Development and utilization of Treponema pallidum expressing green fluorescent protein to study spirochete-host interactions and antibody-mediated clearance: expanding the toolbox for syphilis research by Kristina N. Delgado, Crystal F. Vicente, Christopher M. Hennelly, Farhang Aghakhanian, Jonathan B. Parr, Kevin P. Claffey, Justin D. Radolf, Kelly L. Hawley, Melissa J. Caimano

“…The alarming increase in syphilis cases globally underscores the importance of developing novel strategies to understand the complexities of syphilis pathogenesis. …”
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Syphilis among Female Sex Workers: Results of Point-of-Care Screening during a Cross-Sectional Behavioral Survey in Burkina Faso, West Africa by Henri Gautier Ouedraogo, Ivlabehire Bertrand Meda, Issaka Zongo, Odette Ky-Zerbo, Ashley Grosso, Benoit Cesaire Samadoulougou, Grissoum Tarnagda, Kadari Cisse, Apoline Sondo, Nongoba Sawadogo, Yves Traoré, Nicolas Barro, Stefan Baral, Seni Kouanda

“…FSW were enrolled and screened for syphilis using a syphilis serological rapid diagnostic test. …”
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Seroprevalence and associated factors of HIV, syphilis, hepatitis B, and hepatitis C infections among sex workers in Chiangmai, Thailand during easing of COVID-19 lockdown measures. by Sayamon Hongjaisee, Woottichai Khamduang, Nang Kham-Kjing, Nicole Ngo-Giang-Huong, Arunrat Tangmunkongvorakul

“…This study aims to assess the seroprevalence of HIV, syphilis, HBV, and HCV and associated factors among SW as COVID-19 restrictions were lifted. …”
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A descriptive study of syphilitic uveitis in patients treated at tertiary hospitals in Johannesburg by Kashmira Rawjee, Mokokomadi A. Makgotloe

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Syphilis Point of Care Rapid Test and Immediate Treatment Evaluation (SPRITE) study: a mixed-methods implementation science research protocol of eight public health units in Ontario, Canada by Patrick O'Byrne, Melissa Richard-Greenblatt, Michael Evans, Jennifer Adams, Brad Stoner, Patrick O’Byrne, Sahar Saeed, Vanessa Tran, Lucy Mackrell, Megan Carter, Maggie Hoover, Natasha Larkin, Felicia Maria G Magpantay, Sicheng Zhao, Bradley Stoner, Kira Mandryk, Kandace Belanger, Jennifer Burbidge, Gilles Charette, Gabrielle Deschenes, Duy A Dinh, Amanda Featherstone, Farhan Khandakar, Jorge Martinez-Cajas, Nicole Szumlanski, Stephanie Vance, Jessica Burnside, Clare Mak, Erin Stienstra, Patrick Sanderson, Eric Geen, Nancy McGeachy, Stephanie McFaul, Susan LaBrie, Brooke Rasinho, Christine Brannan, Michelle Street, Melanie St John, Casey Cassan, Sandra Dereski, Taylor Labadie, Mary France, Lynn Leggett Caron-Bruneau

“…Introduction Urgent, tailored and equitable action is needed to address the alarming rise in syphilis rates in Canada. In the last decade, the rates of infectious syphilis have increased by 345% in Ontario, Canada. …”
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Prevalence and Risk Factors of Human Herpes Virus Type 8 (HHV-8), Human Immunodeficiency Virus-1 (HIV-1), and Syphilis among Female Sex Workers in Malindi, Kenya by M. M. Nzivo, R. M. Lwembe, E. O. Odari, J. M. Kang’ethe, N. L. M. Budambula

“…The prevalence of Human Herpes Virus type 8 (HHV-8), Human Immunodeficiency virus (HIV), and syphilis is high in Sub-Saharan Africa. Studies on HHV-8 in Kenya are few and data on its coinfection with HIV and syphilis scanty. …”
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Sexual Abuse as a Cause of Sexually Transmitted Infections (STI) and Human Immunodeficiency Virus (HIV) in a Bisexual Adolescent Indonesian: A Case Report by Achdiat PA, Wibowo RG, Larasati R, Rowawi R, Usman HA, Maharani RH

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Standardised protocol for a prospective cross-sectional multicentre clinical utility evaluation of two dual point-of-care tests in non-clinical settings for the screening of HIV and syphilis in men who have sex with men by James Kiarie, Karel Blondeel, Igor Toskin, Jordi Casabona, Soe Soe Thwin, Massimo Mirandola, Rosanna Peeling, Ronald Ballard, Laura Fernàndez-López, Inga Upmace, Juliana Reyes-Urueña, Mara Vaselova, Mitja Ćosić, Simon Maljevac, William Mejías, Ander Pazos, Andrii Chernyshev

“…Introduction Point-of-care dual tests (POCTs) for simultaneously detecting antibodies to HIV and syphilis (dual HIV-syphilis POCTs) have been developed recently and show encouraging performance compared with the reference tests in laboratory-based studies. …”
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Imunopatogenesis Treponema pallidum dan Pemeriksaan Serologi by Efrida ., Elvinawaty .

