Fibroblast growth factor receptor 3 mutation promotes HSPB6-mediated cuproptosis in hypochondroplasia by impairing chondrocyte autophagy by Jing Chen, Dan He, Chengrun Yuan, Na Li, Baohong Shi, Conway Niu, Jiangfei Yang, Liangkai Zheng, Lin Che, Ren Xu

“…Results: We observed that Fgfr3 (V376D) mutant mice exhibit a bone-specific phenotype, with symmetrically short limb bones, partially resembling the dwarfism phenotype of patients with HCH. …”
Get full text

Une inscription méconnue de Cos/Cosa dans la cité des Cadurques by Sabine Armani

“…Indeed, a hole is located below, perhaps for mounting purposes, which might indicate that the engraving of the last line was centered in order to highlight it. The absence of a symmetrical hole in the upper part of the plate may most likely be explained by the fragmentary nature of the object. …”
Get full text

Mixture density networks for re-constructing historical ocean-color products over inland and coastal waters: demonstration and validation by Sundarabalan V. Balasubramanian, Ryan E. O’Shea, Ryan E. O’Shea, Arun M. Saranathan, Arun M. Saranathan, Christopher C. Begeman, Christopher C. Begeman, Daniela Gurlin, Caren Binding, Claudia Giardino, Michelle C. Tomlinson, Krista Alikas, Kersti Kangro, Moritz K. Lehmann, Moritz K. Lehmann, Lisa Reed

“…Using hold-out (80–20 split) and leave-one-out testing methods, the retrieved parameters exhibited variable uncertainty represented by the Median Symmetric Residual (MdSR) for each parameter and sensor combination. …”
Get full text

Phasic and periodic change of drought under greenhouse effect by Yang Li, Zhicheng Zheng, Yaochen Qin, Haifeng Tian, Zhixiang Xie, Peijun Rong

“…Subsequently, the Bernaola-Galvan segmentation algorithm was proposed to divide the periods of drought change and the newly developed extreme-point symmetric mode decomposition to analyze the periodic drought patterns. …”
Get full text

Self-Normalized Moderate Deviations for Degenerate <i>U</i>-Statistics by Lin Ge, Hailin Sang, Qi-Man Shao

“…Let <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>{</mo><msub><mi>X</mi><mi>i</mi></msub><mo>,</mo><mi>i</mi><mo>≥</mo><mn>1</mn><mo>}</mo></mrow></semantics></math></inline-formula> be i.i.d. random variables and consider symmetric and degenerate kernel functions in the form <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>h</mi><mrow><mo>(</mo><mi>x</mi><mo>,</mo><mi>y</mi><mo>)</mo></mrow><mo>=</mo><msubsup><mo>∑</mo><mrow><mi>l</mi><mo>=</mo><mn>1</mn></mrow><mo>∞</mo></msubsup><msub><mi>λ</mi><mi>l</mi></msub><msub><mi>g</mi><mi>l</mi></msub><mrow><mo>(</mo><mi>x</mi><mo>)</mo></mrow><msub><mi>g</mi><mi>l</mi></msub><mrow><mo>(</mo><mi>y</mi><mo>)</mo></mrow></mrow></semantics></math></inline-formula>, where <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>λ</mi><mi>l</mi></msub><mo>></mo><mn>0</mn></mrow></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>E</mi><msub><mi>g</mi><mi>l</mi></msub><mrow><mo>(</mo><msub><mi>X</mi><mn>1</mn></msub><mo>)</mo></mrow><mo>=</mo><mn>0</mn></mrow></semantics></math></inline-formula>, and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>g</mi><mi>l</mi></msub><mrow><mo>(</mo><msub><mi>X</mi><mn>1</mn></msub><mo>)</mo></mrow></mrow></semantics></math></inline-formula> is in the domain of attraction of a normal law for all <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>l</mi><mo>≥</mo><mn>1</mn></mrow></semantics></math></inline-formula>. …”
Get full text