Pulmonary artery catheter use in acute myocardial infarction‐cardiogenic shock by Saraschandra Vallabhajosyula, Aditi Shankar, Sri Harsha Patlolla, Abhiram Prasad, Malcolm R. Bell, Jacob C. Jentzer, Shilpkumar Arora, Saarwaani Vallabhajosyula, Bernard J. Gersh, Allan S. Jaffe, David R. Holmes Jr, Shannon M. Dunlay, Gregory W. Barsness

“…Admissions with concomitant cardiac surgery or non‐AMI aetiology for cardiogenic shock were excluded. …”
Get full text

Influence of cervical muscle strength and pain severity on functional balance and limits of stability in elderly individuals with chronic nonspecific neck pain: a cross-sectional s... by Shaker Hassan S. Alshehri, Ravi Shankar Reddy, Mohammad A. ALMohiza, Mastour Saeed Alshahrani, Batool Abdulelah Alkhamis, Hani Hassan Alnakhli, Ghada Mohammed Koura, Ajay Prashad Gautam, Debjani Mukherjee, Raee S. Alqhtani, Saeed Y. Al Adal, Abdullah Mohammed Alyami, Faisal M. Alyazedi

Get full text

Cancer Cell‐Derived Exosomal miR‐500a‐3p Modulates Hepatic Stellate Cell Activation and the Immunosuppressive Microenvironment by Yu Zhang, Xin Li, Huiyan Chen, Jiawei Li, Xiaohuan Guo, Yilin Fang, Linjie Chen, Kaiqiang Li, Yi Zhang, Fei Kong, Aodong Chen, Jianxin Lyu, Wei Zhang, Zhen Wang

Get full text

Discontinuation of immune checkpoint inhibitors for reasons other than disease progression and the impact on relapse and survival of advanced melanoma patients. A systematic review... by Konstantinos Lallas, Eftychia Chatziioannou, Derya Durak, Georg Frey, Lina Maria Serna-Higuita, Marie-Lena Rasch, Athanassios Kyrgidis, Eleni Timotheadou, Zoe Apalla, Ulrike Leiter, Lukas Flatz, Lukas Flatz, Aimilios Lallas, Teresa Amaral, Teresa Amaral

Get full text

PRMT5 promotes ovarian cancer growth through enhancing Warburg effect by methylating ENO1 by Fei Xie, Han Zhang, Kongkai Zhu, Cheng‐Shi Jiang, Xiaoya Zhang, Hongkai Chang, Yaya Qiao, Mingming Sun, Jiyan Wang, Mukuo Wang, Junzhen Tan, Tao Wang, Lianmei Zhao, Yuan Zhang, Jianping Lin, Chunze Zhang, Shuangping Liu, Jianguo Zhao, Cheng Luo, Shuai Zhang, Changliang Shan

Get full text

Potential pharmacological effect of Quercetin Phytosome™ in the management of hyperuricemia: results from real-life clinical studies by Francesco Di Pierro, Francesco Di Pierro, Francesco Di Pierro, Fazle Rabbani, Meherullah Tareen, Roohi Nigar, Amjad Khan, Nicola Zerbinati, Maria L. Tanda, Massimiliano Cazzaniga, Alexander Bertuccioli, Alexander Bertuccioli, Paolo Falasca, Gabriele Damiani, Nicola Villanova

Get full text

Effects of Electroacupuncture Preconditioning at Baihui and Zusanli Acupoints on the Expression of Inflammatory Factors in Brain and Intestines of Rats with Cerebral Ischemia/Reper... by ZHANG Jiyao, TANG Qiang, ZHU Luwen

