Electrochemotherapy with bleomycin, oxaliplatin, or cisplatin in mouse tumor models, from tumor ablation to in situ vaccination by Katja Uršič Valentinuzzi, Katja Uršič Valentinuzzi, Urška Kamenšek, Urška Kamenšek, Simona Kranjc Brezar, Chloe Heranney, Chloe Heranney, Tilen Komel, Tilen Komel, Simon Buček, Simon Buček, Maja Čemažar, Maja Čemažar, Gregor Serša, Gregor Serša

“…IntroductionIn addition to its direct cytotoxic effects, ablative therapies as electrochemotherapy (ECT) can elicit indirect antitumor effects by triggering immune system responses. Here, we comprehensively analyzed this dual effectiveness of intratumoral ECT with chemotherapeutic drugs bleomycin (BLM), oxaliplatin (OXA), and cisplatin (CDDP). …”
Get full text

Cost-Consequence Analysis of Apixaban Versus Rivaroxaban for Managing Patients with Venous Thromboembolism in Saudi Arabia by Abdulaali R. Almutairi PhD, Yazed Alruthia PhD, Majed S. Alyami PharmD, Omar A. Alshaya PharmD, Taif Z. Alanazi PharmD, Sarah I. Al Daghreer PharmD, Ghazwa B. Korayem PharmD, Sarah A. Alrasheed PharmD, Reema A. Alorf PharmD, Omar A. Almohammed PhD

“…The incremental cost-effectiveness ratio (ICER) was computed from the perspective of the Saudi National Health System, therefore only direct costs were considered. …”
Get full text

Mechanical properties and energy absorption of CoCrNi functionally graded TPMS cellular structures by Zhaoyi Wang, Junxian Zhou, Yunzhuo Lu, Dongming Li, Deyu Yue, Xu Zhang, Bingzhi Chen

“…The quasi-static and dynamic mechanical performance, deformation behavior, and energy absorption properties of each structure were investigated by universal testing machine and Split Hopkinson Pressure Bar (SHPB) system. Additionally, based on experimental validation, the Johnson-Cook constitutive model for SLM-ed CoCrNi was successfully developed and applied to finite element analysis (FEA) predictions. …”
Get full text

Changes on the Development of Rigor Mortis in Cultured Tilapia (Oreochromis niloticus) Fed with a Mixture of Plant Proteins by Nathaly Montoya Camacho, Enrique Márquez Ríos, Francisco Javier Castillo Yáñez, Saúl Ruíz Cruz, Aldo Alejandro Arvizu Flores, Wilfrido Torres Arreola, Jose Luis Cárdenas López, Santiago Valdéz Hurtado, Víctor Manuel Ocaño Higuera

“…The experiment was conducted in a tank system at 26.8°C water temperature for 67 days. The chemical composition of experimental diets and muscle were determined. …”
Get full text

Spinal pain prevalence and associated determinants: A population‐based study using the National Survey for Wales by David C. Byfield, Benjamin S. Stacey, Hywel T. Evans, Ian W. Farr, Leon Yandle, Lora Roberts, Teresa Filipponi, Damian M. Bailey

“…For various comorbidities included in the NSWD, significant associations with SP were confirmed for: mental illness (aOR = 1.42, p = <0.001), migraine (aOR = 2.73, p = <0.001), nervous system issues (aOR = 1.61, p = <0.001), arthritis (aOR = 1.30, p = <0.001) and issues with bones/joints/muscles (aOR = 1.93, p = <0.001). …”
Get full text

Environmental innovations as factor of development of petrochemical industry in Russia by A. I. Shinkevich, S. S. Kudryavtseva, Yu. N. Khakimullin, M. I. Farakhov

“…Methods applied: general scientific methods are used — system analysis, causeand-effect relationships, description and generalization; as well as special methods — graphical analysis, component analysis, factor analysis, descriptive statistics. …”
Get full text

