In vitro antitumor and immunomodulatory activities of 1,2,4-oxadiazole derivatives by Héverton Mendes Araújo, Gabriel Acácio de Moura, Yasmim Mendes Rocha, Cristian Vicson Pinheiro Gomes, Valentina Nascimento e Melo de Oliveira, Ronaldo Nascimento de Oliveira, Larissa Deadame de Figueiredo Nicolete, Emanuel Paula Magalhães, Ramon R.P.P.B. de Menezes, Roberto Nicolete

“…The main strategy for treating melanoma is surgery to completely remove the lesion and its margins. …”
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Spontaneous high clonal expansion of Wilms’ tumor gene 1-specific cytotoxic T-lymphocytes in patients with Wilms’ tumor gene 1-expressing solid tumor by Soyoko Morimoto, Yukie Tanaka, Jun Nakata, Fumihiro Fujiki, Kana Hasegawa, Hiroko Nakajima, Sumiyuki Nishida, Akihiro Tsuboi, Naoki Hosen, Naoki Kagawa, Motohiko Maruno, Akira Myoui, Takayuki Enomoto, Shuichi Izumoto, Mitsugu Sekimoto, Naoya Hashimoto, Toshiki Yoshimine, Atsushi Kumanogoh, Yusuke Oji, Yoshihiro Oka, Haruo Sugiyama

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Development of a Sensitive Quantum Dot-Linked Immunoassay for the Multiplex Detection of Biochemical Markers in a Microvolumeric Format by Kalvaityte U, Bagdonas E, Kirdaite G, Kausaite-Minkstimiene A, Uzieliene I, Ramanaviciene A, Popov A, Butkiene G, Karabanovas V, Denkovskij J, Mobasheri A, Bernotiene E

“…Ursule Kalvaityte,1 Edvardas Bagdonas,1 Gailute Kirdaite,2 Asta Kausaite-Minkstimiene,3,4 Ilona Uzieliene,1 Almira Ramanaviciene,3,4 Anton Popov,3,4 Greta Butkiene,1,5 Vitalijus Karabanovas,1,5 Jaroslav Denkovskij,1 Ali Mobasheri,1,6– 8 Eiva Bernotiene1,9 1Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, LT-08406, Lithuania; 2Department of Personalised Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; 3Department of Immunology and Bioelectrochemistry, State Research Institute Centre for Innovative Medicine, Vilnius, LT-08406, Lithuania; 4NanoTechnas - Center of Nanotechnology and Materials Science, Faculty of Chemistry and Geosciences, Vilnius University, Vilnius, LT-03225, Lithuania; 5Biomedical Physics Laboratory, National Cancer Institute, Baublio 3b, Vilnius, LT-08406, Lithuania; 6Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, 90014, Finland; 7World Health Organization Collaborating Center for Public Health Aspects of Musculoskeletal Health and Aging, Université de Liège, Liège, B-4000, Belgium; 8Department of Joint Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, People’s Republic of China; 9Faculty of Fundamental Sciences, Vilnius Gediminas Technical University, Vilnius, LT-10223, LithuaniaCorrespondence: Eiva Bernotiene, Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Santariskiu G. 5, Vilnius, LT-08406, Lithuania, Tel +37068377130, Email eiva.bernotiene@imcentras.ltPurpose: For the diagnosis of various diseases, simultaneous sensitive detection of multiple biomarkers using low sample volumes is needed. …”
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Pharmacokinetics and pharmacodynamics of ciprofol after continuous infusion in elderly patients by Xiaowen Guo, Yang Qiao, Sijie Yin, Fengqin Luo, Lingmei Yi, Jiajia Chen, Man Lu

“…For elderly patients undergoing gastrointestinal tumor surgery, an optimal maintenance dose of 0.8 mg/kg/h is recommended. …”
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Evaluation of Root Canal Diameters and Radicular Wall Thickness of the Human Primary Molars by using Multidetector Computed Tomography: A Cross-sectional Study by Piyali Datta, Shabnam Zahir, Kaushik Dutta, Pratik Kumar Lahiri, Sudipta Kar, Biswaroop Chandra, Trishik Basak, Shreya Tripathi

