Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression by Daniël G. Aynekulu Mersha, Sarah E. Fromme, Frank van Boven, Gara Arteaga-Henríquez, Annemarie Wijkhuijs, Marianne van der Ent, Raf Berghmans, Bernard T. Baune, Hemmo A. Drexhage, Virgil Dalm

“…It is known that T cells are essential for limbic system development/function. Treatment with thymosin α1 (Tα1) is capable to increase the thymus output of naïve T cells. …”
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Experimental study and gyrokinetic simulations of isotope effects on core heat transport in JET tokamak deuterium and tritium plasmas by D. Brioschi, P. Mantica, A. Mariani, N. Bonanomi, E. Delabie, J. Garcia, N. Hawkes, I. Jepu, D. Keeling, E. Lerche, E. Litherland-Smith, C.F. Maggi, S. Menmuir, G. Szepesi, D. Taylor, D. Van Eester, JET Contributors

“…To this aim, a database of H, D and T shots is analyzed, including new dedicated shots, comparing experiments with lower and higher power injected by the NBI system. In order to characterize the turbulence dependence on the isotope mass, three of these discharges (two in T and one in D) with same external heating scheme are studied in detail and interpreted with gyrokinetic linear and nonlinear simulations. …”
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Assessment of upper respiratory and gut bacterial microbiomes during COVID-19 infection in adults: potential aerodigestive transmission by Hafez Al-Momani, Andrew Nelson, Hadeel Al Balawi, Dua’a Al Balawi, Iman Aolymat, Ashraf I. Khasawneh, Hala Tabl, Ayman Alsheikh, AbdelRahman M. Zueter, Jeffrey Pearson, Christopher Ward

“…Connections and interactions between the microbiome of the gut and respiratory system have been linked with viral infections via what has been referred to as the ‘gut-lung axis’ with potential aerodigestive communication in health and disease. …”
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Template switching during DNA replication is a prevalent source of adaptive gene amplification by Julie N Chuong, Nadav Ben Nun, Ina Suresh, Julia Cano Matthews, Titir De, Grace Avecilla, Farah Abdul-Rahman, Nathan Brandt, Yoav Ram, David Gresham

“…Using a CNV reporter system and neural network simulation-based inference (nnSBI) we quantified the formation rate and fitness effect of CNVs for each strain. …”
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Decoding links between magmatic processes and eruption dynamics: whole-rock time series petrology of the 2021 Tajogaite eruption, La Palma by Jane H. Scarrow, Matthew J. Pankhurst, Olivia A. Barbee, Katy J. Chamberlain, Daniel J. Morgan, Marc-Antoine Longpré, Samantha Tramontano, James Hickey, David A. Neave, Gavin K. Rollinson, Alexander G. Stewart, Penny E. Wieser, Beverley C. Coldwell, William Hernández, Luca D’Auria, Nemesio M. Pérez

“…High temporal resolution sampling of near-continuously erupted alkali-basalt lava and tephra over the 85-day event reveals magma plumbing system dynamics from compositional trends. Initial deposits were mineralogically varied, reflecting mobilisation of shallow, evolved mush perturbed by fresh deep, primitive magma influx (Stage 1 - initiation). …”
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Diagnostics and Treatment of Esophageal Achalasia (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medicine, Russ... by V. T. Ivashkin, A. S. Trukhmanov, I. V. Maev, O. M. Drapkina, A. I. Martynov, O. A. Storonova, E. A. Godgello, M. P. Korolev, T. L. Lapina, P. V. Pavlov, A. V. Paraskevova, I. A. Tarasova, E. D. Fedorov, A. T. Tskhovrebov, M. P. Shapka, A. L. Shestakov, A. V. Yurasov

“…However, it is believed that the key role belongs to the changes in the myenteric (Auerbach’s) intermuscular plexus of the enteric nervous system of the esophagus, leading to loss of neuronal function. …”
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mTORC2 Activation Mediated by Mesenchymal Stem Cell-Secreted Hepatocyte Growth Factors for the Recovery of Lipopolysaccharide-Induced Vascular Endothelial Barrier by Shan-Shan Meng, Feng-Mei Guo, Li-Li Huang, Ying-Zi Huang, Jian-Feng Xie, Cong-Shan Yang, Hai-Bo Qiu, Yi Yang

