The SPES3 Experimental Facility Design for the IRIS Reactor Simulation by Mario Carelli, Lawrence Conway, Milorad Dzodzo, Andrea Maioli, Luca Oriani, Gary Storrick, Bojan Petrovic, Andrea Achilli, Gustavo Cattadori, Cinzia Congiu, Roberta Ferri, Marco Ricotti, Davide Papini, Fosco Bianchi, Paride Meloni, Stefano Monti, Fabio Berra, Davor Grgic, Graydon Yoder, Alessandro Alemberti

“…SPES3 simulates the primary, secondary, and containment systems of IRIS with 1 : 100 volume scale, full elevation, and prototypical thermal-hydraulic conditions. …”
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Host protein PRPS2 interact with the non-structural protein p17 of Avian Reovirus and promote viral replication by Hu Xiaomiao, Zhao Ruihong, Li Wei, Pan Xiaocheng, Dai Yin, Wu Huimin, Wu Yantao, Zhang Chengcheng

“…To further elucidate the pathogenic mechanism basis of ARV p17 protein function, we employed a yeast two-hybrid system to identify Phosphoribosyl pyrophosphate synthetase 2 (PRPS2) as an interacting host protein with p17. …”
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Fecal microbiome change in patients with ulcerative colitis after fecal microbiota transplantation by A. Y. Tikunov, V. V. Morozov, A. N. Shvalov, A. V. Bardasheva, E. V. Shrayner, O. A. Maksimova, I. O. Voloshina, V. V. Morozova, V. V. Vlasov, N. V. Tikunova

“…Intestinal human microbiota is a dynamic system that is under the pressures of its host organism and external factors. …”
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Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of gynecologic cancer by Anne Mills, Leisha A Emens, Mary L Disis, Kunle Odunsi, John B Liao, Tyler Curiel, Margaret Gatti-Mays, Amir Jazaeri, Emese Zsiros, Marcus O Butler, Jyoti Bajpai, Katherine C Kurnit, Haider Mahdi, Laura Doherty, Claire F Friedman, Melissa A Geller, Sarah F Adams, Shelley A Dodt, Veena S John

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Tobacco Use, Risk Perceptions, and Characteristics of Adults Who Used a Heated Tobacco Product (IQOS) in the United States: Cross-Sectional Survey Study by Hui G Cheng, Brendan Noggle, Andrea R Vansickel, Edward G Largo, Pierpaolo Magnani

“… BackgroundThe Tobacco Heating System (THS; commercialized as IQOS) is a smoke-free heated tobacco product introduced in the United States in 2019 and authorized by the US Food and Drug Administration as a modified risk tobacco product (MRTP) in 2020. …”
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IDH-mutant gliomas in children and adolescents - from biology to clinical trials by Louise Evans, Sarah Trinder, Sarah Trinder, Andrew Dodgshun, Andrew Dodgshun, David D. Eisenstat, David D. Eisenstat, David D. Eisenstat, James R. Whittle, James R. Whittle, James R. Whittle, Jordan R. Hansford, Jordan R. Hansford, Jordan R. Hansford, Santosh Valvi, Santosh Valvi, Santosh Valvi

“…Gliomas account for nearly 30% of all primary central nervous system (CNS) tumors in children and adolescents and young adults (AYA), contributing to significant morbidity and mortality. …”
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Comparative analysis of feeding strategies and post mortem aging time on the oxidative status and color of the longissimus thoracis et lumborum muscle in Braford steers by María Sofía Castaño Ledesma, Gustavo Adolfo Palma, Gustavo Adolfo Palma, Claudio Darío Borsarelli, Claudio Darío Borsarelli, María Sumampa Coria, María Sumampa Coria