“…Materials and Methods: This cross-sectional study study was performed in the Department of Paediatric and Preventive Dentistry in collaboration with the Department of Oral and Maxillofacial Surgery, Department of Antaomy of Guru Nanak Institute, Kolkata, West Bengal,India on selected 64 human primary maxillary and mandibular molars through inclusion and exclusion criteria and grouped them (Group 1, maxillary 1st molars; Group 2, maxillary 2nd molars; Group 3, mandibular 1st molars; and Group 4, mandibular 2nd molars). …”
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Therapeutic effects of traditional Chinese medicine Hua-Feng-Dan in a rat model of ischemic stroke involve renormalization of gut microbiota by Xiaoxia He, Xiaofeng Yuan, Qilin Shu, Yayang Gao, Youli Chen, Yao Liu, Yao Liu, Yao Liu, Jian Xu, Jian Xu, Jian Xu, Yongping Zhang, Yongping Zhang, Yongping Zhang, Guoqiong Cao, Guoqiong Cao, Guoqiong Cao

“…Rats were subjected to middle cerebral artery occlusion as a model of ischemic stroke or to sham surgery, then treated or not with Hua-Feng-Dan. The different groups of animals were compared in terms of neurological score, cerebral infarct volume, brain edema, brain and gut histopathology to assess stroke severity. …”
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Nineteen years retrospective analysis of epidemiology, antifungal resistance and a nomogram model for 30-day mortality in nosocomial candidemia patients by Zhang Dai, Xuhong Lan, Minjing Cai, Yunhui Liao, Jingwen Zhang, Naifang Ye, Xinxin Lu, Jiajia Wang, Yun Xiao, Yan Zhang, Yihui Yao, Xianming Liang

“…Departments with a higher detection of candidemia included intensive care unit (n=55), emergency department (n=24) and hepatobiliary surgery (n=22). Candida tropicalis performed the highest resistance to azole (fluconazole: 55.81%, voriconazole:55.00% and itraconazole:58.14%). …”
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Investigating Elevated E-Selectin and P-Selectin Levels in Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Patients: The Stepping Stone to a Future Clinical Approach by Syntia Nusanti, Andhika Rachman, Brigitta Marcia Budihardja, Lourisa Ruth Eldinia, Nadia Delima Andini, Arief Kartasasmita, M Sidik, Seskoati Prayitnaningsih, Alida Roswita Harahap, Aria Kekalih, Tjahjono Darminto Gondhowiardjo

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Brain Iron Deposition Alterations in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment Based on Quantitative Susceptibility Mapping by Qiuyue Zhao, Subinuer Maimaitiaili, Yan Bi, Ming Li, Xin Li, Qian Li, Xinyi Shen, Min Wu, Linqing Fu, Zhengyang Zhu, Xin Zhang, Jiu Chen, Anning Hu, Zhou Zhang, Wen Zhang, Bing Zhang

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Semaphorin 3A Shifts Adipose Mesenchymal Stem Cells towards Osteogenic Phenotype and Promotes Bone Regeneration In Vivo by Xiangwei Liu, Naiwen Tan, Yuchao Zhou, Xueying Zhou, Hui Chen, Hongbo Wei, Ji Chen, Xiaoru Xu, Sijia Zhang, Guodong Yang, Yingliang Song

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Abnormal Expression of DICER1 Leads to Dysregulation of Inflammatory Effectors in Human Synoviocytes by Congshan Jiang, Jing Xu, Wenhua Zhu, Yongsong Cai, Si Wang, Yuanxu Guo, Ke Xu, Manman Geng, Nazim Hussain, Yan Han, Fujun Zhang, Qilan Ning, Liesu Meng, Shemin Lu

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Decreased sirtuin 1 in type 2 diabetes patients with abnormal BMD by Yao Xu, Tianxiao Hu, Peiwu Jiang, Xiujing Wang, Jiaqi Yao, Huiling Shen, Zhenying Zhang, Bojing Zheng, Ting Wang, Yanxia Ren, Jing Wang, Qingying Tan

