety and Environmental Influencing Factors Thereof by Lin LI, Yu YE, Yong CHEN

“…New data and technologies support the analysis of core environmental factors influencing walking safety. 3) Based on CNKI database, the analysis of keywords shows that domestic research focuses on the spatial quality of walking environment and the special needs of vulnerable walkers, and it is urgent to establish a walking safety environment evaluation system in China. In addition, the keyword analysis also shows that the impact of built environment on pedestrian safety accidents and pedestrian safety perception has become a focus of attention. …”
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Immune Modulation Effect of Administration of Rice Bran Extract with Increased Solubility Fermented by <i>Lentinus edodes</i> UBC-V88 in Cyclophosphamide-Treated Mice Model by Gi-Jung Kim, Yelim Jang, Ji-Yoon Hong, Kyoung-Tae Kwon, Dae-Weon Kim, Dae-Jung Kang, Sung-Joo Hwang, Jung-Yun Lee, Emmanouil Apostolidis, Young-In Kwon

“…These results suggest that FRB administration could stimulate the innate immune system by increasing the expression of cytokines in splenocytes and serum, especially IFN-γ, IL-2, and IL-12 (p70), which are associated with TNF-α and NK cell activities. …”
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MP-LLAVRec: an agricultural product recommendation algorithm based on LLAVA and user modal preference by Peishan Li, Peishan Li, Peishan Li, Lutao Gao, Lutao Gao, Lutao Gao, Lilian Zhang, Lilian Zhang, Lilian Zhang, Lin Peng, Lin Peng, Lin Peng, Chunhui Bai, Chunhui Bai, Chunhui Bai, Linnan Yang, Linnan Yang, Linnan Yang

“…It consisted of three main components: (1) LLAVA data enhancement, which introduced a multimodal macromodel to improve the understanding of node attributes; (2) agricultural product association relationship fusion, which constructed and improved the complex association network structure among products to ensure that the system can better understand the substitution relationship, complementary relationship, and implied consumption logic among products; (3) user modal preference feature extraction block, which deeply mined the interaction data between consumers and products, and advanced the effective user feature information from the correspondence between global user representations and local modal user representations.Results and DiscussionWe conduct experiments on a real dataset from Amazon's large-scale e-commerce platform to verify the effectiveness of MP-LLAVRec. …”
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Metformin exerted tumoricidal effects on colon cancer tumoroids via the regulation of autophagy pathway by Roya Shabkhizan, Çığır Biray Avci, Sanya Haiaty, Marziyeh Sadat Moslehian, Fatemeh Sadeghsoltani, Ahad Bazmani, Mahdi Mahdipour, Leila Sabour Takanlou, Maryam Sabour Takanlou, Arezoo Rezaie Nezhad Zamani, Reza Rahbarghazi

“…Abstract Background Despite the existence of promising outcomes from standard 2D culture systems, these data are not completely akin to in vivo tumor parenchyma. …”
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Black Boarding Academies as a Prudential Reparation by Roy Brooks

“…The goal of such transitional reparations is to extinguish the menace of white supremacy and systemic racism across the board.  Restructuring in housing, education, employment, voting, law enforcement, health care, and the environment—social transformation—is absolutely needed in the United States if the race problem is ever to be resolved. …”
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Leveraging RRT^*: Probabilistically Interpreted Mechanisms Enhanced With P-HOPE and FLEX-OPT for Complex Path Planning by Yujie Miao, Haiyang Liu, Ziqiang Zhang, Yanju Liang

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Qualitative and quantitative characteristics of black patch trait in Oujiang color common carp by Ke Jing, Huifan Chen, Nusrat Hasan Kanika, Penghui Zhang, Roland Nathan Mandal, Chunxiao Zeng, Zhiyi Zhang, Jun Wang, Chenghui Wang

“…Gene editing on Ednrb by using the CRISPR/Cas9 system showed that the mutants displayed a significantly reduced number of black patches in comparison to the wild-type RB, accompanied by noticeably smaller melanocytes. …”
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Evaluating the Acceptance and Usability of an Independent, Noncommercial Search Engine for Medical Information: Cross-Sectional Questionnaire Study and User Behavior Tracking Analy... by Lisa Specht, Raphael Scheible, Martin Boeker, Erik Farin-Glattacker, Nikolas Kampel, Marina Schmölz, Andrea Schöpf-Lazzarino, Stefan Schulz, Christian Schlett, Fabian Thomczyk, Sebastian Voigt-Radloff, Constanze Wegner, Katharina Wollmann, Andy Maun

“…ConclusionsUser questionnaires and behavior tracking showed the platform was well received, particularly by older and less educated users, especially for its advertisement-free design and filtering system. While feedback highlighted areas for improvement in design and filter functionality, the search engine’s focus on transparency, evidence-based content, and user privacy shows promise in addressing health literacy and navigational needs. …”
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Restorative Neurostimulation Therapy Compared to Optimal Medical Management: A Randomized Evaluation (RESTORE) for the Treatment of Chronic Mechanical Low Back Pain due to Multifid... by Frank Schwab, Nagy Mekhail, Kiran V. Patel, Meredith Langhorst, Robert D. Heros, Jonathan Gentile, Sherif Costandi, Gregory Moore, Christopher Gilmore, Smith Manion, Krishnan Chakravarthy, S. Craig Meyer, Justin V. Bundy, Jordan L. Tate, Rebecca Sanders, Sandeep Vaid, Oszkar Szentirmai, Johnathan Goree, Vikas V. Patel, Jeff Lehmen, Mehul J. Desai, Jason E. Pope, Anthony Giuffrida, Salim Hayek, Sohrab Singh Virk, Richard Paicius, William R. Klemme, Robert Levy, Christopher Gilligan, the RESTORE investigators