“…The EP group was intervened by electroacupuncture preconditioning at Baihui (DU20) and Zusanli (ST36) acupoints for two weeks, and was given the operation of MCAO/R model after the last electroacupuncture intervention for 24 hours, the cerebral blood perfusion was restored after 120 minutes. Before surgery for one day, after reperfusion for 12 h and after reperfusion for 1,3,7 days, the grip tester was used to measure the forelimb grasping strength; after reperfusion for 7 days, ELISA methods was used to determine the content of IL-17A and IL-10 in serum, Western blot method was used to detect the expression of IL-17A and IL-10 protein in ischemic cortex and colon tissue, immunohistochemistry method was used to calculate the average optical density (AOD) value of IL-17A and IL-10 in ischemic cortex and colon tissue, and HE staining method was used to observe the pathological change of ischemic cortex.Results① Forelimb grasping strength: compared with the S-con group, the forelimb grasping strength of rats in the M-con group after reperfusion for 12 h, 1 d, 3 d, 7 d was decreased significantly (<italic>P</italic>&lt;0.05); compared with the M-con group, the forelimb grasping strength of rats in the EP group was increased significantly (<italic>P</italic>&lt;0.05). ② Content of IL-17A and IL-10 in serum: after reperfusion for 7 days , compared with the S-con group, the content of serum IL-17A and IL-10 of rats in the M-con group were significantly increased (<italic>P</italic>&lt;0.05); compared with the M-con group, the content of serum IL-17A in the EP group were significantly decreased (<italic>P</italic>&lt;0.05), and IL-10 in the EP group were significantly increased (<italic>P</italic>&lt;0.05). ③ Expression of IL-17A and IL-10 protein: after reperfusion for 7 days, compared with the S-con group, the expression of IL-17A and IL-10 protein in ischemic cortex and colon tissue in the M-con group were significantly increased (<italic>P</italic>&lt;0.05); compared with the M-con group, the expression of IL-17A in the EP group was significantly decreased (<italic>P</italic>&lt;0.05), and the expression of IL-10 protein in the EP group was significantly increased (<italic>P</italic>&lt;0.05). ④ AOD value of IL-17A and IL-10: after reperfusion for 7 days, compared with the S-con group, the AOD value of IL-17A and IL-10 in ischemic cortex and colon tissue in the M-con group were significantly increased (<italic>P</italic>&lt;0.05); compared with the M-con group, the AOD value of IL-17A in the EP group was significantly decreased (<italic>P</italic>&lt;0.05), the AOD value of IL-10 in the EP group was significantly increased (<italic>P</italic>&lt;0.05). ⑤ Pathological change of ischemic cortex: after reperfusion for 7 days, compared with the M-con group, the pathological change of ischemic cortex in EP group was significantly decreased (<italic>P</italic>&lt;0.05).ConclusionElectroacupuncture preconditioning at Baihui and Zusanli acupoints can reduce the pathological damage degree of the ischemic cortex and intestinal-central inflammation, improve neurobehavioral function, which may be related to brain-gut protection.…”
Get full text

The association of physical activity and carotid intima-media-thickness in adolescents—data of the prospective early vascular ageing-tyrol cohort study by Bernhard Winder, Bernhard Winder, Bernhard Winder, Sophia J. Kiechl, Sophia J. Kiechl, Benoît Bernar, Benoît Bernar, Nina Gande, Anna Staudt, Anna K. Stock, Anna K. Stock, Christoph Hochmayr, Ralf Geiger, Andrea Griesmacher, Stefan Kiechl, Stefan Kiechl, Ursula Kiechl-Kohlendorfer, Michael Knoflach, Michael Knoflach, the Early Vascular Ageing (EVA)-Tyrol Study Group, Carmen Reiter, Christina Schreiner Julia Klingenschmid, Julia Marxer, Martina Kothmayer, Maximilian Pircher, Manuela Bock-Bartl, Mandy Asare, Maximilian Bohl, Raimund Pechlaner

Get full text

Immunomodulation with M2 macrophage–derived extracellular vesicles for enhanced titanium implant osseointegration under diabetic conditions by Yuzhao Cheng, Xin Dong, Jing Shi, Guangsheng Wu, Pei Tao, Nan Ren, Yimin Zhao, Fenglan Li, Zhongshan Wang

Get full text

Integrated bioinformatics analysis to explore potential therapeutic targets and drugs for small cell carcinoma of the esophagus by Maofei Zhu, Maofei Zhu, Yueming Chu, Yueming Chu, Qiang Yuan, Qiang Yuan, Junfeng Li, Silin Chen, Lin Li, Lin Li, Lin Li

Get full text

Machine learning for predicting neoadjuvant chemotherapy effectiveness using ultrasound radiomics features and routine clinical data of patients with breast cancer by Pu Zhou, Pu Zhou, Hongyan Qian, Pengfei Zhu, Jiangyuan Ben, Jiangyuan Ben, Guifang Chen, Qiuyi Chen, Lingli Chen, Jia Chen, Ying He, Ying He

Get full text

Emergency volunteering willingness and participation: a cross-sectional survey of residents in northern China by Hong Sun, Chaojie Liu, Wei Xu, Ye Li, Qunhong Wu, Lijun Gao, Zheng Kang, Yanhua Hao, Ning Ning, Mingli Jiao, Libo Liang, Yu Cui, Mengli Shi, Chao Liang, Xiaowen Zhao, Jie Fei, Qiuyu Wei, Ming Yi

Get full text

Total neoadjuvant therapy based on short-course radiotherapy versus standard long-course chemoradiotherapy for locally advanced rectal cancer: a systematic review and meta-analysis... by Wenji Pu, Wenji Pu, Wenji Pu, Wenqi Chen, Haiman Jing, Jishi Li, Yong Jiang, Shasha Li, Weijie Wen, Zhiyuan Xu, Jing Jin

