Conjugation of LasR Quorum-Sensing Inhibitors with Ciprofloxacin Decreases the Antibiotic Tolerance of P. aeruginosa Clinical Strains by Daria Bortolotti, Claudio Trapella, Alessandra Bragonzi, Paolo Marchetti, Vinicio Zanirato, Andrea Alogna, Valentina Gentili, Carlo Cervellati, Giuseppe Valacchi, Mariangela Sicolo, Giulia Turrin, Anna Fantinati, Dario Di Luca, Roberta Rizzo

“…Pseudomonas aeruginosa is a Gram-negative bacterium that commonly infects subjects with weakened immune system causing deadly infections above all at pulmonary level. …”
Get full text

From Acceptance to Dependence: Exploring Influences of Smart Healthcare on Continuous Use Intention of Mobile Health Services Among Older Adults with Chronic Illnesses in China by Jiacheng Luo, Kewei Zhang, Qianghong Huang, Shan Jiang, Younghwan Pan

“…With the acceleration of the aging process in China, chronic diseases have become one of the main health threats for older adults, creating significant pressure on society and the healthcare system. As information technology and artificial intelligence advance rapidly, smart health services have become readily accessible. …”
Get full text

Ductal Carcinoma In Situ (DCIS) Diagnosed by MRI-Guided Biopsy among BRCA1/BRCA2 Mutation Carriers by Renata Faermann, Eitan Friedman, Orit Kaidar-Person, Jonathan Weidenfeld, Malka Brodsky, Anat Shalmon, Osnat Halshtok Neiman, Michael Gotlieb, Yael Yagil, David Samoocha, Dana Madorsky Feldman, Miri Sklair-Levy

“…Clinical data, pathology information, and imaging characteristics were retrieved from the computerized archiving system. Results. 18/121 (15.2%) participating BRCA1 PSV carriers and 8/81 (10.1%) BRCA2 PSV-carriers who underwent MRI-guided biopsy were diagnosed with DCIS. …”
Get full text

Wastewater Monitoring During the COVID-19 Pandemic in the Veneto Region, Italy: Longitudinal Observational Study by Honoria Ocagli, Marco Zambito, Filippo Da Re, Vanessa Groppi, Marco Zampini, Alessia Terrini, Franco Rigoli, Irene Amoruso, Tatjana Baldovin, Vincenzo Baldo, Francesca Russo, Dario Gregori

“…ObjectiveWe aimed to evaluate the effectiveness of the cumulative sum (CUSUM) control chart method in detecting changes in SARS-CoV-2 concentrations in wastewater and its potential as an early warning system for COVID-19 outbreaks. Additionally, we aimed to validate these findings over different time periods to ensure robustness. …”
Get full text

Insufficient gene expression and lost gene regulatory network may underlie the mechanism of Hirschsprung Disease in 5p–syndrome by Yizhao Luan, Peng Li, Yuanyuan Luo, Hong Zhang, Xiaochun Zhu, Yan Zhang, Aihua Yin, Qiang Wu, Chengwei Chai

“…On the one hand, leveraging human single-cell atlas for developing enteric nervous system, we demonstrated that some affected genes in these two patients overlapped with those showing expression changes along the development pseudotime of enteric nervous cells (ENC) and overlapped with known HSCR genes including RET, NRG1, ERBB (ERBB2 and ERBB3), ITGB (ITGB1). …”
Get full text

Positional embeddings and zero-shot learning using BERT for molecular-property prediction by Medard Edmund Mswahili, JunHa Hwang, Jagath C. Rajapakse, Kyuri Jo, Young-Seob Jeong

“…Abstract Recently, advancements in cheminformatics such as representation learning for chemical structures, deep learning (DL) for property prediction, data-driven discovery, and optimization of chemical data handling, have led to increased demands for handling chemical simplified molecular input line entry system (SMILES) data, particularly in text analysis tasks. …”
Get full text

Sistem Pendukung Keputusan untuk Penentuan Prioritas Pemberdayaan Masyarakat melalui Perilaku Hidup Bersih dan Sehat Menggunakan Metode Topsis by Alif Catur Murti, Ahmad Abdul Chamid

“…It can be said that this health promotion still cannot be said to be effective, because there is no system that can prioritize people who need empowerment in the form of health promotion and counseling. …”
Get full text

Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein by Yanxiao Han, John R.D. Dawson, Kevin R. DeMarco, Kyle C. Rouen, Khoa Ngo, Slava Bekker, Vladimir Yarov-Yarovoy, Colleen E. Clancy, Yang K. Xiang, Surl-Hee Ahn, Igor Vorobyov

Get full text

Prediction of digestible energy requirement in growing finishing stage of pigs using machine learning models by Nibas Chandra Deb, Jayanta Kumar Basak, Sijan Karki, Elanchezhian Arulmozhi, Dae Yeong Kang, Niraj Tamrakar, Eun Wan Seo, Junghoo Kook, Myeong Yong Kang, Hyeon Tae Kim

“…The livestock environment management system sensor and two load cells were used to measure the IT, IRH, ICO2, BW and DE intake of pigs, respectively. …”
Get full text

Preventing epileptogenesis by interaction between inositol isomers and proteins by Lia Tsverava, Luka Kharkhelauri, Vincenzo Lagani, Giorgi Gamkrelidze, Veriko Bokuchava, Tamar Kiguradze, Merab Kokaia, Revaz Solomonia

