Generation of novel oncolytic vaccinia virus with improved intravenous efficacy through protection against complement-mediated lysis and evasion of neutralization by vaccinia virus... by Dong-Sup Lee, Mi-Ju Park, Namhee Lee, Yun-Hui Jeon, Jiyoon Yoo, Suk-kyung Shin, Songyi Lee, Byung-Jin Jung, Yun-Kyoung Hong, Keunhee Oh

“…Although systemic delivery of the oncolytic virus would maximize viral immunotherapy’s potential, this remains a hurdle due to the rapid removal of the administered virus by the complement and innate immune system. …”
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A Digital Tool (Technology-Assisted Problem Management Plus) for Lay Health Workers to Address Common Mental Health Disorders: Co-production and Usability Study in Pakistan by Maham Saleem, Shamsa Zafar, Thomas Klein, Markus Koesters, Adnan Bashir, Daniela C Fuhr, Siham Sikander, Hajo Zeeb

“…Stage 1 (evidence review and stakeholder consultation) included 3 focus group discussions with 32 LHWs and 7 in-depth interviews with key stakeholders working in the health system or at the health policy level. Thematic analyses using the Capability, Opportunity, and Motivation for Behavioral Change (COM-B) model were conducted. …”
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Stem Cells from Human Exfoliated Deciduous Teeth Ameliorate Diabetic Nephropathy In Vivo and In Vitro by Inhibiting Advanced Glycation End Product-Activated Epithelial-Mesenchymal... by Nanquan Rao, Xiaotong Wang, Jing Xie, Jingzhi Li, Yue Zhai, Xiaoxia Li, Tengjiaozi Fang, Yuanyuan Wang, Yuming Zhao, Lihong Ge

“…This study is the first to apply a transwell system for coculture to explore the effects of MSCs on the EMT of human proximal tubular epithelial (HK-2) cells. …”
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Artificial intelligence-assisted clinical decision support for childhood asthma management: A randomized clinical trial. by Hee Yun Seol, Pragya Shrestha, Joy Fladager Muth, Chung-Il Wi, Sunghwan Sohn, Euijung Ryu, Miguel Park, Kathy Ihrke, Sungrim Moon, Katherine King, Philip Wheeler, Bijan Borah, James Moriarty, Jordan Rosedahl, Hongfang Liu, Deborah B McWilliams, Young J Juhn

“…<h4>Objectives</h4>To assess the effectiveness and efficiency of Asthma-Guidance and Prediction System (A-GPS), an Artificial Intelligence (AI)-assisted CDS tool, in optimizing asthma management through a randomized clinical trial (RCT).…”
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Impact of zero-markup consumable policy and national procurement of coronary stents on hospitalization expenses: an interrupted time series analysis by Shao-long Wu, Shao-long Wu, Kun Wang, Xin Yang, Ning Liu, Ning Liu, Wen-xin Zou, Xiao-wei Li, Dan-hua Huang, Tian-hao Yu

“…Currently, research on the zero-markup consumable policy and national procurement of coronary stents for medical consumables at the hospital level lacks analysis of changes in cost structures (other expenses) and studies on hospital response strategies.ObjectiveThis study aims to examine the effects of these reforms on hospitalization expenses for patients undergoing coronary stent implantation, including the specific changes in total hospitalization expenses, the component of total expenses, and the proportion of each expense category following the implementation of the reforms.MethodsData were obtained from the case management system of Guangdong Provincial Second People’s Hospital in China. …”
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Land use variation impacts on trace elements in the tissues and health risks of a commercial fish by N.D. Takarina, O.M. Chuan, T.G. Pin, I. Femnisya, A. Fathinah, A.N.B. Ramadhan, R. Hermawan, A. Adiwibowo

“…This study combined remote sensing and Geographic Information System analysis with heavy metal analysis using inductively coupled plasma and studied heavy metals, including cadmium, copper, and zinc, in fish tissues such as the gill, digestive tract, and muscle. …”
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Research on ion cyclotron emission driven by deuterium–deuterium fusion-produced tritium ions on the Experimental Advanced Superconducting Tokamak by Huapeng Zhang, Lunan Liu, Wei Zhang, Xuan Sun, Xinjun Zhang, Zhengshuyan Wang, Zelin Xu, Jiadong Zhang, Weijian Qin, Liuxin Li, Yuhao Jiang, Sichun Qiu, Chengming Qin, Guanghui Zhu, Yongxin Zhu, Kai Zhang, Tao Jin, Zhiping Li