“…We introduced MSC-PMVEC coculture transwell system and recombinant murine HGF on LPS-induced endothelial cell barrier dysfunction in vitro and then explored potential mechanisms by lentivirus vector-mediated HGF, mTORC1 (raptor), and mTORC2 (rictor) gene knockdown modification. …”
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AI-based carbon peak prediction and energy transition optimization for thermal power industry in energy-intensive regions of China by Chenhao Huang, Zhongyang Lin, Jian Wu, Penghan Li, Chaofeng Zhang, Yanzhao Liu, Weirong Chen, Xin Xu, Jinsong Deng

“…Firstly, a highly explanatory system of carbon emission impact indicators in the thermal power industry was established utilizing an Optimal Parameters-based Geographical Detector. …”
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Epidemiological Dynamics of Extended-Spectrum β-Lactamase- or AmpC β-Lactamase-Producing Escherichia coli Screened in Apparently Healthy Chickens in Uganda by Steven Kakooza, Damien Munyiirwa, Paul Ssajjakambwe, Edrine Kayaga, Dickson Stuart Tayebwa, Dickson Ndoboli, Loreen Basemera, Esther Nabatta, Maria Agnes Tumwebaze, John Baligwamunsi Kaneene

“…Univariable screening hypothesized that carriage was probably influenced by a type of commercial chicken, geographical location, age group, flock size, and housing system (p<0.05). Modeling exposed that broiler birds were at a higher risk of being ESBL-/AmpC-EC carriers (COR = 9.82, CI = 3.85–25.07). …”
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Robot-Assisted versus Laparoscopic-Assisted Gastrectomy among Gastric Cancer Patients: A Retrospective Short-Term Analysis from a Single Institution in China by Li-Fei Sun, Kai Liu, Xue-Shang Su, Xuan Wei, Xiao-Long Chen, Wei-Han Zhang, Xin-Zu Chen, Kun Yang, Zong-Guang Zhou, Jian-Kun Hu

“…The da Vinci robotic system was considered an effectively alternative treatment option for early gastric cancer patients in recent years. …”
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Angel or devil: the dual roles of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucopyranoside in the development of liver injury based on integrating pharmacological techniques: a system... by Jiajie Jiang, Jiajie Jiang, Qixiu Wang, Qiang Wu, Bobin Deng, Cui Guo, Jie Chen, Jinhao Zeng, Yaoguang Guo, Xiao Ma

“…The purpose of this study is to evaluate both the hepatoprotective and hepatotoxic effects of TSG and give therapeutic guidance.MethodsThis study performed a systematic search of eight databases to identify preclinical literature up until March 2024. The CAMARADES system evaluated evidence quality and bias. STATA and Python were used for statistical analysis, including dose-effect maps, 3D maps and radar charts to show the dose-time-effect relationship of TSG on hepatoprotection and hepatotoxicity.ResultsAfter a rigorous screening process, a total of 24 studies encompassing 564 rodents were selected for inclusion in this study. …”
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Roles of the rpoEc-chrR-chrA operon in superoxide tolerance and β-lactam susceptibility of Stenotrophomonas maltophilia by Ren-Hsuan Ku, Hsu-Feng Lu, Li-Hua Li, Li-Hua Li, Ting-Yu Yeh, Yi-Tsung Lin, Yi-Tsung Lin, Tsuey-Ching Yang

“…IntroductionThe rpoE-chrR pair is a regulatory system used by photosynthetic microorganisms to overcome singlet oxygen stress. rpoE and chrR encode the sigma factor σE and anti-sigma factor ChrR, respectively. …”
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Moss-pathogen interactions: a review of the current status and future opportunities by Huan Zhang, Huan Zhang, Qilin Yang, Qilin Yang, Leyi Wang, Leyi Wang, Huawei Liu, Huawei Liu, Daoyuan Zhang, Daoyuan Zhang, Cheng-Guo Duan, Xiaoshuang Li, Xiaoshuang Li

“…Mosses, representing early divergent lineages of land plants, lack traditional vascular systems yet demonstrate remarkable adaptability across diverse habitats. …”
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Dietary protein requirement of Chinese hook snout carp (Opsariichthys bidens) and transcriptomic analysis of the liver in response to different protein diets by Yijiang Bei, Linqiang He, Jin Jing, Xiaoming Chen, Fan Yuan, Gaohua Yao, XueYan Ding, Lei Wang, Fan Zhou

