Clinically relevant orthotopic pancreatic cancer models for adoptive T cell transfer therapy by Gregory B. Lesinski, Chrystal M. Paulos, Maggie Phillips, Jacklyn Hammons, Isaac Karpovsky, Zaid Mahdi, Natalie K. Horvat, Megan M. Wyatt, Margaret A. Hall, Cameron J. Herting, Richard A. Moffitt

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The Relationship between Homocysteine Levels, MTHFR C677T and A1298C Polymorphism, and Pregnancy Outcomes in Georgian Women with Polycystic Ovary Syndrome: A Case-Control Study by Elene Asanidze, Zurab R. Tsetskhladze, Jenaro Kristesashvili, Marina Pirtskhalava, Manana Urjumelashvili, Shorena Tchiokadze, Malkhaz Vakhania, Nino Parunashvili, Aleksandre Asanidze

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Clinical analysis of molecular typing of 146 cases of endometrial carcinoma by Bo Zhang, Bo Zhang, Dan Zhou, Shuo Zhang, Jinbowen Yan, Qingwei Meng, Qiubo Lv

“…However, no significant difference was observed in CA125 levels before surgery among the four TCGA types (p = 0.587). There were significant differences observed among the four TCGA types and pathological types, pathological grades, FIGO stage, lymph node metastasis, and LVSI. …”
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Self-Reported COVID-19 Vaccine Status and Barriers for Pediatric Emergency Patients and Caregivers by Amanda M. Szarzanowicz, Kendra Fabian, Maya Alexandri, Carly A. Robinson, Sonia Singh, Michael Wallace, Michelle D. Penque, Nan Nan, Changxing Ma, Bradford Z. Reynolds, Bethany W. Harvey, Heidi Suffoletto, E. Brooke Lerner

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A novel nomogram to predict all‐cause readmission or death risk in Chinese elderly patients with heart failure by Mengxi Yang, Liyuan Tao, Hui An, Gang Liu, Qiang Tu, Hu Zhang, Li Qin, Zhu Xiao, Yu Wang, Jiaxai Fan, Dongping Feng, Yan Liang, Jingyi Ren

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Blockade of IL-17A/IL-17R Pathway Protected Mice from Sepsis-Associated Encephalopathy by Inhibition of Microglia Activation by Bo Ye, Tianzhu Tao, Andong Zhao, Liyuan Wen, Xiaofei He, Yi Liu, Qiang Fu, Weidong Mi, Jingsheng Lou

“…Cytokine expression and microglia activation in brain tissue were determined at 6 h, 12 h, 24 h, 48 h, and day 7 post surgery. Further, septic mice were intracerebral ventricle- (i.c.v.-) injected with recombinant IL-17A, anti-IL-17A ab, anti-IL-17R ab, or isotype controls to evaluate the potential effects of IL-17A/IL-17R blockade in the prevention of SAE. …”
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Intervening to eliminate the centre-effect variation in home dialysis use: protocol for Inter-CEPt—a sequential mixed-methods study designing an intervention bundle by Sarah Damery, Kerry Allen, Lisa Dikomitis, Harry Hill, David Coyle, Maatla Tshimologo, Mark Lambie, Simon J Davies, Iestyn Williams, James Fotheringham, Louise Phillips-Darby, Ivonne Solis-Trapala

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Anemia in pregnancy: a systematic review and meta-analysis of prevalence, determinants, and health impacts in Egypt by Ahmed Azzam, Heba Khaled, Alrefaey K. Alrefaey, Amar Basil, Sarah Ibrahim, Mohamed S. Elsayed, Muhammad Khattab, Nashwa Nabil, Esraa Abdalwanees, Hala Waheed Abdel Halim

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PD-L1 positive platelets mediate resistance to immune checkpoint inhibitors in patients with colorectal cancer by Jiacheng Li, Jia Liu, Shifeng Yang, Yu Xia, Qingzhe Meng, Biying Sun, Yansong Liu, Bin Zhao, Jiaqi Jin, Hui Xu, Lihong Wang, Pengxia Zhang, Zhuoxin Cheng

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Shen Shuai II recipe improves renal hypoxia to attenuate renal injury in 5/6 renal ablation/infarction rats and effect evaluation using blood oxygenation level-dependent functional... by Yizeng Xu, Fang Lu, Meng Wang, Lingchen Wang, Chaoyang Ye, Shuohui Yang, Chen Wang