“…The results demonstrated that the finishing system did not exert any discernible influence on the rates of lipid oxidation, antioxidant capacity, or muscle microstructure. …”
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Real-Time G-Protein-Coupled Receptor Imaging to Understand and Quantify Receptor Dynamics by María S. Aymerich, J. López-Azcárate, J. Bonaventura, G. Navarro, D. Fernández-Suárez, V. Casadó, F. Mayor, C. Lluís, M. Valencia, J. Artieda, Rafael Franco

“…The aim of this study was to develop a method to characterize receptor dynamics using this system which offers the advantage of very fast image acquisition with minimal cell perturbation. …”
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Identification of Behavioral, Clinical, and Psychological Antecedents of Acute Stimulant Poisoning: Development and Implementation of a Mixed Methods Psychological Autopsy Study by Marley Antolin Muñiz, Vanessa M McMahan, Xochitl Luna Marti, Sarah Brennan, Sophia Tavasieff, Luke N Rodda, James Knoll, Phillip O Coffin

“…MethodsWe ascertained death records from the California Electronic Death Reporting System (CA-EDRS) and the San Francisco Office of the County Medical Examiner (OCME) from June 2022 through December 2023. …”
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Transcranial vibration stimulation at 40 Hz induced neural activity and promoted the coupling of global brain activity and cerebrospinal fluid flow by Linghan Kong, Wei Jin, Yue Jiang, Fuhua Yan, Jun Liu, Eric C. Leuthardt, Guang-Zhong Yang, Yuan Feng

“…Additionally, this study investigates alterations in the global blood-oxygen-level-dependent (gBOLD) signal and cerebrospinal fluid (CSF) inflow coupling, which serve as indicators of glymphatic system function. Methods: A custom-built head actuator was used to apply 40 Hz TVS to human brain. …”
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The Real-World Clinical Outcomes of Heavily Pretreated HER2+ and HER2-Low Metastatic Breast Cancer Patients Treated with Trastuzumab Deruxtecan at a Single Centre by Anna-Maria Lazaratos, Matthew Dankner, Aalya Hamouda, Soumaya Labidi, Victor Cohen, Lawrence Panasci, Jennifer E. Friedmann, François Patenaude, Cristiano Ferrario, Mark Basik, April A. N. Rose, Parvaneh Fallah

“…Of these, 15 patients had classically defined HER2-positive (HER2+) breast cancer, 4 of whom had active central nervous system (CNS) metastases. A total of 23 patients had HER2-low breast cancer, 2 of whom had active CNS disease. …”
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Development of Tandem Ion Mobility Spectrometry with High-voltage Fragmentation Unit at Atmospheric Pressure for Explosives Detection by Kang-yi LIU, Tian-xin XIAN, Ling-feng LI, Yun-jing ZHANG, Xing-li HE, Peng LI

“…By changing the switch status of the ion gate and fragmentation grid, this system is capable of selecting specific parent mobility ions for fragmentation under ambient pressure. …”
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Can electronic monitoring with a digital smart spacer support personalised medication adherence and inhaler technique education in patients with asthma?: Protocol of the randomised... by Job F. M. van Boven, Boudewijn H.J. Dierick, Maria Achterbosch, Sandra Been-Buck, Titia Klemmeier, Susanne J. van de Hei, Paul Hagedoorn, Huib A.M. Kerstjens, Janwillem W.H. Kocks

“…At t=1, usability and satisfaction will be analysed using the System Usability Scale and interviews with patients and healthcare providers. …”
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Bisphenol A induces apoptosis and disrupts testosterone synthesis in TM3 cells via reactive oxygen species-mediated mitochondrial pathway and autophagic flux inhibition by Wenzhe Yang, Feilong Pan, Tong Zhao, Fangfang Chen, Wenqi Shao, Jinhao Wang, Shirui Wang, Zichen Zhao, Kexiang Liu, Shuchen Zhao, Lijia Zhao

