AOZORA: long-term safety and joint health in paediatric persons with haemophilia A without factor VIII inhibitors receiving emicizumab – protocol for a multicentre, open-label, pha... by Seitaro Yoshida, Masashi Taki, Hideyuki Takedani, Midori Shima, Keiji Nogami, Azusa Nagao, Haruko Yamaguchi-Suita, Yui Kyogoku, Akira Ishiguro, Kaoru Kitsukawa

Get full text

Diagnostic and Management Pathways for Pulmonary Carcinoid Tumours in the United Kingdom: Results from the National Lung Neuroendocrine Tumour Pathway Project by Wasat Mansoor, Stuart Ferguson, Victoria Ross, Denis Talbot

“…Reported frequency of initial follow-up after primary surgery ranged from every 2 months to annual, and total follow-up duration ranged from 2 years to indefinite depending on disease type (TC/AC) and stage. …”
Get full text

Efficacy Of Vocal Cord Medialization by Injection Thyroplasty Using Liquid Paraffin In Relieving Hoarseness Of Voice In Idiopathic And Traumatic Unilateral Vocal Cord Paralysis by Muhammad Saleem, Muhammad Sarim Khan, Ashar Alamgir, Muhammad Hamza Rana, Hafiz Sajjad Hyder, Syeda Jamila Ali

“…Out of patients presenting after 6 months, 11 patients (79%) underwent transcervical phonation surgery. The p-value calculated was <0.05 which is statistically significant. …”
Get full text

Oral phenotype and scoring of vascular Ehlers–Danlos syndrome: a case–control study by Lisa Golmard, Ariane Berdal, François Côme Ferré, Michael Frank, Bruno Gogly, Adrien Naveau, Hafida Chérifi, Joseph Emmerich, Frédérick Gaultier, Xavier Jeunemaitre, Benjamin P J Fournier

“…The authors aimed to check this assumption since bibliographical search related to gingival recession in vEDS proved scarce.Design Prospective case–control study.Setting Dental surgery department in a French tertiary hospital.Participants 17 consecutive patients with genetically proven vEDS, aged 19–55 years, were compared with 46 age- and sex-matched controls.Observations Complete oral examination (clinical and radiological) with standardised assessment of periodontal structure, temporomandibular joint function and dental characteristics were performed. …”
Get full text

Endoscopic ultrasound-guided hepaticogastrostomy and endoscopic retrograde cholangiopancreatography-guided biliary drainage for distal malignant biliary obstruction due to pancreat... by Naminatsu Takahara, Yousuke Nakai, Kensaku Noguchi, Tatsunori Suzuki, Tatsuya Sato, Ryunosuke Hakuta, Kazunaga Ishigaki, Tomotaka Saito, Tsuyoshi Hamada, Mitsuhiro Fujishiro

Get full text

Evaluation of 3D-CRT Radiotherapy Treatment Planning with Radiobiological Effects in Patient-Specific 3D Printed Anthropomorphic Phantom Postmastectomy Breast Cancer Axillary Metas... by Endarko Endarko, Aditya Hariyanto, Siti Aisyah, Nandia Kavilani, Ahmad Syafi&#039;i

“…Introduction: The aim of this study was to evaluate and measure the effectiveness of a particular radiotherapy treatment planning system, namely 3D conformal radiation therapy (3D-CRT), and radiobiological effects in postmastectomy breast cancer axillary lymph metastases using a patient-specific 3D printed anthropomorphic phantom of the right breast after surgery. Material and Methods: The chest wall and axilla were the two treatment targets for 3D-CRT planning techniques. …”
Get full text

How spinal GABAergic circuits modulate cerebral processing of postsurgical pain by Bruno Pradier, Daniel Segelcke, Nathalie Just, Mirjam Augustin, Nina Nagelmann, Cornelius Faber, Esther Pogatzki-Zahn

“…Enhancing spinal GABAergic tone increased functional connectivity (FC) in parts of these subnetworks during mechanical stimulation, but not at rest, highlighting spino-cerebral interactions in pain regulation relevant for mechanical hypersensitivity and potentially the transisition to chronic pain after surgery but likely not for pain at rest. These findings underscore the complex and interconnected nature of brain networks in post-surgical pain processing, and provide insights into potential spinal targets for pharmacological intervention to alleviate post-surgical pain and prevent it's chronification.…”
Get full text

Administration of a Probiotic Mixture Ameliorates Cisplatin-Induced Mucositis and Pica by Regulating 5-HT in Rats by Yuanhang Wu, Jianlin Wu, Zhikun Lin, Qian Wang, Ying Li, Aman Wang, Xiu Shan, Jiwei Liu

