Functional and Cognitive Impairment in Patients with Relapsing–Remitting Multiple Sclerosis: Cognitive Tests and Plasma Neurofilament Light Chain Levels by Elina Polunosika, Joel Simren, Arta Akmene, Nikita Klimovskis, Kaj Blennow, Daina Pastare, Henrik Zetterberg, Renars Erts, Guntis Karelis

“…<i>Background and Objectives:</i> Multiple sclerosis (MS) is a chronic inflammatory, autoimmune, and neurodegenerative disease of the central nervous system. The disease can manifest and progress with both physical and cognitive symptoms, affecting the patient’s daily activities. …”
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CeRNA profiling and the role in regulating gonadal development in gold pompano by Changcan Yang, Yijun Zhao, Wendong Zhao, Hai Huang, Quanqi Zhang, Jinxiang Liu

“…Dual-luciferase gene reporter system and fluorescence in situ hybridization analyses preliminary verified the regulation relationship between Rspo1 and oni-let-7d-1-p3, as well as lnc-TGFβR and oni-let-7d-1-p3 in the cytoplasm of sertoli cells. …”
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The Petri Dish-N2B27 Culture Condition Maintains RPE Phenotype by Inhibiting Cell Proliferation and mTOR Activation by Hui Lou, Chunpin Lian, Fanjun Shi, Liqun Chen, Sicheng Qian, Hui Wang, Xiaoyun Zhao, Xiaoyan Ji, Jingfa Zhang, Guoxu Xu

“…To develop a method for the rapid isolation of rat RPE cells with high yield and maintain its epithelial state in modified culture system. Methods. The eyeballs were incubated with dispase. …”
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Trends in the use and dual use of factory-made combustible cigarettes, other tobacco products and electronic cigarettes: Results from South African Social Attitudes Surveys during... by Catherine O. Egbe, Siphesihle Gwambe, Mukhethwa Londani, Olufemi Erinoso, Olalekan A. Ayo-Yusuf

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After neonatal care, what next? A qualitative study of mothers’ post-discharge experiences after premature birth in Kenya by Justinah Maluni, Dorothy Oluoch, Sassy Molyneux, Mwanamvua Boga, Caroline Jones, Florence Murila, Mike English, Sue Ziebland, Lisa Hinton

“…Prominent healthcare structural and socio-economic factors in SSA, for example poverty and weak health systems, amplify vulnerabilities for mothers and premature babies; often leading to poor outcomes. …”
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It is time to tackle psychological determinants of obesity and eating disorders by Pietro Crescenzo

“…As stated by the EAT-Lancet Commission on Healthy Diets for Sustainable Food Systems, nutrition is a global problem that would require a dedicated Sustainable Development Goal (SDG) [2]. …”
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Co-producing a safe mobility and falls informatics platform to drive meaningful quality improvement in the hospital setting: a mixed-methods protocol for the insightFall study by Ben Glampson, Clare Leon-Villapalos, Erik Mayer, Rachael Lear, Phoebe Averill, Catalina Carenzo, Rachel Tao, Robert Latchford

“…Routine care delivery generates a large volume of relevant data in disparate systems, yet these data are seldom integrated and transformed into real-time, actionable insights for frontline staff. …”
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A proposal of visual assessment of serotonergic deficits in parkinsonian syndromes: An 123I-FP-CIT SPECT study by Tomoko Totsune, Toru Baba, Yoko Sugimura, Hideki Oizumi, Hiroyasu Tanaka, Toshiaki Takahashi, Masaru Yoshioka, Ken-ichi Nagamatsu, Atsushi Takeda

“…Objectives: The aims of this study were to propose a visual assessment grading system of brainstem 123I-FP-CIT uptake and investigate the ability of this method to differentiate PD from PS. …”
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A novel approach for unveiling co-occurrence patterns of UV filter mixtures in sunscreens: Prioritization for hazard and risk assessment by Ah-Reum Jo, Ba Reum Kwon, Inae Lee, Jieun Min, Sohyeon Choi, Na-Youn Park, Younglim Kho, Jeongim Park, Ho Kim, Kyungho Choi

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RadBone: bone toxicity following pelvic radiotherapy – a prospective randomised controlled feasibility study evaluating a musculoskeletal health package in women with gynaecologica... by Janelle Yorke, Sarah O’Connell, Sally Taylor, Karen Johnson, Robert G Bristow, Martin Eden, Kate Haslett, John Moore, Rohit Kochhar, Victoria Chatzimavridou Grigoriadou, Lisa H Barraclough, Ivona Baricevic-Jones, Zoe Merchant, Thomas Westwood, Anthony David Whetton, Claire E Higham

“…Introduction Patients receiving radiotherapy are at risk of developing radiotherapy-related insufficiency fractures, which are associated with increased morbidity and pose a significant burden to patients’ quality of life and to the health system. Therefore, effective preventive techniques are urgently required. …”
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Perbedaan Kadar Endotelin-1 Plasma pada Penderita Preeklampsia dengan Kehamilan Normotensif by Susi Hartati, Rahmatina B Herman, Darwin Amir

“…The increasing of endothelin-1 caused a resistence across the maternal vascular system that has endothelial layer make a clinical manifestations of preeclampsia. …”
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A High-Throughput Method as a Diagnostic Tool for HIV Detection in Patient-Specific Induced Pluripotent Stem Cells Generated by Different Reprogramming Methods by Daniela Hübscher, Sabine Rebs, Luis Haupt, Thomas Borchert, Celina Isabell Guessoum, Franziska Treu, Steffen Köhne, Andreas Maus, Mario Hambrecht, Samuel Sossalla, Ralf Dressel, Angela Uy, Mark Jakob, Gerd Hasenfuss, Katrin Streckfuss-Bömeke