“…Abstract Objective Inositols play significant roles in biological systems. Myo‐inositol (MI), the most prevalent isomer, functions as an osmolyte and mediates cell signal transduction. …”
Get full text

Evaluating the quality of care for heart failure hospitalizations in inflammatory arthritis – A population-based cohort study by Bindee Kuriya, Lihi Eder, Sahil Koppikar, Jessica Widdifield, Anna Chu, Jiming Fang, Irene Jeong, Douglas Lee, Jacob Udell

Get full text

Impacts of Land Use on Soil Erosion: RUSLE Analysis in a Sub-Basin of the Peruvian Amazon (2016–2022) by Moises Ascencio-Sanchez, Cesar Padilla-Castro, Christian Riveros-Lizana, Rosa María Hermoza-Espezúa, Dayan Atalluz-Ganoza, Richard Solórzano-Acosta

“…The present study aimed to evaluate the increase in erosion levels, at a sub-basin of the central–eastern Amazon of Peru, in a Geographic Information System (GIS) environment. The revised universal soil loss equation (RUSLE) model was used for assessing the effect of vegetation cover change from 2016 to 2022. …”
Get full text

Analysis of the Heterogeneity of CD4+CD25+ T Cell TCR β CDR3 Repertoires in Breast Tumor Tissues, Lung Metastatic Tissues, and Spleens from 4T1 Tumor-Bearing BALB/c Mice by Teng Zhang, Fangfang Duan, Danhua Su, Long Ma, Jiezuan Yang, Bin Shi, Xiaoyan He, Rui Ma, Suhong Sun, Xinsheng Yao

“…However, the number and characteristics of overlapping CDR3 sequences suggested that there were some different CD4+CD25+ T cells in tumors and in the circulatory immune system. The study may be used to further explore the characteristics of the CDR3 repertoires and determine the source of the CD4+CD25+ T cells in the breast cancer microenvironment.…”
Get full text

Virulence profile of carbapenem-resistant Klebsiella pneumoniae strains by an in vivo model of Galleria mellonella by María Guembe, Rama Hafian, Marta Díaz-Navarro, Andrés Visedo, Flavio De Maio, Fulvia Pimpinelli, Ilaria Cavallo, Mauro Truglio, Francesca Sivori, Enea Gino Di Domenico

“…The G. mellonella model may serve as an effective in vivo system for evaluating the virulence of emerging K. pneumoniae lineages.IMPORTANCEWe demonstrate that the Galleria mellonella model is a useful tool to analyze the virulence of carbapenem-resistant Klebsiella pneumoniae strains. …”
Get full text

Immune Dysfunction and Coinfection with Human Immunodeficiency Virus and Schistosoma japonicum in Yi People by Yu Yang, Peng-Lei Xiao, Ya Yang, Jian-Chuan Gao, Yan Shi, Wan-Ting Cheng, Yue Chen, Xiu-Xia Song, Qing-Wu Jiang, Yi-Biao Zhou

“…To explore the association between infections with HIV and Schistosoma japonicum, and to determine the influences of the HIV-S. japonicum coinfections on the immune system of Yi people. Methods. A block design study was conducted in a Yi county in southwestern China, one of the endemic areas of both HIV/AIDS and S. japonicum in China. …”
Get full text

Sigma1 inhibitor suppression of adaptive immune resistance mechanisms mediated by cancer cell derived extracellular vesicles by Paola A. Castagnino, Derick A. Haas, Luca Musante, Nathalia A. Tancler, Bach V. Tran, Rhonda Kean, Alexandra R. Steck, Luis A. Martinez, Elahe A. Mostaghel, D. Craig Hooper, Felix J. Kim

Get full text

The cAMP Pathway Amplifies Early MyD88-Dependent and Type I Interferon-Independent LPS-Induced Interleukin-10 Expression in Mouse Macrophages by Orna Ernst, Yifat Glucksam-Galnoy, Muhammad Athamna, Iris Ben-Dror, Hadar Ben-Arosh, Galit Levy-Rimler, Iain D. C. Fraser, Tsaffrir Zor

Get full text

Solar Modulation of Low-energy Cosmic-Ray Nitrogen and Its Comparison with Oxygen by Yun Li, Xiaoping Zhang, Shuai Fu, Zhenning Shen, Yi Xu, Haoyu Lu, Jinbin Cao, Tianle Zhu

“…The heliospheric environment is very complex and filled with diverse high-energy particles from various origins, and among these particles, cosmic rays (CRs), including anomalous and Galactic components (ACRs and GCRs), are unique as they originate from beyond the solar system. Due to their stable and long-lasting presence in the heliosphere, the study of CRs is crucial for protecting humanity and other lifeforms against the hazards of high-energy radiation. …”
Get full text

Informed Design of a Gravity Science Experiment for the Future Geophysical Investigation of the Uranian Moons by Valerio Filice, Gael Cascioli, Sébastien Le Maistre, Rose-Marie Baland, Antony Trinh, Erwan Mazarico, Sander Goossens

“…The outer solar system beyond Saturn remains unexplored by dedicated orbital missions. …”
Get full text

Calorimetric studies of microwave ion thruster by I. S. Vavilov, K. I. Zharikov, P. S. Yachmenev, V. V. Fedyanin, P. V. Stepen, A. I. Lukyanchuk, I. A. Kuzmenko

“…Calorimetric studies of the prototype with a two-electrode accelerating system are carried out at the same accelerating voltages and power of the microwave generator and different mass gas flow rates. …”
Get full text