Get full text

The Creation of the Arabic Version of the Hyperhidrosis Quality of Life Index (HidroQoL&copy;) with Validation and Cross-Cultural Adaptation by Almuhaideb QA, AbuDujain NM, Alghamdi KM

“…Because of the absence of an Arabic version of the HidroQoL©, this research aimed to create, validate, and adapt the HidroQoL© into Arabic.Patients and Methods: A quantitative, analytical, cross-sectional study was conducted with HH patients followed up in dermatology or thoracic surgery clinics. We assessed the results reliability through internal consistency and reproducibility by assessing test‒retest reliability. …”
Get full text

Improving dexamethasone drug loading and efficacy in treating rheumatoid arthritis via liposome: Focusing on inflammation and molecular mechanisms by Mohammad Yasin Zamanian, Hamidreza Zafari, Maria K. Osminina, Alla A. Skakodub, Raed Fanoukh Aboqader Al‐Aouadi, Maryam Golmohammadi, Nikta Nikbakht, Iman Fatemi

Get full text

Exosomal PVRL4 Promotes Lung Adenocarcinoma Progression by Enhancing the Generation of Myeloid‐Derived Suppressor Cell‐Secreted TGF‐β1 by Yahai Liang, Jinmei Li, Lihua Zhang, Jinling Zhou, Meilian Liu, Xiaoxia Peng, Weizhen Zheng, Zhennan Lai

Get full text

Predicting Outcomes in Esophageal Squamous Cell Carcinoma Using scRNA‐Seq and Bulk RNA‐Seq: A Model Development and Validation Study by Jiaqi Zhang, Shunzhe Song, Yuqing Li, Aixia Gong

“…Patients diagnosed with ESCC after surgery were enrolled for further validation. Results A total of 13 kinds of cell clusters were screened, and the squamous epithelium was identified with the highest score. …”
Get full text

Targeting cryptic allosteric sites of G protein-coupled receptors as a novel strategy for biased drug discovery by Xin Qiao, Xiaolong Li, Mingyang Zhang, Ning Liu, Yanmei Wu, Shaoyong Lu, Ting Chen

Get full text

Clinical Efficacy of Platelet-Rich Plasma in the Treatment of Neurotrophic Corneal Ulcer by Dominika Wróbel-Dudzińska, Jorge Alio, Alejandra Rodriguez, Ewa Suchodoła-Ratajewicz, Ewa Kosior-Jarecka, Beata Rymgayłło-Jankowska, Agnieszka Ćwiklińska-Haszcz, Tomasz Żarnowski

Get full text

Oral nutritional supplements for gastric cancer – the review of current evidence by A. L. Potapov, V. E. Khoronenko, E. V. Gameeva, Zh. V. Khailova, A. D. Dorozhkin, V. Yu. Scoropad

“…The use of this type of medical nutrition in the first 5 days after surgery is safe and does not increase the rate of anastomotic leak. …”
Get full text

ADvAnced PhysioTherapy in MuSculosKeletal Triage: Investigating prognostic factors, healthcare utilisation and clinical outcomes (ADAPT MSK) - a cohort study protocol. [version 2;... by Louise Keating, Fiona Callan, Helen P. French, Sarah Casserley-Feeney

Get full text

The Effect of Diacerein on Type 2 Diabetic Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis by Shizhe Guo, Xianshan Guo, Hongya Zhang, Xuan’e Zhang, Zhen Li

Get full text

Different activation of MAPKs and Akt/GSK3β after preload vs. afterload elevation by Nico Hartmann, Lena Preuß, Belal A. Mohamed, Moritz Schnelle, Andre Renner, Gerd Hasenfuß, Karl Toischer

Get full text

A Case of Mucosal Cancer of the Stomach Treated by Endoscopic Submucosal Dissection after Which Nodal Metastasis Became Evident by Takashi Obana, Naotaka Fujita, Yutaka Noda, Dai Hirasawa, Kei Ito, Toshiki Sugawara, Yoshihiro Harada, Tetsuya Oohira, Hiroshi Honda, Takashi Sawai

Get full text

Prevalence of Prediabetes, Diabetes, and Its Associated Risk Factors among Males in Saudi Arabia: A Population-Based Survey by Khaled K. Aldossari, Abdulrahman Aldiab, Jamaan M. Al-Zahrani, Sameer H. Al-Ghamdi, Mohammed Abdelrazik, Mohammed Ali Batais, Sundas Javad, Shanila Nooruddin, Hira Abdul Razzak, Ashraf El-Metwally

Get full text