“…There were 9 study indicators, including the pathologic complete remission (pCR) rate, tumor downstaging rate, R0 resection rate, sphincter preservation rate, disease-free survival (DFS), overall survival (OS), acute ≥3 grade toxicity rate, surgery complication rate, and distant recurrence rate. …”
Get full text

Targeting PCSK9, through an innovative cVLP-based vaccine, enhanced the therapeutic activity of a cVLP-HER2 vaccine in a preclinical model of HER2-positive mammary carcinoma by Laura Scalambra, Francesca Ruzzi, Olga Maria Pittino, Maria Sofia Semprini, Chiara Cappello, Stefania Angelicola, Arianna Palladini, Patrizia Nanni, Louise Goksøyr, Cyrielle Fougeroux, Manuel L. Penichet, Adam Frederik Sander, Pier-Luigi Lollini

Get full text

Effect of the modified method of preoperative skin cleaning on prevention of surgical site infection (改良术野皮肤清洁方法预防手术部位感染的效果分析) by ZHANG Wenjun (章文军), ZHANG Mingyang (章明阳), LUO Xiaoping (罗小平)

“…Methods A total of 1450 patients undergoing spinal surgery were divided into the study group (n=747)and the control group(n=713)According to the preference of surgeons on method of preoperative skin cleaning. …”
Get full text

Sex-specific analysis of individual and ski geometry-related risk factors for ACL injuries in recreational alpine skiing: A case-control study by Gerhard Ruedl, Martin Faulhaber, Markus Posch

“…In recreational alpine skiing, the ACL is predominantly injured in all knee injuries needing hospitalisation. Knee Surgery, Sports Traumatology, Arthroscopy, 29(6), 1790–1796. https://doi.org/10.1007/s00167-020-06221-z Ruedl, G., Posch, M., Tecklenburg, K., Schranz, L., Greier, K., Faulhaber, M., Scher, I., & Burtscher, M. (2022). …”
Get full text

Large‐Vessel Occlusion Stroke Knowledge and Training for Stroke Severity Assessment Among Emergency Medical Services Personnel in the United States by Kaiz S. Asif, Robin Novakovic, Thanh N. Nguyen, Santiago Ortega‐Gutierrez, Youngran Kim, Amanda Jagolino‐Cole, Sushanth Aroor, Alicia Castonguay, Prateek Kumar, Ashutosh P. Jhadav, Dileep Yavagal, May Nour, Gabor Toth, Maxim Mokin, Sunil A. Sheth, Mouhammad A. Jumaa, Alhamza Al‐bayati, Mohamed Teleb, Ossama Y. Mansour, Shashvat M. Desai, Joshua Hartman, David S. Liebeskind, Ameer E. Hassan, Brijesh P. Mehta

Get full text

Comparison of the adequacies of the OSCE and vOSCE to assess the competencies required under Brazilian medical curriculum guidelines: a multicenter study by Hervaldo Sampaio Carvalho, Maria do Carmo Barros Melo, Fabiana Maria Kakehasi, Priscila Menezes Ferri Liu, Fernanda Gontijo Minafra Silveira Santos, Ricardo Luiz de Melo Martins, Marilene Vale de Castro Monteiro, Marcelo Esteves Chaves Campos, Roberto Zonato Esteves, Matheus Belloni Torsani, Iolanda de Fátima Lopes Calvo Tiberio, Akihito Inca Atahualpa Urdiales, Andrea Mora De Marco Novellino, Rosiane Viana Zuza Diniz, Helena Ferreira Moura, Maria Alice de Vilhena Toledo, Célia Regina Machado Saldanha, Andrea Pedrosa Ribeiro Alves Oliveira, Patricia Zen Tempski, Itamar de Souza Santos, Milton de Arruda Martins

Get full text

Effect of Electroacupuncture Prestimulation with Mental Tri-Needles on the Inflammatory Response of Hippocampus in Aged Rats with Perioperative Neurocognitive Disorders by WANG Xiangfeng, HUANG Jinyan, LIU Wei, LUO Huiqin, WANG Guanhui, LIN Qin, CHEN Bin

“…The aged PND rat model was established by intramedullary nailing surgery for femoral neck fracture in the operation group and the acupuncture group. …”
Get full text

Characteristic alterations of gut microbiota and serum metabolites in patients with chronic tinnitus: a multi-omics analysis by Jiang Wang, Jia-Hui Xiang, Xu-Yuan Peng, Min Liu, Le-Jia Sun, Min Zhang, Li-Yuan Zhang, Zhi-Bin Chen, Zheng-Quan Tang, Lei Cheng

Get full text