“…Participants were randomized to either restorative neurostimulation with the ReActiv8 system or OMM. The primary endpoint was a comparison of the mean change in the Oswestry Disability Index (ODI) between the treatment and control arms at 1 year, and secondary endpoints included pain (numeric rating scale [NRS]) and health-related quality of life (EuroQol Five-Dimension [EQ-5D-5L]). …”
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Exploring the role of district clinical specialist teams in maternal health outcomes in a South African district: A mixed method study from 2012 to 2020 by J Basu, A Stewart, D Basu, J Wing, U Feucht

“…Interviews were conducted by the interviewer using a data collection tool focused on the scope of work and acceptance of the DCST in improving maternal health services in a geographically defined district health system. Data collection tools were completed by the interviewer upon questioning the participants. …”
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Adoption and implementation of extended producer responsibility for sustainable management of end-of-life solar photovoltaic panels by S.E. Kabir, M.N.I. Mondal, M.K. Islam, I.A. Alnaser, M.R. Karim, M.A. Ibrahim, K. Sopian, M. Akhtaruzzaman

“…Nonetheless, successful implementation required addressing specific domestic concerns, such as the absence of a pre-existing waste take-back system and weak institutional capacity. Regulators should also proactively take measures to leverage enabling factors, including gaining users' acceptance, reducing costs, and potentially tapping into secondary material markets. …”
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Designing a Model for Implementing Digital Banking Policy Based on Using Big Data in Iranian Banking Industry by Rahmatollah Gholipour Souteh, Hamed Esmaeili Rad

“…Results The resulting model identifies 15 main themes, including Big Data Management, Data Governance (encompassing Data Collection, Data Refinement, Data Design and Modeling, Data Security), Data Regulation, Various Sources of Data Acquisition, Trust in Big Data Analysis, the Banking System Ecosystem, Organizational Agility, Big Data Analysis Tools, Scenario Development (practical application of data), Executive Structure, Improvement of Banks' Business, Customer Orientation, Transparency, Technological Infrastructure, and Dominant Culture. …”
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Perencanaan Coverage Jaringan 5G Berdasarkan Propagasi Rugi Rugi Lintasan dan Shadowing by Made Niama Dwi Susila, Linawati Linawati, Nyoman Gunantara

“…So that in this study, a 5G network planning was carried out using a 5G system with a frequency of 869 MHz in Denpasar City using a rooftop tower. …”
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Overexpression of Tear Inflammatory Cytokines as Additional Finding in Keratoconus Patients and Their First Degree Family Members by Ioana Catalina Ionescu, Catalina Gabriela Corbu, Cristiana Tanase, Gabriela Ionita, Cristina Nicula, Valeria Coviltir, Vasile Potop, Mihaela Constantin, Elena Codrici, Simona Mihai, Ionela Daniela Popescu, Ana-Maria Enciu, Dana Dascalescu, Miruna Burcel, Radu Ciuluvica, Liliana-Mary Voinea

“…The diagnosis of keratoconus had to be confirmed in addition to a minimum of 47 D corneal refractive power by corneal topography readings provided by a Placido-based topography system and analysis of the pattern: irregular astigmatism with an asymmetric “bow-tie.” …”
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Healthy at home for COPD: an integrated digital monitoring, treatment, and pulmonary rehabilitation intervention by Laurel O’Connor, Stephanie Behar, Seanan Tarrant, Pamela Stamegna, Caitlin Pretz, Biqi Wang, Brandon Savage, Thomas Scornavacca, Jeanne Shirshac, Tracey Wilkie, Michael Hyder, Adrian Zai, Shaun Toomey, Marie Mullen, Kimberly Fisher, Emil Tigas, Steven Wong, David D. McManus, Eric Alper, Peter K. Lindenauer, Eric Dickson, John P. Broach, Vik Kheterpal, Apurv Soni

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Therapeutic potential of the neutralizing monoclonal antibody 45G3 against encephalomyocarditis virus by Yanfang Zhang, Zhiying Wang, Yaohui Fang, Qiong Zhu, Jie Fu, Sijing Hu, Jiayin Jin, Min Zhou, Xijia Liu, Danna Zhang, Shouwei Huang, Yali Deng, Lingling Xie, Shu Shen, Jing Ye, Fei Deng, Shengbo Cao

“…Using recombinant DNA technology, we engineered a baculovirus system to express EMCVs P12A and 3C, facilitating the production of VLPs in Sf9 cells. …”
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AI-Driven Innovations for Early Sepsis Detection by Combining Predictive Accuracy With Blood Count Analysis in an Emergency Setting: Retrospective Study by Tai-Han Lin, Hsing-Yi Chung, Ming-Jr Jian, Chih-Kai Chang, Hung-Hsin Lin, Chiung-Tzu Yen, Sheng-Hui Tang, Pin-Ching Pan, Cherng-Lih Perng, Feng-Yee Chang, Chien-Wen Chen, Hung-Sheng Shang

“…The primary objective was to implement this model within an artificial intelligence–clinical decision support system (AI-CDSS) to enhance early sepsis detection and management in critical care settings. …”
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