“…Bisphenol A (BPA) is a common endocrine disruptor chemical that is widely used in the production of food plastic packaging, and it has been shown to potentially harm the reproductive system. However, the specific mechanism by which BPA induces apoptosis of Leydig cells (LCs) and inhibits testosterone synthesis in these cells is unclear. …”
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Urban and rural residence: their influence on food group consumption in Iran by Susan Darroudi, Sara Saffar Soflaei, Farzam Kamrani, Zahra Khorasanchi, Zahra Abdollahi, Nasrin Talkhi, Maryam Allahyari, Seyyed Reza Sobhani, Maryam Mohammadi-Bajgiran, Amirmohammad Naderkhmseh, Maliheh Aghasizadeh, Habibollah Esmaily, Gordon Ferns, Majid Ghayour-Mobarhan

“…Methods This study utilized data from Iran’s Food and Nutrition Surveillance System (FNS). A total of 1697 participants were randomly recruited from different rural (N = 568), urban (N = 568), and suburban (N = 561) regions across Iran. …”
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Rapid diagnostic testing combined with an immediate infectious disease consultation increases the rate of septic intensive care unit patients on targeted antibiotic therapy by Evelyn Kramme, Nadja Käding, Nadja Käding, Tobias Graf, Karolin Schmoll, Heidi Linnen, Katharina Nagel, Esther Grote-Levi, Susanne Hauswaldt, Dennis Nurjadi, Dennis Nurjadi, Jan Rupp, Jan Rupp, Jan Rupp

“…Overall adherence to the local antibiotic therapy guideline for sepsis was significantly lower in the control than in the intervention group (27.8% versus 89.3%, p<0.001).ConclusionIntegration of an RDT system in the microbiological workflow for septic patients in ICU combined with a standardized ID intervention led to a significantly higher percentage of adequate antimicrobial treatment and greater adherence to local antibiotic therapy recommendations, even in a setting where 24/7 service is not available.…”
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Detection of atrial fibrillation in primary care with radial pulse palpation, electronic blood pressure measurement and handheld single-lead electrocardiography: a diagnostic accur... by Wim A M Lucassen, Henk C P M van Weert, Bjorn Winkens, Henri E J H Stoffers, J André Knottnerus, Steven B Uittenbogaart, Nicole Verbiest-van Gurp, Petra M G Erkens

“…We present pooled diagnostic parameters.Setting 47 general practices participated between September 2015 and August 2018.Participants In the electronic medical record system of the participating general practices (n=47), we randomly marked 200 patients of ≥65 years without AF. …”
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Nicotine promotes M2 macrophage polarization through α5-nAChR/SOX2/CSF-1 axis in lung adenocarcinoma by Guiyu Kang, Hui Song, Lei Bo, Qi Liu, Qiang Li, Jingtan Li, Pan Pan, Jingting Wang, Yanfei Jia, Haiji Sun, Xiaoli Ma

“…Through diverse bioinformatics analyses and immunohistochemistry, the expressions of α5-nAChR and SOX2 as well as their relations were dissected. α5-nAChR regulated the differentiation of monocytes into M2 macrophages by targeting the STAT3/SOX2/CSF-1 signaling in the coculture system by western blotting and ChIP. α5-nAChR-mediated macrophage-mediated LUAD cell migration via SOX2/CSF-1 signaling in the cocultured medium. …”
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The potential endocrine-disrupting of fluorinated pesticides and molecular mechanism of EDPs in cell models by Yalan Liu, Fengzhong Wang, Lin Li, Bei Fan, Zhiqiang Kong, Jianxin Tan, Minmin Li

“…Environmental endocrine disruptors constitute a category of exogenous compounds that interfere with the endocrine system's functions in organisms or cells. As a class of particularly representative endocrine-disrupting chemicals, the accumulation of per- and polyfluoroalkyl substances potentially leads to adverse health effects, including hormonal disruptions, developmental issues, and cancer. …”
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The role of the Global Observatory in addressing Gender Based Violence in Sport+ by Hayley Truskewycz, Lombe Mwambwa

“…Gender equality, sport and the United Nation’s system: A historical overview of the slow pace of progress. …”
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