“…We used the high-throughput cobas® 6800/8800 system, which is normally used for detection of HIV-1 in plasma of patients, and found that footprint-free reprogramming methods as episomal plasmids and Sendai virus are useful for the described virus detection method. …”
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Bilateral alterations in sensorimotor function and altered sensory strategy in individuals with unilateral chronic ankle instability by Xiaomei Hu, Xihe Hou, Lin Wang

“…MCT and SOT tests were conducted using NeuroCom Balance Manager System. Except for SOT, all tests evaluated bilateral limbs, and the order of limbs was randomly selected. 2 (group) × 2 (limb) mixed model analyses of variance were performed for outcome measures of unilateral stance, Y balance and MCT, and independent t-test was used to analyse the outcomes of SOT between two groups. …”
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Long-Lasting Anti-Inflammatory Activity of Human Microfragmented Adipose Tissue by Sara Nava, Valeria Sordi, Luisa Pascucci, Carlo Tremolada, Emilio Ciusani, Offer Zeira, Moris Cadei, Gianni Soldati, Augusto Pessina, Eugenio Parati, Mark Slevin, Giulio Alessandri

“…Over the last few years, human microfragmented adipose tissue (MFAT), containing significant levels of mesenchymal stromal cells (MSCs) and obtained from fat lipoaspirate (LP) through a minimal manipulation in a closed system device, has been successfully used in aesthetic medicine as well as in orthopedic and general surgery. …”
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Warifteine, an Alkaloid Purified from Cissampelos sympodialis, Inhibits Neutrophil Migration In Vitro and In Vivo by Thaline F. A. Lima, Juliana D. B. Rocha, Anderson B. Guimarães-Costa, José M. Barbosa-Filho, Débora Decoté-Ricardo, Elvira M. Saraiva, Luciana B. Arruda, Marcia R. Piuvezam, Ligia M. T. Peçanha

“…In addition, fLMP-induced neutrophil migration in a transwell system was blocked by warifteine; this effect was mimicked by cAMP mimetic/inducing substances, and warifteine increased intracellular cAMP levels in neutrophils. …”
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Assessment of the Photosynthetic Response of Potato Plants Inoculated with <i>Rhizoctonia solani</i> and Treated with Flesh-Colored Potato Extracts Nanoencapsulated with Solid Lipi... by Sheina Rivas, Paola Fincheira, Felipe González, Christian Santander, Sebastián Meier, Cledir Santos, Boris Contreras, Antonieta Ruiz

“…During inoculation and commercial fungicide application, stomatal conductance, the photosynthetic rate, and the internal CO₂ concentration increased compared with those of the non-inoculated control (NT), whereas the nanoencapsulated extract maintained levels similar to those of the NT, suggesting the possible regulation of the photosynthetic defense system. In terms of photosynthetic pigments, SLN + FCP maintained chlorophyll concentrations, unlike those in inoculated plants, which significantly decreased. …”
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Research trends in glioma chemoradiotherapy resistance: a bibliometric analysis (2003–2023) by Shishi Yu, Jinya Wu, Yuan Jing, Ping Lin, Lang Lang, Yifan Xiong, Wangzhong Chen, Wenhua Liu, Changpeng Sun, Yuntao Lu

“…BackgroundGlioma is the most aggressive primary malignant tumor of the central nervous system, characterized by high recurrence rates and resistance to chemoradiotherapy, making therapeutic resistance a major challenge in neuro-oncology. …”
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TangBi Formula for Painful Diabetic Distal Symmetric Polyneuropathy: A Multicenter, Randomized, Double‐Blind, Placebo‐Controlled and Parallel‐Group Trial by Xuefei Zhao, Xuedong An, Yashan Cui, Liu Dong, Zhaohui Fang, Zhonghua Zheng, Xinhe Zuo, Huailin Gao, Tianshu Gao, Qing Ni, Fengmei Lian, Xiaolin Tong

“…Secondary outcomes were changes in nerve conduction velocity (NCV) and single clinical signs and symptoms as measured by the visual‐analogue scale (VAS) and Toronto clinical scoring system (TCSS). Results Compared with the placebo group, after 24 weeks of treatment, the MDNS score of TangBi Formula group was significantly reduced (p < 0.001). …”
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Marginal and Internal Adaptation Evaluation of Dental Composites Using Micro-CT by Adrian Tudor Stan, Laura Cîrligeriu, Laura Idorași, Meda Lavinia Negruțiu, Cosmin Sinescu, Daniela Maria Pop, Tareq Hajaj, Şerban Talpoș, Mihai Romînu

“…Forty previously extracted human molars, kept in 10% formalin to preserve the bonding capabilities of the tooth structures, were divided into four groups based on the composite system used and different light-curing times. Class II (vertical slot) cavities were prepared on one proximal side and restored with dental composite using a Tofflemire matrix, with a bulk-fill composite resin (Venus Bulk Fill, Heraeus Kulzer) and a universal posterior composite (G-ænial Posterior, GC). …”
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Women Are More Susceptible to Caries but Individuals Born with Clefts Are Not by Aditi Jindal, Michelle McMeans, Somnya Narayanan, Erin K. Rose, Shilpa Jain, Mary L. Marazita, Renato Menezes, Ariadne Letra, Flavia M. Carvalho, Carla A. Brandon, Judith M. Resick, Juan C. Mereb, Fernando A. Poletta, Jorge S. Lopez-Camelo, Eduardo E. Castilla, Iêda M. Orioli, Alexandre R. Vieira

“…Caries continues to be the most common infectious noncontagious disease worldwide and a great burden to any health system. The identification of individuals of higher susceptibility to caries is of great interest. …”
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