“…Compared with those in the P41 group, some genes related to the digestive system (e.g., carboxypeptidases, elastase 2, trypsin-2, and bile salt-activated lipase) and immune response (e.g., NF-kappa B inhibitor alpha, tumor necrosis factor alpha-induced protein 3, complement C3, and C7) were significantly upregulated in the P47 group. …”
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NLRX1 limits inflammatory neurodegeneration in the anterior visual pathway by Alexander J. Gill, Matthew D. Smith, Danny Galleguillos, Thomas Garton, Jackson W. Mace, Sachin P. Gadani, Swati Kumar, Aayush Pokharel, Krista Solem, Saahith Potluri, Omar Hussein, Giuliana Sardi Rogines, Arihant Singh, Annatje Clark, Peter A. Calabresi, Marjan Gharagozloo

“…Abstract Chronic innate immune activation in the central nervous system (CNS) significantly contributes to neurodegeneration in progressive multiple sclerosis (MS). …”
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Automated diagnosis and grading of lumbar intervertebral disc degeneration based on a modified YOLO framework by Aobo Wang, Tianyi Wang, Xingyu Liu, Xingyu Liu, Xingyu Liu, Ning Fan, Shuo Yuan, Peng Du, Congying Zou, Ruiyuan Chen, Yu Xi, Zhao Gu, Hongxing Song, Qi Fei, Yiling Zhang, Yiling Zhang, Lei Zang

“…This study aimed to develop and evaluate a deep-learning-assisted automated system for diagnosing and grading lumbar intervertebral disc degeneration based on lumbar T2-weighted sagittal and axial MR images.MethodsThis study included a total of 472 patients who underwent lumbar MR scans between January 2021 and November 2023, with 420 in the internal dataset and 52 in the external dataset. …”
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Sistem Monitoring Tekanan Darah Berbasis Maximum Amplitude Algorithm Menggunakan Android Secara Realtime by Barlian Henryranu Prasetio, Brylliano Maza Putra, Dahnial Syauqy

“…In the developed tool, the result value of the processing using the MAA method will be sent using the bluetooth module HC-05 to be displayed on the android device. In testing the system, obtained the reading accuracy rate of systole value of 78.23% and diastole reading accuracy rate of 88.39% compared with readings using a manual tensimeter. …”
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Efficacy of yeast beta-glucan 1,3/1,6 supplementation on respiratory infection, fatigue, immune markers and gut health among moderate stress adults in Klang Valley of Malaysia: pro... by Suzana Shahar, Kalavathy Ramasamy, Norhayati Ibrahim, Nur Nadia Mohamad Habibullah, Munirah Ismail, Mohd Zul Amin Kamaruddin, Shirley Gee Hoon Tang, Mohd Faisal Abdul Hamid

“…Introduction Yeast beta-glucan (YBG) are recognised for enhancing the immune system by activating macrophages, a key defence mechanism. …”
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Investigating the effect of 1,25 dihydroxycholecalciferol-glycosides and phytogenic antioxidants against bacterial chondronecrosis induced by aerosol transmission model by Khawla Alharbi, Andi Asnayanti, Amer Hasan, Wesley J. Vaught, Kathrin Buehler, Jan Dirk Van der Klis, Javier Gonzalez, Michael T. Kidd, Adnan Alrubaye

“…Supplementation of 1,25(OH)2D3 is crucial in regulating calcium and phosphorus homeostasis, immune system, and bone metabolism. 1,25(OH)2D3 glycosides derived from Solanum glaucophyllum (G-1,25(OH)2D3) were hypothesized to mitigate BCO lameness in broilers. …”
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Comparative Analysis of Automated and Handheld Breast Ultrasound Findings for Small (≤1 cm) Breast Cancers Based on BI-RADS Category by Han Song Mun, Eun Young Ko, Boo-Kyung Han, Eun Sook Ko, Ji Soo Choi, Haejung Kim, Myoung Kyoung Kim, Jieun Kim

“…<b>Objectives</b>: This study aimed to compare ultrasound (US) findings between automated and handheld breast ultrasound (ABUS and HHUS, respectively) in small breast cancers, based on the breast imaging reporting and data system (BI-RADS) category. <b>Methods</b>: We included 51 women (mean age: 52 years; range: 39–66 years) with breast cancer (invasive or DCIS), all of whom underwent both ABUS and HHUS. …”
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