“…A fusion product derived from the deuterium–deuterium (D−D) fusion reaction, whose spectral peak matches the fundamental cyclotron frequency of the tritium ions ( ω _CT ) in the plasma edge near the last closed flux surface, was observed using the ion cyclotron range of frequency (ICRF) antenna-based diagnostic system at the plasma boundary on the low field side in the EAST. …”
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Evaluation of patient immunocompetence for immune checkpoint inhibitor therapy using the psoas muscle index: a retrospective cohort study by Toshiaki Tsurui, Toshiaki Tsurui, Toshiaki Tsurui, Toshiaki Tsurui, Kazuyuki Hamada, Emiko Mura, Risako Suzuki, Nana Iriguchi, Tomoyuki Ishiguro, Yuya Hirasawa, Ryotaro Ohkuma, Masahiro Shimokawa, Hirotsugu Ariizumi, Yutaro Kubota, Atsushi Horiike, Satoshi Wada, Satoshi Wada, Kiyoshi Yoshimura, Kiyoshi Yoshimura, Mayumi Tsuji, Yuji Kiuchi, Yuji Kiuchi, Takuya Tsunoda

“…Skeletal muscle interacts with the immune system, and sarcopenia is associated with immune senescence. …”
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Pengembangan Fast Render Objek Grafis Menggunakan Shader dan Non-Shader Berbasis WebGL dari Primitive Object untuk Membuat Raw Metaverse Material Objek Skybox 3D di Filkom UB by Imam Cholissodin, Eriq Muhammad Adams Jonemaro, Bayu Rahayudi, Willyan Eka Ksatria, Annisa Sukmawati, Muhammad Farid Muzayyani

“…Since the emergence of WebGL, many browser developers have utilized it into their browsers. Because the system is interactive and does not require plug-ins, WebGL gets the name of “the future of the internet”. …”
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Cost-effectiveness analysis of three surgical approaches for parathyroidectomy in secondary hyperparathyroidism patients by Qila Sa, Qila Sa, Yinghui Zhou, Guangming Cheng, Boyuan Nan, Yingnan Feng, Yingnan Feng, Ningyuan Zhang, Ningyuan Zhang, Wantao Xie, Wantao Xie, Wei Zhang

“…Sensitivity analysis results indicate that varying any parameter within a certain range over the given time interval will not cause the ICER to exceed the WTP threshold and will not reverse the primary analysis results.ConclusionIn the Chinese healthcare system, tPTX is considered the most cost-effective treatment for refractory hyperparathyroidism, when compared to tPTX+AT and sPTX.…”
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Optogenetic control of horizontally acquired genes prevent stuck fermentations in yeast by David Figueroa, Diego Ruiz, Nicolò Tellini, Matteo De Chiara, Eduardo I. Kessi-Pérez, Claudio Martínez, Gianni Liti, Amparo Querol, José M. Guillamón, Francisco Salinas

“…We then implemented an optogenetic system in this wine yeast strain to precisely regulate the expression of each gene, generating a collection of 12 strains that allow for light-activated gene expression. …”
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Computational identification of anti-cancer compounds targeting the RNA-binding domain of human FOX-1 protein (RBFOX1) by Muhammad Tahir ul Qamar, Pablo Sanz-Jimenez, Shaima Rabeea Banoon, Xi-Tong Zhu, Fahad M. Aldakheel, Nahlah Makki Almansour, Leen A. Aldaiji, Wafa Abdullah I. Al-Megrin, Faisal Ahmad

“…Phe52, Arg10, Thr84, Ala85 and Arg86 has demonstrated the stability of the system due to robust hydrogen bonds. All of the top hit inhibitor exhibited more stability in comparison to the control inhibitor, where it penetrated deeply, as depicted in PCA analysis. …”
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Short-Term Effect of Air Pollution on Daily Hospital Visits for Anxiety Disorders in Southern China with Low Pollution Concentrations by Xinyuan Zhong, Tingting Guo, Jianghui Zhang, Qiong Wang, Rong Yin, Kunpeng Wu, Qing Zou, Meng Zheng, Brian J. Hall, Andre M. N. Renzaho, Kangning Huang, Wen Chen

“…A generalized additive model was used to perform a time-series analysis on data from a Southern China city’s medical insurance system between 1 March 2021, and 31 July 2023. Although the daily levels of most pollutants (PM₁₀, SO₂, CO, NO₂ and O₃) were consistently below China and WHO’s Ambient Air-Quality Standards, significant associations were observed between daily hospital visits for ADs and all six air pollutants. …”
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Canadian Rhinology Working Group consensus statement: biologic therapies for chronic rhinosinusitis by Andrew Thamboo, S. Kilty, I. Witterick, Y. Chan, C. J. Chin, A. Janjua, A. Javer, J. Lee, E. Monterio, B. Rotenberg, J. Scott, K. Smith, D. D. Sommer, L. Sowerby, M. Tewfik, E. Wright, M. Desrosiers

