PROTAC-based therapeutics for targeting HPV oncoproteins in head and neck cancers by Nobendu Mukerjee, Dattatreya Mukherjee

“…Proteolysis Targeting Chimeras (PROTACs) present a novel therapeutic strategy, leveraging the ubiquitin-proteasome system to specifically degrade the oncogenic HPV proteins E6 and E7. …”
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Treatment of neuro-invasive listeriosis: an overview by P. Gudeikaitė, J. Valaikienė, R. Mameniškienė

“…Listeria monocytogenes is an aerobic gram-positive bacillus that can cause invasive listeriosis in humans, which most commonly affects the central nervous system. Clinically, neurolisteriosis occurs as meningoencephalitis, which is associated with the highest mortality rate in patients with severe conditions. …”
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A MRAC Principle for a Single-Link Electrically Driven Robot with Parameter Uncertainties by Carlos Aguilar-Avelar, Javier Moreno-Valenzuela

“…The proposed control methodology addresses the problem of trajectory tracking with parameter uncertainties in the dynamic model of the system and proposes adaptation laws for the electrical and mechanical parameters. …”
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Comparative analysis of decision-making factors of hybrid and emission-free heat source users in single-family houses by Nadolny Michał, Walaszczyk Ewa, Walerysiak Sebastian

“…The aim of this study was to determine whether the choice of house heating system using different sources than fossil fuels is driven by any additional components of single-family house users’ purchasing decisions besides cost. …”
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Looking and listening in a technical world : Effects of discontinuity in work schedules on nurses’ work activity by Ana-Maria Seifert, Karen Messing

“…The structure of work schedules and its effects on the work activity of health care workers in a short-term care facility were analyzed in a context of changes to the Québec health care system. The analysis revealed short patient stays and a great discontinuity in work periods for nursing personnel : 60 % of health care workers in one department worked for fewer than five shifts per month in this department. …”
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Management of Early Stage, High-Risk Endometrial Carcinoma: Preoperative and Surgical Considerations by Sareena Singh, Shandhini Raidoo, Gaetan Pettigrew, Robert DeBernardo

“…There exists a subgroup of patients with early, high-risk disease, whose management remains controversial, as current data is clouded by inclusion of early stage tumors with different high-risk features for recurrence, unstandardized protocols for surgical staging, and an evolving staging system by which we are grouping these patients. Here, we present preoperative and intraoperative considerations that should be taken into account when planning surgical management for this population of patients.…”
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Influence of the urban vegetation on thermal dissipation and gaseous pollutants by Teresa Milagros Defilippi Shinzato, Alexis Dueñas, Julián Ccasani, Vanessa García, Gianinna Morales

“…Since the city is unthinkable without natural elements, therefore, it is important to study the tolerance to the ‘denaturalization’ urban system. The main objective of the article is to determine the benefits of urban vegetation on thermal dissipation and gaseous pollutants. …”
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Antiretroviral therapies and status of people living with HIV in Japan: An update from hospital survey and national database. by Yoshiyuki Yokomaku, Tatsuya Noda, Mayumi Imahashi, Yuichi Nishioka, Tomoya Myojin, Aikichi Iwamoto, Tomoaki Imamura

“…These results underscore the efficacy of Japan's universal health insurance system in ensuring consistent access to HIV care and treatment, supporting both individual patient outcomes and national surveillance efforts.…”
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Experimental Study of Composite Members in Spatial Grid Structure Subjected to Ultralow-Cyclic Axial Force by Jie Zhang, Haiwang Li, Xiayun Song

“…The results show that the joint stiffness and loading system have a significant effect on the ultralow-cycle fatigue performance of the assembly. …”
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Expert consensus on the management of migrant patients with leprosy by 王晓华, Guangdong Leprosy Control and Prevention Expert Group

“…According to the different types of the medical institutions at the time of case diagnosed, leprosy prevention institutions where patient lives, other medical institutions where patient lives, and non-local medical institutions, the medical institutions should carry out the following measures according to the corresponding responsibility: collection of patients′ information, report of the case, referral when needed, entry into the specialized disease system, treatment, follow-up, rehabilitation services, and moving in or out. …”
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Les enjeux de l’implantation de l’approche neurolinguistique, une nouvelle méthode d’apprentissage du français langue seconde auprès d’élèves allophones en contexte scolaire... by Delphine Guedat-Bittighoffer, Marie-Ange Dat, Camille Humeau, Isabelle Nocus

“…In France, allophone pupils face a difficult situation within the french school system with respect to the acquisition of french as a second language (FSL). …”
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Analysis of the Virtual Experiment of the Roller in Dredger Grab Machine by Xu Cijun