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Development of quality indicators for hand osteoarthritis care – Results from an European consensus study by Daniel H. Bordvik, Yeliz Prior, Rachael Bamford, Francis Berenbaum, Mathilda Björk, Thalita Blanck, Barbara Slatkowsky Christensen, Krysia Dziedzic, John Edwards, Nazemin Gilanliogullari, Carol Graham, Ida K. Haugen, Margreet Kloppenburg, Hellen Laheij, Marco J.P.F. Ritt, Tanja Stamm, Anne Therese Tveter, Nina Østerås, Ingvild Kjeken

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Lymphocyte-C-reactive protein ratio upon admission to predict disease progression and ICU admission in adult patients with diabetic ketoacidosis by Yi-Jia Hu, Shu-Xiao Qiu, Jian-Nan Zhang, Qi-Qi Lai, Yi-Lu Lin, Lin-Qiong Liu, Di Wu, Hui-Ying Liu, Huan Meng, Jia-Xi Xu, Jia-Ning Zhang, Bo-Wen Liu, Yan Gao, Kai Kang, Yang Gao

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Performance of the AmpliSeq NGS panel in thyroid nodules with indeterminate cytology by Wiame Potonnier, Erell Guillerm, Claude Bigorgne, Cécile Ghander, Malanie Roy, Florence Coulet, François Ansart, Fabrice Menegaux, Laurence Leenhardt, Isabelle Brocheriou, Gabrielle Deniziaut, Camille Buffet

“…Conclusions: The performances of the AmpliSeq panel are promising; however, the NPV is not sufficient to avoid diagnostic surgery in cytologically indeterminate thyroid nodules.…”
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Sport-related concussion in Brazilian professional soccer: A four-year prospective epidemiological analysis by Guilherme Corrêa de Araújo Moury Fernandes, Ewerton Borges de Souza Lima, Paulo Henrique Schmidt Lara, Ana Camila de Castro Gandolfi, Jorge Roberto Pagura, Gustavo Gonçalves Arliani, Moisés Cohen

“…Data related to players (age and position) and injuries (diagnosis, type, body location, laterality, field location, tests performed, need for surgery, time lost in sports, and recurrence) were collected. …”
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Intracranial aneurysm instability prediction model based on 4D-Flow MRI and HR-MRI by Fei Peng, Jiaxiang Xia, Fandong Zhang, Shiyu Lu, Hao Wang, Jiashu Li, Xinmin Liu, Yao Zhong, Jiahuan Guo, Yonghong Duan, Binbin Sui, Chuyang Ye, Yi Ju, Shuai Kang, Yizhou Yu, Xin Feng, Xingquan Zhao, Rui Li, Aihua Liu

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3D synergistic tumor-liver analysis further improves the efficacy prediction in hepatocellular carcinoma: a multi-center study by Yurong Jiang, Jiawei Zhang, Zhaochen Liu, Jinxiong Zhang, Xiangrong Yu, Danyan Lin, Dandan Dong, Mingyue Cai, Chongyang Duan, Shuyi Liu, Wenhui Wang, Yuan Chen, Qiyang Li, Weiguo Xu, Meiyan Huang, Sirui Fu

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Evaluation of the potential value of artificial intelligence (AI) in public health using fluoride intake as the example by Wei Wei, Tianshu Gu, Yanhong Cao, Shuqiu Sun, Dan Wei, Minghui Li, Alyce D. Fly, Weikuan Gu, Lan Yao, Dianjun Sun

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Study Protocol of the Korean EGFR Registry: A Multicenter Prospective and Retrospective Cohort Study in Nonsmall Cell Lung Cancer Patients With EGFR Mutation by Chang Dong Yeo, Dong Won Park, Seong Hoon Yoon, Eun Young Kim, Jeong Eun Lee, Shin Yup Lee, Chang‐Min Choi, In‐Jae Oh, Do Jin Kim, Jeong Seon Ryu, Jae Cheol Lee, Young‐Chul Kim, Tae Won Jang, Kye Young Lee, Seung Hun Jang, Seung Joon Kim, for the Korean EGFR Registry Investigators

“…The primary endpoint is disease‐free survival in patients who have undergone radical therapy (surgery and radiotherapy) or progression‐free survival in those receiving targeted therapy (first, second, and subsequent lines), chemotherapy (first and subsequent lines), combination therapy, and palliative/maintenance therapy according to stages of EGFR‐mutated NSCLC. …”
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