“…Advanced stage of syphilis include tertiary syphilis (gumatous, cardiovascular syphilis, and neurosyphilis) and late latent syphilis. …”
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A Rare Case of Neurosyphilis with Calvaria Osteitis Presenting in Pregnancy by Gisella M. Newbery, Christine E. Henricks, Julie A. Vircks, Andreina Colina, David C. Mundy

“…Background. The incidence of syphilis throughout the world is increasing. Rates in pregnancy are similarly rising, presenting risks of an untreated syphilis infection that can be detrimental to the mother and fetus. …”
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Neurosyphilis: An Unresolved Case of Meningitis by Shagufta Ahsan, Joesph Burrascano

“…Here we present a case of early neurosyphilis/symptomatic syphilitic meningitis in a non-HIV patient who presented with rash but was mistakenly treated for early latent or secondary syphilis. Syphilis presenting with a skin rash and an extremely high RPR titer could indicate CNS infection rather than simply secondary syphilis because rash is a nonspecific manifestation of disseminated infection. …”
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Justified Suspicion: Symptomatic Syphilitic Alopecia in a Patient with Well-Controlled HIV by Robert Jame, Yousif Al-Saeigh, Leo L. Wang, Kevin Wang

“…In HIV-positive patients, primary syphilis infection may progress more rapidly to the tertiary, and most destructive, stage and reinfection can start with the latent or tertiary stage; in such patients, advanced syphilis may arise without clinical warning signs (Kenyan et al., 2018). …”
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Neurosyphilis Presenting as Asymptomatic Optic Perineuritis by Sarah E. Parker, John H. Pula

“…There has been an increase in the rate of syphilis in the United States, especially in persons with HIV. …”
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Otosyphilis with Clinical and Serologic Responses with Weekly Intramuscular Penicillin: A Case Report and Literature Review by Ali Etemady-Deylamy, Getahun Abate

“…With the increasing prevalence of syphilis in different parts of the world, it is important to be cognizant of serious forms of syphilis. …”
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Sexually Transmitted Infections by LE Nicolle

“…In the late 1970s and early 1980s, research and treatment of the 'classic' STIs - gonorrhea, syphilis and chlamydia - were a major focus of infectious diseases practice and research. …”
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Syphilitic aortitis: from the past to the present (view of a dermatovenerologist) by S.V. Zakharov, T.V. Svyatenko, V.K. Zakharov, V.V. Gorbuntsov, L.A. Pohrebniak

“…Serological tests for syphilis, ultrasound examination of the heart, extracardiac vessels and internal organs; X-ray examinations were used when examining patients. …”
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Prevalence and epidemiological characteristics of inmates diagnosed with infectious diseases living in a region with a high number of prisons in São Paulo state, Brazil by Charlene Troiani do Nascimento, Danilo Zangirolami Pena, Rogério Giuffrida, Fernanda Nobre Bandeira Monteiro, Francisco Assis da Silva, Edilson Ferreira Flores, Luiz Euribel Prestes-Carneiro

“…Locations of prisons were obtained and maps were constructed using geographic information systems.Results A total of 741 of 37 497 inmates (1.97%) were diagnosed with HIV, HBV, HCV, syphilis or TB. HIV was the most prevalent infectious disease (0.68%), followed by TB (0.66%), syphilis (0.2%), HCV (0.2%) and HBV (0.04%). …”
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Granulomatous Hepatitis in Association with Fever and a Palmar Rash by Desmond J Leddin, James A Barrowman

“…Secondary syphilis may present without the classical features of the disease and should be considered in patients acutely ill with abnormal liver function tests and a nonspecific pattern on liver biopsy. …”
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Seroprevalence of Malaria and Hepatitis B Coinfection among Pregnant Women in Tamale Metropolis of Ghana: A Cross-Sectional Study by Gideon Kofi Helegbe, Paul Armah Aryee, Baba Sulemana Mohammed, Anthony Wemakor, David Kolbila, Abdul-Wahid Abubakari, Salam Askanda, Rashid Alhassan, Collins Barnie, Afua Aboagyewaa Donkoh, Ernest Ofosu

“…Of the total number, seroprevalence was high for malaria (11.6%) and HBV infection (4.2%) and low for HIV infection (1.0%) and syphilis (0.4%) monoinfections. Mal/HBV coinfection was higher (0.7%) when compared with Mal/HIV (0.1%), Mal/syphilis (0.0%), HBV/HIV (0.0%), HBV/syphilis (0.1%), and HIV/syphilis (0.0%) coinfections. …”
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The Burden and Trend of Blood-Borne Pathogens among Asymptomatic Adult Population in Akwatia: A Retrospective Study at the St. Dominic Hospital, Ghana by Sylvester Yao Lokpo, Mavis Popuelle Dakorah, Gameli Kwame Norgbe, James Osei-Yeboah, Godwin Adzakpah, Isaac Sarsah, John Gameli Deku, Innocent Afeke, Emmanuel Akomanin Asiamah, Nana Yaw Barimah Manaphraim, Isaac Asare, Bright Justice Ayidzoe, Emmanuel Alote Allotey, Emmanuel Agbeko Nani, Paul Amoah

“…This study was aimed at evaluating the seroprevalence and trend of blood-borne pathogens (HIV, HCV, HBV, and Syphilis) among asymptomatic adults at Akwatia during a four-year period (2013–2016). …”
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