Size effect-based improved antioxidant activity of selenium nanoparticles regulating Anti-PI3K-mTOR and Ras-MEK pathways for treating spinal cord injury to avoid hormone shock-indu... by Peixin Liu, Xiaodong Liu, Zihao Wu, Kui Shen, Zhaofeng Li, Xiaowei Li, Qifeng Wu, Leung Chan, Zhong Zhang, Yutong Wu, Liwen Liu, Tianfeng Chen, Yi Qin

“…Abstract Spinal cord injury (SCI) is a critical condition affecting the central nervous system that often has permanent and debilitating consequences, including secondary injuries. …”
Get full text

MftG is crucial for ethanol metabolism of mycobacteria by linking mycofactocin oxidation to respiration by Ana Patrícia Graça, Vadim Nikitushkin, Mark Ellerhorst, Cláudia Vilhena, Tilman E Klassert, Andreas Starick, Malte Siemers, Walid K Al-Jammal, Ivan Vilotijevic, Hortense Slevogt, Kai Papenfort, Gerald Lackner

“…In conclusion, this work closes an important knowledge gap concerning the mycofactocin system and adds a new pathway to the intricate web of redox reactions governing the metabolism of mycobacteria.…”
Get full text

Transcriptomic analysis of melatonin on the mechanism of embryonic gonadal development in female Jilin white geese by Jin Yu, Ichraf Mabrouk, Qiuyuan Liu, Yuxuan Zhou, Yupu Song, Jingyun Ma, Fengshuo Liu, Xiangman Hu, Zhiyi Yang, Yuxia Zeng, Jingtao Hu, Yongfeng Sun

“…The protein-protein interaction network analysis (PPI) indicated that selected DEGs, such as PDIA3, ATCB, PKM, PGAM1, NME2, LDHB, and CALM2, were highly related to the regulation of the reproduction system development. Additionally, the expression trends of 4 identified DEGs were validated by RT-qPCR. …”
Get full text

Analysis of the spatial pattern and causes of ecological environmental quality in Myanmar based on the RSEI model and the Geodetector-GCCM method by Shuangfu Shi, Shuangfu Shi, Shuangyun Peng, Shuangyun Peng, Zhiqiang Lin, Zhiqiang Lin, Bangmei Huang, Dongling Ma, Dongling Ma, Ziyi Zhu, Ziyi Zhu, Yilin Zhu, Yilin Zhu, Rui Zhang, Ting Li

“…It enriched the understanding of human-environment interactions within coupled systems and delved into the complex mechanisms and causal effects among multiple factors within the ecological system. …”
Get full text

April 15th war and hemodialysis patients in Sudan: a cross-sectional study by Malaz Hassan Dafaalla Idrees, Moez Mohammed Ibrahim Bashir, Balqees Abdeen Ahmed Mohamed, Amal Essam Ali Ahmed, Hamid Mohieldin Mohamed Abdalla, Kamil Mirghani Ali Shaaban

“…The ongoing armed conflict in Sudan has led to a worsening humanitarian catastrophe, posing serious challenges to the country’s health-care system and even its collapse. Healthcare facilities have been severely affected, with barely one-third of hospitals operating in conflict zones. …”
Get full text

Assessment of relative energy deficiency in sport and malnutrition prevalence in female endurance runners by energy availability questionnaire, bioelectrical impedance analysis and... by Samantha Sharp, Roni Mashiach-Fransis, Nicola Keay, Adrian Slee

“…All participants answered the Energy Availability Questionnaire, and a scoring system was used to assess REDs risk. 56 from this group underwent anthropometric measurements using multifrequency BIA, and 20 subsequently underwent finger prick capillary blood test to evaluate oestrogen, progesterone, follicle-stimulating hormone, luteinising hormone, and testosterone levels 7 days before their predicted period. …”
Get full text

Experimental Investigation on Shear Strength between Ultra-High-Performance Concrete and Normal Concrete Substrates by Xinghong Jiang, Hengxiang Song, Ke Li, Jing Qiang, Jing Tian