“…The driving roller in dredger grab machine has the characteristic of limited installation space and complicated load condition,is an effective supporting connector which ensures the machine works safely.According to the virtual prototype of dredger built on simplified model of mooring system,the virtual experiment model of driving roller is constructed between pedestals and workbench of grab machine.And according to the restriction of adding contact of the forces applied on the roller during the motion process of the grab machine,the statics analysis and dynamics analysis are carried out based on ADAMS software.The force curve of driving roller is fitted into subsection function and the finite element model is constructed in ANSYS,so that the stress distribution and the displacement deformation can be analyzed in time domain.The analysis results show that virtual experiment of driving roller in dredger grab machine effectively finds out the failure condition of roller during the working process of grab machine,and a reliable simulation model to its structure optimization as well as mechanical structure analysis on the offshore work platform is provided.…”
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Sclerotic Bone Metastasis in Pulmonary Adenocarcinoma by Riyadh Ali Mohammed Hammamy, Khalid Farooqui, Wisam Ghadban

“…Lung cancer metastasis may occur virtually in every organ system. Patients with non-small-cell lung cancer commonly have extrathoracic metastases to the adrenal glands, liver, brain, bones, and lymph nodes at presentation. …”
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Ne plus se laisser prendre à leurs Jeux. by Anaïs Bohuon, Lucie Pallesi

“…Because they are the first victims of the mechanisms for maintaining the system of gender bicategorization in sport, some intersex and trans athletes create a counter-discourse to the hegemonic one of equity. …”
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O papel da legislação no processo de reconfiguração da periferia urbana em cidades médias brasileiras by Maria Jose Martinelli Silva Calixto, Marcus Vinícius Mariano de Souza, Sergio Moreno Redón

“…The following methodological procedures were adopted: bibliographic survey; information collected on the spot; collection of data and/or information from the municipal governments; secondary data research, which sources were municipal legislation and the Sistema Integrado de Seleção Habitacional-Sishab (Integrated Housing Selection System)/Ministry of Regional Development/Minha Casa Minha Vida (My house My Life) social housing program. …”
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Hypothalamus-pituitary-adrenal and gut-brain axes in biological interaction pathway of the depression by Amanda Gollo Bertollo, Camila Ferreira Santos, Margarete Dulce Bagatini, Zuleide Maria Ignácio

“…In parallel, the gut-brain axis, a bidirectional communication network between the gut microbiota and the central nervous system, influences emotional and cognitive functions. …”
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COMMUNITY-ACQUIRED PNEUMONIA COMPLICATED BY SEPSIS CAUSED BY KLEBSIELLA PNEUMONIAE: A CASE REPORT by A.V. Lavrenko

“…Analyzed pathological changes that occur in sepsis on the part of various organs and systems . Shown the diagnostic algorithm, which is acceptable both in the presence and in the absence of laboratory verification of the disease. …”
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Enhancing preservation of ancient buildings through color imagery analysis and activation: take yuelu academy as an example by Qian Huang, Keyi Liu, Jianan Gu, Zhaozhe Yang, Yi He, Yishen Zhao

“…This study addresses this issue by introducing a comprehensive methodological framework that encompasses acquisition, analysis, activation, and application of color information based on the NCD (Nippon Color & Design) color system, an innovative color semantic quantification theory. …”
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Cloud server aging prediction method based on hybrid model of auto-regressive integrated moving average and recurrent neural network by Haining MENG, Xinyu TONG, Yuekai SHI, Lei ZHU, Kai FENG, Xinhong HEI

“…In view of the nonlinear, stochastic and sudden characteristics of operating environment of cloud server system, a software aging prediction method based on hybrid auto-regressive integrated moving average and recurrent neural network model (ARIMA-RNN) was proposed.Firstly, the ARIMA model performs software aging prediction of time series data in cloud server.Then the grey relation analysis method was used to calculate the correlation of the time series data to determine the input dimension of RNN model.Finally, the predicted value of ARIMA model and historical data were used as the input of RNN model for secondary aging prediction, which overcomes the limitation that ARIMA model has low prediction accuracy for time series data with large fluctuation.The experimental results show that the proposed ARIMA-RNN model has higher prediction accuracy than ARIMA model and RNN model, and has faster prediction convergence speed than RNN model.…”
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Effective Method for Analysis of Electrothermally Coupled Fields by Jacek Korytkowski, Stanisław Wincenciak

“…An effective method is presented for solving a nonlinear system of partial differential equations that describe the time-dependent electrothermally coupled fields for passage of constant electric current in a three-dimensional conductive medium. …”
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