“…This study aimed to explore the effect of SSR on renal hypoxia and injury in CKD rats.Methods Twenty-five Wistar rats underwent 5/6 renal ablation/infarction (A/I) surgery were randomly divided into three groups: 5/6 (A/I), 5/6 (A/I) + losartan (LOS), and 5/6 (A/I) + SSR groups. …”
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Mechanistic investigation and the optimal dose based on baicalin in the treatment of ulcerative colitis–A preclinical systematic review and meta-analysis by Jinchen Chong, Zepeng Chen, Jiaze Ma, Linhai He, Yijia Zhu, Zhihua Lu, Zhengxi Qiu, Chen Chen, Yugen Chen, Feng Jiang

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Implant-Supported Rehabilitation Using GBR Combined with Bone Graft on a Reconstructed Maxilla with the Fibula Free Flap by S. Di Carlo, V. Valentini, E. Grasso, F. De Angelis, L. Piccoli, A. Quarato, S. Jamshir, E. Brauner

“…Alveolar ridge augmentation procedures allow restoring jaw defects due to teeth extractions, periodontal diseases, trauma, or outcomes from a previous surgery. This case report describes a patient suffering from Fibrous Dysplasia of the right upper maxilla surgically reconstructed by fibula free flap. …”
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Identification of major trauma using the simplified abbreviated injury scale to estimate the injury severity score: a diagnostic accuracy and validation study by David Eidenbenz, Tobias Gauss, Tobias Zingg, Vincent Darioli, Cécile Vallot, Pierre-Nicolas Carron, Pierre Bouzat, François-Xavier Ageron

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Growth of the prefrontal cortical glioblastoma altered cognitive and emotional behaviors via mediating miRNAs and GABA-A receptor signaling pathways in rats by Sepide Nateghi, Ameneh Rezayof, Fatemeh Kouhkan, Ladan Delphi, Yavar Bagheri Davisaraei, Fatemeh Rostami, Fatemeh Tirgar, Houri Sepehri

“…The implantation of C6 cells into the mPFC induced GBM in this brain region (referred to as the mPFC-GBM) in male Wistar rats via stereotaxic surgery, as confirmed by Magnetic Resonance Imaging (MRI), and Hematoxylin and Eosin (H&E) staining. …”
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Transient Elastography for Significant Liver Fibrosis and Cirrhosis in Chronic Hepatitis B: A Meta-Analysis by Xiaolong Qi, Min An, Tongwei Wu, Deke Jiang, Mengyun Peng, Weidong Wang, Jing Wang, Chunqing Zhang, on behalf of the CHESS Study Group

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GPR137-RAB8A activation promotes ovarian cancer development via the Hedgehog pathway by Chao Tang, Lin Li, Chongying Zhu, Qiang Xu, Zihao An, Shouying Xu, Chao Lin

“…While treatments in clinic includes primary surgery and targeted chemotherapy, curative and survival trends in OC have not significantly improved. …”
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Detection and characterization of multidrug resistant Escherichia coli carrying virulence gene isolated from broilers in Bangladesh by Md. Sirazul Islam, Chandan Nath, F. M. Yasir Hasib, Tahia Ahmed Logno, Md. Helal Uddin, Mohammad Mahmudul Hassan, Sharmin Chowdhury

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A Fetus with Imperforate Anus Developing Pulmonary Hypoplasia Triggered by Transient Urethral Obstruction by Masatake Toshimitsu, Takayuki Iriyama, Seisuke Sayama, Kan Suzuki, Satsuki Kakiuchi, Mari Ichinose, Takahiro Seyama, Kenbun Sone, Keiichi Kumasawa, Takeshi Nagamatsu, Tomoyuki Fujii, Yutaka Osuga

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Significance of Glutathione Peroxidase 1 and Caudal-Related Homeodomain Transcription Factor in Human Gastric Adenocarcinoma by Jing Jing Han, De Rong Xie, Li Li Wang, Ye Qing Liu, Gong Fa Wu, Qing Sun, Yan Xian Chen, Ying Wei, Zhi Quan Huang, Hai Gang Li

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Lateral Extra-Articular Tenodesis as an Adjunct to ACL Reconstruction by Madeline M. McGovern MD, Sercan Yalcin MD, Natalie A. Lowenstein MPH, Jillian L. Mazzocca BA, Elizabeth G. Matzkin MD, Giovanna Medina MD, PhD

“…Remaining subcutaneous tissue and skin are closed in standard fashion based on the order of the surgery. Results: In the STABILITY randomized controlled trial, 2-year outcomes demonstrated a clinically and statistically significant decrease in clinical failure from 40% to 25% and graft rupture rate from 11% to 4% with the addition of LET to ACLR with hamstring autograft. …”
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