“…Through the oblique shear test, combined with the XTDIC full-field strain monitoring system, the failure process and failure mode of UHPC-NC specimens were studied and analyzed under different interface keyway numbers (0, 1, 2, and 3), interface agents (meshless interface agent, cement slurry, silica fume modified cement slurry, modified cement slurry mesh, cement slurry, and expansion agent), and NC pouring grades (C30, C35, C40, and C50), as well as the influencing factors of shear strength, shear stiffness, and the slip model of the bonding interface. …”
Get full text

CHI study: protocol for an observational cohort study on ageing and mental health in community-dwelling older adults by Lei Feng, Lieng Hsi Ling, Qiushi Feng, Rachael Zhi Yi Lee, Junhong Yu, Iris Rawtaer, Patrick Finbarr Allen, Zhiming Bao, Jeong Kyu Lee, Chin Tat Lim, Leng Leng Thang, Thet Naing, D Y Wang, Kai Zhen Yap, EH Kua, Rathi Mahendran

Get full text

Implementasi Algoritma Naïve Bayes untuk Mendeteksi Resiko Tinggi Diabetes Melitus Pada Ibu Hamil (Studi Kasus : Puskesmas Kabupaten Malang) by Fatmawati Fatmawati, Satrio Agung Wicaksono, Satrio Hadi Wijoyo

“…In addition, recommendations from the system can support a midwife's decision making in taking action to pregnant women. …”
Get full text

S’approprier, c’est résister. Appropriations spatiales et mobilisation infra-politique des femmes en immobilité résidentielle et sociale dans les bidonvilles de Salé (Maroc)... by Myriame Ali-Oualla

“…Home ownership offers little or no economic opportunity and does not weaken the systemic gender and class domination that conditions their inertia. …”
Get full text

Synergetic effects of network interconnections in the conditions of virtual reality by Kraus Kateryna, Kraus Nataliia, Shtepa Olena

“…METHODOLOGY: On the basis of dialectical, systemic and matrix methods and using the institutional-network approach, the characteristic features of network interactions of cluster formations in the conditions of virtual reality are studied, which are becoming the norm today, a good quality and effective rule for the practical implementation of various sectors of the economy in the course of digitalization of the economy. …”
Get full text

Health-related adverse work outcomes associated with post COVID-19 condition: a cross-sectional study by Peter M Smith, Hind Sbihi, Wei Zhang, Adeera Levin, Naveed Z Janjua, Hiten Naik, Bingyue Zhu, Lee Er, Karen Tran

“…This is an important consideration for clinicians, employers and health system leaders.…”
Get full text

Human neural rosettes secrete bioactive extracellular vesicles enriched in neuronal and glial cellular components by Malena Herrera Lopez, Matías Bertone Arolfo, Mónica Remedi, Laura Gastaldi, Carlos Wilson, Gonzalo G. Guendulain, Danilo Ceschin, Andrés Cardozo Gizzi, Alfredo Cáceres, Ana Lis Moyano

“…Abstract Extracellular vesicles (EVs) play a critical role in the development of neural cells in the central nervous system (CNS). Human neural rosettes (hNRs) are radial cell structures that assemble from induced pluripotent stem cells (hiPSCs) and recapitulate some stages of neural tube morphogenesis. …”
Get full text

Addition of Vitamin C on Diet to Improve Immunity on Tiger Grouper, Epinephelus fuscoguttatus to Infection Viral Nervous Necrosis by F. Johnny, K. Mahardika, I.N.A. Giri, D. Roza

“…Each tank is equipped with flow-through water system and aeration.  Experimental diets were formulated to have the same nutrients content except of vitamin C stable form (L-ascorbyl-2-Phosphate-Magnesium) with different dose, that is 0; 300; 600; 1.200 mg/kg diet was added to each formula.  …”
Get full text