PKA Inhibitor H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulfonamide) Attenuates Synaptic Dysfunction and Neuronal Cell Death following Ischemic Injury by Juhyun Song, So Yeong Cheon, Won Taek Lee, Kyung Ah Park, Jong Eun Lee

“…The data suggest that H89 may contribute to brain recovery after ischemic stroke by regulating neuronal death and proteins related to synaptic plasticity.…”
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Drosophila Torsin Protein Regulates Motor Control and Stress Sensitivity and Forms a Complex with Fragile-X Mental Retardation Protein by Phuong Nguyen, Jong Bok Seo, Hyo-Min Ahn, Young Ho Koh

“…Taken together, our evidences suggested that DTor and DFMRP might be present in the same signaling pathway regulating synaptic plasticity. In addition, we also found that human Torsin1A and human FMRP were present in the same protein complexes, suggesting that this phenomenon is evolutionarily conserved.…”
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A hypothesis about interrelations of epigenetic factors and transposable elements in memory formation by R. N. Mustafin

“…Also, a number of studies on different animals have revealed the preservation of long-term memory without the participation of synaptic plasticity. The data obtained suggest that transposons, which are genome sensors highly sensitive to various environmental and internal influences, form memory at the nuclear coding level. …”
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Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders by Heechul Jun, Syed Mohammed Qasim Hussaini, Michael J. Rigby, Mi-Hyeon Jang

“…Adult neurogenesis, the process of generating new neurons from neural stem cells, plays significant roles in synaptic plasticity, memory, and mood regulation. In the mammalian brain, it continues to occur well into adulthood in discrete regions, namely, the hippocampus and olfactory bulb. …”
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Investigation of Cortical Signal Propagation and the Resulting Spatiotemporal Patterns in Memristor-Based Neuronal Network by Ke Ding, Zahra Rostami, Sajad Jafari, Boshra Hatef

“…It also is reported to be able to emulate synaptic long-term plasticity as well as short-term plasticity. Synaptic plasticity is one of the important foundations of learning and memory as the high-order functional properties of the brain. …”
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A model of activity-dependent changes in dendritic spine density and spine structure by S. M. Crook, M. Dur-e-Ahmad, S. M. Baer

“…Recent evidence indicates that the morphology and density of dendritic spines are regulated during synaptic plasticity. See, for instance, a review by Hayashi and Majewska [9]. …”
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Development and Structural Variety of the Chondroitin Sulfate Proteoglycans-Contained Extracellular Matrix in the Mouse Brain by Noriko Horii-Hayashi, Takayo Sasagawa, Wataru Matsunaga, Mayumi Nishi

“…In adult mammals, CSPGs form the specialized ECM structure perineuronal nets (PNNs) that surround somata and dendrites of certain types of neurons. PNNs restrict synaptic plasticity and regulate the closure of critical periods. …”
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From light sensing to adaptive learning: hafnium diselenide reconfigurable memcapacitive devices in neuromorphic computing by Bashayr Alqahtani, Hanrui Li, Abdul Momin Syed, Nazek El-Atab

“…Although charge-based or emerging memory technologies such as memristors have been developed to emulate synaptic plasticity, replicating the key functionality of neurons—integrating diverse presynaptic inputs to fire electrical impulses—has remained challenging. …”
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Methyl-Arginine Profile of Brain from Aged PINK1-KO+A53T-SNCA Mice Suggests Altered Mitochondrial Biogenesis by Georg Auburger, Suzana Gispert, Nadine Brehm

“…The strongest effects were documented for the adhesion modulator CMAS, the mRNA decapping/deadenylation factor PATL1, and the synaptic plasticity mediator CRTC1/TORC1. In addition, an intriguing effect was observed for the splicing factor PSF/SFPQ, known to interact with the dopaminergic differentiation factor NURR1 as well as with DJ-1, the protein responsible for the autosomal recessive PARK7 variant of PD. …”
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Intracellular Ca2+ Stores and Ca2+ Influx Are Both Required for BDNF to Rapidly Increase Quantal Vesicular Transmitter Release by Michelle D. Amaral, Lucas Pozzo-Miller

“…Brain-derived neurotrophic factor (BDNF) is well known as a survival factor during brain development as well as a regulator of adult synaptic plasticity. One potential mechanism to initiate BDNF actions is through its modulation of quantal presynaptic transmitter release. …”
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PLGA scaffold combined with MSCs transplantation improved neural function and brain tissue structure in rats with traumatic brain injury by Na Xu, Zihuan Sun, Weikang Guan, Yiming Liu, Yun Gao, Chaoxian Yang