“…Consensus was defined by removing the highest and lowest of the scores and using the “3 point relaxed system”. Results After three rounds, a total of 11 statements achieved consensus. …”
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Development and Evaluation of an Immunochromatographic Strip and a Magnetic Chemiluminescence Immunoassay for Detection of <i>Porcine Circovirus Type 2</i> Antigen by Sirui Tao, Yu Duan, Yinhe Zha, Xiaxia Tong, Yulong He, Huapeng Feng, Jianhong Shu

“…The recombinant protein was constructed using a prokaryotic expression system, and the polyclonal antibody was obtained by animal experiments. …”
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Single dose of recombinant baculovirus vaccine expressing sigma B and sigma C genes provides good protection against novel duck reovirus challenge in ducks by Yufei Wang, Siyi Xu, Xia Chen, Yunlong Dou, Xingzhu Yang, Zenglei Hu, Shuang Wu, Xiaoquan Wang, Jiao Hu, Xiufan Liu

“…Here, we developed two subunit vaccine candidates for NDRV based on the insect cell-baculovirus expression system (IC-BEVS). Two recombinant viruses, namely rBac-σB and rBac-σC, were successfully generated based on the consensus sequence of NDRV. …”
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Deciphering the role of flutamide, fluorouracil, and furomollugin based ionic liquids in potent anticancer agents: Quantum chemical, medicinal, molecular docking and MD simulation... by Danish Ali, Muhammad Arif Ali, Muhammad Sarfraz, Afifa Yousuf, Rasham Zulfiqar, Abdul Rauf, Hong-Liang Xu, Muhammad Arshad

“…The metabolic prediction for [FM1]+ was consistent with its expected behavior in the biological system with its likelihood ranging from 89 % to 83 %. …”
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A new phase of China-ASEAN health cooperation: the China-ASEAN Beijing Declaration on Cooperation in Innovation of Health Products and Technologies by Jie Qiao, Siyan Zhan, Minghui Ren, Haijun Wang, Yangmu Huang, Zhenyu Zhang, Yanan Luo, Hui Yin, Zhongwei Jia, Wei Huang, Hong Zhou, Jue Liu, Xiaoyun Liu, Qiudan Sun, Xiaojia Li, Jing Bai, Fangjing Liu, Yihong Liu, Yinzi Jin, Ming Xu, on behalf of China-ASEAN Science and Technology Cooperation Center for Public Health

“…The Center held the Second Annual Forum on China-ASEAN Cooperation in Public Health on June 26–28, 2024, and the participants reached consensus on launching the China-ASEAN Beijing Declaration on Cooperation in Innovation of Health Products and Technologies, which calls on China and ASEAN countries to carry out the following actions: (1) Establish a more effective, open, and inclusive cooperation mechanism for health product innovation towards a China-ASEAN innovation ecosystem; (2) Enhance R&D capabilities by targeting new technologies, methods and appropriate and affordable health products for key populations and addressing diseases prevalent in China and ASEAN; (3) Establish a China-ASEAN Collaboration Center for Health Product Innovation, coordinate regional development plans, and enhance equitable access to pharmaceutical products at the regional level; (4) Accelerate regulatory harmonization in the region by optimizing and improving regulatory modalities of China and ASEAN Countries; and (5) Strengthen cross-sectoral cooperation to build resilient health system and achieve sustainable development of innovation cooperation. …”
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Characteristics and Outcomes of 79 Patients with an Insulinoma: A Nationwide Retrospective Study in Finland by Elina Peltola, Päivi Hannula, Heini Huhtala, Saara Metso, Ulla Kiviniemi, Martine Vornanen, Juhani Sand, Johanna Laukkarinen, Mirja Tiikkainen, Camilla Schalin-Jäntti, Johanna Arola, Jukka Sirén, Antti Piiroinen, Minna Soinio, Pirjo Nuutila, Mirva Söderström, Hanna Hämäläinen, Leena Moilanen, David Laaksonen, Elina Pirinen, Fia Sundelin, Tapani Ebeling, Pasi Salmela, Markus J. Mäkinen, Pia Jaatinen

“…To shorten the delay, clinicians should be informed and alert to consider the possibility of hypoglycemia and insulinoma, when symptomatic attacks are investigated in different sectors of the healthcare system. Developing the surgical treatment is another major target, in order to lower the overall complication rate, without compromising the high cure rate of insulinomas.…”
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Analisis Perbandingan Algoritma Machine Learning dan Deep Learning untuk Klasifikasi Citra Sistem Isyarat Bahasa Indonesia (SIBI) by Mohammad Farid Naufal, Selvia Ferdiana Kusuma

“…They can only communicate through sign language, one of which is the Indonesian Language Sign System or Sistem Isyarat Bahasa Indonesia (SIBI). …”
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