“…Furthermore, compared to PLGA transplantation alone, PLGA+MSCs transplantation further reduced brain injury and cell apoptosis, promoted neuron survival, and improved synaptic plasticity. Overall, the adhesion of MSCs to PLGA can enhance the therapeutic efficacy of PLGA in rats following TBI.…”
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Hippocampal Dendritic Spines Are Segregated Depending on Their Actin Polymerization by Nuria Domínguez-Iturza, María Calvo, Marion Benoist, José Antonio Esteban, Miguel Morales

“…Their morphology, dynamics, and density have been related to synaptic plasticity and learning. The main determinant of spine shape is filamentous actin. …”
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Increased N-Ethylmaleimide-Sensitive Factor Expression in Amygdala and Perirhinal Cortex during Habituation of Taste Neophobia by Beatriz Gómez-Chacón, Fernando Gámiz, Thomas C. Foster, Milagros Gallo

“…In addition the expression of the synaptic plasticity related immediate early genes, Homer 1 and Narp, was also assessed. …”
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The role of microRNAs in learning and long-term memory by L. N. Grinkevich

“…A number of microRNAs have been shown to be involved in the process of synaptic plasticity, as well as in the long-term memory formation. …”
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Timing of Acupuncture during LTP-Like Plasticity Induced by Paired-Associative Stimulation by Xiao-kuo He, Qian-qian Sun, Hui-hua Liu, Xin-yi Guo, Cheng Chen, Li-dian Chen

“…Our results indicated that acupuncture modulated the excitability of M1, and the synaptic plasticity was time-dependent. We concluded that acupuncture should be combined with rehabilitation techniques to improve the motor function in stroke patients. …”
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Research Progress on the Mechanism of Acupuncture Treatment of Ischemic Stroke Based on the Space Construction of Nerve-vascular Unit by LI Mengxing, WNAG Yu, LI Zhen, LIU Fang, SHI Kejian

“…Acupuncture could inhibit neuronal apoptosis, regulate synaptic plasticity, and reorganize and compensate brain functional network and induce neovascularization, regulate cerebral blood flow, and coordinate the coupling between nerves and blood vessels. …”
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Role of insulin-like growth factor-2 in Alzheimer’s disease induced memory impairment and underlying mechanisms by Ruiqi Chen, Xing Lu, Anqi Xiao, Junpeng Ma, Junpeng Ma

“…Insulin-like growth factor-2 (IGF2), which is widely expressed in the central nervous system (CNS), has emerged as a crucial mechanism of synaptic plasticity and learning and memory, and many studies have indicated that this neurotrophic peptide is a viable candidate for treating and preventing AD-induced cognitive decline. …”
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Cilostazol Combats Lipopolysaccharide-Induced Hippocampal Injury in Rats: Role of AKT/GSK3β/CREB Curbing Neuroinflammation by Doaa Abou El-ezz, Waleed Aldahmash, Tuba Esatbeyoglu, Sherif M. Afifi, Marawan Abd Elbaset

“…Furthermore, cilostazol administration suppressed LPS-induced rises in hippocampus caspase-3 and NF-κB levels while elevating rat B-cell/lymphoma 2 (BCL2) and brain-derived neurotrophic factor (BDNF) levels, which are implicated in neuronal survival and synaptic plasticity. Cilostazol treatment also restored the decreased phosphorylation of protein kinase B (p-AKT) and reduced the elevated levels of phosphorylated glycogen synthase kinase-3 beta (p-GSK3β) and cAMP response element-binding protein (CREB) in the hippocampus of LPS-treated rats. …”
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Large-scale high uniform optoelectronic synapses array for artificial visual neural network by Fanqing Zhang, Chunyang Li, Zhicheng Chen, Haiqiu Tan, Zhongyi Li, Chengzhai Lv, Shuai Xiao, Lining Wu, Jing Zhao

“…The highly uniform floating-gate synaptic transistors array were constructed by the wafer-scale grown monolayer molybdenum disulfide with Au nanoparticles (NPs) acting as the electrons capture layers. Various synaptic plasticity behaviors have been achieved owing to the switchable electronic storage performance. …”
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Bifidobacterium breve BB05 alleviates depressive symptoms in mice via the AKT/mTOR pathway by Yanni Pan, Qingling Huang, Yuan Liang, Yuwuqi Xie, Fang Tan, Xingyao Long

“…Mechanistic analysis revealed that BB05 exerts antidepressant effects by activating the AKT/mTOR signaling pathway in the prefrontal cortex, promoting neuroprotection, neurogenesis, and synaptic plasticity.DiscussionThese findings suggest that BB05, particularly at higher doses, effectively alleviates CUMS-induced depressive behaviors and improves physiological outcomes, supporting the use of probiotics as a potential treatment for depression by targeting the AKT/mTOR pathway.…”
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